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Author : Pierre Guermonprez
Publisher : Frontiers Media SA
ISBN 13 : 2889664775
Total Pages : 205 pages
Book Rating : 4.8/5 (896 download)
Download or read book Monocyte Heterogeneity and Function written by Pierre Guermonprez and published by Frontiers Media SA. This book was released on 2021-02-11 with total page 205 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Marek Zembala
Publisher :
ISBN 13 :
Total Pages : 584 pages
Book Rating : 4.3/5 (91 download)
Download or read book Human Monocytes written by Marek Zembala and published by . This book was released on 1989 with total page 584 pages. Available in PDF, EPUB and Kindle. Book excerpt: Monocytes represent one of the major types of white blood cells in man which prevent infection by ingesting and killing invading pathogens and by releasing factors which stimulate and regulate lymphocytes. Monocytes "purify" the blood, removing immune complexes, mediating inflammatory responses, and initiating tissue repair. Human Monocytes represents an up-to-date, definitive account of this important cell. It covers the cells biochemical, immunological, and inflammatory functionsand its role in many diseases, including asthma, atherosclerosis, rheumatoid arthritis, and AIDS.
Author : Othmar Förster
Publisher :
ISBN 13 :
Total Pages : 576 pages
Book Rating : 4.3/5 (91 download)
Download or read book Heterogeneity of Mononuclear Phagocytes written by Othmar Förster and published by . This book was released on 1981 with total page 576 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : David S. Nelson
Publisher : Academic Press
ISBN 13 : 1483274772
Total Pages : 652 pages
Book Rating : 4.4/5 (832 download)
Download or read book Immunobiology of the Macrophage written by David S. Nelson and published by Academic Press. This book was released on 2014-06-28 with total page 652 pages. Available in PDF, EPUB and Kindle. Book excerpt: Immunobiology of the Macrophage presents an account of the state of knowledge of the immunobiology of the macrophage. The book's contributors—immunologists of diverse scientific and geographic backgrounds—have been encouraged to give personal accounts of developments in their special fields of interest as well as critical surveys of the backgrounds leading to these developments. The book begins with a study on the functions of macrophages in the initiation and regulation of antibody responses in vitro. This is followed by separate chapters on topics such as the role of macrophages in making antigen more immunogenic and less tolerogenic; functional distinctions between macrophages at different sites; and the role of the macrophage in antigen recognition by T lymphocytes. Subsequent chapters examine interactions between macrophages and lymphocytes in the production of interferon and other mediators of cellular immunity; macrophage cell lines and their uses in immunobiology; and cytotoxic macrophages in allograft rejection.
Author : Thomas C. Jones
Publisher : Springer Science & Business Media
ISBN 13 : 3642841104
Total Pages : 644 pages
Book Rating : 4.6/5 (428 download)
Download or read book Hemopoietic System written by Thomas C. Jones and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 644 pages. Available in PDF, EPUB and Kindle. Book excerpt: The International Life Sciences Institute (ILSI) was estab lished in 1978 to stimulate and support scientific research and educational programs related to nutrition, toxicology, and food safety, and to encourage cooperation in these programs among scientists in universities, industry, and government agencies to assist in the resolution of health and safety issues. To supplement and enhance these efforts, ILSI has made a major commitment to supporting programs to harmon ize toxicologic testing, to advance a more uniform inter pretation of bioassay results worldwide, to promote a common understanding of lesion classifications, and to encourage wide discussion of these topics among scien tists. The Monographs on the Pathology of Laboratory Ani mals are designed to facilitate communication among those involved in the safety testing of foods, drugs, and chemicals. The complete set will cover all organ systems and is intended for use by pathologists, toxicologists, and others concerned with evaluating toxicity and carcinogen icity studies. The international nature of the project - as reflected in the composition of the editorial board and the diversity of the authors and editors - strengthens our ex pectations that understanding and cooperation will be im proved worldwide through the series. Alex Malaspina President International Life Sciences Institute Preface This book, on the hemopoietic system, is the eighth volume of a set prepared under the sponsorship of the International Life Sciences In stitute (ILSI).
Author : F. Schmalzl
Publisher : Springer Science & Business Media
ISBN 13 : 3642816967
Total Pages : 321 pages
Book Rating : 4.6/5 (428 download)
Download or read book Disorders of the Monocyte Macrophage System written by F. Schmalzl and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 321 pages. Available in PDF, EPUB and Kindle. Book excerpt: The origin and function of normal monocytes and macrophages have been clearly defined by extensive investigations in human and in animal models. The central importance ofthis cell system for the biological defense mecha nisms is well established: phagocytosis, inactivation and destruction of organic and inorganic materials, an important role in the initiation ofhumo ral and cell mediated immunological responses, and the secretion of a varie ty of chemical mediator and effector substances are the most important fea tures of this ontogenetically ancient cell system. However, the data on this cellular system are rather recent, and this may explain why relatively little attention has been payed to the pathology of the monocyte-macrophage system (MMS) until now. In addition, this monograph should focus attention on the secondarypa thophysiological implications of the MMS in disorders not primarily origi nating from this system. Several techniques are available to identify even abnormal individuals of this cell system and, therefore, can be employed for the study of severely altered or neoplastic monocytic cells.
Author : Jean-Marc Cavaillon
Publisher : John Wiley & Sons
ISBN 13 : 3527338993
Total Pages : 1818 pages
Book Rating : 4.5/5 (273 download)
Download or read book Inflammation, 4 Volume Set written by Jean-Marc Cavaillon and published by John Wiley & Sons. This book was released on 2018-02-20 with total page 1818 pages. Available in PDF, EPUB and Kindle. Book excerpt: Dieses Fachbuch erläutert die molekularen Grundlagen von Entzündungen, spannt den Bogen zu Infektionskrankheiten und den Zusammenhang zwischen Entzündungen und chronischen Erkrankungen, behandelt abschließend den Heilungsprozess und zeigt Therapiemöglichkeiten.
Author : Anirban Ghosh
Publisher : BoD – Books on Demand
ISBN 13 : 9535131230
Total Pages : 174 pages
Book Rating : 4.5/5 (351 download)
Download or read book Biology of Myelomonocytic Cells written by Anirban Ghosh and published by BoD – Books on Demand. This book was released on 2017-05-10 with total page 174 pages. Available in PDF, EPUB and Kindle. Book excerpt: Myelomonocytes are the multipotent cells in the stage of blood cell differentiation, which mainly comprise blood monocytes, tissue macrophages and subset of dendritic cells. Actually, their position and ability of judgement of the health of tissue or organ environment are the key initiators of tissue-specific immune response in a local and global fashion. Interestingly, the morpho-functional aspects of this group of cells vary to a wide range with their positional diversity. Their ability to communicate or represent the tissue microenvironment to the peripheral immune system and efficiency to engage the system to effector activation hold the key for a successful immune endeavour. The present volume shows some glimpses of such an extensive area of current immunology research.
Author : Marwan Qubaja
Publisher :
ISBN 13 :
Total Pages : 370 pages
Book Rating : 4.:/5 (495 download)
Download or read book Heterogeneity of Monocytes and Monocyte-derived Cells in Human Lymph Nodes and Bone Marrow written by Marwan Qubaja and published by . This book was released on 2008 with total page 370 pages. Available in PDF, EPUB and Kindle. Book excerpt: Background: Human monocytes originate in the bone marrow from a common myeloid progenitor, and they are then released into the peripheral blood. Circulating monocytes are capable of differentiating into morphologically and functionally heterogeneous effector cells, including macrophages and dendritic cells. Based on CD14 and CD16 expression, human peripheral blood monocytes can be divided into a major CD14highCD16- population and two minor CD14highCD16+ and CD14dimCD16+ subpopulations. Objective: We aimed to study the heterogeneity of monocytes and monocyte-derived cells in human bone marrow and lymph nodes, in reactive and tumoral states, with the help of new monocyte/macrophage-derived markers evaluable on paraffin-embedded tissue. Materials and Methods: For this purpose, we studied a series of 33 bone marrow biopsies (BMBs) consisted of 8 normal BMBs, 15 cases of chronic myelomonocytic leukemia (CMML) and 10 cases of chronic myeloid leukemia (CML). We also studied a series of 27 lymph node biopsies including 15 biopsies of reactive lymph nodes and 12 diffuse large B cell lymphoma (DLBCL) nodal biopsies. We evaluated the expression of the following markers on bone marrow and lymph node biopsies: MPO, CD68 (KP1 and PG-M1), CD15, Glycophorin C, CD14, CD16, CD169, CD163, DC-SIGN, CD1a, CD11c, and CD123. Results: In normal BMBs, we clearly identified CD14+ monocytes with mono or bilobated nuclei, very difficult to differentiate from some neutrophils on morphology. These CD14+ monocytes were negative for PG-M1 and CD163. CD16+ monocytes were extremely rare on normal BMBs. Medullary macrophages and granulocytes were CD14-. We showed a significant expansion of dispersed CD14+ monocytes in CMML compared to CML and normal BMBs, but no increase in CD16+ monocytes. We also showed a significant decrease in the number of granulocytes expressing MPO, CD15 and CD16 in CMML, probably related to dysgranulopoiesis often encounterd in this disease. In reactive human lymph nodes, we showed that most sinusoidal histiocytes were strongly positive for CD14, CD16, CD169, and DC-SIGN. CD163 and CD11c variably stained sinusoidal histiocytes and a few cells in the germinal center having the morphology of dendritic cells. However, sinusoidal histiocytes with erythrophagocytosis lacked CD14, but expressed CD16 and CD169. In the lymph nodes of Kikuchi Fujimoto's disease, we demonstrated a strong expansion of the number of MPO+ monocyte-derived cells, and numerous monocyte-derived cells were also positive for CD123, CD14, CD11c and CD163. In DLBCL, we demonstrated a strong expansion of CD14+ monocyte-derived cells, except in cases associated with numerous mitosis, apoptotic bodies, and tingible body macrophages. We showed no increase in number of monocyte-derived cells positive for CD169, CD1a or DC-SIGN. Conclusion: We demonstrated that CD14 immunostaining makes it possible to clearly identify the rare monocyte population on normal BMBs and this is therefore useful for the histopathological diagnosis of CMML, being probably mainly associated with the expansion of the CD14+CD16- monocyte subpopulation. We also demonstrated the morphological and phenotypical heterogeneity of monocyte-derived cells in human lymph nodes. In reactive human lymph nodes, sinusoidal histiocytes are CD14+CD16+ whereas these sinusoidal histiocytes with erythrophagocytosis are CD14-CD16+. DLBCL is associated with the presence of numerous CD14+ monocyte-derived cells except in cases where numerous mitosis and tingible body macrophages are found. Whether these phenotypical changes are due to the recruitment of a different monocyte subpopulation (CD14+CD16-, CD14-CD16+) or to a downregulation of some receptors remains to be demonstrated. However, these changes are probably linked to the differential effector functions of these monocyte-derived cells.
Author : Charles Dudley Mills
Publisher : Frontiers Media SA
ISBN 13 : 288919499X
Total Pages : 281 pages
Book Rating : 4.8/5 (891 download)
Download or read book M1/M2 Macrophages: The Arginine Fork in the Road to Health and Disease written by Charles Dudley Mills and published by Frontiers Media SA. This book was released on 2015-03-23 with total page 281 pages. Available in PDF, EPUB and Kindle. Book excerpt: Macrophages have unique and diverse functions necessary for survival. And, in humans (and other species), they are the most abundant leukocytes in tissues. The Innate functions of macrophages that are best known are their unusual ability to either “Kill” or “Repair”. Since killing is a destructive process and repair is a constructive process, it was stupefying how one cell could exhibit these 2 polar – opposite functions. However, in the late 1980’s, it was shown that macrophages have a unique ability to enzymatically metabolize Arginine to Nitric Oxide (NO, a gaseous non – specific killer molecule) or to Ornithine (a precursor of polyamines and collagen for repair). The dual Arginine metabolic capacity of macrophages provided a functional explanation for their ability to kill or repair. Macrophages predominantly producing NO are called M1 and those producing Ornithine are called M2. M1 and M2 – dominant responses occur in lower vertebrates, and in T cell deficient vertebrates being directly driven by Damage and Pathogen Associated Molecular Patterns (DAMP and PAMP). Thus, M1 and M2 are Innate responses that protect the host without Adaptive Immunity. In turn, M1/M2 is supplanting previous models in which T cells were necessary to “activate” or “alternatively activate” macrophages (the Th1/Th2 paradigm). M1 and M2 macrophages were named such because of the additional key findings that these macrophages stimulate Th1 and Th2 – like responses, respectively. So, in addition to their unique ability to kill or repair, macrophages also govern Adaptive Immunity. All of the foregoing would be less important if M1 or M2 – dominant responses were not observed in disease. But, they are. The best example to date is the predominance of M2 macrophages in human tumors where they act like wound repair macrophages and actively promote growth. More generally, humans have become M2 – dominant because sanitation, antibiotics and vaccines have lessened M1 responses. And, M2 dominance seems the cause of ever - increasing allergies in developed countries. Obesity represents a new and different circumstance. Surfeit energy (e.g., lipoproteins) causes monocytes to become M1 dominant in the vessel walls causing plaques. Because M1 or M2 dominant responses are clearly causative in many modern diseases, there is great potential in developing the means to selectively stimulate (or inhibit) either M1 or M2 responses to kill or repair, or to stimulate Th1 or Th2 responses, depending on the circumstance. The contributions here are meant to describe diseases of M1 or M2 dominance, and promising new methodologies to modulate the fungible metabolic machinery of macrophages for better health.
Author : Masayoshi Okubo
Publisher : Springer Science & Business Media
ISBN 13 : 9783540229230
Total Pages : 388 pages
Book Rating : 4.2/5 (292 download)
Download or read book Polymer Particles written by Masayoshi Okubo and published by Springer Science & Business Media. This book was released on 2005-02-10 with total page 388 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this special volume on polymer particles, recent trends and developments in the synthesis of nano- to micron-sized polymer particles by radical polymerization (Emulsion, Miniemulsion, Microemulsion, and Dispersion Polymerizations) of vinyl monomers in environmentally friendly heterogeneous aqueous and supercritical carbon dioxide fluid media are reviewed by prominent worldwide researchers. In addition to the important challenges and possibilities with regards to design and preparation of functionalized polymer particles of controlled size, the topics described are of great current interest due to the increased awareness of environmental issues.
Author : Ronald F. Tuma
Publisher : Academic Press
ISBN 13 : 0080569935
Total Pages : 999 pages
Book Rating : 4.0/5 (85 download)
Download or read book Microcirculation written by Ronald F. Tuma and published by Academic Press. This book was released on 2011-04-28 with total page 999 pages. Available in PDF, EPUB and Kindle. Book excerpt: This reference is a volume in the Handbook of Physiology, co-published with The American Physiological Society. Growth in knowledge about the microcirculation has been explosive with the field becoming fragmented into numerous subdisciplines and subspecialties. This volume pulls all of the critical information into one volume. - Meticulously edited and reviewed. Benefit: Provides investigators a unique tool to explore the significance of their findings in the context of other aspects of the microcirculation. In this way, the updated edition has a direct role in helping to develop new pathways of research and scholarship - Highlights the explosive growth in knowledge about the microcirculation including the biology of nitric oxide synthase (NOS), endothelial cell signaling, angiogenesis, cell adhesion molecules, lymphocyte trafficking, ion channels and receptors, and propagated vasomotor responses. Benefit: Microcirculatory biology has become fragmented into numerous sub-disciplines and subspecialties, and these reference reintegrates the information in one volume
Author : Masaki Ieda
Publisher : Springer
ISBN 13 : 3319561065
Total Pages : 274 pages
Book Rating : 4.3/5 (195 download)
Download or read book Cardiac Regeneration written by Masaki Ieda and published by Springer. This book was released on 2017-10-27 with total page 274 pages. Available in PDF, EPUB and Kindle. Book excerpt: This Volume of the series Cardiac and Vascular Biology offers a comprehensive and exciting, state-of-the-art work on the current options and potentials of cardiac regeneration and repair. Several techniques and approaches have been developed for heart failure repair: direct injection of cells, programming of scar tissue into functional myocardium, and tissue-engineered heart muscle support. The book introduces the rationale for these different approaches in cell-based heart regeneration and discusses the most important considerations for clinical translation. Expert authors discuss when, why, and how heart muscle can be salvaged. The book represents a valuable resource for stem cell researchers, cardiologists, bioengineers, and biomedical scientists studying cardiac function and regeneration.
Author : D. Neil Granger
Publisher : Morgan & Claypool Publishers
ISBN 13 : 1615041656
Total Pages : 99 pages
Book Rating : 4.6/5 (15 download)
Download or read book Inflammation and the Microcirculation written by D. Neil Granger and published by Morgan & Claypool Publishers. This book was released on 2010 with total page 99 pages. Available in PDF, EPUB and Kindle. Book excerpt: The microcirculation is highly responsive to, and a vital participant in, the inflammatory response. All segments of the microvasculature (arterioles, capillaries, and venules) exhibit characteristic phenotypic changes during inflammation that appear to be directed toward enhancing the delivery of inflammatory cells to the injured/infected tissue, isolating the region from healthy tissue and the systemic circulation, and setting the stage for tissue repair and regeneration. The best characterized responses of the microcirculation to inflammation include impaired vasomotor function, reduced capillary perfusion, adhesion of leukocytes and platelets, activation of the coagulation cascade, and enhanced thrombosis, increased vascular permeability, and an increase in the rate of proliferation of blood and lymphatic vessels. A variety of cells that normally circulate in blood (leukocytes, platelets) or reside within the vessel wall (endothelial cells, pericytes) or in the perivascular space (mast cells, macrophages) are activated in response to inflammation. The activation products and chemical mediators released from these cells act through different well-characterized signaling pathways to induce the phenotypic changes in microvessel function that accompany inflammation. Drugs that target a specific microvascular response to inflammation, such as leukocyte-endothelial cell adhesion or angiogenesis, have shown promise in both the preclinical and clinical studies of inflammatory disease. Future research efforts in this area will likely identify new avenues for therapeutic intervention in inflammation. Table of Contents: Introduction / Historical Perspectives / Anatomical Considerations / Impaired Vasomotor Responses / Capillary Perfusion / Angiogenesis / Leukocyte-Endothelial Cell Adhesion / Platelet-Vessel Wall Interactions / Coagulation and Thrombosis / Endothelial Barrier Dysfunction / Epilogue / References
Author : Mohamed Boutjdir
Publisher : Frontiers Media SA
ISBN 13 : 2889633977
Total Pages : 263 pages
Book Rating : 4.8/5 (896 download)
Download or read book Cardioimmunology: Inflammation and Immunity in Cardiovascular Disease written by Mohamed Boutjdir and published by Frontiers Media SA. This book was released on 2020-01-30 with total page 263 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Alvin Volkman
Publisher : Marcel Dekker
ISBN 13 :
Total Pages : 536 pages
Book Rating : 4.3/5 (91 download)
Download or read book Mononuclear Phagocyte Biology written by Alvin Volkman and published by Marcel Dekker. This book was released on 1984 with total page 536 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : J Philip McCoy Jr
Publisher : Humana
ISBN 13 : 9781493996490
Total Pages : 375 pages
Book Rating : 4.9/5 (964 download)
Download or read book Immunophenotyping written by J Philip McCoy Jr and published by Humana. This book was released on 2019-09-29 with total page 375 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume presents the latest collection of immunophenotypic techniques and applications used in research and clinical settings. Chapters in this book cover topics such as constructions of high dimensions fluorescence and mass cytometry panels; fluorescence barcoding; using dried or lyophilized reagents; and immunophenotypic examples of specific cell types. The book concludes with a discussion on the critical roles of quality control and immunophenotyping in the clinical environment. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and comprehensive, Immunophenotyping: Methods and Protocols is a valuable resource for any researchers, clinician, or scientist interested in learning more about this evolving field.
