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Mutant Animals
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Download or read book Mutant Animals written by Sally Lee and published by Capstone. This book was released on 2014 with total page 33 pages. Available in PDF, EPUB and Kindle. Book excerpt: "Describes various animals that have been genetically altered by scientists"--
Download or read book Mutant Animals written by Sally Lee and published by Capstone. This book was released on 2014 with total page 33 pages. Available in PDF, EPUB and Kindle. Book excerpt: "Describes various animals that have been genetically altered by scientists"--
Book Synopsis Guidelines for the Care and Use of Mammals in Neuroscience and Behavioral Research by : National Research Council
Download or read book Guidelines for the Care and Use of Mammals in Neuroscience and Behavioral Research written by National Research Council and published by National Academies Press. This book was released on 2003-08-22 with total page 223 pages. Available in PDF, EPUB and Kindle. Book excerpt: Expanding on the National Research Council's Guide for the Care and Use of Laboratory Animals, this book deals specifically with mammals in neuroscience and behavioral research laboratories. It offers flexible guidelines for the care of these animals, and guidance on adapting these guidelines to various situations without hindering the research process. Guidelines for the Care and Use of Mammals in Neuroscience and Behavioral Research offers a more in-depth treatment of concerns specific to these disciplines than any previous guide on animal care and use. It treats on such important subjects as: The important role that the researcher and veterinarian play in developing animal protocols. Methods for assessing and ensuring an animal's well-being. General animal-care elements as they apply to neuroscience and behavioral research, and common animal welfare challenges this research can pose. The use of professional judgment and careful interpretation of regulations and guidelines to develop performance standards ensuring animal well-being and high-quality research. Guidelines for the Care and Use of Mammals in Neuroscience and Behavioral Research treats the development and evaluation of animal-use protocols as a decision-making process, not just a decision. To this end, it presents the most current, in-depth information about the best practices for animal care and use, as they pertain to the intricacies of neuroscience and behavioral research.
Book Synopsis Scientific Frontiers in Developmental Toxicology and Risk Assessment by : National Research Council
Download or read book Scientific Frontiers in Developmental Toxicology and Risk Assessment written by National Research Council and published by National Academies Press. This book was released on 2000-12-21 with total page 348 pages. Available in PDF, EPUB and Kindle. Book excerpt: Scientific Frontiers in Developmental Toxicology and Risk Assessment reviews advances made during the last 10-15 years in fields such as developmental biology, molecular biology, and genetics. It describes a novel approach for how these advances might be used in combination with existing methodologies to further the understanding of mechanisms of developmental toxicity, to improve the assessment of chemicals for their ability to cause developmental toxicity, and to improve risk assessment for developmental defects. For example, based on the recent advances, even the smallest, simplest laboratory animals such as the fruit fly, roundworm, and zebrafish might be able to serve as developmental toxicological models for human biological systems. Use of such organisms might allow for rapid and inexpensive testing of large numbers of chemicals for their potential to cause developmental toxicity; presently, there are little or no developmental toxicity data available for the majority of natural and manufactured chemicals in use. This new approach to developmental toxicology and risk assessment will require simultaneous research on several fronts by experts from multiple scientific disciplines, including developmental toxicologists, developmental biologists, geneticists, epidemiologists, and biostatisticians.
Book Synopsis Swaiman's Pediatric Neurology E-Book by : Kenneth F. Swaiman
Download or read book Swaiman's Pediatric Neurology E-Book written by Kenneth F. Swaiman and published by Elsevier Health Sciences. This book was released on 2017-03-16 with total page 2955 pages. Available in PDF, EPUB and Kindle. Book excerpt: Since 1975, Dr. Kenneth Swaiman's classic text has been the reference of choice for authoritative guidance in pediatric neurology, and the 6th Edition continues this tradition of excellence with thorough revisions that bring you fully up to date with all that's new in the field. Five new sections, 62 new chapters, 4 new editors, and a reconfigured format make this a comprehensive and clearly-written resource for the experienced clinician as well as the physician-in-training. - Nearly 3,000 line drawings, photographs, tables, and boxes highlight the text, clarify key concepts, and make it easy to find information quickly.
Book Synopsis Liver Growth and Repair by : A. Strain
Download or read book Liver Growth and Repair written by A. Strain and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 681 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nelson Fausto The Greek myth of Prometheus with its picture of a vulture feasting on its chained victimhas traditionallyprovided a visualimageofliverregeneration. Itis apowerful and frightening representationbut ifone were to substitute the vulture by a surgeon and Prometheus by a patient laying on a properly prepared operating table, the outcomeoftheprocedurewould not differ significantlyfrom that describedbyGreek poets. Yet few of us who work in the field have stopped long enough to ask where this myth originated. Did the poet observe a case of liver regeneration in a human being? Was it brilliant intuition or perhaps, literally, just a 'gut feeling' of a poet looking for good rhymes that led to the prediction that livers grow when part of the tissueisremoved? Thisbookdoesnotattemptto solve these historical issues. Itdoes, instead, cover in detail some of the major modem themes of research on liver regen eration, injury and repair. As indicated in Dr. N. Bucher's chapter, the modem phase ofexperimental studies on liver regeneration started in 1931 with the publication by Higgins and Anderson of a method to perform a two-thirds resection of the liver of a rat. The technique described has 3 remarkable features: 1) it is highly reproducible, resulting in the removal of 68% of the liver, 2) it has minimal if any mortality, and 3) it consists only of blood vessel ligation and does not involve cutting through or wounding hepatic tissue.
Book Synopsis Arrhythmogenic RV Cardiomyopathy/Dysplasia by : Frank I. Marcus
Download or read book Arrhythmogenic RV Cardiomyopathy/Dysplasia written by Frank I. Marcus and published by Springer Science & Business Media. This book was released on 2007-11-05 with total page 221 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book covers all aspects (biological, pathological, genetic, clinical and therapeutical) of arrhythmogenic right ventricular cardiomyopathy/dysplasia, a recent cardiomyopathy which represents a very high risk of sudden death in the young and in the athletes. This monograph gathers the results of a five-year research program on ARVC/D which allowed the discovery of 5 disease-causing genes, thus opening new avenues for the early identification of affected patients.
Book Synopsis Invertebrate Models of Natural and Drug‐Sensitive Reward by : Robert Huber
Download or read book Invertebrate Models of Natural and Drug‐Sensitive Reward written by Robert Huber and published by Frontiers Media SA. This book was released on 2019-10-17 with total page 172 pages. Available in PDF, EPUB and Kindle. Book excerpt: The rewarding properties of drugs depend on their capacity to activate appetitive motivational states. Because the mechanisms underlying natural reward are an important life-sustaining process and strongly conserved throughout metazoan evolution, invertebrate models provide a powerful complement to the mammalian systems traditionally used in addiction research. A wide range of organizational complexity, combined with genetically manipulable, and relatively simple, accessible nervous systems, make invertebrates excellent models in which to explore general addiction principles. These include the role of natural reward systems in learning, the basic biological mechanisms of drug addiction, and the long-term effects of early drug exposure. The contributions to this e-book illustrate the current state of invertebrate addiction research. The chapters show that the reward circuits of invertebrate taxa are surprisingly sensitive to human drugs of abuse. Employing learning paradigms typically used in vertebrate studies (viz., conditioned place preference and operant, self-administration paradigms), invertebrates are shown to exhibit aspects of the addiction cycle from activational effects of common psychostimulants, sensitization with repeated application, to extinction, withdrawal, and reinstatement. This highlights the value of the comparative approach for both exploring conserved mechanisms underlying drug addiction and the utility of invertebrate models in seeking potential solutions.
Book Synopsis Advances in Cancer Research by : George F. Vande Woude
Download or read book Advances in Cancer Research written by George F. Vande Woude and published by Academic Press. This book was released on 2009-10-22 with total page 161 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advances in Cancer Research provides invaluable information on the exciting and fast-moving field of cancer research. Here, once again, outstanding and original reviews are presented on a variety of topics, including nitric oxide-induced apoptosis in tumor cells, detection of minimal residual disease, immunity to oncogenetic human papillomavirus, and modeling prostate cancer in the mouse.
Book Synopsis Whole-Body Regeneration by : Simon Blanchoud
Download or read book Whole-Body Regeneration written by Simon Blanchoud and published by Springer Nature. This book was released on 2022 with total page 673 pages. Available in PDF, EPUB and Kindle. Book excerpt: This Open Access volume provides a comprehensive overview of the latest tools available to scientists to study the many facets of whole-body regeneration (WBR). The chapters in this book are organized into six parts. Part One provides a historical overview on the study of the WBR phenomena focusing on the primary challenges of this research. Parts Two and Three explore a series of non-vertebrate zoological contexts that provide experimental models for WBR, showing how they can be approached with cellular tools. Parts Four, Five, and Six discuss the future advancements of WBR, reporting about the cutting-edge techniques in genetics and omics used to dissect the underlying mechanisms of WBR, and systems biology approaches to reach a synthetic view of WBR. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and thorough, Whole-Body Regeneration: Methods and Protocols is a valuable resource for scientists and researchers who want to learn more about this important and developing field.
Book Synopsis Discoidin Domain Receptors in Health and Disease by : Rafael Fridman
Download or read book Discoidin Domain Receptors in Health and Disease written by Rafael Fridman and published by Springer. This book was released on 2016-08-13 with total page 358 pages. Available in PDF, EPUB and Kindle. Book excerpt: The interactions of cells with their surrounding extracellular matrix (ECM) plays a pivotal role in driving normal cell behavior, from development to tissue differentiation and function. At the cellular level, organ homeostasis depends on a productive communication between cells and ECM, which eventually leads to the normal phenotypic repertoire that characterize each cell type in the organism. A failure to establish these normal interactions and to interpret the cues emanating from the ECM is one of the major causes in abnormal development and the pathogenesis of multiple diseases. To recognize and act upon the biophysical signals that are generated by the cross talk between cells and ECM, the cells developed specific receptors, among them a unique set of receptor tyrosine kinases (RTKs), known as the Discoidin Domain Receptors (DDRs). The DDRs are the only RTKs that specifically bind to and are activated by collagen, a major protein component of the ECM. Hence, the DDRs are part of the signaling networks that translate information from the ECM, and thus they are key regulators of cell-matrix interactions. Under physiological conditions, DDRs control cell and tissue homeostasis by acting on collagen sensors; transducing signals that regulate cell polarity, tissue morphogenesis, cell differentiation, and collagen deposition. DDRs play a key role in diseases that are characterized by dysfunction of the stromal component, which lead to abnormal collagen deposition and the resulting fibrotic response that disrupt normal organ function in disease of the cardiovascular system, lungs and kidneys, just to mention a few. In cancer, DDRs are hijacked by tumor and stromal cells to disrupt normal cell-collagen communication and initiate pro-oncogenic programs. Importantly, several cancer types exhibit DDR mutations, which are thought to alter receptor function, and contribute to cancer progression. Therefore, the strong causative association between altered RTK function and disease it is been translated today in the development of specific tyrosine kinase inhibitors targeting DDRs for various disease conditions. In spite of the accumulating evidence highlighting the importance of DDRs in health and diseases, there is still much to learn about these unique RTKs, as of today there is a lack in the medical literature of a book dedicated solely to DDRs. This is the first comprehensive volume dedicated to DDRs, which will fill a gap in the field and serve those interested in the scientific community to learn more about these important receptors in health and disease.
Book Synopsis Cytoskeletal Mechanisms During Animal Development by :
Download or read book Cytoskeletal Mechanisms During Animal Development written by and published by Academic Press. This book was released on 1996-02-09 with total page 523 pages. Available in PDF, EPUB and Kindle. Book excerpt: The cytoskeleton is central to cell biology and is instrumental in developmental events. Volume 31 is divided into two major sections: nonchordate development and chordate development. Summaries of each section compare evolutionary conservation among organisms.
Book Synopsis Regulation of Synaptic Structure and Function by : Zhiyong Shao
Download or read book Regulation of Synaptic Structure and Function written by Zhiyong Shao and published by Frontiers Media SA. This book was released on 2022-11-18 with total page 252 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Statistics of scientific procedures on living animals by : Great Britain. Home Office
Download or read book Statistics of scientific procedures on living animals written by Great Britain. Home Office and published by The Stationery Office. This book was released on 2004 with total page 104 pages. Available in PDF, EPUB and Kindle. Book excerpt: This annual publication contains data on animal experimentation carried out during 2003, subject to the provisions of the Animals (Scientific Procedures) Act 1986. Under this Act, any scientific procedure carried out on any living vertebrate animal, and one species of octopus, which is likely to cause pain, suffering, distress or lasting harm is a regulated procedure requiring licence authority. The data is structured to comply with EU requirements, although it is far more extensive than required by Europe. In 2003, there were 2.79 million scientific procedures conducted, an increase of 2.2 per cent on the previous year. Most experiments and tests were conducted on mice, rats and other rodents (85 per cent), with the remainder on birds (four per cent) and fish (six per cent). Dogs, cats, horses and non-human primates (usually macaques and marmosets) combined amounted to less than one per cent of procedures. Genetically modified animals were used in 27 per cent of cases, an increase of one per cent on 2002 and 19 per cent on 1995). Non-toxicological procedures accounted for 84 per cent of procedures, with the main areas of use being for immunological studies, pharmaceutical research and development, and cancer research.
Book Synopsis The Origins of Schizophrenia by : Alan S. Brown
Download or read book The Origins of Schizophrenia written by Alan S. Brown and published by Columbia University Press. This book was released on 2011-11-01 with total page 445 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Origins of Schizophrenia synthesizes key findings on a devastating mental disorder that has been increasingly studied over the past decade. Advances in epidemiology, translational neuroscience technology, and molecular and statistical genetics have recast schizophrenia's neurobiological nature, identifying new putative environmental risk factors and candidate susceptibility genes. Providing the latest clinical and neuroscience research developments in a comprehensive volume, this collection by world-renowned investigators answers a pressing need for balanced, thorough information, while pointing to future directions in research and interdisciplinary collaboration. The book, featuring a foreword by Robert Freedman, M.D., thoroughly examines these topics from the vantage points of epidemiologic, clinical, and basic neuroscience approaches, making it an essential resource for researchers in psychiatry, psychology, and neuroscience and for clinical mental health professionals.
Book Synopsis Pediatric Bone by : Francis H. Glorieux
Download or read book Pediatric Bone written by Francis H. Glorieux and published by Academic Press. This book was released on 2011-08-22 with total page 885 pages. Available in PDF, EPUB and Kindle. Book excerpt: The second edition of this classic reference deals exclusively with the biology and diseases of bone as they affect children. Rapid advances have been made in our understanding of the mechanisms and factors controlling the growth and development of bone, and these are discussed in detail in this book. Further, the various diseases of bone that are peculiar to children are highlighted and discussed in the light of our current knowledge with regard to causation, clinical signs and treatment. The book is aimed to provide those clinicians interested in children's diseases and basic scientists with a comprehensive resource covering the various aspects of bone health and disease in children. - Deals exclusively with bone development and diseases of children and each chapter is written by an expert in the field - Fully referenced providing an appendix of usually difficult to find information on the investigation of pediatric bone disease and reference values - Covers both the physiology of bone and mineral homeostasis in children and diseases in one book
Book Synopsis Caenorhabditis Elegans by : Henry F. Epstein
Download or read book Caenorhabditis Elegans written by Henry F. Epstein and published by Academic Press. This book was released on 1995 with total page 687 pages. Available in PDF, EPUB and Kindle. Book excerpt: The first of its kind, this laboratory handbook emphasizes diverse methods and technologies needed to investigate C. elegans, both as an integrated organism and as a model system for research inquiries in cell, developmental, and molecular biology, as well as in genetics and pharmacology. Four primary sections--Genetic and Culture Methods, Neurobiology, Cell and Molecular Biology, and Genomics and Informatics--reflect the cross-disciplinary nature of C. elegans research. Because C. elegans is a simple and malleable organism with a small genome and few cell types, it provides an elegant demonstr.