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Molecular Mechanisms Of Synaptic Plasticity Dynamic Changes In Neurons Functions
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Book Synopsis Molecular Mechanisms of Synaptic Plasticity: Dynamic Changes in Neurons Functions by : Giuseppina Martella
Download or read book Molecular Mechanisms of Synaptic Plasticity: Dynamic Changes in Neurons Functions written by Giuseppina Martella and published by . This book was released on 2023 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: The human brain has hundreds of billions of neurons, and at least 7 million dendrites have been hypothesized to exist for each neuron, with over 100 trillion neuron-neuron, neuron-muscle, and neuron-endocrine cell synapses [1,2]. Our body continually receives stimuli from the outer environment, and our brain's ability to respond to these stimuli is ensured through synaptic processes, motivating the foundations of this Special Issue.This reprint aims to underline the role of synaptic plasticity phenomena in our body and clarify the mechanism operated by neurons to guarantee these phenomena. The collection in the Issue comprises 14 papers, including 8 reviews and 6 original works, one of which is a protocol for differentiating neurons from human stem cells, and 5 are preclinical works.
Book Synopsis Molecular Mechanisms of Synaptic Plasticity 2.0 by : Giuseppina Martella
Download or read book Molecular Mechanisms of Synaptic Plasticity 2.0 written by Giuseppina Martella and published by Mdpi AG. This book was released on 2023-11-23 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This Special Issue is a continuation of our previous Special Issue "Molecular Mechanisms of Synaptic Plasticity: Dynamic Changes in Neurons Functions". With the aim to present good research papers provided by specialists, this Special Issue published basic research and pre-clinical research articles, case reports, case series or clinical image articles, short communications, and review articles.
Book Synopsis Neural Plasticity and Memory by : Federico Bermudez-Rattoni
Download or read book Neural Plasticity and Memory written by Federico Bermudez-Rattoni and published by CRC Press. This book was released on 2007-04-17 with total page 368 pages. Available in PDF, EPUB and Kindle. Book excerpt: A comprehensive, multidisciplinary review, Neural Plasticity and Memory: From Genes to Brain Imaging provides an in-depth, up-to-date analysis of the study of the neurobiology of memory. Leading specialists share their scientific experience in the field, covering a wide range of topics where molecular, genetic, behavioral, and brain imaging techniq
Book Synopsis Synaptic Plasticity by : Michael R. Kreutz
Download or read book Synaptic Plasticity written by Michael R. Kreutz and published by Springer Science & Business Media. This book was released on 2012-02-18 with total page 611 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book introduces the current concepts of molecular mechanisms in synaptic plasticity and provides a comprehensive overview of cutting-edge research technology used to investigate the molecular dynamics of the synapses. It explores current concepts on activity-dependent remodeling of the synaptic cytoskeleton and presents the latest ideas on the different forms of plasticity in synapses and dendrites. Synaptic Plasticity in Health and Disease not only supplies readers with extensive knowledge on the latest developments in research, but also with important information on clinical and applied aspects. Changes in spine synapses in different brain disease states, so-called synaptopathies, are explained and described by experts in the field. By outlining basic research findings as well as physiological and pathophysiological impacts on synaptic plasticity, the book represents an essential state-of-the-art work for scientists in the fields of biochemistry, molecular biology and the neurosciences, as well as for doctors in neurology and psychiatry alike.
Book Synopsis Molecular Mechanisms of Synaptic Plasticity by : Giuseppina Martella
Download or read book Molecular Mechanisms of Synaptic Plasticity written by Giuseppina Martella and published by Mdpi AG. This book was released on 2023-08-28 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: The human brain has hundreds of billions of neurons, and at least 7 million dendrites have been hypothesized to exist for each neuron, with over 100 trillion neuron-neuron, neuron-muscle, and neuron-endocrine cell synapses [1,2]. Our body continually receives stimuli from the outer environment, and our brain's ability to respond to these stimuli is ensured through synaptic processes, motivating the foundations of this Special Issue. This reprint aims to underline the role of synaptic plasticity phenomena in our body and clarify the mechanism operated by neurons to guarantee these phenomena. The collection in the Issue comprises 14 papers, including 8 reviews and 6 original works, one of which is a protocol for differentiating neurons from human stem cells, and 5 are preclinical works.
Book Synopsis Molecular Mechanisms of Synaptogenesis by : Alexander Dityatev
Download or read book Molecular Mechanisms of Synaptogenesis written by Alexander Dityatev and published by Springer Science & Business Media. This book was released on 2006-11-24 with total page 504 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides a new compilation of information that link changes in the basic structure of synapses and brain diseases. The book shows that specific secreted proteins, and short peptide mimicking the function of neural cell adhesion molecules can significantly enhance the formation of synapses in the brain. It describes recent advances in research that lay necessary scientific groundwork to develop pharmacological treatments.
Book Synopsis Cellular and Molecular Mechanisms of Synaptic Plasticity at Hippocampal and Cortical Synapses by : Roberto De Pasquale
Download or read book Cellular and Molecular Mechanisms of Synaptic Plasticity at Hippocampal and Cortical Synapses written by Roberto De Pasquale and published by Frontiers Media SA. This book was released on 2022-08-11 with total page 129 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Translational Research in Traumatic Brain Injury by : Daniel Laskowitz
Download or read book Translational Research in Traumatic Brain Injury written by Daniel Laskowitz and published by CRC Press. This book was released on 2016-04-21 with total page 388 pages. Available in PDF, EPUB and Kindle. Book excerpt: Traumatic brain injury (TBI) remains a significant source of death and permanent disability, contributing to nearly one-third of all injury related deaths in the United States and exacting a profound personal and economic toll. Despite the increased resources that have recently been brought to bear to improve our understanding of TBI, the developme
Book Synopsis Homeostatic Synaptic Plasticity: From Synaptic Circuit Assembly to Neurological Disorders by : Lorenzo A. Cingolani
Download or read book Homeostatic Synaptic Plasticity: From Synaptic Circuit Assembly to Neurological Disorders written by Lorenzo A. Cingolani and published by Frontiers Media SA. This book was released on 2021-07-08 with total page 174 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Molecular Mechanisms of Synaptic Plasticity by : Hongik Hwang
Download or read book Molecular Mechanisms of Synaptic Plasticity written by Hongik Hwang and published by . This book was released on 2016 with total page 122 pages. Available in PDF, EPUB and Kindle. Book excerpt: Synaptic plasticity serves as a central molecular mechanism underlying learning and memory formation in the brain. An increase in intracellular calcium concentrations triggered by neuronal activity induces synaptic plasticity, and calmodulin is a key protein that detects the elevated calcium levels and propagates downstream signaling. Neurogranin is a neuron-specific protein that binds to calmodulin and regulates the availability of calmodulin in the postsynaptic compartments of excitatory neurons. Dysregulation of neurogranin has been reported to cause altered synaptic plasticity as well as impairment in hippocampus-dependent learning, and is also associated with the higher risk of developing neurodegenerative and psychiatric diseases. Therefore, it is critical to understand how neurogranin regulates the induction of synaptic plasticity in the brain at the molecular level. The focus of this thesis is to examine how the changes in neurogranin expression levels contribute to the induction of synaptic plasticity in the hippocampus with a spike-timing-dependent plasticity paradigm and to understand the underlying molecular mechanisms. Using lentivirus-mediated manipulations of neurogranin levels in hippocampal CAl neurons, we found that increasing neurogranin levels in CAI neurons prolongs the timing window for spike-timing-dependent long-term potentiation (LTP), whereas acute knockdown of neurogranin inhibits the expression of LTP via regulating PP2B activity. We have also found that neurogranin interferes with calcium-dependent inactivation of neuronal L-type calcium channels and allows a sustained influx of calcium during the membrane depolarization in hippocampal neurons. Our results indicate that dynamic changes in neurogranin levels play a crucial role in setting the threshold for inducing LTP in spike-timing-dependent plasticity in the hippocampus.
Book Synopsis Synaptic Plasticity by : Thomas Heinbockel
Download or read book Synaptic Plasticity written by Thomas Heinbockel and published by BoD – Books on Demand. This book was released on 2017-06-21 with total page 224 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nerve cells form thousands of contact points, the synapses, to communicate information with other neurons and target cells. Synapses are sites for changes in brain function through modification of synaptic transmission termed synaptic plasticity. The study of synaptic plasticity has flourished over the years with the advancement of technical breakthroughs and is a timely scientific endeavor today just like it was several decades ago. This book contributes to our understanding of synaptic plasticity at the molecular, biochemical, and cellular systems and behavioral level and informs the reader about its clinical relevance. The book contains ten chapters in three sections: (1) "Mechanisms of Synaptic Plasticity," (2) "Neural Plasticity," and (3) "Plasticity and Neurological Diseases." The book provides detailed and current reviews in these different areas written by experts in their respective fields. The mechanisms of synaptic plasticity and its relation to neurological diseases are featured prominently as a recurring theme throughout most chapters. This book will be most useful for neuroscientists and other scientists alike and will contribute to the training of current and future students who find the plastic nervous system as fascinating as many generations before them.
Book Synopsis Mechanisms of Memory by : J. David Sweatt
Download or read book Mechanisms of Memory written by J. David Sweatt and published by Academic Press. This book was released on 2009-09-28 with total page 362 pages. Available in PDF, EPUB and Kindle. Book excerpt: This fully revised second edition provides the only unified synthesis of available information concerning the mechanisms of higher-order memory formation. It spans the range from learning theory, to human and animal behavioral learning models, to cellular physiology and biochemistry. It is unique in its incorporation of chapters on memory disorders, tying in these clinically important syndromes with the basic science of synaptic plasticity and memory mechanisms. It also covers cutting-edge approaches such as the use of genetically engineered animals in studies of memory and memory diseases. Written in an engaging and easily readable style and extensively illustrated with many new, full-color figures to help explain key concepts, this book demystifies the complexities of memory and deepens the reader's understanding. - More than 25% new content, particularly expanding the scope to include new findings in translational research. - Unique in its depth of coverage of molecular and cellular mechanisms - Extensive cross-referencing to Comprehensive Learning and Memory - Discusses clinically relevant memory disorders in the context of modern molecular research and includes numerous practical examples
Book Synopsis Plasticity of GABAergic Synapses by : Andrea Barberis
Download or read book Plasticity of GABAergic Synapses written by Andrea Barberis and published by Frontiers Media SA. This book was released on 2016-01-22 with total page 177 pages. Available in PDF, EPUB and Kindle. Book excerpt: Learning and memory are believed to depend on plastic changes of neuronal circuits due to activity-dependent potentiation or depression of specific synapses. During the last two decades, plasticity of brain circuits was hypothesized to mainly rely on the flexibility of glutamatergic excitatory synapses, whereas inhibitory synapses were assumed relatively invariant, to ensure stable and reliable control of the neuronal network. As a consequence, while considerable efforts were made to clarify the main mechanisms underlying plasticity at excitatory synapses, the study of the cellular/molecular mechanisms of inhibitory plasticity has received much less attention. Nevertheless, an increasing body of evidence has revealed that inhibitory synapses undergo several types of plasticity at both pre- and postsynaptic levels. Given the crucial role of inhibitory interneurons in shaping network activities, such as generation of oscillations, selection of cell assemblies and signal integration, modifications of the inhibitory synaptic strength represents an extraordinary source of versatility for the fine control of brain states. This versatility also results from the rich diversity of GABAergic neurons in several brain areas, the specific role played by each inhibitory neuron subtype within a given circuit, and the heterogeneity of the properties and modulation of GABAergic synapses formed by specific interneuron classes. The molecular mechanisms underlying the potentiation or depression of inhibitory synapses are now beginning to be unraveled. At the presynaptic level, retrograde synaptic signaling was demonstrated to modulate GABA release, whereas postsynaptic forms of plasticity involve changes in the number/gating properties of GABAA receptors and/or shifts of chloride gradients. In addition, recent research indicates that GABAergic tonic inhibition can also be plastic, adding a further level of complexity to the control of the excitatory/inhibitory balance in the brain. The present Topic will focus on plasticity of GABAergic synapses, with special emphasis on the molecular mechanisms of plasticity induction and/or expression.
Book Synopsis Molecular mechanisms of synaptic plasticity by :
Download or read book Molecular mechanisms of synaptic plasticity written by and published by Cuvillier Verlag. This book was released on 2002-01-01 with total page 198 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Make Life Visible by : Yoshiaki Toyama
Download or read book Make Life Visible written by Yoshiaki Toyama and published by Springer Nature. This book was released on 2019-10-02 with total page 292 pages. Available in PDF, EPUB and Kindle. Book excerpt: This open access book describes marked advances in imaging technology that have enabled the visualization of phenomena in ways formerly believed to be completelyimpossible. These technologies have made major contributions to the elucidation of the pathology of diseases as well as to their diagnosis and therapy. The volume presents various studies from molecular imaging to clinical imaging. It also focuses on innovative, creative, advanced research that gives full play to imaging technology inthe broad sense, while exploring cross-disciplinary areas in which individual research fields interact and pursuing the development of new techniques where they fuse together. The book is separated into three parts, the first of which addresses the topic of visualizing and controlling molecules for life. Th e second part is devoted to imaging of disease mechanisms, while the final part comprises studies on the application of imaging technologies to diagnosis and therapy. Th e book contains the proceedings of the 12th Uehara International Symposium 2017, “Make Life Visible” sponsored by the Uehara Memorial Foundation and held from June 12 to 14, 2017. It is written by leading scientists in the field and is an open access publication under a CC BY 4.0 license.
Download or read book Synaptic Plasticity written by and published by . This book was released on 19?? with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Handbook of in Vivo Neural Plasticity Techniques by :
Download or read book Handbook of in Vivo Neural Plasticity Techniques written by and published by Academic Press. This book was released on 2018-09-01 with total page 576 pages. Available in PDF, EPUB and Kindle. Book excerpt: Handbook of in Vivo Neural Plasticity Techniques, Volume 28: A Systems Neuroscience Approach to the Neural Basis of Memory and Cognition gives a comprehensive overview of the current methods and approaches that are used to study neural plasticity from a systems neuroscience perspective. In addition, the book offers in-depth methodological advice that provides the necessary foundation for researchers establishing methods and students who need to understand the theoretical and methodological bases of these approaches. This is the ideal resource for anyone new to the study of cognitive and behavioral neuroscience who seeks an introduction to state-of-the-art techniques. Offers a comprehensive overview of state-of-the-art approaches to studying neuroplasticity in vivo Combines discussions of theoretical underpinnings with the methodological and technical aspects necessary to guarantee success Arranged in a uniform format that clearly and concisely lays out descriptions, methods and the pitfalls of various techniques
