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Monte Carlo Simulation Of Medical Linear Accelerators In Radiotherapy
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Book Synopsis Monte Carlo Simulation of Medical Linear Accelerators in Radiotherapy by : Andy Ma
Download or read book Monte Carlo Simulation of Medical Linear Accelerators in Radiotherapy written by Andy Ma and published by LAP Lambert Academic Publishing. This book was released on 2010-04 with total page 232 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cancer is the number two killer after cardiovascular diseases and radiotherapy is beneficial to about half of the cancer patients. In radiotherapy, medical linear accelerators (linac) are frequently used to deliver high-energy x-ray beams to treat the tumour site with minimal damage to the nearby healthy tissues. Monte Carlo simulations offer accurate calculation of the radiation dose for treatment planning by tracking millions of randomly sampled x-ray photons from their generation to their absorption in the patient. Due to its time-consuming nature, a Monte Carlo simulation is carried out in steps. The data set about the photons emerging from the first, patient-independent step is a phase space. Phase space modeling allows fast generation and easy manipulation of those photons that will be transported through the second, patient-specific part of the simulation. This book examines some existing models and introduces a new one - the directional spectrum model (DSM). DSM excels in the dose calculations both inside and outside the x-ray field. The out-of-field dose calculation is important because it is where the healthy tissues are and it is where we need to minimise the damage.
Book Synopsis Automation of the Monte Carlo Simulation of Medical Linear Accelerators by : Miguel Lázaro Rodríguez Castillo
Download or read book Automation of the Monte Carlo Simulation of Medical Linear Accelerators written by Miguel Lázaro Rodríguez Castillo and published by . This book was released on 2016 with total page 219 pages. Available in PDF, EPUB and Kindle. Book excerpt: The main result of this thesis is a software system, called PRIMO, which simulates clinical linear accelerators and the subsequent dose distributions using the Monte Carlo method. PRIMO has the following features: (i) it is self- contained, that is, it does not require additional software libraries or coding; (ii) it includes a geometry library with most Varian and Elekta linacs; (iii) it is based on the general-purpose Monte Carlo code PENELOPE; (iv) it provides a suite of variance-reduction techniques and distributed parallel computing to enhance the simulation efficiency; (v) it is graphical user interfaced; and (vi) it is freely distributed through the website http://www.primoproject.net In order to endow PRIMO with these features the following tasks were conducted: - PRIMO was conceived with a layered structure. The topmost layer, named the GLASS, was developed in this thesis. The GLASS implements the GUI, drives all the functions of the system and performs the analysis of results. Lower layers generate geometry files, provide input data and execute the Monte Carlo simulation. - The geometry of Elekta linacs from series SU and MLCi were coded in the PRIMO system. - A geometrical model of the Varian True Beam linear accelerator was developed and validated. This model was created to surmount the limitations of the Varian distributed phase-space files and the absence of released information about the actual geometry of that machine. This geometry model was incorporated into PRIMO. - Two new variance-reduction techniques, named splitting roulette and selective splitting, were developed and validated. In a test made with an Elekta linac it was found that when both techniques are used in conjunction the simulation efficiency improves by a factor of up to 45. - A method to automatically distribute the simulation among the available CPU cores of a computer was implemented. The following investigations were done using PRIMO as a research tool : - The configu ration of the condensed history transport algorithm for charged particles in PENELOPE was optimized for linac simulation. Dose distributions in the patient were found to be particularly sensitive to the values of the transport parameters in the linac target. Use of inadequate values of these parameters may lead to an incorrect determination of the initial beam configuration or to biased dose distributions. - PRIMO was used to simulate phase-space files distributed by Varian for the True Beam linac. The results were compared with experimental data provided by five European radiotherapycenters. It was concluded thatthe latent variance and the accuracy of the phase-space files were adequate for the routine clinical practice. However, for research purposes where low statistical uncertainties are required the phase-space files are not large enough. To the best of our knowledge PRIMO is the only fully Monte Carlo-based linac and dose simulation system , addressed to research and dose verification, that does not require coding tasks from end users and is publicly available.
Book Synopsis Monte Carlo Methods for Radiation Transport by : Oleg N. Vassiliev
Download or read book Monte Carlo Methods for Radiation Transport written by Oleg N. Vassiliev and published by Springer. This book was released on 2016-10-17 with total page 292 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is a guide to the use of Monte Carlo techniques in radiation transport. This topic is of great interest for medical physicists. Praised as a "gold standard" for accurate radiotherapy dose calculations, Monte Carlo has stimulated a high level of research activity that has produced thousands of papers within the past few years. The book is designed primarily to address the needs of an academically inclined medical physicist who wishes to learn the technique, as well as experienced users of standard Monte Carlo codes who wish to gain insight into the underlying mathematics of Monte Carlo algorithms. The book focuses on the fundamentals—giving full attention to and explaining the very basic concepts. It also includes advanced topics and covers recent advances such as transport of charged particles in magnetic fields and the grid-based solvers of the Boltzmann equation.
Book Synopsis Measurement and Monte Carlo Simulation of Electron Fields for Modulated Electron Radiation Therapy by : Samantha A. M. Lloyd
Download or read book Measurement and Monte Carlo Simulation of Electron Fields for Modulated Electron Radiation Therapy written by Samantha A. M. Lloyd and published by . This book was released on 2017 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: This work establishes a framework for Monte Carlo simulations of complex, modulated electron fields produced by Varian's TrueBeam medical linear accelerator for investigations into modulated electron radiation therapy (MERT) and combined modulated photon and electron radiation therapy (MPERT). Both MERT and MPERT have shown potential for reduced low dose to normal tissue without compromising target coverage in the external beam radiation therapy of some breast, chest wall, head and neck, and scalp cancers. This reduction in low dose could translate into the reduction of immediate radiation side effects as well as long term morbidities and incidence of secondary cancers.Monte Carlo dose calculations are widely accepted as the gold standard for complex radiation therapy dose modelling, and are used almost exclusively for modelling the complex electron fields involved in MERT and MPERT. The introduction of Varian's newest linear accelerator, the TrueBeam, necessitated the development of new Monte Carlo models in order to further research into the potential role of MERT and MPERT in radiation therapy. This was complicated by the fact that the field independent internal schematics of TrueBeam were kept proprietary, unlike in previous generations of Varian accelerators.Two approaches are presented for performing Monte Carlo simulations of complex electron fields produced by TrueBeam. In the first approach, the dosimetric characteristics of electron fields produced by the TrueBeam were first compared with those produced by an older Varian accelerator, the Clinac 21EX. Differences in depth and profile characteristics of fields produced by the TrueBeam and those produced by the Clianc 21EX were found to be within 3%/3 mm. Given this information, complete accelerator models of the Clinac 21EX, based on its known internal geometry, were then successfully modified in order to simulate 12 and 20 MeV electron fields produced by the TrueBeam to within 2%/2 mm of measured depth and profile curves and to within 3.7% of measured relative output. While the 6 MeV TrueBeam model agreed with measured depth and profile data to within 3%/3 mm, the modified Clinac 21EX model was unable to reproduce trends in relative output as a function of fieldsize with acceptable accuracy.The second approach to modelling TrueBeam electron fields used phase-space source files provided by Varian that were scored below the field-independent portions of the accelerator head geometry. These phase-spaces were first validated for use in MERT and MPERT applications, in which simulations using the phase-space source files were shown to model depth dose curves that agreed with measurement within 2%/2 mm and profile curves that agreed with measurement within 3%/3 mm. Simulated changes in output as a function of field size fell within 2.7%, for the most part.In order to inform the positioning of jaws in MLC-shaped electron field delivery, the change in output as a function of jaw position for fixed MLC-apertures was investigated using the phase-space source files. In order to achieve maximum output and minimize treatment time, a jaw setting between 5 and 10 cm beyond the MLC- field setting is recommended at 6 MeV, while 5 cm or closer is recommended for 12 and 20 MeV with the caveat that output is most sensitive to jaw position when the jaws are very close to the MLC-field periphery. Additionally, output was found to be highly sensitive to jaw model. A change in divergence of the jaw faces from a point on the source plane to a 3x3 mm^2 square in the source plane changed the shape of the output curve dramatically.Finally, electron backscatter from the jaws into the monitor ionization chamber of the TrueBeam was measured and simulated to enable accurate absolute dose calculations. Two approaches were presented for measuring backscatter into the monitor ionization chamber without specialized electronics by turning o the dose and pulse forming network servos. Next, a technique was applied for simulating backscatter factors for the TrueBeam phase-space source models without the exact specifications of the monitor ionization chamber. By using measured backscatter factors, the forwarddose component in a virtual chamber was determined and then used to calculate backscatter factors for arbitrary fields to within 0.21%. Backscatter from the jaws was found to contribute up to 2.6% of the overall monitor chamber signal. The measurement techniques employed were not sensitive enough to quantify backscatter from the MLC, however, Monte Carlo simulations predicted this contribution to be 0.3%, at most, verifying that this component can be neglected.
Book Synopsis Measurements of Photon and Neutron Leakage from Medical Linear Accelerators and Monte Carlo Simulation of Tenth Value Layers of Concrete Used for Intensity Modulated Radiation Therapy Treatment by : Adnan K. Jaradat
Download or read book Measurements of Photon and Neutron Leakage from Medical Linear Accelerators and Monte Carlo Simulation of Tenth Value Layers of Concrete Used for Intensity Modulated Radiation Therapy Treatment written by Adnan K. Jaradat and published by . This book was released on 2005 with total page 216 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Advanced Monte Carlo for Radiation Physics, Particle Transport Simulation and Applications by : Andreas Kling
Download or read book Advanced Monte Carlo for Radiation Physics, Particle Transport Simulation and Applications written by Andreas Kling and published by Springer Science & Business Media. This book was released on 2014-02-22 with total page 1200 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book focuses on the state of the art of Monte Carlo methods in radiation physics and particle transport simulation and applications. Special attention is paid to algorithm development for modeling, and the analysis of experiments and measurements in a variety of fields.
Book Synopsis Monte Carlo Study of Photon Beams from Medical Linear Accelerators, Optimization, Benchmark and Spectra by :
Download or read book Monte Carlo Study of Photon Beams from Medical Linear Accelerators, Optimization, Benchmark and Spectra written by and published by . This book was released on 1999 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Monte Carlo Techniques in Radiation Therapy by : Frank Verhaegen
Download or read book Monte Carlo Techniques in Radiation Therapy written by Frank Verhaegen and published by CRC Press. This book was released on 2021-11-29 with total page 291 pages. Available in PDF, EPUB and Kindle. Book excerpt: About ten years after the first edition comes this second edition of Monte Carlo Techniques in Radiation Therapy: Introduction, Source Modelling, and Patient Dose Calculations, thoroughly updated and extended with the latest topics, edited by Frank Verhaegen and Joao Seco. This book aims to provide a brief introduction to the history and basics of Monte Carlo simulation, but again has a strong focus on applications in radiotherapy. Since the first edition, Monte Carlo simulation has found many new applications, which are included in detail. The applications sections in this book cover the following: Modelling transport of photons, electrons, protons, and ions Modelling radiation sources for external beam radiotherapy Modelling radiation sources for brachytherapy Design of radiation sources Modelling dynamic beam delivery Patient dose calculations in external beam radiotherapy Patient dose calculations in brachytherapy Use of artificial intelligence in Monte Carlo simulations This book is intended for both students and professionals, both novice and experienced, in medical radiotherapy physics. It combines overviews of development, methods, and references to facilitate Monte Carlo studies.
Book Synopsis Monte Carlo in Heavy Charged Particle Therapy by : Pablo Cirrone
Download or read book Monte Carlo in Heavy Charged Particle Therapy written by Pablo Cirrone and published by CRC Press. This book was released on 2023-11-08 with total page 528 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book explores the current difficulties and unsolved problems in the field of particle therapy and, after analysing them, discusses how (and if) innovative Monte Carlo approaches can be used to solve them. Each book chapter is dedicated to a different sub-discipline, including multi-ion treatments, flash-radiotherapy, laser-accelerated beams, nanoparticles effects, binary reactions to enhance radiobiology, and space-related issues. This is the first book able to provide a comprehensive insight into this exciting field and the growing use of Monte Carlo in medical physics. It will be of interest to graduate students in medicine and medical physics, in addition to researchers and clinical staff. Key Features: Explores the exciting and interdisciplinary topic of Monte Carlo in particle therapy and medicine. Addresses common challenges in the field. Edited by an authority on the subject, with chapter contributions from specialists. Pablo Cirrone is a medical physicist and researcher at the Laboratori Nazionali del Sud of INFN, Italy, where he supports and coordinates various experimental groups. Dr. Cirrone is an expert in the use of proton and ion in radiation treatment and of absolute and relative dosimetry in electron, photon and ion beam. He is an expert in the development and test of detectors for medical applications, of the production and use of laser-driven beams for medical and multidisciplinary applications and recipient of the Michael Gotein Award. He is active on many scientific committees and organizes national and international conferences. Giada Petringa is a researcher at the Laboratori Nazionali del Sud of INFN, Italy. Dr. Petringa has a professional experience in the field of Monte Carlo simulations for medical applications, dosimetry, microdosimetry, and diagnostics with conventional and laser-driven proton beams. In 2019 she had a MSCA-IF-2019 (Marie Sklodowska-Curie Actions-Individual Fellowship) grant funded by the European Community in the framework of the H2020 program. She is a member of the Editorial Board of the international journal Physica Medica - European Journal of Medical. She organized more than fifteen international Geant4 Schools. She is an official member of the Geant4 code Collaboration at CERN since 2019. She is a code developer, and she collaborates to maintain two of the official examples of the code.
Book Synopsis Medical Electron Accelerators by : C. J. Karzmark
Download or read book Medical Electron Accelerators written by C. J. Karzmark and published by McGraw-Hill Companies Health Professions Division. This book was released on 1993 with total page 342 pages. Available in PDF, EPUB and Kindle. Book excerpt: Organized to serve as a ready reference, this book covers the design & principles of operation of microwave electron linear accelerators for the radiation treatment of cancer. Designed for use by persons without extensive knowledge & experience of accelerator technology, the book assumes a knowledge of elementary physics & mathematics & places its emphasis on how accelerators actually function & how they are used in cancer treatment. Coverage includes the history of development & application, general theory of acceleration, accelerator systems, radiation beam systems & associated equipment, performance characteristics, testing & use. The major modules of a representative medical accelerator are described, including principles of operation & how these models function collectively to produce electron & X-ray beams for radiotherapy.
Book Synopsis Application of Monte Carlo Simulations to the Development of Energy- and Intensity-modulated Electron Beam Radiation Therapy by : Michael C. Lee
Download or read book Application of Monte Carlo Simulations to the Development of Energy- and Intensity-modulated Electron Beam Radiation Therapy written by Michael C. Lee and published by . This book was released on 2002 with total page 276 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis A Primer on Theory and Operation of Linear Accelerators in Radiation Therapy by : C. J. Karzmark
Download or read book A Primer on Theory and Operation of Linear Accelerators in Radiation Therapy written by C. J. Karzmark and published by . This book was released on 2018-02-28 with total page 56 pages. Available in PDF, EPUB and Kindle. Book excerpt: By the mid-1950s, a linear accelerator suitable for treating deep-seated tumors was built in the Stanford Microwave Laboratory and installed at Stanford Hospital. It served as a prototype for commercial units that were built later. Since that time, medical linear accelerators gained in popularity as major radiation therapy devices, but few basic training materials on their operation had been produced for use by medical professionals. C.J. Karzmark, a radiological physicist at Stanford University, was involved with medical linacs since their development, and he agreed to collaborate with Robert Morton of the Center for Devices and Radiological Health (formerly the Bureau of Radiological Health), U.S. Food and Drug Administration, in writing the first edition of this primer.
Book Synopsis Therapeutic Applications of Monte Carlo Calculations in Nuclear Medicine by : H. Zaidi
Download or read book Therapeutic Applications of Monte Carlo Calculations in Nuclear Medicine written by H. Zaidi and published by CRC Press. This book was released on 2002-09-01 with total page 441 pages. Available in PDF, EPUB and Kindle. Book excerpt: Therapeutic Applications of Monte Carlo Calculations in Nuclear Medicine examines the applications of Monte Carlo (MC) calculations in therapeutic nuclear medicine, from basic principles to computer implementations of software packages and their applications in radiation dosimetry and treatment planning. With chapters written by recognized authorit
Book Synopsis Investigation of Radiation Protection Methodologies for Radiation Therapy Shielding Using Monte Carlo Simulation and Measurement by : Sean Tanny
Download or read book Investigation of Radiation Protection Methodologies for Radiation Therapy Shielding Using Monte Carlo Simulation and Measurement written by Sean Tanny and published by . This book was released on 2015 with total page 128 pages. Available in PDF, EPUB and Kindle. Book excerpt: The advent of high-energy linear accelerators for dedicated medical use in the 1950's by Henry Kaplan and the Stanford University physics department began a revolution in radiation oncology. Today, linear accelerators are the standard of care for modern radiation therapy and can generate high-energy beams that can produce tens of Gy per minute at isocenter. This creates a need for a large amount of shielding material to properly protect members of the public and hospital staff. Standardized vault designs and guidance on shielding properties of various materials are provided by the National Council on Radiation Protection (NCRP) Report 151. However, physicists are seeking ways to minimize the footprint and volume of shielding material needed which leads to the use of non-standard vault configurations and less-studied materials, such as high-density concrete. The University of Toledo Dana Cancer Center has utilized both of these methods to minimize the cost and spatial footprint of the requisite radiation shielding. To ensure a safe work environment, computer simulations were performed to verify the attenuation properties and shielding workloads produced by a variety of situations where standard recommendations and guidance documents were insufficient. This project studies two areas of concern that are not addressed by NCRP 151, the radiation shielding workload for the vault door with a non-standard design, and the attenuation properties of high-density concrete for both photon and neutron radiation. Simulations have been performed using a Monte-Carlo code produced by the Los Alamos National Lab (LANL), Monte Carlo Neutrons, Photons 5 (MCNP5). Measurements have been performed using a shielding test port designed into the maze of the Varian Edge treatment vault.
Book Synopsis Monte Carlo Techniques in Radiation Therapy by : Joao Seco
Download or read book Monte Carlo Techniques in Radiation Therapy written by Joao Seco and published by Taylor & Francis. This book was released on 2016-04-19 with total page 334 pages. Available in PDF, EPUB and Kindle. Book excerpt: Modern cancer treatment relies on Monte Carlo simulations to help radiotherapists and clinical physicists better understand and compute radiation dose from imaging devices as well as exploit four-dimensional imaging data. With Monte Carlo-based treatment planning tools now available from commercial vendors, a complete transition to Monte Carlo-base
Book Synopsis Handbook of Radiotherapy Physics by : P Mayles
Download or read book Handbook of Radiotherapy Physics written by P Mayles and published by CRC Press. This book was released on 2007-06-12 with total page 1472 pages. Available in PDF, EPUB and Kindle. Book excerpt: From background physics and biological models to the latest imaging and treatment modalities, the Handbook of Radiotherapy Physics: Theory and Practice covers all theoretical and practical aspects of radiotherapy physics. In this comprehensive reference, each part focuses on a major area of radiotherapy, beginning with an introduction by the
Book Synopsis Monte Carlo Calculations in Nuclear Medicine, Second Edition by : Michael Ljungberg
Download or read book Monte Carlo Calculations in Nuclear Medicine, Second Edition written by Michael Ljungberg and published by CRC Press. This book was released on 2012-11-06 with total page 361 pages. Available in PDF, EPUB and Kindle. Book excerpt: From first principles to current computer applications, Monte Carlo Calculations in Nuclear Medicine, Second Edition: Applications in Diagnostic Imaging covers the applications of Monte Carlo calculations in nuclear medicine and critically reviews them from a diagnostic perspective. Like the first edition, this book explains the Monte Carlo method and the principles behind SPECT and PET imaging, introduces the reader to some Monte Carlo software currently in use, and gives the reader a detailed idea of some possible applications of Monte Carlo in current research in SPECT and PET. New chapters in this edition cover codes and applications in pre-clinical PET and SPECT. The book explains how Monte Carlo methods and software packages can be applied to evaluate scatter in SPECT and PET imaging, collimation, and image deterioration. A guide for researchers and students developing methods to improve image resolution, it also demonstrates how Monte Carlo techniques can be used to simulate complex imaging systems.
