Molecular Hematology

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Molecular Hematology

Author : Drew Provan
Publisher : John Wiley & Sons
ISBN 13 : 1119252873
Total Pages : 424 pages
Book Rating : 4.1/5 (192 download)

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Book Synopsis Molecular Hematology by : Drew Provan

Download or read book Molecular Hematology written by Drew Provan and published by John Wiley & Sons. This book was released on 2019-11-25 with total page 424 pages. Available in PDF, EPUB and Kindle. Book excerpt: The new and fully-revised volume of hematologic molecular biology for practicing and trainee hematologists Molecular Hematology is a comprehensive resource for hematologists to increase their understanding of the molecular basis of various blood diseases, their pathogeneses, and current and emerging molecular research and therapies. The impact of molecular research on the field of hematology is significant—molecular techniques are continuing to play a central role in in the diagnosis and treatment of blood diseases. Molecular characterization of genes and proteins has increased our comprehension of the causes of hematological diseases and led to the development of new drug therapies and recombinant proteins. Now in its fourth edition, Molecular Hematology has been thoroughly revised and updated to reflect current advances in molecular research. Chapters introduce and summarize specific disorders, such as hemophilia, anemia, and multiple myeloma, and illustrate the impact of molecular research on their diagnoses and treatments. Contributions written by respected clinicians and researchers offer accessible coverage of topics including lymphoma genetics, molecular coagulation and thrombophilia, platelet disorders, pharmacogenomics, and many others. Demonstrates the clinical relevance of molecular biology in hematology Provides overviews of recent advances in cancer-cell biology, with an emphasis on leukemia and lymphoma Offers new and updated chapters written by an international team of experts in the field Presents new full-color charts, graphs, and illustrations Includes access to a Wiley Companion Digital Edition providing search across the book, downloadable illustrations and notation tools Molecular Hematology is an essential volume for both trainee and practicing hematologists and oncologists, molecular biologists, and research scientists working in the field of hematology.

Molecular Hematology

Author : Drew Provan
Publisher : John Wiley & Sons
ISBN 13 : 1394180470
Total Pages : 452 pages
Book Rating : 4.3/5 (941 download)

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Book Synopsis Molecular Hematology by : Drew Provan

Download or read book Molecular Hematology written by Drew Provan and published by John Wiley & Sons. This book was released on 2024-03-05 with total page 452 pages. Available in PDF, EPUB and Kindle. Book excerpt: Provides a core knowledgebase for those with minimal exposure to hematologic molecular biology, fully revised and updated Molecular Hematology brings together the most up-to-date and reliable information on the molecular basis of major hematologic diseases. Edited and authored by leading experts in the field, this volume demonstrates the clinical relevance of molecular biology in the diagnosis and treatment of blood disorders. Concise, accessible chapters address key topics in modern hematology, such as lymphoma genetics, molecular coagulation, thrombophilia, pharmacogenomics, platelet disorders, hemophilia, anemia, and multiple myeloma. Chapters introduce and summarize specific hematologic diseases, explore the pathogenesis of the disorder, highlight new and emerging molecular strategies, and more. Now in its fifth edition, Molecular Hematology is fully revised to incorporate contemporary hematology research and practice. Entirely new chapters cover topics such as CAR-T cell technology, COVID, cancer cell biology, gene therapy and gene editing in clinical practice, as well as the impact of molecular research on the diagnosis and treatment of various malignant hematologic diseases. This edition includes updated suggested readings and a wealth of new full-color charts, graphs, and illustrations throughout. Covers the molecular biology of different blood diseases, their pathogeneses, and current molecular research and therapies Illustrates the impact of molecular research on hematologic investigations and therapeutics Discusses how progress in basic science and therapeutics has improved the diagnosis and care of patients with various hematologic disorders Surveys recent developments in cancer-cell biology, with an emphasis on leukemia and lymphoma Includes access to a companion Digital Edition providing search across the book, downloadable illustrations, and notation tools Molecular Hematology is a must-have resource for established and trainee clinicians, clinical scientists and researchers, medical students, and upper-level undergraduates in the fields of hematology, oncology, and molecular biology.

Small Molecules in Hematology

Author : Uwe M. Martens
Publisher : Springer
ISBN 13 : 3319914391
Total Pages : 297 pages
Book Rating : 4.3/5 (199 download)

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Book Synopsis Small Molecules in Hematology by : Uwe M. Martens

Download or read book Small Molecules in Hematology written by Uwe M. Martens and published by Springer. This book was released on 2018-08-01 with total page 297 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book, written by respected experts, discusses in detail the latest developments in targeted therapy for hematologic malignancies using small molecules. It covers a wide range of small molecules including tyrosine kinase inhibitors, immunomodulatory drugs, the IDH-2 inhibitor enasidenib, the BCL-2 inhibitor venetoclax, and the proteasome inhibitor carfilzomib. For each molecule, aspects such as the chemical structure, mechanism of action, drug targets, drug interactions, preclinical studies, clinical trials, treatment applications, and toxicity are discussed. Extensive research into the molecular mechanisms of cancer has heralded a new age of targeted therapy. The field of precision cancer therapy is now growing rapidly, and the advances being made will mean significant changes in the treatment algorithms for cancer patients. Numerous novel targets that are crucial for the survival of cancer cells can be attacked by small molecules such as protein tyrosine kinase inhibitors. An accompanying volume addresses the use of small molecules in oncology, and the two volumes together represent the third edition of the book originally published under the same title.

Molecular Aspects of Hematologic Malignancies

Author : Michal Witt
Publisher : Springer Science & Business Media
ISBN 13 : 3642294677
Total Pages : 468 pages
Book Rating : 4.6/5 (422 download)

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Book Synopsis Molecular Aspects of Hematologic Malignancies by : Michal Witt

Download or read book Molecular Aspects of Hematologic Malignancies written by Michal Witt and published by Springer Science & Business Media. This book was released on 2012-06-30 with total page 468 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides a state-of-the-art approach to the molecular basis of hematologic diseases and its translation into improved diagnostics and novel therapeutic strategies. Several representative hemato-oncologic malignancies are analyzed in detail: acute lymphoblastic leukemia, acute myeloid leukemia, B-cell Non-Hodgkin lymphomas, multiple myeloma, chronic lymphocytic leukemia, chronic myeloid leukemia, myelodysplastic syndromes, and myeloproliferative neoplasms. Experts in the field describe the molecular methods applied for modern diagnostics and therapies, such as hematopoietic stem cell transplantation, donor recipient matching, banking of biological material, analyses of post-transplant chimerism, and minimal residual disease monitoring. The volume concludes with an extensive section comprising thorough step-by-step protocols of molecular techniques in hematology, all of them validated in the authors’ own laboratories.

Laboratory Hematology Practice

Author : Kandice Kottke-Marchant
Publisher : John Wiley & Sons
ISBN 13 : 1444398571
Total Pages : 777 pages
Book Rating : 4.4/5 (443 download)

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Book Synopsis Laboratory Hematology Practice by : Kandice Kottke-Marchant

Download or read book Laboratory Hematology Practice written by Kandice Kottke-Marchant and published by John Wiley & Sons. This book was released on 2012-06-06 with total page 777 pages. Available in PDF, EPUB and Kindle. Book excerpt: Expertly edited and endorsed by the International Society for Laboratory Hematology, this is the newest international textbook on all aspects of laboratory hematology. Covering both traditional and cutting-edge hematology laboratory technology this book emphasizes international recommendations for testing practices. Illustrative case studies on how technology can be used in patient diagnosis are included. Laboratory Hematology Practice is an invaluable resource for all those working in the field.

Rodak's Hematology - E-Book

Author : Elaine M. Keohane
Publisher : Elsevier Health Sciences
ISBN 13 : 0323549632
Total Pages : 910 pages
Book Rating : 4.3/5 (235 download)

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Book Synopsis Rodak's Hematology - E-Book by : Elaine M. Keohane

Download or read book Rodak's Hematology - E-Book written by Elaine M. Keohane and published by Elsevier Health Sciences. This book was released on 2019-02-22 with total page 910 pages. Available in PDF, EPUB and Kindle. Book excerpt: **Selected for Doody’s Core Titles® 2024 in Laboratory Technology** Make sure you are thoroughly prepared to work in a clinical lab. Rodak’s Hematology: Clinical Principles and Applications, 6th Edition uses hundreds of full-color photomicrographs to help you understand the essentials of hematology. This new edition shows how to accurately identify cells, simplifies hemostasis and thrombosis concepts, and covers normal hematopoiesis through diseases of erythroid, myeloid, lymphoid, and megakaryocytic origins. Easy to follow and understand, this book also covers key topics including: working in a hematology lab; complementary testing areas such as flow cytometry, cytogenetics, and molecular diagnostics; the parts and functions of the cell; and laboratory testing of blood cells and body fluid cells. UPDATED nearly 700 full-color illustrations and photomicrographs make it easier for you to visualize hematology concepts and show what you’ll encounter in the lab, with images appearing near their mentions in the text to minimize flipping pages back and forth. UPDATED content throughout text reflects latest information on hematology. Instructions for lab procedures include sources of possible errors along with comments. Hematology instruments are described, compared, and contrasted. Case studies in each chapter provide opportunities to apply hematology concepts to real-life scenarios. Hematology/hemostasis reference ranges are listed on the inside front and back covers for quick reference. A bulleted summary makes it easy for you to review the important points in every chapter. Learning objectives begin each chapter and indicate what you should achieve, with review questions appearing at the end. A glossary of key terms makes it easy to find and learn definitions. NEW! Additional content on cell structure and receptors helps you learn to identify these organisms. NEW! New chapter on Introduction to Hematology Malignancies provides and overview of diagnostic technology and techniques used in the lab.

Introduction to Molecular Immunohematology

Author : Tony S. Casina
Publisher :
ISBN 13 : 9781563953668
Total Pages : pages
Book Rating : 4.9/5 (536 download)

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Book Synopsis Introduction to Molecular Immunohematology by : Tony S. Casina

Download or read book Introduction to Molecular Immunohematology written by Tony S. Casina and published by . This book was released on 2020 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: "The book will be an approachable guide to learning about molecular testing as it relates to blood banking and Immunohematology. Methods will be discussed, allele tables explained, and nuances taught, so that the reader will feel comfortable understanding and using the resources that are available. It will be a useful tool to the SBB student or pathology resident studying for exams"--Provided by publisher.

Hematologic Malignancies

Author : Manorama Bhargava
Publisher : Springer Nature
ISBN 13 : 9813347996
Total Pages : 246 pages
Book Rating : 4.8/5 (133 download)

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Book Synopsis Hematologic Malignancies by : Manorama Bhargava

Download or read book Hematologic Malignancies written by Manorama Bhargava and published by Springer Nature. This book was released on 2021-02-13 with total page 246 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is a compendium of case studies in hematologic malignancies such as acute leukemias, myelodysplastic and myeloproliferative neoplasms, chronic leukemias and multiple myeloma covering cytogenetics (karyotyping Fluorescence in sitn hybridization (FISH)) and molecular studies in detail. The first few chapters describe the methodology employed for karyotyping, FISH and Real Time PCR technology conducive to establishment of these labs if required. Each case study is described in detail by including the clinical history of the patient, findings of peripheral blood, bone marrow aspirate and bone biopsy morphological details. This is then followed by flowcytometric immunophenotyping, cytogenetic and molecular observations leading collectively to a final diagnosis, A discussion follows based on the relevance of this data in informing the prognosis, treatment response and survival in these patients. Additionally, this data serves as a key determinant for clinical decision making involving evidence based rational management of patients including targeted therapy. For better understanding, each case study is accompanied by black and white or colour images as appropriate. This book is a source of learning and a valuable read for clinical hematologists, hematopathologists, medical oncologists, residents, interns, DM Hematology students and DNB Hematology students as well.

Molecular Pathology in Clinical Practice

Author : Debra G.B. Leonard
Publisher : Springer Science & Business Media
ISBN 13 : 0387332278
Total Pages : 589 pages
Book Rating : 4.3/5 (873 download)

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Book Synopsis Molecular Pathology in Clinical Practice by : Debra G.B. Leonard

Download or read book Molecular Pathology in Clinical Practice written by Debra G.B. Leonard and published by Springer Science & Business Media. This book was released on 2007-11-25 with total page 589 pages. Available in PDF, EPUB and Kindle. Book excerpt: This authoritative textbook embodies the current standard in molecular testing for practicing pathologists, and residents and fellows in training. The text is organized into eight sections: genetics, inherited cancers, infectious disease, neoplastic hematopathology, solid tumors, HLA typing, identity testing, and laboratory management. Discussion of each diagnostic test includes its clinical significance, available assays, quality control and lab issues, interpretation, and reasons for testing. Coverage extends to HIV, hepatitis, developmental disorders, bioterrorism, warfare organisms, lymphomas, breast cancer and melanoma, forensics, parentage, and much more. Includes 189 illustrations, 45 in full-color. This textbook is a classic in the making and a must-have reference.

Molecular Haematology

Author : Andrew Provan
Publisher : Wiley-Blackwell
ISBN 13 : 9780632050376
Total Pages : 240 pages
Book Rating : 4.0/5 (53 download)

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Book Synopsis Molecular Haematology by : Andrew Provan

Download or read book Molecular Haematology written by Andrew Provan and published by Wiley-Blackwell. This book was released on 2000 with total page 240 pages. Available in PDF, EPUB and Kindle. Book excerpt: Written with the non-specialist in mind, this book demonstrates the relevance of advances in molecular biology to hematologists' day-to-day practice -- highlighting the impact molecular biology has had on the diagnostic aspects of disease management as well as therapeutic strategies that have been developed as a result of basic molecular biological investigation. Provan (Southampton General Hospital, UK) and Gribben (Harvard Medical School) have assembled 16 chapters covering topics such as molecular cytogenetics; detection of minimal residual disease in hematological malignancies; hemoglobinopathies due to structural mutations; hematopoietic growth factors; and molecular therapeutics in hematology.

American Society of Hematology Self-Assessment Program

Author : Timothy Graubert
Publisher :
ISBN 13 : 9780982843512
Total Pages : 637 pages
Book Rating : 4.8/5 (435 download)

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Book Synopsis American Society of Hematology Self-Assessment Program by : Timothy Graubert

Download or read book American Society of Hematology Self-Assessment Program written by Timothy Graubert and published by . This book was released on 2013-06-04 with total page 637 pages. Available in PDF, EPUB and Kindle. Book excerpt: Hematologists and others working in hematology-related fields need to stay current with the latest advances in the rapidly evolving disciplines of adult and pediatric hematology. The American Society of Hematology Self-Assessment Program (ASH-SAP) is the only complete, comprehensive, educational resource available that fulfills this need, while also providing thorough board and recertification preparation, as well as AMA PRA Category 1 Credit'.

Atlas of Diagnostic Hematology

Author : Mohamed E. Salama
Publisher : Elsevier Health Sciences
ISBN 13 : 0323567347
Total Pages : 415 pages
Book Rating : 4.3/5 (235 download)

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Book Synopsis Atlas of Diagnostic Hematology by : Mohamed E. Salama

Download or read book Atlas of Diagnostic Hematology written by Mohamed E. Salama and published by Elsevier Health Sciences. This book was released on 2020-09-01 with total page 415 pages. Available in PDF, EPUB and Kindle. Book excerpt: Ideal as a quick, easy-to-use reference in the laboratory or clinical setting, Atlas of Diagnostic Hematology is an abundantly illustrated guide to the vast range of malignant and non-malignant disorders of the blood. More than 1,200 vibrant, full-color images enable you to identify and compare the unique clinical and histologic features of various blood disorders and confidently reach a diagnosis. Coverage includes photos of actual cases that span the entire range of this complex field, including rare conditions and difficult diagnoses. Features more than 1,200 images including full-color pathologic and clinical images covering a wide range of hematologic malignant and non-malignant conditions. Covers a range of disease stages, from the slightest indication where diagnosis can be complicated or missed entirely, to what the average blood or biopsy sample signifying disease may look like, to an advanced stage where disease indications are abundantly clear. Helps you distinguish between similar and overlapping features and symptoms to arrive at an accurate diagnosis. Provides up-to-date information on infectious processes in blood and bone marrow, classification system of myeloid neoplasms, and indolent and aggressive mature T and NK-cell lymphomas. Includes diagnostic algorithms with differential diagnoses for conditions with similar histologic features and clinical symptoms. Contains the latest WHO classifications for pathologic, genetic, and clinical information.

Cytogenetics, FISH and Molecular Testing in Hematologic Malignancies

Author : Wojciech Gorczyca
Publisher : CRC Press
ISBN 13 : 9780415420099
Total Pages : 0 pages
Book Rating : 4.4/5 (2 download)

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Book Synopsis Cytogenetics, FISH and Molecular Testing in Hematologic Malignancies by : Wojciech Gorczyca

Download or read book Cytogenetics, FISH and Molecular Testing in Hematologic Malignancies written by Wojciech Gorczyca and published by CRC Press. This book was released on 2008-08-01 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cytogenetics, fluorescence in situ hybridization (FISH) and molecular tests, especially polymerase chain reaction (PCR), play an important role in the management of patients with hematologic malignancies by helping to establish the diagnosis, as well as predict prognosis, response to treatment and disease progression. Chromosomal and molecular abnormalities provide the most reliable criteria for classification of hematopoietic tumors and often comprise the basis for targeted therapy. Cytogenetics, FISH and Molecular Testing in Hematologic Malignancies, provides a review of chromosomal and molecular changes in hematologic malignancies and correlates the karyotypic and genetic abnormalities with morphology, immunophenotype and clinical data. With over 180 figures and diagnostic algorithms, this text is essential reading for all pathologists, hematopathologists, hematologic oncologists, cytogenetists, cytogenetic technologists and cell biologists.

Pediatric Hematology

Author : Nicholas J. Goulden
Publisher : Springer Science & Business Media
ISBN 13 : 1592594336
Total Pages : 273 pages
Book Rating : 4.5/5 (925 download)

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Book Synopsis Pediatric Hematology by : Nicholas J. Goulden

Download or read book Pediatric Hematology written by Nicholas J. Goulden and published by Springer Science & Business Media. This book was released on 2008-02-01 with total page 273 pages. Available in PDF, EPUB and Kindle. Book excerpt: Much of the progress in the diagnosis, classification, and treatment of childhood hematological disorders has come from a partnership between clinicians and scientists. Indeed, access to molecular techniques is now an integral part of the practice of modern pediatric hematology. The aim of Pediatric Hematology: Methods and Protocols is to provide a collection of scientific protocols that cover the major aspects of the discipline. Most clinicians will be familiar with the difficulties inherent in establishing the underlying diagnosis in genetic marrow failure syndromes. A particular concern is failure to diagnose those associated with DNA repair defects. In Chapter 1, Dokal and colleagues present simple protocols for the molecular investigation of Fanconi anemia and dyskeratosis congenita. Molecular diagnosis is also important in children with congenital pure red cell aplasia, owing to the highly variable phenotype of this condition. In Chapter 2, Ball describes relevant protocols for the investigation of Diamond–Blackfan anemia. Hereditary hemoglobinopathy is a major cause of death and morbidity throughout the world. This area has seen great advances in screening and antenatal diagnosis. In Chapter 3, Old details protocols for the molecular diagnosis of most forms of hemoglobinopathy. High-quality, accurate molecular testing on small amounts of material has been fundamental to progress in antenatal diagnostics. The introduction to his comprehensive chapter includes a discussion of the general principles that underpin these studies. In contrast to hemoglobinopathy, severe hemophilia is uncommon.

Molecular Aspects of Hematologic Malignancies

Author : Michal Witt
Publisher : Springer
ISBN 13 : 9783642445224
Total Pages : 0 pages
Book Rating : 4.4/5 (452 download)

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Book Synopsis Molecular Aspects of Hematologic Malignancies by : Michal Witt

Download or read book Molecular Aspects of Hematologic Malignancies written by Michal Witt and published by Springer. This book was released on 2015-06-26 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides a state-of-the-art approach to the molecular basis of hematologic diseases and its translation into improved diagnostics and novel therapeutic strategies. Several representative hemato-oncologic malignancies are analyzed in detail: acute lymphoblastic leukemia, acute myeloid leukemia, B-cell Non-Hodgkin lymphomas, multiple myeloma, chronic lymphocytic leukemia, chronic myeloid leukemia, myelodysplastic syndromes, and myeloproliferative neoplasms. Experts in the field describe the molecular methods applied for modern diagnostics and therapies, such as hematopoietic stem cell transplantation, donor recipient matching, banking of biological material, analyses of post-transplant chimerism, and minimal residual disease monitoring. The volume concludes with an extensive section comprising thorough step-by-step protocols of molecular techniques in hematology, all of them validated in the authors’ own laboratories.

Williams Hematology, 10th Edition

Author : Kenneth Kaushansky
Publisher : McGraw Hill Professional
ISBN 13 : 126046413X
Total Pages : 2705 pages
Book Rating : 4.2/5 (64 download)

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Book Synopsis Williams Hematology, 10th Edition by : Kenneth Kaushansky

Download or read book Williams Hematology, 10th Edition written by Kenneth Kaushansky and published by McGraw Hill Professional. This book was released on 2021-01-14 with total page 2705 pages. Available in PDF, EPUB and Kindle. Book excerpt: The landmark text that has guided generations of hematologists and related practitioners―updated with the latest research findings and improved format and presentation Long revered for its comprehensiveness and extraordinary depth of detail, Williams Hematology provides essential coverage of the origins, pathophysiological mechanisms, and management of benign and malignant disorders of blood and marrow cells and coagulation proteins. The text contains a wealth of basic science and translational pathophysiology for optimal, lifelong learning. Experts in research and clinical hematology, the editors are known worldwide for their contributions to the field. This new edition contains everything that has made Williams Hematology the go-to resource for decades and has been updated with new chapters and critical new research into the molecular mechanisms responsible for hematological disorders and the impact on diagnosis and treatment. And the new format enables you to access each chapter via content modules covering key topics, with summaries, infographics, and cases―all linked to review questions for self-assessment. The full-color presentation integrates images of blood and tissue findings where they are cited in the text. NEW TO THIS EDITION: Updated and revised content reflecting the latest research and developments Convenient format that streamlines the learning process and improves retention Additional chapters added on: Immune Checkpoint Inhibitors Immune Cell Therapy: Chimeric Antigen Receptor T Cell Therapy Immune Cell Therapy Dendritic Cell and Natural Killer Cell Therapy The processes of cell death and survival Application of Big Data and Deep Learning in Hematology Williams Hematology Cases with multiple-choice questions including detailed explanations—perfect preparation for the boards Continuously updated online content with comprehensive drug therapy database and other resources

Practical Flow Cytometry in Haematology Diagnosis

Author : Mike Leach
Publisher : John Wiley & Sons
ISBN 13 : 9780470671207
Total Pages : 0 pages
Book Rating : 4.6/5 (712 download)

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Book Synopsis Practical Flow Cytometry in Haematology Diagnosis by : Mike Leach

Download or read book Practical Flow Cytometry in Haematology Diagnosis written by Mike Leach and published by John Wiley & Sons. This book was released on 2013-04-22 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: The accurate diagnosis of haematologic malignancies is a complex and challenging task. It routinely involves morphologic, molecular, cytogenetic and flow cytometric expertise. To determine what treatment protocol will be followed, it is vital to integrate, interpret and report these results accurately. Flow cytometry is key in this diagnostic pathway. This book guides the reader as to how flow cytometry results should be interpreted and applied to optimize patient care. At the core of this text is an appreciation of clinical, morphological and immunophenotypic correlation and the importance of constant liaison and discussion between the medical and scientific teams. The authors present a logical and practical approach to the diagnosis of blood disorders (both neoplastic and reactive) and evaluate the diagnostic applications of flow cytometry. Practical Flow Cytometry in Haematology Diagnosis provides: A clinical reference source on all aspects of flow cytometry, covering both malignant and benign conditionsCarefully chosen real-life cases in each chapter, complemented by high quality morphological images Help in making a diagnosis, together with an understanding of the limitations of the technique and the potential pitfalls All those who instigate, perform, interpret or act upon flow cytometry patient material will find this book an invaluable guide.