Molecular Testing In Laboratory Medicine

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Diagnostic Molecular Pathology

Author : William B. Coleman
Publisher : Academic Press
ISBN 13 : 0128229934
Total Pages : 846 pages
Book Rating : 4.1/5 (282 download)

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Book Synopsis Diagnostic Molecular Pathology by : William B. Coleman

Download or read book Diagnostic Molecular Pathology written by William B. Coleman and published by Academic Press. This book was released on 2023-10-18 with total page 846 pages. Available in PDF, EPUB and Kindle. Book excerpt: Diagnostic Molecular Pathology: A Guide to Applied Molecular Testing, Second Edition assembles a group of experts to discuss the molecular basis and mechanisms of major human diseases and disease processes and how the molecular features of disease can be harnessed to develop practical molecular tests for disease detection, diagnosis and prognosis. The book explains how molecular tests are utilized in the treatment of patients in personalized medicine, highlights new technologies and approaches of applied molecular pathology, and discusses how this discovery-based research yields new and useful biomarkers and tests. As it is essential to stay up-to-date on new molecular diagnostics in this changing field, this book covers critically important areas in the practice of personalized medicine and reflects our understanding of the pathology, pathogenesis and pathophysiology of human disease. - Includes new material on mass spectrometry for infectious diseases, microbiome, homology-directed repair for PARPi, whole genome sequencing for constitutional testing, and much more - Provides insights on the value of the molecular test in comparison to traditional methods, which include speed, precision, sensitivity and clinical impacts for the patient - Focuses on the menu of molecular diagnostic tests available in modern molecular pathology or clinical laboratories that can be applied to disease detection, diagnosis and classification in the clinical workup of a patient - Explains how molecular tests are utilized to guide the treatment of patients in personalized medicine (guided therapies) and for the prognostication of disease

Molecular Diagnostics

Author : William B. Coleman
Publisher : Springer Science & Business Media
ISBN 13 : 1475725884
Total Pages : 387 pages
Book Rating : 4.4/5 (757 download)

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Book Synopsis Molecular Diagnostics by : William B. Coleman

Download or read book Molecular Diagnostics written by William B. Coleman and published by Springer Science & Business Media. This book was released on 2013-04-18 with total page 387 pages. Available in PDF, EPUB and Kindle. Book excerpt: Notable practitioners describe how laboratory medicine is practiced today and illuminate how it will function tomorrow as the revolutionary advances afforded by molecular diagnostics become increasingly central to effective analysis. Proceeding from a discussion of elementary nucleic acid technology to a review of the more advanced techniques, the distinguished contributors lay the groundwork for a comprehensive understanding of their applications throughout clinical medicine. The result is a detailed description of those molecular technologies currently used in diagnostic laboratories, as well as those that seem particularly promising. Detailed discussions of specific clinical applications include those for cancer, hematological malignancies, cardiovascular disease, and neuromuscular, endocrine, and infectious diseases.

Molecular Diagnostics

Author : Wayne W. Grody
Publisher : Academic Press
ISBN 13 : 0080919049
Total Pages : 518 pages
Book Rating : 4.0/5 (89 download)

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Book Synopsis Molecular Diagnostics by : Wayne W. Grody

Download or read book Molecular Diagnostics written by Wayne W. Grody and published by Academic Press. This book was released on 2009-11-06 with total page 518 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advances in genomic and proteomic profiling of disease have transformed the field of molecular diagnostics, thus leading the way for a major revolution in clinical practice. While the range of tests for disease detection and staging is rapidly expanding, many physicians lack the knowledge required to determine which tests to order and how to interpret results. Molecular Diagnostics provides a complete guide to the use and interpretation of molecular testing in the clinical arena. No other available resource offers this emphasis, comprehensive scope, and practical utility in the clinical setting. - Serves as the definitivereference for molecular pathologists worldwide - Covers a variety of molecular techniques including next generation sequencing, tumor somatic cell genotyping, infectious and genetic disease tecting, and pharmacogenetics - Discusses in the detail issues concerning quality assurance, regulation, ethics, and future directions for the science

Molecular Testing in Laboratory Medicine

Author : David E. Bruns
Publisher : Amer. Assoc. for Clinical Chemistry
ISBN 13 : 9781890883607
Total Pages : 396 pages
Book Rating : 4.8/5 (836 download)

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Book Synopsis Molecular Testing in Laboratory Medicine by : David E. Bruns

Download or read book Molecular Testing in Laboratory Medicine written by David E. Bruns and published by Amer. Assoc. for Clinical Chemistry. This book was released on 2002 with total page 396 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Molecular Diagnostics

Author : W. Edward Highsmith, Jr.
Publisher : Springer Science & Business Media
ISBN 13 : 1461481279
Total Pages : 260 pages
Book Rating : 4.4/5 (614 download)

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Book Synopsis Molecular Diagnostics by : W. Edward Highsmith, Jr.

Download or read book Molecular Diagnostics written by W. Edward Highsmith, Jr. and published by Springer Science & Business Media. This book was released on 2013-09-20 with total page 260 pages. Available in PDF, EPUB and Kindle. Book excerpt: Molecular Diagnostics: 12 Tests That Changed Everything focuses on specific laboratory tests and emphasizes how the availability of these tests has altered how clinicians treat their patients. Presented as a standard outline, each chapter focuses on a specific molecular test and provides background on the test and its clinical applications. Continuing with some discussion on how the test is done, interpreted, and used clinically, each chapter then concludes with a discussion of how that test has changed the way medicine is practiced with respect to the disease or condition in question. Authored by renowned experts in the field, Molecular Diagnostics: 12 Tests That Changed Everything is a valuable resource for pathologists, pathology residents, laboratory directors, development personnel, lab medicine fellows and those working in the broad area of oncology, infectious disease and genetics.

Clinical Molecular Diagnostics

Author : Shiyang Pan
Publisher : Springer Nature
ISBN 13 : 9811610371
Total Pages : 889 pages
Book Rating : 4.8/5 (116 download)

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Book Synopsis Clinical Molecular Diagnostics by : Shiyang Pan

Download or read book Clinical Molecular Diagnostics written by Shiyang Pan and published by Springer Nature. This book was released on 2021-07-08 with total page 889 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book covers the discovery of molecular biomarkers, the development of laboratory testing techniques and their clinical applications, focusing on basic research to clinical practice. It introduces new and crucial knowledge and ethics of clinical molecular diagnosis. This book emphasizes the applications of clinical molecular diagnostic test on health management, especially from different diseased organs. It lets readers to understand and realize precision healthcare.

Principles and Applications of Molecular Diagnostics

Author : Nader Rifai
Publisher : Elsevier
ISBN 13 : 0128160624
Total Pages : 424 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis Principles and Applications of Molecular Diagnostics by : Nader Rifai

Download or read book Principles and Applications of Molecular Diagnostics written by Nader Rifai and published by Elsevier. This book was released on 2018-06-13 with total page 424 pages. Available in PDF, EPUB and Kindle. Book excerpt: Principles and Applications of Molecular Diagnostics serves as a comprehensive guide for clinical laboratory professionals applying molecular technology to clinical diagnosis. The first half of the book covers principles and analytical concepts in molecular diagnostics such as genomes and variants, nucleic acids isolation and amplification methods, and measurement techniques, circulating tumor cells, and plasma DNA; the second half presents clinical applications of molecular diagnostics in genetic disease, infectious disease, hematopoietic malignancies, solid tumors, prenatal diagnosis, pharmacogenetics, and identity testing. A thorough yet succinct guide to using molecular testing technology, Principles and Applications of Molecular Diagnostics is an essential resource for laboratory professionals, biologists, chemists, pharmaceutical and biotech researchers, and manufacturers of molecular diagnostics kits and instruments. - Explains the principles and tools of molecular biology - Describes standard and state-of-the-art molecular techniques for obtaining qualitative and quantitative results - Provides a detailed description of current molecular applications used to solve diagnostics tasks

Fundamentals of Molecular Diagnostics

Author : David E. Bruns
Publisher : Elsevier Health Sciences
ISBN 13 : 1416037373
Total Pages : 298 pages
Book Rating : 4.4/5 (16 download)

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Book Synopsis Fundamentals of Molecular Diagnostics by : David E. Bruns

Download or read book Fundamentals of Molecular Diagnostics written by David E. Bruns and published by Elsevier Health Sciences. This book was released on 2007-05-25 with total page 298 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book offers an introduction to the newest, fastest-growing field in laboratory science. Explaining and clarifying the molecular techniques used in diagnostic testing, this text provides both entry-level and advanced information. It covers the principles of molecular biology along with genomes and nucleic acid alterations, techniques and instrumentation, and applications of molecular diagnostics. Written by leading experts, including Patrick Bossuyt, Angela Caliendo, Rossa W.K. Chiu, Kojo S.J. Elenitoba-Johnson, Andrea Ferreira-Gonzalez, Amy Groszbach, Sultan Habeebu, Doris Haverstick, Malek Kamoun, Anthony Killeen, Noriko Kusukawa, Y.M. Dennis Lo, Elaine Lyon, Gwendolyn McMillin, Christopher Price, James Versalovic, Cindy Vnencak-Jones, Victor Weedn, Peter Wilding, Thomas Williams, and Carl Wittwer, this book includes illustrations, tables, and a colorful design to make information easy to find and easy to use. A full-color, 4-page insert shows realistic images of the output for many molecular tests. Learning Objectives open each chapter with an overview of what you should achieve. Key Words are listed and defined at the beginning of each chapter, and are bolded in the text. Review Questions at the end of every chapter let you measure your comprehension. Advanced Concepts are included, but set apart from the rest of the text, for students who want a higher level of learning. Ethics boxes address ethical issues, allowing you to apply your knowledge to real-life scenarios. A glossary of all key words may be easily accessed in the back of the book.

Molecular Pathology in Clinical Practice

Author : Debra G.B. Leonard
Publisher : Springer Science & Business Media
ISBN 13 : 0387332278
Total Pages : 589 pages
Book Rating : 4.3/5 (873 download)

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Book Synopsis Molecular Pathology in Clinical Practice by : Debra G.B. Leonard

Download or read book Molecular Pathology in Clinical Practice written by Debra G.B. Leonard and published by Springer Science & Business Media. This book was released on 2007-11-25 with total page 589 pages. Available in PDF, EPUB and Kindle. Book excerpt: This authoritative textbook embodies the current standard in molecular testing for practicing pathologists, and residents and fellows in training. The text is organized into eight sections: genetics, inherited cancers, infectious disease, neoplastic hematopathology, solid tumors, HLA typing, identity testing, and laboratory management. Discussion of each diagnostic test includes its clinical significance, available assays, quality control and lab issues, interpretation, and reasons for testing. Coverage extends to HIV, hepatitis, developmental disorders, bioterrorism, warfare organisms, lymphomas, breast cancer and melanoma, forensics, parentage, and much more. Includes 189 illustrations, 45 in full-color. This textbook is a classic in the making and a must-have reference.

Molecular Diagnostics

Author : George P. Patrinos
Publisher : Academic Press
ISBN 13 : 0128029889
Total Pages : 526 pages
Book Rating : 4.1/5 (28 download)

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Book Synopsis Molecular Diagnostics by : George P. Patrinos

Download or read book Molecular Diagnostics written by George P. Patrinos and published by Academic Press. This book was released on 2016-10-27 with total page 526 pages. Available in PDF, EPUB and Kindle. Book excerpt: Molecular Diagnostics, Third Edition, focuses on the technologies and applications that professionals need to work in, develop, and manage a clinical diagnostic laboratory. Each chapter contains an expert introduction to each subject that is next to technical details and many applications for molecular genetic testing that can be found in comprehensive reference lists at the end of each chapter. Contents are divided into three parts, technologies, application of those technologies, and related issues. The first part is dedicated to the battery of the most widely used molecular pathology techniques. New chapters have been added, including the various new technologies involved in next-generation sequencing (mutation detection, gene expression, etc.), mass spectrometry, and protein-specific methodologies. All revised chapters have been completely updated, to include not only technology innovations, but also novel diagnostic applications. As with previous editions, each of the chapters in this section includes a brief description of the technique followed by examples from the area of expertise from the selected contributor. The second part of the book attempts to integrate previously analyzed technologies into the different aspects of molecular diagnostics, such as identification of genetically modified organisms, stem cells, pharmacogenomics, modern forensic science, molecular microbiology, and genetic diagnosis. Part three focuses on various everyday issues in a diagnostic laboratory, from genetic counseling and related ethical and psychological issues, to safety and quality management. - Presents a comprehensive account of all new technologies and applications used in clinical diagnostic laboratories - Explores a wide range of molecular-based tests that are available to assess DNA variation and changes in gene expression - Offers clear translational presentations by the top molecular pathologists, clinical chemists, and molecular geneticists in the field

Diagnostic Molecular Pathology in Practice

Author : Iris Schrijver
Publisher : Springer Science & Business Media
ISBN 13 : 3642196772
Total Pages : 329 pages
Book Rating : 4.6/5 (421 download)

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Book Synopsis Diagnostic Molecular Pathology in Practice by : Iris Schrijver

Download or read book Diagnostic Molecular Pathology in Practice written by Iris Schrijver and published by Springer Science & Business Media. This book was released on 2011-09-09 with total page 329 pages. Available in PDF, EPUB and Kindle. Book excerpt: This entirely case-based book covers a broad cross-section of the practical issues frequently encountered in the day-to-day activities of a molecular genetic pathologist. The book is divided into four sections on the principal areas addressed in molecular genetic pathology (MGP): inherited diseases, hematopathology, solid tumors, and infectious diseases. The topics covered by the cases in each section include test selection, qualitative and quantitative laboratory techniques, test interpretation, prognostic and therapeutic considerations, ethical considerations, technical troubleshooting, and result reporting. This book will be ideal for trainees in MGP and clinical molecular genetics who require a practice-based preparation for board examinations. It will also be very useful for residents and fellows in medical specialties to which MGP is pertinent, and for practicing pathologists who want to learn more about the current practice of molecular diagnostics.

Practical Oncologic Molecular Pathology

Author : Yi Ding
Publisher : Springer Nature
ISBN 13 : 3030732274
Total Pages : 449 pages
Book Rating : 4.0/5 (37 download)

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Book Synopsis Practical Oncologic Molecular Pathology by : Yi Ding

Download or read book Practical Oncologic Molecular Pathology written by Yi Ding and published by Springer Nature. This book was released on 2021-07-10 with total page 449 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is a review and high-yield reference on the clinical molecular diagnostics of malignant neoplasms. It aims to address the practical questions frequently encountered in the molecular oncology practice, as well as key points and pitfalls in the clinical interpretation of molecular tests in guiding precision cancer management. The text uses a Q&A format and case presentations, with emphasis on understanding the molecular test methods, diagnosis, classification, risk assessment and clinical correlation. Starting with an update on the molecular biology of cancer, the book focuses on the topics related to molecular diagnostics and genetics-based precision oncology. Separate chapters are dedicated to discussion of the bioinformatics for the analysis of genetic/genomic data generated from molecular assays, and quality control (QC)/quality assurance (QA) programs in the clinical laboratories; both are critical in producing high quality results for clinical care of cancer patients. These are followed by organ system-based reviews and discussions on the molecular genetic abnormalities and related tests covering diverse types of common to rare malignant neoplasms. This book also provides up-to-date knowledge related to malignant neoplasms, discusses the established as well as evolving requirements for pathologic diagnosis of these malignancies. It also discusses the cost effective utilization of molecular tests in clinical oncology. Written by experts in the field, Practical Oncologic Molecular Pathology serves as a valuable reference for practicing pathologists, fellows, residents and other health care professionals.

Clinical Laboratory Medicine

Author : Kenneth D. McClatchey
Publisher : Lippincott Williams & Wilkins
ISBN 13 : 9780683307511
Total Pages : 1732 pages
Book Rating : 4.3/5 (75 download)

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Book Synopsis Clinical Laboratory Medicine by : Kenneth D. McClatchey

Download or read book Clinical Laboratory Medicine written by Kenneth D. McClatchey and published by Lippincott Williams & Wilkins. This book was released on 2002 with total page 1732 pages. Available in PDF, EPUB and Kindle. Book excerpt: This thoroughly updated Second Edition of Clinical Laboratory Medicine provides the most complete, current, and clinically oriented information in the field. The text features over 70 chapters--seven new to this edition, including medical laboratory ethics, point-of-care testing, bone marrow transplantation, and specimen testing--providing comprehensive coverage of contemporary laboratory medicine. Sections on molecular diagnostics, cytogenetics, and laboratory management plus the emphasis on interpretation and clinical significance of laboratory tests (why a test or series of tests is being done and what the results mean for the patient) make this a valuable resource for practicing pathologists, residents, fellows, and laboratorians. Includes over 800 illustrations, 353 in full color and 270 new to this edition. Includes a Self-Assessment and Review book.

Developing Norms for the Provision of Biological Laboratories in Low-Resource Contexts

Author : National Academies of Sciences, Engineering, and Medicine
Publisher : National Academies Press
ISBN 13 : 0309486564
Total Pages : 121 pages
Book Rating : 4.3/5 (94 download)

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Book Synopsis Developing Norms for the Provision of Biological Laboratories in Low-Resource Contexts by : National Academies of Sciences, Engineering, and Medicine

Download or read book Developing Norms for the Provision of Biological Laboratories in Low-Resource Contexts written by National Academies of Sciences, Engineering, and Medicine and published by National Academies Press. This book was released on 2019-05-01 with total page 121 pages. Available in PDF, EPUB and Kindle. Book excerpt: On June 27-28, 2018, the U.S. National Academies of Sciences, Engineering, and Medicine (the National Academies) convened an international workshop in Amsterdam, the Netherlands, on developing norms for the provision of laboratories in low-resource contexts. The U.S. Department of State's Biosecurity Engagement Program requested that the National Academies organize this workshop to engage an international group of organizations that provide funding for construction, upgrades, and maintenance of biological laboratories in countries without the means to build such labs themselves. Twenty-one people from 19 organizations participated. The intent was to advance the conversation about the identification and application of guiding principles and common norms for use by these organizations in their grants, partnerships, and aid. This publication summarizes the presentations and discussions from the workshop.

Tietz's Applied Laboratory Medicine

Author : Mitchell G. Scott
Publisher : John Wiley & Sons
ISBN 13 : 0470086076
Total Pages : 701 pages
Book Rating : 4.4/5 (7 download)

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Book Synopsis Tietz's Applied Laboratory Medicine by : Mitchell G. Scott

Download or read book Tietz's Applied Laboratory Medicine written by Mitchell G. Scott and published by John Wiley & Sons. This book was released on 2007-02-26 with total page 701 pages. Available in PDF, EPUB and Kindle. Book excerpt: Using a problem-based approach, Tietz's Applied Laboratory Medicine, Second Edition presents interesting cases to illustrate the current use and interpretation of the most commonly available clinical laboratory tests. The cases present detailed descriptions of the symptoms, diagnosis, and treatment of disease. The book begins with an up-to-date general discussion of selection and use of laboratory diagnostic and prognostic tests. Cases are then grouped by category, including cardiovascular, pulmonary, renal, liver, gastrointestinal, endocrine, gynaecologic & obstetrical, haematological, CNS, lipid, congenital, toxicological, infectious, and autoimmune diseases. Tietz's Applied Laboratory Medicine, Second Edition: Presents over 100 cases organised by disease group Reflects latest treatment and risk factor guidelines, testing algorithms and recommendations Newly covers coagulopathies, infectious diseases, and autoimmune diseases Provides excellent coverage of relevant pathophysiology and biochemistry, and includes cases in molecular diagnostics Discusses legal implications This book is an invaluable resource for all clinical chemists, clinical lab technologists, pathologists, and allied health professionals. It is also of interest for general practitioners, residents, medical students, and educators.

Covid-19 Molecular Testing and Clinical Correlates, an Issue of the Clinics in Laboratory Medicine, 42

Author : Sanjat Kanjilal
Publisher : Elsevier
ISBN 13 : 9780323849524
Total Pages : 240 pages
Book Rating : 4.8/5 (495 download)

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Book Synopsis Covid-19 Molecular Testing and Clinical Correlates, an Issue of the Clinics in Laboratory Medicine, 42 by : Sanjat Kanjilal

Download or read book Covid-19 Molecular Testing and Clinical Correlates, an Issue of the Clinics in Laboratory Medicine, 42 written by Sanjat Kanjilal and published by Elsevier. This book was released on 2022-06-28 with total page 240 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this issue of Clinics in Laboratory Medicine, guest editors Drs. Christopher P. Holstege and Joshua D. King bring their considerable expertise to the topic of COVID-19 Molecular Testing and Clinical Correlates. Top experts in the field cover key topics such as point-of-care molecular assays for SARS-CoV-2; strategies for scaling up SARS-CoV-2 molecular testing capacity; cycle threshold values from SARS-CoV-2 PCR assays; and more. Contains 12 relevant, practice-oriented topics including analytic and clinical performance of major commercial SARS-CoV-2 PCR assays in the United States; isothermal assays for SARS-CoV-2 detection; rapid antigen assays for SARS-CoV-2; approaches to deployment of molecular testing for SARS-CoV-2 in resource-limited settings; and more. Provides in-depth clinical reviews on COVID-19 molecular testing and clinical correlates, offering actionable insights for clinical practice. Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.

Molecular Pathology: An Update, An Issue of the Clinics in Laboratory Medicine, Ebook

Author : Martin H. Bluth
Publisher : Elsevier Health Sciences
ISBN 13 : 0323610730
Total Pages : 249 pages
Book Rating : 4.3/5 (236 download)

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Book Synopsis Molecular Pathology: An Update, An Issue of the Clinics in Laboratory Medicine, Ebook by : Martin H. Bluth

Download or read book Molecular Pathology: An Update, An Issue of the Clinics in Laboratory Medicine, Ebook written by Martin H. Bluth and published by Elsevier Health Sciences. This book was released on 2018-05-23 with total page 249 pages. Available in PDF, EPUB and Kindle. Book excerpt: This updated issue of Clinics in Laboratory Medicine, edited by Martin H. Bluth, will focus on Molecular Pathology. Topics include, but are not limited to, The Impact of Molecular Pathology on the Practice of Pathology; Molecular pathology techniques; Clinical Implication of MicroRNAs in Molecular Pathology; Diagnostic Molecular Microbiology; Molecular Pathology in Transfusion Medicine; Molecular Diagnosis of Hematopoietic Neoplasms; Molecular Diagnostics in Colorectal Carcinoma; Molecular Diagnostics in the Neoplasms of Small Intestine and Appendix; Molecular Diagnostics in Esophageal and Gastric Neoplasms; Molecular Diagnostics in the Neoplasms of the Pancreas, Liver, Gall Bladder, and Extrahepatic Biliary Tract; Current Applications of Molecular Genetic Technologies to the Diagnosis and Treatment of Cutaneous Melanocytic Neoplasms; Breast Carcinoma; and Gynecologic Cancers.