Author : Konstantinos Mitsakakis
Publisher : LAP Lambert Academic Publishing
ISBN 13 : 9783847304883
Total Pages : 200 pages
Book Rating : 4.3/5 (48 download)
Book Synopsis Multi-Analyte Acoustic Biosensing Platform by : Konstantinos Mitsakakis
Download or read book Multi-Analyte Acoustic Biosensing Platform written by Konstantinos Mitsakakis and published by LAP Lambert Academic Publishing. This book was released on 2012-03 with total page 200 pages. Available in PDF, EPUB and Kindle. Book excerpt: The early, rapid, and reliable diagnosis of a pathological condition is of critical importance for the subsequent treatment of a patient. Molecular diagnostic methods using biomarkers are increasingly advancing due to their non-invasive nature and are greatly benefited by the implementation of microsystems, as minute amounts of sample can be analyzed in a quick, cost-effective and highly sensitive way. Still a challenging feature is multiplexity in analysis: diseases like tumor, cardiovascular, Alzheimer s, are related to not only one but several biomarkers which should all be addressed in a test in order to assess reliably the patient s condition. This work describes an acoustic wave microsystem integrating microfluidics to compartmentalize its surface into discrete domains and achieve multiplicity. The development steps are described from concept to design, fabrication, evaluation, and proof-of-principle through detection of four protein cardiac markers. The sensitivity and reproducibility of the sensing domains, as well as the highly selective capture of the desired biomarkers are very promising for the development of the system into an integrated lab-on-chip diagnostic platform.