Molecular Biology of Neuropsychiatric Disorders

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Author :
Publisher : Springer Science & Business Media
ISBN 13 : 3540853839
Total Pages : 303 pages
Book Rating : 4.5/5 (48 download)

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Book Synopsis Molecular Biology of Neuropsychiatric Disorders by : Dieter B. Wildenauer

Download or read book Molecular Biology of Neuropsychiatric Disorders written by Dieter B. Wildenauer and published by Springer Science & Business Media. This book was released on 2008-11-28 with total page 303 pages. Available in PDF, EPUB and Kindle. Book excerpt: It is generally accepted that neuropsychiatric disorders have a biological basis. Pathological changes leading to illness have been confirmed for Alzheimer’s (amyloid plaques) and Parkinson’s disease (loss of dopaminergic transmission) and are the foundation for studies on the molecular biology of these disorders. For other neuropsychiatric disorders, in particular for schizophrenic and affective disorders, molecular causes appear to be more complex and therefore remain hypothetical, despite decades of research. Changes in a number of neuronal pathways and structures have been reported to be associated with these disorders and are currently under extensive investigation. The present volume reviews recent knowledge with emphasis on ongoing research findings. Current hypotheses based on these findings are described and discussed.

Molecular Basis of Neuropsychiatric Disorders: from Bench to Bedside

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Author :
Publisher : Academic Press
ISBN 13 : 0128188561
Total Pages : 266 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis Molecular Basis of Neuropsychiatric Disorders: from Bench to Bedside by : Shafiqur Rahman

Download or read book Molecular Basis of Neuropsychiatric Disorders: from Bench to Bedside written by Shafiqur Rahman and published by Academic Press. This book was released on 2019-10-05 with total page 266 pages. Available in PDF, EPUB and Kindle. Book excerpt: Progress in Molecular Biology and Translational Science, Volume 167, provides the most topical, informative and exciting monographs available on a wide variety of research topics related to Models and Biological Targets in Drug Discovery for Attention Deficit Hyperactivity Disorder, Novel Targets for Parkinson-Depression Co-morbidity. Utility of Cannabidiol (CBD) in Neuropsychiatric Disorders: A Short Review of the Recent Pre-clinical and Clinical Findings, The Many Sides of Microglia in Alcohol Use Disorders, Stress, Anxiety, Molecular Targets and More, Calcineurin Signaling in Psychiatric Disorders, Emerging Evidence for the Role of Pituitary Adenylate Cyclase- Activating Peptide (PACAP) in Neuropsychiatric Disorders, and more. Includes comprehensive coverage of molecular biology Presents ample use of tables, diagrams, schemata and color figures to enhance the reader's ability to rapidly grasp the information provided Contains contributions from renowned experts in the field

Molecular and Cell Biology of Neuropsychiatric Diseases

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Author :
Publisher : Springer Science & Business Media
ISBN 13 : 9401107092
Total Pages : 211 pages
Book Rating : 4.4/5 (11 download)

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Book Synopsis Molecular and Cell Biology of Neuropsychiatric Diseases by : F. Owen

Download or read book Molecular and Cell Biology of Neuropsychiatric Diseases written by F. Owen and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 211 pages. Available in PDF, EPUB and Kindle. Book excerpt: The fourth volume in the Molecular and Cell Biology of Neuropsychiatric Diseases series provides a comprehensive, timely review of the use of modern biological techniques in the investigation of the major neuropsychiatric diseases. The scope of the book is wide, and an introductory section at the beginning of each chapter enables non-specialist and specialist alike to appreciate the significance of this research.

Molecular and Functional Models in Neuropsychiatry

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Publisher : Springer Science & Business Media
ISBN 13 : 3642197035
Total Pages : 400 pages
Book Rating : 4.6/5 (421 download)

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Book Synopsis Molecular and Functional Models in Neuropsychiatry by : Jim J. Hagan

Download or read book Molecular and Functional Models in Neuropsychiatry written by Jim J. Hagan and published by Springer Science & Business Media. This book was released on 2011-04-02 with total page 400 pages. Available in PDF, EPUB and Kindle. Book excerpt: The development of more effective treatments for neuropsychiatric disorders requires scientific progress on a broad front. Animal models have a vital role to play in advancing the field. When deployed in conjunction with detailed study of these diseases in man they bring the power to make controlled experimental interventions which allow the functional consequences of genetic variations and polymorphisms to be understood in terms of their cellular, systems and behavioural effects. Further, they provide a means by which complex cognitive and behavioural phenomena may be dissected and understood. Finally, they provide a bridge to understanding the effects of drugs on the functioning of the central nervous system, thereby improving our understanding of the actions of those drugs in man.

The Molecular Foundations of Psychiatry

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Author :
Publisher : American Psychiatric Pub
ISBN 13 : 9780880483537
Total Pages : 270 pages
Book Rating : 4.4/5 (835 download)

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Book Synopsis The Molecular Foundations of Psychiatry by : Steven E. Hyman

Download or read book The Molecular Foundations of Psychiatry written by Steven E. Hyman and published by American Psychiatric Pub. This book was released on 1993 with total page 270 pages. Available in PDF, EPUB and Kindle. Book excerpt: This text offers a comprehensive introduction to molecular biology, genetics, and neurobiology relevant to psychiatry. Generously illustrated chapters are organized to be read at both an introductory and a more advanced level. Both beginners and advanced professionals will benefit from this text's discussion of how psychotropic drugs work and how gene-environment interactions may contribute to the pathogenesis of psychiatric disorders. The authors demonstrate how molecular investigations in psychiatry will revolutionize the field by leading to improved diagnostic testing, to new and more effective treatments, and ultimately to the development of preventive measures for mental illness.

The Molecular Biology of Neurological Disease

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Author :
Publisher : Butterworth-Heinemann
ISBN 13 : 148316330X
Total Pages : 277 pages
Book Rating : 4.4/5 (831 download)

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Book Synopsis The Molecular Biology of Neurological Disease by : Roger N. Rosenberg

Download or read book The Molecular Biology of Neurological Disease written by Roger N. Rosenberg and published by Butterworth-Heinemann. This book was released on 2013-10-22 with total page 277 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Molecular Biology of Neurological Disease reviews advances that have been made in understanding the molecular mechanisms of neurological disorders as well as immediate and future applications of molecular biological techniques to clinical practice. This book explores the molecular genetics of neurological disease such as muscular dystrophy, Joseph disease, and Huntington's disease, along with the mitochondrial genes implicated in such conditions. This text is comprised of 18 chapters and begins by introducing the reader to the basic principles and methods of molecular genetic techniques used in the diagnosis of neurological disease. Attention then turns to several aspects of genetic expression in the brain, including the extent to which the genome is expressed in the brain. The next chapter focuses on the visualization of polyadenylated messenger RNAs in individual cells in mammalian brain using in situ hybridization techniques, combined with immunohistochemical localization of specific proteins and neuropeptides implicated in diseases such as Alzheimer dementia. This book also discusses the molecular biology of chemical synaptic neurotransmission; proteins involved in the regulation of nervous system development; and gene expression in skeletal muscle. This text then concludes with a summary of the ""neurological gene map"" as it stands in the latter part of 1987. This book is intended for physicians who grapple with the problems of neurological disorders on a daily basis, including neurologists, neurologists in training, and those in related fields such as neurosurgery, internal medicine, psychiatry, and rehabilitation medicine.

Neurobiology of Mental Illness

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Author :
Publisher : Oxford University Press, USA
ISBN 13 : 0199934959
Total Pages : 1259 pages
Book Rating : 4.1/5 (999 download)

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Book Synopsis Neurobiology of Mental Illness by : Dennis S. Charney

Download or read book Neurobiology of Mental Illness written by Dennis S. Charney and published by Oxford University Press, USA. This book was released on 2013-07-04 with total page 1259 pages. Available in PDF, EPUB and Kindle. Book excerpt: Our understanding of the neurobiological basis of psychiatric disease has accelerated in the past five years. The fourth edition of Neurobiology of Mental Illness has been completely revamped given these advances and discoveries on the neurobiologic foundations of psychiatry. Like its predecessors the book begins with an overview of the basic science. The emerging technologies in Section 2 have been extensively redone to match the progress in the field including new chapters on the applications of stem cells, optogenetics, and image guided stimulation to our understanding and treatment of psychiatric disorders. Sections' 3 through 8 pertain to the major psychiatric syndromes-the psychoses, mood disorders, anxiety disorders, substance use disorders, dementias, and disorders of childhood-onset. Each of these sections includes our knowledge of their etiology, pathophysiology, and treatment. The final section discusses special topic areas including the neurobiology of sleep, resilience, social attachment, aggression, personality disorders and eating disorders. In all, there are 32 new chapters in this volume including unique insights on DSM-5, the Research Domain Criteria (RDoC) from NIMH, and a perspective on the continuing challenges of diagnosis given what we know of the brain and the mechanisms pertaining to mental illness. This book provides information from numerous levels of analysis including molecular biology and genetics, cellular physiology, neuroanatomy, neuropharmacology, epidemiology, and behavior. In doing so it translates information from the basic laboratory to the clinical laboratory and finally to clinical treatment. No other book distills the basic science and underpinnings of mental disorders and explains the clinical significance to the scope and breadth of this classic text. The result is an excellent and cutting-edge resource for psychiatric residents, psychiatric researchers and doctoral students in neurochemistry and the neurosciences.

Neuropsychiatric Disorders and Epigenetics

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Author :
Publisher : Academic Press
ISBN 13 : 9780443185168
Total Pages : 0 pages
Book Rating : 4.1/5 (851 download)

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Book Synopsis Neuropsychiatric Disorders and Epigenetics by : Jacob Peedicayil

Download or read book Neuropsychiatric Disorders and Epigenetics written by Jacob Peedicayil and published by Academic Press. This book was released on 2023-09-28 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Neuropsychiatric Disorders and Epigenetics, Second Edition is a comprehensive reference on the epigenetic basis of common neuropsychiatric disorders. The volume is organized into chapters covering individual neuropsychiatric disorders, from addiction to anxiety and autism spectrum disorders, and is contributed by leading experts in their respective fields. The epigenetic aspects of each disorder are discussed in the context of the full range of associated epigenetic mechanisms, including DNA modification, histone post-translational modification, chromatin organization, and non-coding RNA. A particular emphasis is placed on potential epigenetic interventions when the effects of environmental stimuli on epigenetic states is particularly relevant to disease. This new edition has been fully updated to reflect recent research advances enabled by genomic technologies, as well as therapeutic interventions for previously unmanageable disorders. Several new chapters have been added on disorders or approaches not considered in the earlier edition, including epigenetics and anxiety disorders, epigenetics and neuroimaging in neuropsychiatric disorders, genome-wide approaches to epigenetic research, and the epigenetics of spinal muscular atrophy.

Neurobiology of Psychiatric Disorders

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Author :
Publisher : Elsevier
ISBN 13 : 0444520023
Total Pages : 781 pages
Book Rating : 4.4/5 (445 download)

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Book Synopsis Neurobiology of Psychiatric Disorders by : Thomas E Schlaepfer

Download or read book Neurobiology of Psychiatric Disorders written by Thomas E Schlaepfer and published by Elsevier. This book was released on 2012-07-09 with total page 781 pages. Available in PDF, EPUB and Kindle. Book excerpt: This new volume in the Handbook of Clinical Neurology presents a comprehensive review of the fundamental science and clinical treatment of psychiatric disorders. Advances in neuroscience have allowed for dramatic advances in the understanding of psychiatric disorders and treatment. Brain disorders, such as depression and schizophrenia, are the leading cause of disability worldwide. It is estimated that over 25% of the adult population in North America are diagnosed yearly with at least one mental disorder and similar results hold for Europe. Now that neurology and psychiatry agree that all mental disorders are in fact, "brain diseases," this volume provides a foundational introduction to the science defining these disorders and details best practices for psychiatric treatment. Provides a comprehensive review of the scientific foundations of psychiatric disorders and psychiatric treatment Includes detailed results from genetics, molecular biology, brain imaging, and neuropathological, immunological, epidemiological, metabolic, therapeutic and historical aspects of the major psychiatric disorders A "must have" reference and resource for neuroscientists, neurologists, psychiatrists, and clinical psychologists as well as all research scientists investigating disorders of the brain

Molecular Neuropathology

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Author :
Publisher : Cambridge University Press
ISBN 13 : 9780521425582
Total Pages : 204 pages
Book Rating : 4.4/5 (255 download)

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Book Synopsis Molecular Neuropathology by : Gareth W. Roberts

Download or read book Molecular Neuropathology written by Gareth W. Roberts and published by Cambridge University Press. This book was released on 1995-06-08 with total page 204 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume provides an introduction to the essential techniques required for studying the molecular biology of brain disease. The approaches and strategies for investigations of gene structure and regulation are described with reference to the molecular genetics of prion and Alzheimer's disease. The effects of aberrant gene regulation can also be examined at the protein level by immunocytochemistry and autoradiography. Improved understanding of basic biology has resulted in new approaches to animal models using transgenic techniques and new therapeutic approaches. The volume is structured to illustrate all these approaches and demonstrate the practice and promise of molecular neuropathology.

Studies on Psychiatric Disorders

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Author :
Publisher : Springer
ISBN 13 : 149390440X
Total Pages : 600 pages
Book Rating : 4.4/5 (939 download)

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Book Synopsis Studies on Psychiatric Disorders by : Anna Dietrich-Muszalska

Download or read book Studies on Psychiatric Disorders written by Anna Dietrich-Muszalska and published by Springer. This book was released on 2015-01-02 with total page 600 pages. Available in PDF, EPUB and Kindle. Book excerpt: This authoritative volume reviews clinical, pathophysiological and therapeutic aspects of oxidative and nitrosative stress in different psychiatric disorders such as schizophrenia, bipolar disorder, autism, and attention deficit hyperactivity disorder (ADHD). Twenty-nine comprehensive chapters are divided into three distinct sections: clinical aspects, pathophysiological aspects, and therapeutic aspects. Together, these chapters present the environmental, genetic and neurodevelopmental factors in the generation of oxidative stress in psychiatric disorders, with particular emphasis on the biochemical changes associated with oxidative stress in dopaminergic and glutamate neurotransmission as well as mitochondrial dysfunction in the brain and peripheral cells. Through an investigation of glutamic acid decarboxylase (GAD) abnormalities in schizophrenia, the book provides a coherent framework to account for the impact of oxidative stress on pathological phenomena ranging from cellular to cognitive and clinical aspects. It describes biomarkers of oxidative damage, the role of oxidative stress in numerous abnormalities of biochemical pathways in the pathophysiology of schizophrenia, the development of new investigative techniques, specially neuroimaging, and studies of apoptotic pathways that seem to prove neurodegenerative and neurodevelopmental theories. Written by leading researchers in their fields, Studies on Psychiatric Disorders explores therapeutic approaches with aspects of various antioxidants, cryostimulation, and hyperbaric oxygen treatment in oxidative stress in neuropsychiatric diseases. The volume also discusses the role of antipsychotics in the treatment of schizophrenia on nitric oxide generation and biomarkers of oxidative stress together with the clinical symptomatology. Overall, it proposes that novel therapeutic strategies such as supplementation with antioxidants—in particular polyphenols, ω-3 fatty acids or combination of both—could be effective for long-term treatment of some neuropsychiatric disorders.

Biology of Brain Disorders

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Author :
Publisher : Frontiers Media SA
ISBN 13 : 2889453804
Total Pages : 586 pages
Book Rating : 4.8/5 (894 download)

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Book Synopsis Biology of Brain Disorders by : Daniela Tropea

Download or read book Biology of Brain Disorders written by Daniela Tropea and published by Frontiers Media SA. This book was released on 2018-01-31 with total page 586 pages. Available in PDF, EPUB and Kindle. Book excerpt: Brain disorders, including neurological and neuropsychiatric conditions, represent a challenge for public health systems and society at large. The limited knowledge of their biology hampers the development of diagnostic tools and effective therapeutics. A clear understanding of the mechanisms that underlie the onset and progression of brain disorders is required in order to identify new avenues for therapeutic intervention. Overlapping genetic risk factors across different brain disorders suggest common linkages and pathophysiological mechanisms that underlie brain disorders. Methodological and technological advances are leading to new insights that go beyond traditional hypotheses. Taking account of underlying molecular, cellular and systems biology underlying brain function will play an important role in the classification of brain disorders in future. In this Research Topic, the latest advances in our understanding of biological mechanisms across different brain disorders are presented. The areas covered include developments in neurogenetics, epigenetics, plasticity, glial cell biology, neuroimmune interactions and new technologies associated with the study of brain function. Examples of how understanding of biological mechanisms are translating into research strategies that aim to advance diagnoses and treatment of brain disorders are discussed.

Psychiatric Disorders

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Author :
Publisher : Humana
ISBN 13 : 9781493995530
Total Pages : 728 pages
Book Rating : 4.9/5 (955 download)

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Book Synopsis Psychiatric Disorders by : Firas H. Kobeissy

Download or read book Psychiatric Disorders written by Firas H. Kobeissy and published by Humana. This book was released on 2019-07-05 with total page 728 pages. Available in PDF, EPUB and Kindle. Book excerpt: This second edition volume expands on the previous edition with updates to chapters and new chapters discussing the latest research in neuropsychiatric diseases. The chapters in this book are organized into eleven sections and cover the diversity and utility of animal models of psychiatric disorders, their development, modelling, and pathophysiological and molecular profiles. Part One looks at experimental modeling of neuropsychiatric studies and the usefulness and need of animal models. Parts Two and Three focus on experimental models of neuropsychiatric illnesses, including self-injurious behavior, bipolar disorder, anxiety, and learning and decision-making testing. Parts Four and Five discuss animal models of substance abuse. Part Six describes protocols to examine animal models related to maladaptive eating habits and behaviors. Parts Seven and Eight cover neurodegenerative diseases stemming from natural causes (aging), abnormal genetic backgrounds, or those brought on by trauma. Part Nine talks about inflammatory and metabolic alteration profiles relevant to autism spectrum disorders and depression. Parts Ten and Eleven conclude the book with a discussion on genetics, epigenetics, and system biology in the field of psychiatric disorders. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and thorough, Psychiatric Disorders: Methods and Protocols, Second Edition is a useful resource for graduates, postdoctoral workers, and established scientists working in the fields of behavioral and molecular neuropsychiatric research.

Genomics, Circuits, and Pathways in Clinical Neuropsychiatry

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Author :
Publisher : Academic Press
ISBN 13 : 0128005300
Total Pages : 798 pages
Book Rating : 4.1/5 (28 download)

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Book Synopsis Genomics, Circuits, and Pathways in Clinical Neuropsychiatry by : Thomas Lehner

Download or read book Genomics, Circuits, and Pathways in Clinical Neuropsychiatry written by Thomas Lehner and published by Academic Press. This book was released on 2016-06-07 with total page 798 pages. Available in PDF, EPUB and Kindle. Book excerpt: This foundational work comprehensively examines the current state of the genetics, genomics and brain circuitry of psychiatric and neurological disorders. It consolidates discoveries of specific genes and genomic regions associated with these conditions, the genetic and anatomic architecture of these syndromes, and addresses how recent advances in genomics are leading to a reappraisal of the biology underlying clinical neuroscience. In doing so, it critically examines the promise and limitations of these discoveries toward treatment, and to the interdisciplinary nature of understanding brain and behavior. Coverage includes new discoveries regarding autism, epilepsy, intellectual disability, dementias, movement disorders, language impairment, disorders of attention, schizophrenia, and bipolar disorder. Genomics, Circuits, and Pathways in Clinical Neuropsychiatry focuses on key concepts, challenges, findings, and methods in genetics, genomics, molecular pathways, brain circuitry, and related neurobiology of neurologic and psychiatric disorders. Provides interdisciplinary appeal in psychiatry, neurology, neuroscience, and genetics Identifies key concepts, methods, and findings Includes coverage of multiple disorders from autism to schizophrenia Reviews specific genes associated with disorders Discusses the genetic architecture of these syndromes Explains how recent findings are influencing the understanding of biology Clarifies the promise of these findings for future treatment

Psychiatric Genetics

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Author :
Publisher : Routledge
ISBN 13 : 1317329635
Total Pages : 234 pages
Book Rating : 4.3/5 (173 download)

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Book Synopsis Psychiatric Genetics by : Michael Arribas-Ayllon

Download or read book Psychiatric Genetics written by Michael Arribas-Ayllon and published by Routledge. This book was released on 2019-02-21 with total page 234 pages. Available in PDF, EPUB and Kindle. Book excerpt: Psychiatric genetics has become ‘Big Biology’. This may come as a surprising development to those familiar with its controversial history. From eugenic origins and contentious twin studies to a global network of laboratories employing high-throughput genetic and genomic technologies, biological research on psychiatric disorders has become an international, multidisciplinary assemblage of massive data resources. How did psychiatric genetics achieve this scale? How is it socially and epistemically organized? And how do scientists experience this politics of scale? Psychiatric Genetics: From Hereditary Madness to Big Biology develops a sociological approach of exploring the origins of psychiatric genetics by tracing several distinct styles of scientific reasoning that coalesced at the beginning of the twentieth century. These styles of reasoning reveal, among other things, a range of practices that maintain an extraordinary stability in the face of radical criticism, internal tensions and scientific disappointments. The book draws on a variety of methods and materials to explore these claims. Combining genealogical analysis of historical literature, rhetorical analysis of scientific review articles, interviews with scientists, ethnographic observations of laboratory practices and international conferences, this book offers a comprehensive and detailed exploration of both local and global changes in the field of psychiatric genetics.

Molecular Biology of Neuropsychiatric Disorders

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Author :
Publisher : Springer
ISBN 13 : 9783540853824
Total Pages : 294 pages
Book Rating : 4.8/5 (538 download)

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Book Synopsis Molecular Biology of Neuropsychiatric Disorders by : Dieter B. Wildenauer

Download or read book Molecular Biology of Neuropsychiatric Disorders written by Dieter B. Wildenauer and published by Springer. This book was released on 2008-11-28 with total page 294 pages. Available in PDF, EPUB and Kindle. Book excerpt: It is generally accepted that neuropsychiatric disorders have a biological basis. Pathological changes leading to illness have been confirmed for Alzheimer’s (amyloid plaques) and Parkinson’s disease (loss of dopaminergic transmission) and are the foundation for studies on the molecular biology of these disorders. For other neuropsychiatric disorders, in particular for schizophrenic and affective disorders, molecular causes appear to be more complex and therefore remain hypothetical, despite decades of research. Changes in a number of neuronal pathways and structures have been reported to be associated with these disorders and are currently under extensive investigation. The present volume reviews recent knowledge with emphasis on ongoing research findings. Current hypotheses based on these findings are described and discussed.

Principles of Psychiatric Genetics

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Author :
Publisher : Cambridge University Press
ISBN 13 : 0521896495
Total Pages : 415 pages
Book Rating : 4.5/5 (218 download)

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Book Synopsis Principles of Psychiatric Genetics by : John I. Nurnberger

Download or read book Principles of Psychiatric Genetics written by John I. Nurnberger and published by Cambridge University Press. This book was released on 2012-09-13 with total page 415 pages. Available in PDF, EPUB and Kindle. Book excerpt: A comprehensive, up-to-date resource providing information about genetic influences on disorders of behavior.