Molecular Research Of Endometrial Pathophysiology

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Molecular Research of Endometrial Pathophysiology

Author : Paola Viganò
Publisher : MDPI
ISBN 13 : 3039214950
Total Pages : 378 pages
Book Rating : 4.0/5 (392 download)

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Book Synopsis Molecular Research of Endometrial Pathophysiology by : Paola Viganò

Download or read book Molecular Research of Endometrial Pathophysiology written by Paola Viganò and published by MDPI. This book was released on 2019-10-14 with total page 378 pages. Available in PDF, EPUB and Kindle. Book excerpt: The endometrium has been the subject of intense research in a variety of clinical settings, because of its importance in the reproductive process and its role in women’s health. In the past 15 years, significant efforts have been invested in defining the molecular phenotype of the receptive phase endometrium as well as of various endometrial pathologies. Although this has generated a wealth of information on the molecular landscape of human endometrium, there is a need to complement this information in light of the novel methodologies and innovative technical approaches. The focus of this International Journal of Molecular Sciences Special Issue is on molecular and cellular mechanisms of endometrium and endometrium-related disorders. The progress made in the molecular actions of steroids, in the metabolism of steroids and intracrinology, in endometrial intracellular pathways, in stem cells biology, as well as in the molecular alterations underlying endometrium-related pathologies has been the focus of the reviews and papers included.]

Molecular Research of Endometrial Pathophysiology

Author : Paola Viganò
Publisher :
ISBN 13 : 9783039214969
Total Pages : 1 pages
Book Rating : 4.2/5 (149 download)

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Book Synopsis Molecular Research of Endometrial Pathophysiology by : Paola Viganò

Download or read book Molecular Research of Endometrial Pathophysiology written by Paola Viganò and published by . This book was released on 2019 with total page 1 pages. Available in PDF, EPUB and Kindle. Book excerpt: The endometrium has been the subject of intense research in a variety of clinical settings, because of its importance in the reproductive process and its role in women's health. In the past 15 years, significant efforts have been invested in defining the molecular phenotype of the receptive phase endometrium as well as of various endometrial pathologies. Although this has generated a wealth of information on the molecular landscape of human endometrium, there is a need to complement this information in light of the novel methodologies and innovative technical approaches. The focus of this International Journal of Molecular Sciences Special Issue is on molecular and cellular mechanisms of endometrium and endometrium-related disorders. The progress made in the molecular actions of steroids, in the metabolism of steroids and intracrinology, in endometrial intracellular pathways, in stem cells biology, as well as in the molecular alterations underlying endometrium-related pathologies has been the focus of the reviews and papers included.].

Molecular Bases of Endometriosis

Author : Giovana Gonçalves
Publisher : BoD – Books on Demand
ISBN 13 : 1789846072
Total Pages : 88 pages
Book Rating : 4.7/5 (898 download)

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Book Synopsis Molecular Bases of Endometriosis by : Giovana Gonçalves

Download or read book Molecular Bases of Endometriosis written by Giovana Gonçalves and published by BoD – Books on Demand. This book was released on 2019-09-04 with total page 88 pages. Available in PDF, EPUB and Kindle. Book excerpt: What are the objectives of the genetic study of individuals? There is great interest from the medical community and also much concern from the lay press about the potential benefits and harms of genetic screening, gene therapy, and even the possibility of cloning individuals. The current use of genetic tests for the detection and treatment of endometriosis is still at an early stage but very important. The determination of susceptibility markers will be increasingly explored in clinical studies and their uses will be much more defined. Still, it seems increasingly likely that major changes will occur over the next decade in how we evaluate and treat our patients. In particular, surgeons and clinicians will have the opportunity to use a number of new tests to predict the future appearance of endometriosis in patients still free of the disease. They may have the power to explore the best therapeutic modality for a particular patient according to his/her genetic makeup. And they will be able to more specifically target prevention measures for family members of people already affected by the disease. It should be understood that molecular diagnosis, especially in asymptomatic individuals, does not mean disease but an increased risk of developing a disease. Ethical implications exist and should not be underestimated. Patients should be advised about the likely implications of such tests, not only after but especially before the achievement of these. A major step has already been overcome and we currently have the basic tools for a new leap in understanding human pathologies responsible for much of the world's mortality. Bridging the great barrier that still separates this basic knowledge and clinical practice is quite a significant challenge.

Endometriosis

Author : Tasuku Harada
Publisher : Springer
ISBN 13 : 4431544216
Total Pages : 475 pages
Book Rating : 4.4/5 (315 download)

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Book Synopsis Endometriosis by : Tasuku Harada

Download or read book Endometriosis written by Tasuku Harada and published by Springer. This book was released on 2014-08-06 with total page 475 pages. Available in PDF, EPUB and Kindle. Book excerpt: Endometriosis is one of the most common gynecological diseases, causing pelvic pain, infertility, and cancer. The condition reduces the quality of life for the estimated 10% of menstruating women who are affected by it. This book provides a clear insight into the pathogenesis and pathophysiology of endometriosis—essential information for clinicians intending to successfully treat the condition. The first part covers a range of topics including stem cells, NK cells, macrophages, inflammation, cytokines, epigenetics, prostaglandin, sex steroids, aromatase, apoptosis, nerve fibers, and malignant transformation to aid in understanding the pathogenesis and pathophysiology of the disease. The second part provides useful tools for therapy, specifically, notable recent techniques in prevention, imaging, biomarkers, medical treatments, surgical treatments, prevention of recurrence, and infertility treatments. Each chapter was written by an expert in the field, with nearly 40 researchers and clinicians contributing to the work. This book will be highly useful to clinicians as well as to research scientists who are interested in this enigmatic disease.

Molecular Investigation Of Endometrial Dysfunction

Author : Joy Kaush
Publisher :
ISBN 13 : 9783949230875
Total Pages : 0 pages
Book Rating : 4.2/5 (38 download)

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Book Synopsis Molecular Investigation Of Endometrial Dysfunction by : Joy Kaush

Download or read book Molecular Investigation Of Endometrial Dysfunction written by Joy Kaush and published by . This book was released on 2023-11-06 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Endometrial dysfunction refers to the disruption of normal endometrial physiology, leading to infertility, abnormal uterine bleeding, and other gynecological disorders. The molecular and signaling mechanisms that contribute to endometrial dysfunction are complex and multifactorial, involving a range of cellular and molecular pathways. As such, investigating these mechanisms requires a deep understanding of the molecular biology of the endometrium and the cellular processes that regulate its function. One key area of investigation in endometrial dysfunction is the role of hormones and their receptors in the regulation of endometrial physiology. The endometrium is sensitive to the effects of ovarian hormones such as estrogen and progesterone, which play critical roles in regulating the menstrual cycle and preparing the endometrium for implantation of a fertilized egg. Dysregulation of hormonal signaling pathways can lead to disruptions in endometrial function, contributing to infertility and other gynecological disorders. Another important area of investigation is the role of inflammatory and immune signaling pathways in the pathogenesis of endometrial dysfunction. Inflammatory cytokines and chemokines play a critical role in modulating endometrial function and regulating the immune response to implantation. Dysregulation of these pathways can lead to a range of gynecological disorders, including endometriosis, adenomyosis, and recurrent pregnancy loss. Molecular investigations into endometrial dysfunction have also focused on the role of epigenetic mechanisms in regulating gene expression and modulating cellular function. Epigenetic modifications such as DNA methylation and histone modifications can play critical roles in regulating endometrial function and influencing the pathogenesis of gynecological disorders. Studies have shown that alterations in DNA methylation patterns and histone modifications can lead to dysregulation of key genes involved in endometrial function, contributing to infertility and other reproductive disorders. Advances in molecular biology techniques have enabled researchers to investigate these pathways in greater detail, uncovering new insights into the molecular mechanisms underlying endometrial dysfunction. Techniques such as gene expression profiling, genome-wide association studies, and next-generation sequencing have enabled researchers to identify novel genes and pathways involved in the regulation of endometrial function and to identify potential targets for therapeutic intervention. In conclusion, molecular investigation of endometrial dysfunction is a rapidly evolving field that has the potential to provide new insights into the pathogenesis of gynecological disorders and to identify new therapeutic targets for their treatment. By gaining a better understanding of the molecular mechanisms underlying endometrial dysfunction, researchers can develop more targeted and effective treatments for infertility, abnormal uterine bleeding, and other gynecological disorders, ultimately improving the health and wellbeing of women worldwide.

Molecular Genetics of Endometrial Carcinoma

Author : Lora Hedrick Ellenson
Publisher : Springer
ISBN 13 : 3319431390
Total Pages : 284 pages
Book Rating : 4.3/5 (194 download)

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Book Synopsis Molecular Genetics of Endometrial Carcinoma by : Lora Hedrick Ellenson

Download or read book Molecular Genetics of Endometrial Carcinoma written by Lora Hedrick Ellenson and published by Springer. This book was released on 2016-12-01 with total page 284 pages. Available in PDF, EPUB and Kindle. Book excerpt: This comprehensive text provides a much-needed review of a disease that is currently garnering the interest of molecular biologists, translational scientists, and clinicians. The volume includes emerging developments in the molecular genetics of endometrial carcinoma. In addition to covering the basic genetics of endometrial carcinoma, chapters also cover a wide range of signaling pathways implicated in endometrial carcinoma. A section of the book includes a number of genetically engineered mouse models, which contribute to understanding the role of various genetic alterations in the development and progression of endometrial carcinoma. These models also provide preclinical models for developing effective targeted therapeutic approaches. Endometrial carcinoma is the most common malignancy of the female genital tract in the United States and the number of cases continues to increase around the world. This book is a meant to serve as a resource for a wide range of scientists, from molecular geneticists to signal transduction biologists, as well as to both clinicians and scientists interested in developing targeted therapeutic approaches for women with endometrial carcinoma.

Molecular and Cellular Advances in Endometriosis Research

Author : Antonio Simone Laganà
Publisher :
ISBN 13 : 9783036528021
Total Pages : 165 pages
Book Rating : 4.5/5 (28 download)

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Book Synopsis Molecular and Cellular Advances in Endometriosis Research by : Antonio Simone Laganà

Download or read book Molecular and Cellular Advances in Endometriosis Research written by Antonio Simone Laganà and published by . This book was released on 2022 with total page 165 pages. Available in PDF, EPUB and Kindle. Book excerpt: Endometriosis is defined as the presence of endometrial-like endometrial cells, glands, and stroma outside the uterus, causing a strong inflammatory-like microenvironment in the affected tissue. The exact prevalence of endometriosis is unknown, but estimates range from 2%-10% of women of reproductive age to 50% of infertile women. The etiopathogenesis of endometriosis remains controversial--immune, hormonal, genetic, and epigenetic factors may all be involved, and several theories have been proposed to explain it.This book aims to summarize some of the most recent advancements in basic and translational science (immunology, cell biology, genetics, and epigenetics) in the field of endometriosis that may create new scenarios and change our perspective of the topic.

An Investigation of the Molecular Pathogenesis of Endometrial Cancer

Author : Shoo Peng Siah
Publisher :
ISBN 13 :
Total Pages : 197 pages
Book Rating : 4.:/5 (224 download)

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Book Synopsis An Investigation of the Molecular Pathogenesis of Endometrial Cancer by : Shoo Peng Siah

Download or read book An Investigation of the Molecular Pathogenesis of Endometrial Cancer written by Shoo Peng Siah and published by . This book was released on 2002 with total page 197 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Molecular and Cellular Advances in Endometriosis Research

Author : Antonio Simone Lagana
Publisher : Mdpi AG
ISBN 13 : 9783036528038
Total Pages : 174 pages
Book Rating : 4.5/5 (28 download)

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Book Synopsis Molecular and Cellular Advances in Endometriosis Research by : Antonio Simone Lagana

Download or read book Molecular and Cellular Advances in Endometriosis Research written by Antonio Simone Lagana and published by Mdpi AG. This book was released on 2022-02-17 with total page 174 pages. Available in PDF, EPUB and Kindle. Book excerpt: Endometriosis is defined as the presence of endometrial-like endometrial cells, glands, and stroma outside the uterus, causing a strong inflammatory-like microenvironment in the affected tissue. The exact prevalence of endometriosis is unknown, but estimates range from 2%-10% of women of reproductive age to 50% of infertile women. The etiopathogenesis of endometriosis remains controversial-immune, hormonal, genetic, and epigenetic factors may all be involved, and several theories have been proposed to explain it. This book aims to summarize some of the most recent advancements in basic and translational science (immunology, cell biology, genetics, and epigenetics) in the field of endometriosis that may create new scenarios and change our perspective of the topic.

Animal Models for Endometriosis

Author : Kathy L. Sharpe-Timms
Publisher : Springer Nature
ISBN 13 : 3030518566
Total Pages : 111 pages
Book Rating : 4.0/5 (35 download)

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Book Synopsis Animal Models for Endometriosis by : Kathy L. Sharpe-Timms

Download or read book Animal Models for Endometriosis written by Kathy L. Sharpe-Timms and published by Springer Nature. This book was released on 2020-12-05 with total page 111 pages. Available in PDF, EPUB and Kindle. Book excerpt: This new volume of our successful book series Advances in Anatomy, Embryology and Cell Biology focuses on the need for and use of animal models when studying endometriosis. Covering models ranging from rodents to baboons, it explores novel mechanisms involved in the pathophysiology of endometriosis. Topics range from the role of miRNAs and environmental endocrine disrupters to pain and endometriosis-associated subfertility. Estimated to affect up to 10% of women, endometriosis is a widespread and in some cases debilitating disease. While studies on the pathophysiology of the disease and the development of treatments for endometriosis-associated subfertility are called for, acquiring appropriate tissues from women with and without endometriosis in combination with physiologically relevant in vitro and in vivo laboratory models is an essential aspect. However, control subjects with similar ages, living environments and medical histories, besides endometriosis, are hard to find and attaining suitable human reproductive tissues is linked to an ongoing ethical discussion, especially when studying embryos. Laboratory models like rodent and monkey models are therefore needed to fill the research gap and support hypothesis-driven, randomized, controlled experimental design studies. In this book we highlight the latest developments and findings in endometriosis research using animal models. The book was written for scientists, physicians and medical students working in the field of reproductive science, and for women with endometriosis.

The Human Endometrium

Author : Carlo Bulletti
Publisher :
ISBN 13 :
Total Pages : 522 pages
Book Rating : 4.F/5 ( download)

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Book Synopsis The Human Endometrium by : Carlo Bulletti

Download or read book The Human Endometrium written by Carlo Bulletti and published by . This book was released on 1994 with total page 522 pages. Available in PDF, EPUB and Kindle. Book excerpt: The structural, biochemical and clinical events related to menstruation, implantation, parturition, endometriosis, abnormal uterine bleeding and endometrial cancer are discussed in this comprehensive volume on the biological functions of the endometrium. New topics, such as the biochemical and molecular mechanisms regulating maternal embryonic interaction, are explored, and gynecologic endoscopy and therapeutic tools are discussed. The proceedings of the first conference is also available from the Academy, as volume 622 of The Annals of The New York Academy of Science.

Molecular Basis of Endometriosis

Author : Priyanka Rai
Publisher : LAP Lambert Academic Publishing
ISBN 13 : 9783659508776
Total Pages : 180 pages
Book Rating : 4.5/5 (87 download)

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Book Synopsis Molecular Basis of Endometriosis by : Priyanka Rai

Download or read book Molecular Basis of Endometriosis written by Priyanka Rai and published by LAP Lambert Academic Publishing. This book was released on 2015-04-02 with total page 180 pages. Available in PDF, EPUB and Kindle. Book excerpt: Endometrium, a heterogeneous tissue lining the uterus, is highly dynamic and exhibits marked cyclic changes during the menstrual cycle. Any aberration in endometrial physiology would lead to diseases like endometriosis, endometrial polyps, hyperplasia and endometrial cancer. The pathogenesis of endometriosis includes the proliferation of heterogeneous endometrial cells and their invasion into ectopic sites within the peritoneal cavity. This may be due to abnormalities of the eutopic endometrium itself, predisposing the cells to survive and implant ectopically. Several studies were carried out to have a better understanding of the endometrium per se as well to have an insight in the pathogenesis of endometriosis. However, the pathogenesis of endometriosis is still poorly understood. This work is designed to identify the proteins that are differentially expressed in different stages of endometriosis and establish the role of candidate protein(s) in endometriosis.

Human Reproduction

Author : Heide Schatten
Publisher : John Wiley & Sons
ISBN 13 : 1118849582
Total Pages : 454 pages
Book Rating : 4.1/5 (188 download)

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Book Synopsis Human Reproduction by : Heide Schatten

Download or read book Human Reproduction written by Heide Schatten and published by John Wiley & Sons. This book was released on 2017-03-06 with total page 454 pages. Available in PDF, EPUB and Kindle. Book excerpt: In vitro fertilization (IVF) and other assisted reproductive technologies (ART) have become a significant part of human reproduction, with already one in 50 children worldwide being born through ART and the demand steadily increasing. To accommodate the various kinds of infertility problems, new methods have been developed to increase IVF and ART success rates and it has also become possible to treat sperm, eggs, and embryos in culture to improve reproductive success, to increase the health state of an embryo, and to prevent disease in the developing child. Human Reproduction: Updates and New Horizons focuses on recent developments and new approaches to study egg and sperm cells and embryo development, as well as addressing the increasing demand for IVF and ART to overcome infertility problems of various kinds that are encountered by an increasing number of couples worldwide. The book includes 10 chapters written by experts in their specific fields to provide information on sperm selection techniques and their relevance to ART; In vitro maturation of human oocytes: current practices and future promises; Molecular biology of endometriosis; Novel immunological aspects for the treatment of age-induced ovarian and testicular infertility, other functional diseases, and early and advanced cancer immunotherapy; Mitochondrial manipulation for infertility treatment and disease prevention; Novel imaging techniques to assess gametes and preimplantation embryos; Clinical application of methods to select in vitro fertilized embryos; New horizons/developments in time-lapse morphokinetic analysis of mammalian embryos; The non-human primate model for early human development; Cytoskeletal functions, defects, and dysfunctions affecting human fertilization and embryo development. This book will appeal to a large interdisciplinary audience, including researchers from both the basic science and medical communities. It will be a valuable reference for IVF clinicians, patients and prospective patients who are considering ART procedures, embryologists, cell biologists and students in the field of reproduction.

Endometriosis Today: Advances in Research and Practice

Author : H. Minaguchi
Publisher : CRC Press
ISBN 13 : 9781850709015
Total Pages : 496 pages
Book Rating : 4.7/5 (9 download)

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Book Synopsis Endometriosis Today: Advances in Research and Practice by : H. Minaguchi

Download or read book Endometriosis Today: Advances in Research and Practice written by H. Minaguchi and published by CRC Press. This book was released on 1997-10-15 with total page 496 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is the latest complete research text and clinical reference work on all aspects of endometriosis. It contains over 90 contributions by the world's leaders in the study of endometriosis and its treatment. Major sections cover the etiology and natural history of endometriosis, endometrial physiology, pain, pathogenesis, laparoscopic and laparotomic surgery, immunology and molecular biology, medical and surgical treatment of infertility, peritoneal environment, assisted reproductive technologies, classification, medical treatment of endometriosis, endometriosis and infertility, medical therapy for benign gynecological disease, GnRH agonist therapy, and LHRH antagonists. The book is fully illustrated and massively referenced.

The Role of ARID1A in Endometriosis-related Infertility

Author : Ryan Michael Marquardt
Publisher :
ISBN 13 :
Total Pages : 0 pages
Book Rating : 4.4/5 (268 download)

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Book Synopsis The Role of ARID1A in Endometriosis-related Infertility by : Ryan Michael Marquardt

Download or read book The Role of ARID1A in Endometriosis-related Infertility written by Ryan Michael Marquardt and published by . This book was released on 2022 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: The inner lining of the uterus, the endometrium, is composed of a luminal epithelial cell layer supported by an underlying stroma which contains epithelial gland structures. These distinct cell types coordinate with complex and dynamic molecular crosstalk tightly controlled by ovarian steroid hormones to regulate a healthy menstrual cycle and support the initiation and maintenance of a healthy pregnancy. Endometriosis occurs when endometrium-like tissue forms lesions outside the uterine cavity, and this painful disease afflicts about 10% of reproductive-age women, an estimated 176 million worldwide. Up to 50% of these individuals also experience infertility, and many cases cannot be explained by morphological or ovarian defects, which implicates a uterine environment that is non-receptive to embryo implantation. The molecular basis for the correlation between endometriotic lesion presence and a non-receptive endometrium is unclear, but available evidence suggests that dysregulation of epigenetic regulators may play a role. Expression of AT-rich interaction domain 1A (ARID1A), a chromatin remodeling factor, is lost in some endometriotic lesions and markedly reduced in endometrial biopsies from infertile women with endometriosis, but it is essential in the uterus for fertility. This dissertation evaluates the overarching hypothesis that ARID1A loss connects endometriosis and infertility by causing increased lesion development and a non-receptive endometrium. Chapter 1 provides a review of the current literature on the topics of normal ovarian steroid hormone regulation of endometrial function, the dysregulation that occurs in endometriosis with its clinical implications and therapeutic options, and the specific involvement of ARID1A in endometrial pathophysiology. Chapter 2 delineates a critical role for endometrial epithelial ARID1A in uterine gland function for fertility. Chapter 3 reports the need for endometrial epithelial ARID1A to maintain uterine immune homeostasis during early pregnancy. Chapter 4 explores the involvement of endometrial ARID1A loss in a mouse model of endometriosis-related infertility. Chapter 5 describes a method for in vivo photoacoustic imaging of this endometriosis mouse model through the application of nanoparticle labeling. Finally, Chapter 6 summarizes the findings, discusses conclusions from the synthesized data in the context of the current literature, and provides ideas for future studies of related topics. Together, the studies herein make the case that endometrial ARID1A loss contributes to endometriosis-related infertility by exacerbating endometriotic lesion formation and compromising the ability of the endometrium to maintain the gland function and immune homeostasis necessary for the establishment and maintenance of pregnancy. Continued investigation through studies like these is key to understanding endometrial pathophysiology at the molecular level in order to enable development of targeted treatment options for women suffering the devastating effects of endometriosis and related infertility.

Genetic Polymorphisms and Molecular Pathogenesis of Endometriosis

Author : Vijayalakshmi Kodati
Publisher :
ISBN 13 : 9789535105244
Total Pages : pages
Book Rating : 4.1/5 (52 download)

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Book Synopsis Genetic Polymorphisms and Molecular Pathogenesis of Endometriosis by : Vijayalakshmi Kodati

Download or read book Genetic Polymorphisms and Molecular Pathogenesis of Endometriosis written by Vijayalakshmi Kodati and published by . This book was released on 2012 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Recent Advances in Endometrial Cancer

Author : Sumita Mehta
Publisher : Springer Nature
ISBN 13 : 9811553173
Total Pages : 306 pages
Book Rating : 4.8/5 (115 download)

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Book Synopsis Recent Advances in Endometrial Cancer by : Sumita Mehta

Download or read book Recent Advances in Endometrial Cancer written by Sumita Mehta and published by Springer Nature. This book was released on 2020-07-23 with total page 306 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book discusses in detail the recent advances in the management of endometrial cancer, including the latest therapies and diagnostic methods. The book focuses on treatment-oriented topics such as the role of lymphadenectomy and sentinel node dissection, surgical complications, radiation techniques, and chemotherapy in endometrial cancer, and also explores treatment options in advanced disease stages, including hormonal therapy and targeted therapy. Providing insights into the evidence-based management guidelines for endometrial cancer, this book is a valuable resource for students, trainees and practitioners in the field of gynecology and gyne-oncology.