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Author : Lai-Shan Tai
Publisher :
ISBN 13 : 9781361205020
Total Pages : pages
Book Rating : 4.2/5 (5 download)
Download or read book Molecular Genetic Characterizations of Human Non-Small Cell Lung Cancer written by Lai-Shan Tai and published by . This book was released on 2017-01-26 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Lai-shan Tai
Publisher :
ISBN 13 :
Total Pages : 366 pages
Book Rating : 4.:/5 (621 download)
Download or read book Molecular Genetic Characterizations of Human Non-small Cell Lung Cancer written by Lai-shan Tai and published by . This book was released on 2005 with total page 366 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : David N Cooper
Publisher : Springer Science & Business Media
ISBN 13 : 3540269541
Total Pages : 399 pages
Book Rating : 4.5/5 (42 download)
Download or read book The Molecular Genetics of Lung Cancer written by David N Cooper and published by Springer Science & Business Media. This book was released on 2005-11-20 with total page 399 pages. Available in PDF, EPUB and Kindle. Book excerpt: Lung cancer is the leading cause of cancer mortality in Western countries. It also provides an archetypal example of how inherited predisposing genetic variants may interact with an environmental influence (smoking) to modulate individual cancer risk. The Molecular Genetics of Lung Cancer describes how the new techniques, methods and approaches of molecular genetics are being used to unravel the complexities of the mechanisms underlying lung tumorigenesis by analysis at the DNA, RNA and protein levels with potentially important implications for tumour classification, diagnosis, prognosis and treatment as well as providing new insights into how lung tumours arise and how they progress to malignancy.
Author : Ka-Wan Kevin Chu
Publisher : Open Dissertation Press
ISBN 13 : 9781360988535
Total Pages : 158 pages
Book Rating : 4.9/5 (885 download)
Download or read book HIGH-THROUGHPUT MOLECULAR CHAR written by Ka-Wan Kevin Chu and published by Open Dissertation Press. This book was released on 2017-01-26 with total page 158 pages. Available in PDF, EPUB and Kindle. Book excerpt: This dissertation, "High-throughput Molecular Characterization of Human Non-small Cell Lung Carcinoma" by Ka-wan, Kevin, Chu, 朱嘉運, was obtained from The University of Hong Kong (Pokfulam, Hong Kong) and is being sold pursuant to Creative Commons: Attribution 3.0 Hong Kong License. The content of this dissertation has not been altered in any way. We have altered the formatting in order to facilitate the ease of printing and reading of the dissertation. All rights not granted by the above license are retained by the author. DOI: 10.5353/th_b4501288 Subjects: Lungs - Cancer - Molecular aspects
Author : Ka-wan Chu (Kevin)
Publisher :
ISBN 13 :
Total Pages : 276 pages
Book Rating : 4.:/5 (217 download)
Download or read book High-throughput Molecular Characterization of Human Non-small Cell Lung Carcinoma written by Ka-wan Chu (Kevin) and published by . This book was released on 2007 with total page 276 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Adi F. Gazdar
Publisher :
ISBN 13 :
Total Pages : 160 pages
Book Rating : 4.:/5 ( download)
Download or read book The Biology and Molecular Genetics of Lung Cancer written by Adi F. Gazdar and published by . This book was released on 1994 with total page 160 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author :
Publisher :
ISBN 13 : 9789155484828
Total Pages : 68 pages
Book Rating : 4.4/5 (848 download)
Download or read book Molecular Characterisation and Prognostic Biomarker Discovery in Human Non-small Cell Lung Cancer written by and published by . This book was released on 2012 with total page 68 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Philip T. Cagle
Publisher : Springer Science & Business Media
ISBN 13 : 1461431972
Total Pages : 217 pages
Book Rating : 4.4/5 (614 download)
Download or read book Molecular Pathology of Lung Cancer written by Philip T. Cagle and published by Springer Science & Business Media. This book was released on 2012-06-14 with total page 217 pages. Available in PDF, EPUB and Kindle. Book excerpt: As with other books in the Molecular Pathology Library Series, Molecular Pathology of Lung Cancer bridges the gap between the molecular specialist and the clinical practitioner, including the surgical pathologist who now has a key role in decisions regarding molecular targeted therapy for lung cancer. Molecular Pathology of Lung Cancer provides the latest information and current insights into the molecular basis for lung cancer, including precursor and preinvasive lesions, molecular diagnosis, molecular targeted therapy, molecular prognosis, molecular radiology and related fields for lung cancer generally and for the specific cell types. As many fundamental concepts about lung cancer have undergone revision in only the past few years, this book will likely be the first to comprehensively cover the new molecular pathology of lung cancer. It provides a foundation in this field for pathologists, medical oncologists, radiation oncologists, thoracic surgeons, thoracic radiologists and their trainees, physician assistants, and nursing staff.
Author : Chi-Leung David Lam
Publisher : Open Dissertation Press
ISBN 13 : 9781374666030
Total Pages : pages
Book Rating : 4.6/5 (66 download)
Download or read book Gene Expression Profiling in Non-Small Cell Lung Cancer written by Chi-Leung David Lam and published by Open Dissertation Press. This book was released on 2017-01-27 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: This dissertation, "Gene Expression Profiling in Non-small Cell Lung Cancer" by Chi-leung, David, Lam, 林志良, was obtained from The University of Hong Kong (Pokfulam, Hong Kong) and is being sold pursuant to Creative Commons: Attribution 3.0 Hong Kong License. The content of this dissertation has not been altered in any way. We have altered the formatting in order to facilitate the ease of printing and reading of the dissertation. All rights not granted by the above license are retained by the author. Abstract: Abstract of thesis entitled Gene Expression Profiling in Non-Small Cell Lung Cancer Submitted by LAM Chi Leung, David for the degree of Doctor of Philosophy at the University of Hong Kong in July 2007 Lung cancer is the worldwide leading cause of cancer morbidity and mortality and Hong Kong is no exception. In some Asian countries/regions including Hong Kong, there is an increasing trend of female, non-smokers and adenocarcinomas among patients with non-small cell lung cancer (NSCLC). Surgical resection for early stage NSCLC remains as the only curative treatment while modern chemoirradiation improves the survival of advanced stage NSCLC patients only marginally. In recent years, molecular targeted therapy has become the focus of clinical trials for advanced stage NSCLC, with epidermal growth factor receptor-tyrosine kinase inhibitor (EGFR-TKI) being one promising therapeutic agent. Clinical characteristics such as female, non-smoker, tumor with activating EGFR gene mutations, adenocarcinoma histology and Asian origin are independent predictors of clinical response to EGFR-TKI. Hong Kong provides an appropriate context for studying the pathogenesis and 1chemotherapeutics in Chinese female non-smokers with lung cancer. The hypotheses being tested were that there is differential gene expression associated with different clinical phenotypes i.e. gender, smoking habits, and EGFR gene mutation status in NSCLC from local Chinese patients. To test these, the gene expression profiles of resected primary lung tumors, normal lung tissues, lung cancer cell lines and normal human bronchial epithelial cells (NHBECs), were analyzed. First, four new lung adenocarcinomas cell lines (HKULC 1 - 4), two from female non-smokers and two from male smokers, were established from local Chinese. They were characterized with morphological and immunohistochemical studies, growth kinetics, and gene expression profiling with microarrays. Differentially expressed genes related to the regulation of cellular proliferation and to EGFR gene exon 18 - 21 mutations were identified. These new cell lines provide tools for future research in lung cancer and for comparisons with research findings from other ethnic groups. Second, gene expression profiling with microarrays was performed for 49 lung adenocarcinomas and 9 normal lung tissues collected from local Chinese. Unsupervised hierarchical clustering revealed stable clusters of lung adenocarcinomas versus normal lung tissues, female non-smokers and tumors bearing EGFR gene mutation at exons 18 - 21. Differential gene expression and molecular classifiers were identified and correlated clinical characteristics. The results were validated with independent test data sets from published microarray data on NSCLC. These gene expression profiling data on lung adenocarcinomas, female non-smokers and EGFR gene mutation status provide 2information for candidate gene selection for further research on lung cancer in Chinese female non-smokers. Third, significant differences were found in the expression levels of nicotinic acetylcholine receptor (nAChR) subunit genes, α6 and β3, between tumors arising from smokers and non-smokers, adjusted for the effects of gender. Gene expression signatures were found associated with high nAChR α6β3 gene expression. Reversible elevations of the expression levels of nAChR α1, α5 and α7 subunit genes were found in
Author : Kwun Meng Fong
Publisher :
ISBN 13 :
Total Pages : 716 pages
Book Rating : 4.:/5 (37 download)
Download or read book Molecular Genetic Abnormalities in Non-small Cell Lung Cancer written by Kwun Meng Fong and published by . This book was released on 1995 with total page 716 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Garden Grove Garden Grove Press
Publisher :
ISBN 13 : 9781545051504
Total Pages : 244 pages
Book Rating : 4.0/5 (515 download)
Download or read book Medical Genetics of Non-Small Cell Lung Cancer written by Garden Grove Garden Grove Press and published by . This book was released on 2017-03-30 with total page 244 pages. Available in PDF, EPUB and Kindle. Book excerpt: This article collection reviews the medical genetics of non-small cell lung cancer and includes 25 papers by various authors. Topics include: Gene mutation discovery research of non-smoking lung cancer patients due to indoor radon exposure; Osteopontin genetic variants are associated with overall survival in advanced non-small-cell lung cancer patients and bone metastasis; Emerging roles of Nrf2 signal in non-small cell lung cancer; Osteopontin is a prognostic biomarker in non-small cell lung cancer; PIWIL2 promotes progression of non-small cell lung cancer by inducing CDK2 and Cyclin A expression; Metabolic diversity in human non-small cell lung cancer; Clinical outcomes in ALK-rearranged lung adenocarcinomas according to ALK fusion variants; MiR-133a is downregulated in non-small cell lung cancer: a study of clinical significance; A genetic variant in long non-coding RNA MALAT1 associated with survival outcome among patients with advanced lung adenocarcinoma: a survival cohort analysis; Mutation status concordance between primary lesions and metastatic sites of advanced non-small-cell lung cancer and the impact of mutation testing methodologies: a literature review; Predictive biomarkers in precision medicine and drug development against lung cancer; Characterization of a genetic mouse model of lung cancer: a promise to identify Non-Small Cell Lung Cancer therapeutic targets and biomarkers; Genetic polymorphisms in the endothelial nitric oxide synthase gene correlate with overall survival in advanced non-small-cell lung cancer patients treated with platinum-based doublet chemotherapy; Major milestones in translational oncology; Detection of the transforming AKT1 mutation E17K in non-small cell lung cancer by high resolution melting; SFRP1 is a possible candidate for epigenetic therapy in non-small cell lung cancer; Synthetic lethality in lung cancer and translation to clinical therapies; Targeted therapies for patients with advanced NSCLC harboring wild-type EGFR: what's new and what's enough; Cisplatin sensitivity is enhanced in non-small cell lung cancer cells by regulating epithelial-mesenchymal transition through inhibition of eukaryotic translation initiation factor 5A2; Genetic polymorphisms of glutathione S-transferase M1 and T1, and evaluation of oxidative stress in patients with non-small cell lung cancer; PD-L1 biomarker testing for non-small cell lung cancer: truth or fiction?; CD73/NT5E is a target of miR-30a-5p and plays an important role in the pathogenesis of non-small cell lung cancer; Genetic polymorphisms of human cytochrome P450 CYP1A1 in an Egyptian population and tobacco-induced lung cancer; Clinical outcome and expression of mutant P53, P16, and Smad4 in lung adenocarcinoma: a prospective study; Towards standardization of next-generation sequencing of FFPE samples for clinical oncology: intrinsic obstacles and possible solutions. Proceeds from the sale of this book go to the support of an elderly disabled person.
Author : Alan Weitberg
Publisher : Springer Science & Business Media
ISBN 13 : 1592590934
Total Pages : 352 pages
Book Rating : 4.5/5 (925 download)
Download or read book Cancer of the Lung written by Alan Weitberg and published by Springer Science & Business Media. This book was released on 2001-10-04 with total page 352 pages. Available in PDF, EPUB and Kindle. Book excerpt: Alan B. Weitberg, MD, and a panel of internationally recognized basic scientists and clinicians present a comprehensive discussion of lung cancer, including a practice-oriented review of its diagnosis, evaluation, and treatment. The contributors offer not only an understandable description of its molecular origins-an essential key to developing future therapies and preventive measures-but also rigorously discuss well-tested approaches, as well as those that are currently being evaluated for future use in both the laboratory and clinic. The book also elucidates the creation and effective deployment of treatment guidelines introduced by third party payers to improve clinical outcomes, even while lowering healthcare costs.
Author : Karol Sikora
Publisher : Wiley
ISBN 13 : 9780471925835
Total Pages : 364 pages
Book Rating : 4.9/5 (258 download)
Download or read book Genes and Cancer written by Karol Sikora and published by Wiley. This book was released on 1990-10-26 with total page 364 pages. Available in PDF, EPUB and Kindle. Book excerpt: This work serves as an introduction to the applications of molecular biology in the field of oncology. It provides a basic understanding of the genetic events involved in fully developed human cancer, including research into inherited and acquired gene defects initiating new neoplasms and the subsequent genetic alterations involved in tumor progression. Some of the specific topics explored include gene control, molecular therapy and antibodies, drug resistance, growth factors and receptors, and tumor biology. While intended primarily as an advanced text for oncologists, postgraduate molecular geneticists and molecular biologists, the book will certainly be of interest to other researchers who frequently encounter cancer in their practice.
Author : Merisa Nisic
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (1 download)
Download or read book Phenotypic and Genetic Characterization of Non-small Cell Lung Cancer Circulating Tumor Cells written by Merisa Nisic and published by . This book was released on 2017 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Circulating tumor cells (CTCs) are thought to be the drivers of metastasis, which is responsible for the majority of cancer-related deaths. CTCs have been established as a prognostic biomarkerhigher CTC count correlates with worse clinical outcomes. Due to their one in a billion rarity, many biological and mechanistic aspects of circulating tumor cells remain unknown. This work describes the characterization of CTCs enriched using the Flexible Micro Spring Array (FMSA) system for label-free enrichment from whole blood. This research effort generated a single cell workflow from whole genome amplification (WGA) to next generation sequencing (NGS) using lung cancer cell lines. The aforementioned workflow was then used to genetically characterize single FMSA-enriched CTCs from clinical samples obtained from non-small cell lung cancer (NSCLC) patients. Higher CTC count was found to correlate to decreased cancer patient overall survival, thereby demonstrating the clinical relevance of FMSA enriched CTCs in non-small cell lung cancer. Further, four distinct phenotypic CTC subtypes were identified from NSCLC patient samples and higher heterogeneity of these subtypes correlated to decreased overall and progression-free survival.
Author :
Publisher :
ISBN 13 : 9780815332183
Total Pages : 0 pages
Book Rating : 4.3/5 (321 download)
Download or read book Molecular Biology of the Cell written by and published by . This book was released on 2002 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Bin Yang
Publisher : Springer
ISBN 13 : 331930741X
Total Pages : 297 pages
Book Rating : 4.3/5 (193 download)
Download or read book Molecular Cytopathology written by Bin Yang and published by Springer. This book was released on 2016-08-12 with total page 297 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book reviews the current applications of molecular tools in cytopathology and provides a concise handbook for those who provide care in this era of personalized medicine. Specifically, the text provides a comprehensive and concise review of the emerging molecular tests available clinically in different subspecialities of diagnostic pathology. It reviews the current data of molecular testing already applied in cytopathology, discusses some of the biomarkers with potential utility in cytopathology in the near future and reviews the technical challenges in applying and validating molecular tools in liquid-based cytologic materials. Molecular Cytopathology will serve as a valuable resource for cytopathologists, cytotechnologists, pathology trainees, and clinicians with an interest in molecular applications in cytopathology.
Author : Jeanette Grant
Publisher :
ISBN 13 :
Total Pages : 105 pages
Book Rating : 4.:/5 (17 download)
Download or read book A Novel Molecular Pathway for Snail-dependent, SPARC-mediated Invasion in Non Small Cell Lung Cancer Pathogenesis written by Jeanette Grant and published by . This book was released on 2013 with total page 105 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the U.S., lung cancer is the leading cause of cancer death, with a median survival of eight months following diagnosis and only 16% of patients surviving more than five years. The low survival rate is attributable, in part, to a lack of early detection, limiting the benefit of surgical resection as metastatic progression has already occurred. The early events of lung cancer pathogenesis have not yet been well defined, contributing to the paucity of early detection techniques clinically. For tumors to progress to metastatic disease, they must acquire characteristics that allow them to become migratory, degrade and invade their local basement membrane, and migrate to a new site before forming a micrometastasis. As part of this process, tumors undergo a series of events known as epithelial-to-mesenchymal transition (EMT), where they lose epithelial characteristics and become mesenchymal in phenotype and molecular profile. Snail is a zinc-finger transcription factor that exerts global effects on epithelial cell gene expression profiles, resulting in regulation of EMT. Recent studies by our lab have shown that Snail is upregulated in human non-small cell lung cancer (NSCLC) tissues, is associated with poor prognosis, and promotes NSCLC tumor progression in vivo. Furthermore, Snail overexpression in NSCLC is associated with differential gene expression related to diverse aspects of lung cancer progression, including angiogenesis. Herein we demonstrate that overexpression of Snail leads to upregulation of Secreted Protein, Acidic and Rich in Cysteine (SPARC). Immunoblot and qRT-PCR analysis of multiple NSCLC cell lines with and without Snail overexpression validated the relationship between Snail and SPARC in established cancers. Similar results were found in Snail-overexpressing Human Bronchial Epithelial Cells (HBECs), a model of early pathogenesis, as well as in human lung adenocarcinomas and squamous cell carcinomas immunostained for Snail and SPARC. Taken together, these data indicate that SPARC is upregulated by Snail at early and late points during lung carcinogenesis and may play a role in lung cancer initiation and progression. In all cell lines evaluated, Snail overexpression leads to increased SPARC-dependent invasion in vitro. The promoter region of SPARC does not contain a binding site for Snail, indicating that Snail upregulates SPARC by an indirect mechanism. Bioinformatic analysis of array data revealed potential intermediaries in Snail-mediated upregulation of SPARC, including miR-29b and the TGF-β and MEK/ERK pathways. Both the TGF-β1 ligand and TGF-βR2 are upregulated following Snail overexpression. In addition, treatment of HBEC cell lines with TGF-β1 resulted in phosphorylation of ERK1/2 as well as upregulation of SPARC and Snail. Inhibition of TGF-β1 mRNA decreased the Snail-dependent activation of ERK1/2 and protein expression of SPARC. Inhibition of MEK phosphorylation by the chemical inhibitor U0126 in Snail-overexpressing cell lines leads to a loss of SPARC upregulation, indicating that the TGF-β-driven MEK/ERK pathway is necessary for Snail-dependent upregulation of SPARC. The microRNA miR-29b is downregulated in Snail-overexpressing cell lines. As the 3'UTR of SPARC mRNA contains multiple consensus sequences for miR-29b, we have hypothesized that downregulation of miR-29b by Snail, downstream of ERK, allows for upregulation of SPARC. Transient overexpression of a miR-29b mimic in both the vector control and Snail-overexpressing cell lines inhibited SPARC expression, confirming the ability of miR-29b to regulate SPARC. In addition, miR-29b was upregulated following ERK inhibition, indicating a pathway by which Snail overexpression leads to activation of TGF-β and ERK signaling, resulting in downregulation of miR-29b and upregulation of SPARC. Upregulation of SPARC is associated with metastatic potential of melanomas and gliomas as well as an invasive phenotype in breast, prostate, and colorectal carcinomas. Expression of SPARC in the tumor stroma of NSCLC is associated with poor patient prognosis, though its role in tumor progression, especially in relation to Snail expression, has not been evaluated. Our novel discovery of SPARC overexpression as an early event during lung carcinogenesis has potentially important implications, especially as related to the parallel model of cancer development and metastatic progression. Delineating pathways involved in Snail-dependent and SPARC-mediated parallel progression may yield new targets for lung cancer prevention and treatment.
