Read Books Online and Download eBooks, EPub, PDF, Mobi, Kindle, Text Full Free.
Molecular Mechanisms In Legionella Pathogenesis
Download Molecular Mechanisms In Legionella Pathogenesis full books in PDF, epub, and Kindle. Read online Molecular Mechanisms In Legionella Pathogenesis ebook anywhere anytime directly on your device. Fast Download speed and no annoying ads. We cannot guarantee that every ebooks is available!
Book Synopsis Molecular Mechanisms in Legionella Pathogenesis by : Hubert Hilbi
Download or read book Molecular Mechanisms in Legionella Pathogenesis written by Hubert Hilbi and published by Springer Science & Business Media. This book was released on 2014-07-08 with total page 297 pages. Available in PDF, EPUB and Kindle. Book excerpt: Legionnaires’ disease, a potentially fatal type of pneumonia primarily affecting elderly and immuno-compromised persons, is caused by the ubiquitous environmental bacterium Legionella pneumophila. This book offers authoritative reviews of different facets of its virulence, focusing on comparative phagocyte infection, virulence gene regulation, biochemical functions of effector proteins and cellular pathogen-host interactions, as well as host responses and immunity to L. pneumophila. Taken together, the contributions in this compilation provide a state-of-the-art overview of current insights into the molecular pathogenesis of the opportunistic and potentially fatal pathogen L. pneumophila.
Author :National Academies of Sciences, Engineering, and Medicine Publisher :National Academies Press ISBN 13 :030949382X Total Pages :291 pages Book Rating :4.3/5 (94 download)
Book Synopsis Management of Legionella in Water Systems by : National Academies of Sciences, Engineering, and Medicine
Download or read book Management of Legionella in Water Systems written by National Academies of Sciences, Engineering, and Medicine and published by National Academies Press. This book was released on 2020-02-20 with total page 291 pages. Available in PDF, EPUB and Kindle. Book excerpt: Legionnaires' disease, a pneumonia caused by the Legionella bacterium, is the leading cause of reported waterborne disease outbreaks in the United States. Legionella occur naturally in water from many different environmental sources, but grow rapidly in the warm, stagnant conditions that can be found in engineered water systems such as cooling towers, building plumbing, and hot tubs. Humans are primarily exposed to Legionella through inhalation of contaminated aerosols into the respiratory system. Legionnaires' disease can be fatal, with between 3 and 33 percent of Legionella infections leading to death, and studies show the incidence of Legionnaires' disease in the United States increased five-fold from 2000 to 2017. Management of Legionella in Water Systems reviews the state of science on Legionella contamination of water systems, specifically the ecology and diagnosis. This report explores the process of transmission via water systems, quantification, prevention and control, and policy and training issues that affect the incidence of Legionnaires' disease. It also analyzes existing knowledge gaps and recommends research priorities moving forward.
Book Synopsis Biology and Pathogenesis of Legionella by : Hayley Newton
Download or read book Biology and Pathogenesis of Legionella written by Hayley Newton and published by Frontiers Media SA. This book was released on 2018-12-07 with total page 181 pages. Available in PDF, EPUB and Kindle. Book excerpt: Legionella pneumophila was first isolated as the causative agent of a deadly infectious pneumonia at a convention of the American Legion forty years ago. Since then, Legionnaires’ disease continues to be a significant public health concern. Today, our understanding of the Legionella genus, comprising environmental bacteria and opportunistic human pathogens, has dramatically increased. The study of how pathogenic Legionella interact with host cells, both protozoan and mammalian, has not only taught us about host-pathogen interactions but has revealed novel and unexpected insights into human cell biology and immunology. The capacity of pathogenic Legionella to commandeer cellular processes such as eukaryotic vesicular trafficking to establish an ER-like replicative niche, reflects the exquisite ability of this pathogen to manipulate eukaryotic cell biology in order to replicate in an intracellular compartment. This requires the specific and targeted action of a cohort of translocated bacterial effector proteins. In addition, we have learnt much about cell autonomous innate immune sensing of intracellular bacteria through the inability of L. pneumophila to avoid intracellular mammalian defense mechanisms. Now, in the age of large-scale comparative “omics”, it is clear that different Legionella species utilize different cohorts of effectors to replicate inside eukaryotic cells. While we understand some of the strategies employed by L. pneumophila and L. longbeachae to replicate within eukaryotic cells, there is still much to learn about many aspects of the Legionella life cycle. This Research Topic highlights the latest findings regarding the biology of Legionella species, their interactions with eukaryotic host cells, and how the application of various technologies has increased our understanding of this important pathogen.
Book Synopsis Microbiology of Waterborne Diseases by :
Download or read book Microbiology of Waterborne Diseases written by and published by Academic Press. This book was released on 2013-11-08 with total page 719 pages. Available in PDF, EPUB and Kindle. Book excerpt: The second edition of Microbiology of Waterborne Diseases describes the diseases associated with water, their causative agents and the ways in which they gain access to water systems. The book is divided into sections covering bacteria, protozoa, and viruses. Other sections detail methods for detecting and identifying waterborne microorganisms, and the ways in which they are removed from water, including chlorine, ozone, and ultraviolet disinfection. The second edition of this handbook has been updated with information on biofilms and antimicrobial resistance. The impact of global warming and climate change phenomena on waterborne illnesses are also discussed. This book serves as an indispensable reference for public health microbiologists, water utility scientists, research water pollution microbiologists environmental health officers, consultants in communicable disease control and microbial water pollution students. Focuses on the microorganisms of most significance to public health, including E. coli, cryptosporidium, and enterovirus Highlights the basic microbiology, clinical features, survival in the environment, and gives a risk assessment for each pathogen Contains new material on antimicrobial resistance and biofilms Covers drinking water and both marine and freshwater recreational bathing waters
Book Synopsis Intracellular Parasitism by : James W. Moulder
Download or read book Intracellular Parasitism written by James W. Moulder and published by CRC Press. This book was released on 2020-10-28 with total page 296 pages. Available in PDF, EPUB and Kindle. Book excerpt: This publication is a collection of essays on the biology of intracellular parasitisms where both bacterial and protozoan parasites are discussed. The juxtaposition of authors representing fields of research emphasizes the many common problems facing intracellular parasites and the hosts that harbor them. In addition, numerous illustrations of how different parasites and host attempt to solve these problems in different ways are provided. The book includes one or more chapters on Bdellovibrio, Chlamydia, Rickettsia, Coxiella, Legionella, Shigellae, Mycobacterium, Microsporidium, Plasmodium, and Toxoplasma. The authors frequently speculate and generalize on the subject matter discussed.
Download or read book Legionella written by James M. Barbaree and published by ASM Press. This book was released on 1993 with total page 334 pages. Available in PDF, EPUB and Kindle. Book excerpt: Drawn from ASM′s 1992 symposium on the subject, this book completely updates information on all aspects of Legionella and Legionnaires disease. Strategy sessions held at the symposium to address current issues involving preventive measures to minimize the presence of Legionella and occurence of Legionnaires disease, the evolution of chemotherapy and diagnostic tests, and prospects for vaccine development are summarized. Legionella is required reading for anyone working in this area of infectious disease. As the sole source of current knowledge and theory on Legionella, it is an extremely useful reference for clinical microbiologists, environmental microbiologists, epidemiologists, infectious disease and other clinical specialists, and environmental engineers.
Book Synopsis Bacterial Biofilms by : Sadik Dincer
Download or read book Bacterial Biofilms written by Sadik Dincer and published by BoD – Books on Demand. This book was released on 2020-10-07 with total page 362 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book examines biofilms in nature. Organized into four parts, this book addresses biofilms in wastewater treatment, inhibition of biofilm formation, biofilms and infection, and ecology of biofilms. It is designed for clinicians, researchers, and industry professionals in the fields of microbiology, biotechnology, ecology, and medicine as well as graduate and postgraduate students.
Download or read book Legionella written by Klaus Heuner and published by Caister Academic Press Limited. This book was released on 2008 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Legionellosis is a disease of significant medical and public interest. Legionella is commonly found in aquatic habitats where its ability to survive and to multiply within different protozoa equips the bacterium to be transmissible and pathogenic to humans. In addition Legionella has become a favored model system to analyse the mechanisms of bacterial survival, acquisition of nutrients and intracellular replication. Following the recent publication of the genome sequences of four L. pneumophila strains it is now feasible to investigate the whole genome in silico, the transcriptome via micro arrays and the proteome by two-dimensional gel electrophoresis. Research in the fields of clinical features, diagnosis, treatment and epidemiology continues to generate new data. The topics covered by this volume range from the history of the identification of Legionella and clinical disease treatment, to the microbe's gene expression and secretion systems as well as its strategies for intracellular multiplication and nutrient acquisition. The main focus of the book is the current state of many of the most critical features of Legionella. Internationally renowned authors have contributed chapters describing and discussing the latest research findings with an emphasis on molecular aspects. The editors and authors have produced an excellent book that will be an extremely useful reference source. This comprehensive publication is aimed at readers with teaching or research interests in microbiology, genetics, genomics, infectious diseases or clinical research. A recommended book for all microbiology and clinical research laboratories.
Download or read book Legionella written by Carmen Buchrieser and published by Humana Press. This book was released on 2016-05-01 with total page 652 pages. Available in PDF, EPUB and Kindle. Book excerpt: This deadly pneumonia has a high mortality rate among the elderly, and the detailed protocols outlined in this new book in the Methods in Molecular Biology series will extend our understanding of the bacterium and aid its elimination from our water supplies.
Book Synopsis Molecular Mechanisms of the Interaction of Legionella Pneumophila with the Pulmonary Epithelium by : Dje Philippe Pacome N'Guessan
Download or read book Molecular Mechanisms of the Interaction of Legionella Pneumophila with the Pulmonary Epithelium written by Dje Philippe Pacome N'Guessan and published by . This book was released on 2013 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Type II Secretion of Virulence Factors and Iron Acquisition Mechanisms of Legionella Pneumophila by : Mark Russell Liles
Download or read book Type II Secretion of Virulence Factors and Iron Acquisition Mechanisms of Legionella Pneumophila written by Mark Russell Liles and published by . This book was released on 1998 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Survival and growth within the intracellular environment of an alveolar macrophage requires Legionella pneumophila to subvert the normal phagocytic pathway and acquire limiting nutrients, such as iron. Many pathogens excrete siderophores to chelate iron from host proteins. Biochemical investigations revealed that L. pneumophila supernatants contain multiple iron-binding molecules: the melanin homogentisic acid, the media component cysteine, and an unidentified low molecular weight molecule produced only in some strains of L. pneumophila. To identify iron uptake mechanisms by a genetic approach, transposon-generated mutants were screened for resistance to the iron-activated drug streptonigrin. While sequencing the L. pneumophila DNA downstream of the transposon in the mutant NU218, genes were discovered whose predicted proteins have strong homology to PilB, PilC, and PilD of Pseudomonas aeruginosa, proteins all required for type IV pilus biogenesis. Northern blot analysis demonstrated that the L. pneumophila pilBCD genes are expressed as an operon, and that pilBCD expression is greater at 30$\sp\circ$C than at 37$\sp\circ$C. This temperature-regulated pilBCD expression was correlated with an increase in piliation at 30$\sp\circ$C. Other investigators recently discovered the L. pneumophila type IV pilin subunit (PilE$\rm\sb{L}),$ and found that a $pilE\sb{L}$ mutant lacks type IV pili, but is fully competent for intracellular replication. Since PilD, the prepilin peptidase, is also required for type II protein secretion in other gram-negative bacteria, a pilD mutant was constructed to establish whether L. pneumophila exports proteins through a type II apparatus and whether this process contributes to pathogenesis. The pilD mutant exhibits a unique colony morphology, lacks type IV pili, and is impaired in replication within cultured human macrophages and amoebae. Additionally, the pilD mutant does not cause respiratory distress, high fever, weight loss, or death in guinea pigs, and is rapidly cleared from the lungs of infected animals. From these data it can be concluded that L. pneumophila has a type II secretion system, and that one or more proteins exported via this pathway are important for the virulence of L. pneumophila.
Book Synopsis Molecular Biology of The Cell by : Bruce Alberts
Download or read book Molecular Biology of The Cell written by Bruce Alberts and published by . This book was released on 2002 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Bacterial Pathogenesis written by and published by Academic Press. This book was released on 1998-07-01 with total page 620 pages. Available in PDF, EPUB and Kindle. Book excerpt: Established almost 30 years ago, Methods in Microbiology is the most prestigious series devoted to techniques and methodology in the field. Now totally revamped, revitalized, with a new format and expanded scope, Methods in Microbiology will continue to provide you with tried and tested, cutting-edge protocols to directly benefit your research. Focuses on the methods most useful for the microbiologist interested in the way in which bacteria cause disease Includes section devoted to 'Approaches to characterising pathogenic mechanisms' by Stanley Falkow Covers safety aspects, detection, identification and speciation Includes techniques for the study of host interactions and reactions in animals and plants Describes biochemical and molecular genetic approaches Essential methods for gene expression and analysis Covers strategies and problems for disease control
Book Synopsis Bacterial Invasion of Host Cells by : Richard J. Lamont
Download or read book Bacterial Invasion of Host Cells written by Richard J. Lamont and published by Cambridge University Press. This book was released on 2004-03-29 with total page 360 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book concerns the intimate association between bacteria and host cells. Many bacterial pathogens are able to invade and survive within cells at mucosal membranes. Remarkably, the bacteria themselves orchestrate this process through the exploitation of host cellular signal transduction pathways. Intracellular invasion can lead to disruption of host tissue integrity and perturbation of the immune system. An understanding of the molecular basis of bacterial invasion and of host cell adaptation to intracellular bacteria will provide fundamental insights into the pathophysiology of bacteria and the cell biology of the host. The book details specific examples of bacteria that are masters of manipulation of eukaryotic cell signaling and relates these events to the broader context of host-pathogen interaction. Written by experts in the field, this book will be of interest to researchers and graduate students in microbiology, immunology, biochemistry, as well as molecular medicine and dentistry.
Book Synopsis Virulence and Pathogenic Mechanisms of Legionella Pneumophila by : Ann Rawkins
Download or read book Virulence and Pathogenic Mechanisms of Legionella Pneumophila written by Ann Rawkins and published by . This book was released on 1994 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Ending the War Metaphor by : Institute of Medicine
Download or read book Ending the War Metaphor written by Institute of Medicine and published by National Academies Press. This book was released on 2006-07-09 with total page 306 pages. Available in PDF, EPUB and Kindle. Book excerpt: Infectious diseases have existed longer than us, as long as us, or are relatively newer than us. It may be the case that a disease has existed for many, many years but has only recently begun affecting humans. At the turn of the century the number of deaths caused by infections in the United States had been falling steadily but since the '80s has seen an increase. In the past 30 years alone 37 new pathogens have been identified as human disease threats and 12% of known human pathogens have been classified as either emerging or remerging. Whatever the story, there is currently a "war" on infectious diseases. This war is simply the systematic search for the microbial "cause" of each disease, followed by the development of antimicrobial therapies. The "war" on infectious diseases, however, must be revisited in order to develop a more realistic and detailed picture of the dynamic interactions among and between host organisms and their diverse populations of microbes. Only a fraction of these microbes are pathogens. Thus, in order to explore the crafting of a new metaphor for host-microbe relationships, and to consider how such a new perspective might inform and prioritize biomedical research, the Forum on Microbial Threats of the Institute of Medicine (IOM) convened the workshop, Ending the War Metaphor: The Changing Agenda for Unraveling the Host-Microbe Relationship on March 16-17, 2005. Workshop participants examined knowledge and approaches to learning about the bacterial inhabitants of the human gut, the best known host-microbe system, as well as findings from studies of microbial communities associated with other mammals, fish, plants, soil, and insects. The perspective adopted by this workshop is one that recognizes the breadth and diversity of host-microbe relationships beyond those relative few that result in overt disease. Included in this summary are the reports and papers of individuals participating in the Forum as well as the views of the editors.
Download or read book Oral Biofilms written by S. Eick and published by Karger Medical and Scientific Publishers. This book was released on 2020-12-21 with total page 247 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biofilms are highly organized polymicrobial communities that are embedded in an extracellular matrix and formed on natural and artificial surfaces. In the oral cavity, biofilms are formed not only on natural teeth, but also on restorative materials, prosthetic constructions, and dental implants. Oral diseases like caries, gingivitis, periodontitis, and also pulp inflammation are associated with biofilms. This publication is an up-to-date overview on oral biofilms from different clinically relevant perspectives. Experts comprising basic researchers and clinicians report on recent research relating to biofilms - from general summaries to recommendations for daily clinical work. This book covers all aspects of oral biofilms, including models used in the laboratory, biofilms in dental water unit lines, periodontal and peri-implant biofilms, caries-related biofilms, halitosis, endodontic biofilms, and Candida infections, as well as biofilms on dental materials and on orthodontic appliances. Several chapters deal with anti-biofilm therapy, from the efficacy of mechanical methods and the use of antimicrobials, to alternative concepts. This publication is particularly recommended to dental medicine students, practitioners, other oral healthcare professionals, and scientists with an interest in translational research on biofilms.
