Moonlighting Proteins

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Moonlighting Proteins

Author : Brian Henderson
Publisher : John Wiley & Sons
ISBN 13 : 1118951115
Total Pages : 493 pages
Book Rating : 4.1/5 (189 download)

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Book Synopsis Moonlighting Proteins by : Brian Henderson

Download or read book Moonlighting Proteins written by Brian Henderson and published by John Wiley & Sons. This book was released on 2017-04-17 with total page 493 pages. Available in PDF, EPUB and Kindle. Book excerpt: Moonlighting Proteins: Novel Virulence Factors in Bacterial Infections is a complete examination of the ways in which proteins with more than one unique biological action are able to serve as virulence factors in different bacteria. The book explores the pathogenicity of bacterial moonlighting proteins, demonstrating the plasticity of protein evolution as it relates to protein function and to bacterial communication. Highlighting the latest discoveries in the field, it details the approximately 70 known bacterial proteins with a moonlighting function related to a virulence phenomenon. Chapters describe the ways in which each moonlighting protein can function as such for a variety of bacterial pathogens and how individual bacteria can use more than one moonlighting protein as a virulence factor. The cutting-edge research contained here offers important insights into many topics, from bacterial colonization, virulence, and antibiotic resistance, to protein structure and the therapeutic potential of moonlighting proteins. Moonlighting Proteins: Novel Virulence Factors in Bacterial Infections will be of interest to researchers and graduate students in microbiology (specifically bacteriology), immunology, cell and molecular biology, biochemistry, pathology, and protein science.

Protein Moonlighting in Biology and Medicine

Author : Brian Henderson
Publisher : John Wiley & Sons
ISBN 13 : 111895209X
Total Pages : 333 pages
Book Rating : 4.1/5 (189 download)

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Book Synopsis Protein Moonlighting in Biology and Medicine by : Brian Henderson

Download or read book Protein Moonlighting in Biology and Medicine written by Brian Henderson and published by John Wiley & Sons. This book was released on 2016-12-12 with total page 333 pages. Available in PDF, EPUB and Kindle. Book excerpt: The past 25 years has seen the emergence of a wealth of data suggesting that novel biological functions of known proteins play important roles in biology and medicine. This ability of proteins to exhibit more than one unique biological activity is known as protein moonlighting. Moonlighting proteins can exhibit novel biological functions, thus extending the function of the proteome, and are also implicated in the pathology of a growing number of idiopathic and infectious diseases. This book, written by a cell biologist, protein evolutionary biologist and protein bioinformatician, brings together the latest information on the structure, evolution and biological function of the growing numbers of moonlighting proteins that have been identified, and their roles in human health and disease. This information is revealing the enormous importance protein moonlighting plays in the maintenance of human health and in the induction of disease pathology. Protein Moonlighting in Biology and Medicine will be of interest to a general readership in the biological and biomedical research community.

Moonlighting Proteins

Author : Source Wikipedia
Publisher : Booksllc.Net
ISBN 13 : 9781230796376
Total Pages : 40 pages
Book Rating : 4.7/5 (963 download)

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Book Synopsis Moonlighting Proteins by : Source Wikipedia

Download or read book Moonlighting Proteins written by Source Wikipedia and published by Booksllc.Net. This book was released on 2013-09 with total page 40 pages. Available in PDF, EPUB and Kindle. Book excerpt: Please note that the content of this book primarily consists of articles available from Wikipedia or other free sources online. Pages: 38. Chapters: Aconitase, Activating transcription factor 2, Crystallin, Cytochrome c, Dihydrolipoamide dehydrogenase, Enolase, ESCRT, Fructose-bisphosphate aldolase, Galactokinase, Glutamate racemase, GroEL, Hexokinase, HSP60, MAPK1, Phosphofructokinase, Presenilin, Protein moonlighting, Pyruvate carboxylase, STAT3, Thioredoxin. Excerpt: Protein moonlighting (or gene sharing) is a phenomenon by which a protein can perform more than one function. Ancestral moonlighting proteins originally possessed a single function but through evolution, acquired additional functions. Many proteins that moonlight are enzymes; others are receptors, ion channels or chaperones. The most common primary function of moonlighting proteins is enzymatic catalysis, but these enzymes have acquired secondary non-enyzmatic roles. Some examples of functions of moonlighting proteins secondary to catalysis include signal transduction, transcriptional regulation, apoptosis, motility, and structural. Protein moonlighting may occur widely in nature. Protein moonlighting through gene sharing differs from the use of a single gene to generate different protein by alternative RNA splicing, DNA rearrangement, or post-translational processing. It is also different from multifunctionality of the protein, in which the protein has multiple domains, each serving a different function. Protein moonlighting by gene sharing means that a gene may acquire and maintain a second function without gene duplication and without loss of the primary function. Such genes are under two or more entirely different selective constraints. Various techniques have been used to reveal moonlighting functions in proteins. The detection of a protein in unexpected locations within cells, cell types, or tissues may suggest that a protein has a moonlighting function. Furthermore, sequence or structure...

Moonlighting Proteins

Author : Brian Henderson
Publisher : John Wiley & Sons
ISBN 13 : 1118951123
Total Pages : 497 pages
Book Rating : 4.1/5 (189 download)

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Book Synopsis Moonlighting Proteins by : Brian Henderson

Download or read book Moonlighting Proteins written by Brian Henderson and published by John Wiley & Sons. This book was released on 2017-03-14 with total page 497 pages. Available in PDF, EPUB and Kindle. Book excerpt: Moonlighting Proteins: Novel Virulence Factors in Bacterial Infections is a complete examination of the ways in which proteins with more than one unique biological action are able to serve as virulence factors in different bacteria. The book explores the pathogenicity of bacterial moonlighting proteins, demonstrating the plasticity of protein evolution as it relates to protein function and to bacterial communication. Highlighting the latest discoveries in the field, it details the approximately 70 known bacterial proteins with a moonlighting function related to a virulence phenomenon. Chapters describe the ways in which each moonlighting protein can function as such for a variety of bacterial pathogens and how individual bacteria can use more than one moonlighting protein as a virulence factor. The cutting-edge research contained here offers important insights into many topics, from bacterial colonization, virulence, and antibiotic resistance, to protein structure and the therapeutic potential of moonlighting proteins. Moonlighting Proteins: Novel Virulence Factors in Bacterial Infections will be of interest to researchers and graduate students in microbiology (specifically bacteriology), immunology, cell and molecular biology, biochemistry, pathology, and protein science.

Glyceraldehyde-3-Phosphate Dehydrogenase (GAPDH)

Author : Michael A. Sirover
Publisher : Academic Press
ISBN 13 : 0128098988
Total Pages : 326 pages
Book Rating : 4.1/5 (28 download)

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Book Synopsis Glyceraldehyde-3-Phosphate Dehydrogenase (GAPDH) by : Michael A. Sirover

Download or read book Glyceraldehyde-3-Phosphate Dehydrogenase (GAPDH) written by Michael A. Sirover and published by Academic Press. This book was released on 2017-05-22 with total page 326 pages. Available in PDF, EPUB and Kindle. Book excerpt: Glyceraldehyde-3-Phosphate Dehydrogenase (GAPDH): The Quintessential Moonlighting Protein in Normal Cell Function and in Human Disease examines the biochemical protein interactions of the multi-dimensional protein GAPDH, further considering the regulatory mechanisms through which cells control their functional diversity. This protein's diverse activities range from nuclear tRNA export and the maintenance of genomic integrity, to cytoplasmic post-transcriptional control of gene expression and receptor mediated cell signaling, to membrane facilitation of iron metabolism, trafficking and fusion. This book will be of great interest to basic scientists, clinicians and students, including molecular and cell biologists, immunologists, pathologists and clinical researchers who are interested in the biochemistry of GAPDH in health and disease. - Contextualizes how GAPDH is utilized by cells in vivo - Provides detailed insight into GAPDH post-translational modifications, including functional diversity and its subcellular localization - Includes forward-thinking exposition on tough topics, such as the exploration of how GAPDG performs functions, how it decides where it should be present and requisite structural requirements

Biocatalysis

Author : Andreas S. Bommarius
Publisher : John Wiley & Sons
ISBN 13 : 352760605X
Total Pages : 634 pages
Book Rating : 4.5/5 (276 download)

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Book Synopsis Biocatalysis by : Andreas S. Bommarius

Download or read book Biocatalysis written by Andreas S. Bommarius and published by John Wiley & Sons. This book was released on 2007-02-27 with total page 634 pages. Available in PDF, EPUB and Kindle. Book excerpt: The whole range of biocatalysis, from a firm grounding in theoretical concepts to in-depth coverage of practical applications and future perspectives. The book not only covers reactions, products and processes with and from biological catalysts, but also the process of designing and improving such biocatalysts. One unique feature is that the fields of chemistry, biology and bioengineering receive equal attention, thus addressing practitioners and students from all three areas.

Cellular Trafficking of Cell Stress Proteins in Health and Disease

Author : Brian Henderson
Publisher : Springer Science & Business Media
ISBN 13 : 9400747403
Total Pages : 300 pages
Book Rating : 4.4/5 (7 download)

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Book Synopsis Cellular Trafficking of Cell Stress Proteins in Health and Disease by : Brian Henderson

Download or read book Cellular Trafficking of Cell Stress Proteins in Health and Disease written by Brian Henderson and published by Springer Science & Business Media. This book was released on 2012-11-19 with total page 300 pages. Available in PDF, EPUB and Kindle. Book excerpt: Since the beginning of the 21st Century there has been a rapid increase in our understanding of the cellular trafficking mechanisms of molecular chaperones in eukaryotes and in prokaryotes. In the former, molecular chaperone trafficking can occur between the various cellular compartments, with concomitant movement of other proteins. Such events can also result in the release of molecular chaperones from cells. In bacteria, molecular chaperones are involved in the trafficking of other proteins and are themselves released into the external milieu. The increasing appreciation of the role of molecular chaperones and Protein-Folding Catalysts in the interplay between bacteria and the cells of their hosts is now an important area of research for understanding the mechanisms of infectious diseases. This volume brings together experts in the biochemistry, cellular biology, immunology and molecular biology of molecular chaperones and Protein-Folding Catalysts with a focus on the mechanisms of cellular trafficking of these proteins and the role of these variegated trafficking mechanisms in both human and animal health and disease.

Proteomic Profiling and Analytical Chemistry

Author : Pawel Ciborowski
Publisher : Elsevier
ISBN 13 : 0444636900
Total Pages : 300 pages
Book Rating : 4.4/5 (446 download)

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Book Synopsis Proteomic Profiling and Analytical Chemistry by : Pawel Ciborowski

Download or read book Proteomic Profiling and Analytical Chemistry written by Pawel Ciborowski and published by Elsevier. This book was released on 2016-03-02 with total page 300 pages. Available in PDF, EPUB and Kindle. Book excerpt: Proteomic Profiling and Analytical Chemistry: The Crossroads, Second Edition helps scientists without a strong background in analytical chemistry to understand principles of the multistep proteomic experiment necessary for its successful completion. It also helps researchers who do have an analytical chemistry background to break into the proteomics field. Highlighting points of junction between proteomics and analytical chemistry, this resource links experimental design with analytical measurements, data analysis, and quality control. This targeted point of view will help both biologists and chemists to better understand all components of a complex proteomic study. The book provides detailed coverage of experimental aspects such as sample preparation, protein extraction and precipitation, gel electrophoresis, microarrays, dynamics of fluorescent dyes, and more. The key feature of this book is a direct link between multistep proteomic strategy and quality control routinely applied in analytical chemistry. This second edition features a new chapter on SWATH-MS, substantial updates to all chapters, including proteomic database search and analytical quantification, expanded discussion of post-hoc statistical tests, and additional content on validation in proteomics. - Covers the analytical consequences of protein and peptide modifications that may have a profound effect on how and what researchers actually measure - Includes practical examples illustrating the importance of problems in quantitation and validation of biomarkers - Helps in designing and executing proteomic experiments with sound analytics

Heat Shock Protein 90 in Human Diseases and Disorders

Author : Alexzander A. A. Asea
Publisher : Springer Nature
ISBN 13 : 3030231585
Total Pages : 607 pages
Book Rating : 4.0/5 (32 download)

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Book Synopsis Heat Shock Protein 90 in Human Diseases and Disorders by : Alexzander A. A. Asea

Download or read book Heat Shock Protein 90 in Human Diseases and Disorders written by Alexzander A. A. Asea and published by Springer Nature. This book was released on 2019-11-04 with total page 607 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book Heat Shock Protein 90 in Human Diseases and Disorders provides the most comprehensive review on contemporary knowledge on the role of HSP90. Using an integrative approach, the contributors provide a synopsis of novel mechanisms, previously unknown signal transduction pathways. To enhance the ease of reading and comprehension, this book has been subdivided into various section including; Section I, reviews current progress on our understanding Oncogenic Aspects of HSP90; Section II, focuses on Bimolecular Aspects of HSP90; Section III, emphasizes and HSP90 in Natural Products Development and Section IV; give the most up to date reviews on Clinical Aspects of HSP90. Key basic and clinical research laboratories from major universities, academic medical hospitals, biotechnology and pharmaceutical laboratories around the world have contributed chapters that review present research activity and importantly project the field into the future. The book is a must read for starters and professionals in the fields of Translational Medicine, Clinical Research, Human Physiology, Biotechnology, Natural Products, Cell & Molecular Medicine, Pharmaceutical Scientists and Researchers involved in Drug Discovery.

How Proteins Work

Author : Michael Williamson
Publisher : Garland Science
ISBN 13 : 1136665498
Total Pages : 464 pages
Book Rating : 4.1/5 (366 download)

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Book Synopsis How Proteins Work by : Michael Williamson

Download or read book How Proteins Work written by Michael Williamson and published by Garland Science. This book was released on 2012-03-26 with total page 464 pages. Available in PDF, EPUB and Kindle. Book excerpt: High-throughputomics' projects such as genome sequencing, structural genomics and proteomics mean that there is no shortage of information on proteins. But the more information we have, the harder it is to make sense of it, to know where to start, and to identify the important results. This book is a clear, up to date and authoritative account of

Molecular Chaperones and Cell Signalling

Author : Brian Henderson
Publisher : Cambridge University Press
ISBN 13 : 1139444018
Total Pages : 366 pages
Book Rating : 4.1/5 (394 download)

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Book Synopsis Molecular Chaperones and Cell Signalling by : Brian Henderson

Download or read book Molecular Chaperones and Cell Signalling written by Brian Henderson and published by Cambridge University Press. This book was released on 2005-07-18 with total page 366 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book reviews understanding of the biological roles of extracellular molecular chaperones. It provides an overview of the structure and function of molecular chaperones, their role in the cellular response to stress and their disposition within the cell. It also questions the basic paradigm of molecular chaperone biology - that these proteins are first and foremost protein-folding molecules. Paradigms of protein secretion are reviewed and the evolving concept of proteins (such as molecular chaperones) as multi-functional molecules for which the term 'moonlighting proteins' has been introduced is discussed. The role of exogenous molecular chaperones as cell regulators is examined and the physiological and pathophysiological role that molecular chaperones play is described. In the final section, the potential therapeutic use of molecular chaperones is described and the final chapter asks the question - what does the future hold for the extracellular biology of molecular chaperones?

Molecular Evolution of the Moonlighting Protein Intelectin in Animal Species

Author : Anthony Izzo
Publisher :
ISBN 13 :
Total Pages : 32 pages
Book Rating : 4.:/5 (967 download)

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Book Synopsis Molecular Evolution of the Moonlighting Protein Intelectin in Animal Species by : Anthony Izzo

Download or read book Molecular Evolution of the Moonlighting Protein Intelectin in Animal Species written by Anthony Izzo and published by . This book was released on 2015 with total page 32 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Between Pathogenicity and Commensalism

Author : Ulrich Dobrindt
Publisher : Springer Science & Business Media
ISBN 13 : 3642365604
Total Pages : 360 pages
Book Rating : 4.6/5 (423 download)

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Book Synopsis Between Pathogenicity and Commensalism by : Ulrich Dobrindt

Download or read book Between Pathogenicity and Commensalism written by Ulrich Dobrindt and published by Springer Science & Business Media. This book was released on 2014-07-08 with total page 360 pages. Available in PDF, EPUB and Kindle. Book excerpt: This comprehensive, interdisciplinary book covers different aspects of relevant human pathogens and commensals. The ongoing development of (meta-)genomic, transcriptomic, proteomic and bioinformatic analyses of pathogenic and commensal microorganisms and their host interaction provides a comprehensive introduction to the microbiological analysis of host-microbe interplay and its consequences for infection or commensalism.

Machine learning for biological sequence analysis

Author : Quan Zou
Publisher : Frontiers Media SA
ISBN 13 : 2832516017
Total Pages : 150 pages
Book Rating : 4.8/5 (325 download)

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Book Synopsis Machine learning for biological sequence analysis by : Quan Zou

Download or read book Machine learning for biological sequence analysis written by Quan Zou and published by Frontiers Media SA. This book was released on 2023-03-09 with total page 150 pages. Available in PDF, EPUB and Kindle. Book excerpt:

From Protein Structure to Function with Bioinformatics

Author : Daniel J. Rigden
Publisher : Springer
ISBN 13 : 9402410694
Total Pages : 509 pages
Book Rating : 4.4/5 (24 download)

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Book Synopsis From Protein Structure to Function with Bioinformatics by : Daniel J. Rigden

Download or read book From Protein Structure to Function with Bioinformatics written by Daniel J. Rigden and published by Springer. This book was released on 2017-04-06 with total page 509 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is about protein structural bioinformatics and how it can help understand and predict protein function. It covers structure-based methods that can assign and explain protein function based on overall folds, characteristics of protein surfaces, occurrence of small 3D motifs, protein-protein interactions and on dynamic properties. Such methods help extract maximum value from new experimental structures, but can often be applied to protein models. The book also, therefore, provides comprehensive coverage of methods for predicting or inferring protein structure, covering all structural classes from globular proteins and their membrane-resident counterparts to amyloid structures and intrinsically disordered proteins. The book is split into two broad sections, the first covering methods to generate or infer protein structure, the second dealing with structure-based function annotation. Each chapter is written by world experts in the field. The first section covers methods ranging from traditional homology modelling and fold recognition to fragment-based ab initio methods, and includes a chapter, new for the second edition, on structure prediction using evolutionary covariance. Membrane proteins and intrinsically disordered proteins are each assigned chapters, while two new chapters deal with amyloid structures and means to predict modes of protein-protein interaction. The second section includes chapters covering functional diversity within protein folds and means to assign function based on surface properties and recurring motifs. Further chapters cover the key roles of protein dynamics in protein function and use of automated servers for function inference. The book concludes with two chapters covering case studies of structure prediction, based respectively on crystal structures and protein models, providing numerous examples of real-world usage of the methods mentioned previously. This book is targeted at postgraduate students and academic researchers. It is most obviously of interest to protein bioinformaticians and structural biologists, but should also serve as a guide to biologists more broadly by highlighting the insights that structural bioinformatics can provide into proteins of their interest.

Applications of Advanced Omics Technologies: From Genes to Metabolites

Author :
Publisher : Elsevier
ISBN 13 : 0444626697
Total Pages : 497 pages
Book Rating : 4.4/5 (446 download)

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Book Synopsis Applications of Advanced Omics Technologies: From Genes to Metabolites by :

Download or read book Applications of Advanced Omics Technologies: From Genes to Metabolites written by and published by Elsevier. This book was released on 2014-05-08 with total page 497 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book contains contributions concerning the application of the new instrumental and methodological developments in omics technologies, including those related to Genomics, Transcriptomics, Proteomics, Peptidomics and Metabolomics, Lipidomics and Foodomics. The16 chapters discuss in detail: innovative applications of functional gene microarrays for profiling microbial communities, microRNA profiling, novel genotyping applications using microarray technology in cancer research, next-generation sequencing applied to the study of human microbiome, emerging RNA-SEQ applications in food science, recent progress in plant proteomics, applications of gel-free proteomic approaches, the challenges and applications of proteomics tools for food authenticity, the role of salivary peptidomics in clinical applications, metabolomic approaches to the study of degenerative, cardiovascular and renal diseases, and neonatal medicine. Also covered are other omics applications such as profiling of genetically modified organisms, the fundamentals, applications and challenges of foodomics, and MS-based lipidomics. Moreover, this volume includes relevant and updated aspects on bioinformatics, data treatment, data integration and systems biology. This book complements the previous volume "Fundamentals of Advanced Omics Technologies: New Advances from Genes to Metabolites" that covered the fundamental aspects of these new omics technologies. - Describes the latest applications of omics technologies - Provides an excellent reference for applications of advanced omics techniques - Includes advanced tools and methodologies for dealing with the data generated

Structure and Intrinsic Disorder in Enzymology

Author : Munishwar Nath Gupta
Publisher : Elsevier
ISBN 13 : 0323995349
Total Pages : 529 pages
Book Rating : 4.3/5 (239 download)

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Book Synopsis Structure and Intrinsic Disorder in Enzymology by : Munishwar Nath Gupta

Download or read book Structure and Intrinsic Disorder in Enzymology written by Munishwar Nath Gupta and published by Elsevier. This book was released on 2022-11-17 with total page 529 pages. Available in PDF, EPUB and Kindle. Book excerpt: Structure and Intrinsic Disorder in Enzymology offers a direct, yet comprehensive presentation of the fundamental concepts, characteristics and functions of intrinsically disordered enzymes, along with valuable notes and technical insights powering new research in this emerging field. Here, more than twenty international experts examine protein flexibility and cryo-enzymology, hierarchies of intrinsic disorder, methods for measurement of disorder in proteins, bioinformatics tools for predictions of structure, disorder and function, protein promiscuity, protein moonlighting, globular enzymes, intrinsic disorder and allosteric regulation, protein crowding, intrinsic disorder in post-translational, and much more. Chapters also review methods for study, as well as evolving technology to support new research across academic, industrial and pharmaceutical labs. - Unifies the roles of intrinsic disorder and structure in the functioning of enzymes and proteins - Examines a range of enzyme and protein characteristics, their relationship to intrinsic disorder, and methods for study - Features chapter contributions from international leaders in the field