Molecular Biology Of Hematopoiesis And Treatment Of Myeloproliferative Diseases

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Molecular Biology of Hematopoiesis 5

Author : Nader G. Abraham
Publisher : Springer Science & Business Media
ISBN 13 : 1461303915
Total Pages : 697 pages
Book Rating : 4.4/5 (613 download)

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Book Synopsis Molecular Biology of Hematopoiesis 5 by : Nader G. Abraham

Download or read book Molecular Biology of Hematopoiesis 5 written by Nader G. Abraham and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 697 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume of Molecular Biology of Hematopoiesis is dedicated to John W. Adam son, M. D. , Tadamitsu Kishimoto, M. D. , Robert C. Gallo, M. D. , Arthur W. Nienhuis, M. D. , and Franco Mandelli, M. D. , for their contributions in developing an overall view of the state-of-the-art knowledge in the field of hematopoiesis. Richard Champlin, among other renowned clinicians, presented updated information on stem cells and T-cell depletion for bone marrow transplant. A clinical update on thrombopoietin was presented by Pamela Hunt of Amgen and by Kenneth Kaushansky. Arthur Nienhuis' and Katherine Turner's contribu tions to our current knowledge and advances in the fields of growth factors and gene transfer were also recognized during the 9th Symposium on Molecular Biology of Hematopoiesis in Genoa. The chapters cover such diverse areas as preclinical and clinical updates on growth factors and positive and negative regulatory molecules. "Advances in Leukemia: Mechanism and Treatment by Interferon" was presented by Professor Sante Tura. Readers will find presentation of exciting advances that have occurred in the area of hematopoiesis. The elucidation of gene structures of key growth factor proteins such as IL-12 and IL-II will lead to new insights and new approaches in understanding the regulation of hematopoiesis, as well as application of new growth factors.

Molecular Biology of Hematopoiesis and Treatment of Myeloproliferative Diseases

Author : Nader G. Abraham
Publisher :
ISBN 13 :
Total Pages : 45 pages
Book Rating : 4.:/5 (455 download)

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Book Synopsis Molecular Biology of Hematopoiesis and Treatment of Myeloproliferative Diseases by : Nader G. Abraham

Download or read book Molecular Biology of Hematopoiesis and Treatment of Myeloproliferative Diseases written by Nader G. Abraham and published by . This book was released on 1999 with total page 45 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Molecular Biology of Hematopoiesis 6

Author : Nader G. Abraham
Publisher : Springer Science & Business Media
ISBN 13 : 1461547970
Total Pages : 393 pages
Book Rating : 4.4/5 (615 download)

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Book Synopsis Molecular Biology of Hematopoiesis 6 by : Nader G. Abraham

Download or read book Molecular Biology of Hematopoiesis 6 written by Nader G. Abraham and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 393 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume of Molecular Biology of Hematopoiesis is dedicated to many inter national scientists and clinicians for their contribution to the field of Hematology/ Oncology presented at the 11th International Symposium on Molecular Biology of Hematopoiesis, which was held in Bormio, Italy, June 25-29, 1998. The continuous support of the Presidents of the meeting, Professor F. Takaku, President of Jichi University, and E. D. Thomas, Nobel Laureate, was greatly acknowledged, especially Professor Takaku, for his vision and support for development of gene therapy in Japan. New information on BMT for autoimmune disease and organ transplantation was presented at the symposium and is published in this volume. Several new findings on gene therapy/transfer into HSC were presented by E. F. Vanin and A. Nienhuis, K. Humphries, 1. A. Nolta, H. E. Heslop, and M. K. Brenner. Professors S. Asano and K. Tani presented new studies on gene transfer into primates. Among the highlights were the new papers on gene transfer presented by G. Wage maker, N. G. Abraham, and M. Onoderea from R. M. BJaese's group. The use of BMT for organ transplant and autoim mune disease was updated and a representative paper is presented in this volume.

Molecular Biology of Hematopoiesis and Treatment of Myeloproliferative Diseases

Author :
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (715 download)

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Book Synopsis Molecular Biology of Hematopoiesis and Treatment of Myeloproliferative Diseases by :

Download or read book Molecular Biology of Hematopoiesis and Treatment of Myeloproliferative Diseases written by and published by . This book was released on 1998 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Molecular Basis of Hematopoiesis

Author : Amittha Wickrema
Publisher : Springer Science & Business Media
ISBN 13 : 0387858164
Total Pages : 260 pages
Book Rating : 4.3/5 (878 download)

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Book Synopsis Molecular Basis of Hematopoiesis by : Amittha Wickrema

Download or read book Molecular Basis of Hematopoiesis written by Amittha Wickrema and published by Springer Science & Business Media. This book was released on 2008-12-26 with total page 260 pages. Available in PDF, EPUB and Kindle. Book excerpt: Although much is known with respect to blood cell formation and function, many new concepts in the areas of the regulation of hematopoietic stem cell commitment and the subsequent survival, proliferation, and differentiation of progenitors have been elucidated in the last five years. Our understanding of the microenvironment where stem cells reside and commit to distinct blood types (the niche) has grown significantly in recent years. Furthermore, blood cells have been used as the key model system to study microRNA function and the role of microRNAs in the transformation of normal cells into cancer cells. The current volume Molecular Basis of Hematopoiesis, edited by Amittha Wickrema & Barbara Kee, provides the most recent developments in the area in addition to a chapter on the utilization of basic science knowledge for the treatment of blood diseases. Each chapter in this book has been written and edited by faculty in major academic and research institutions around the world, who are pushing the frontiers of research in this important area.

Biology and Treatment of Leukemia and Bone Marrow Neoplasms

Author : Vinod Pullarkat
Publisher : Springer Nature
ISBN 13 : 3030783111
Total Pages : 200 pages
Book Rating : 4.0/5 (37 download)

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Book Synopsis Biology and Treatment of Leukemia and Bone Marrow Neoplasms by : Vinod Pullarkat

Download or read book Biology and Treatment of Leukemia and Bone Marrow Neoplasms written by Vinod Pullarkat and published by Springer Nature. This book was released on 2021-10-09 with total page 200 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides a concise update on current understanding of the biology of acute and chronic leukemias and other bone marrow neoplasms, including myelodysplastic and myeloproliferative disorders, and explores new and emerging treatments. There is a particular focus on the molecular abnormalities that are drivers of leukemia and on their detection by modern molecular techniques. Knowledge of the ways in which genomic and metabolic abnormalities in the hematologic neoplasms affect prognosis and treatment decision making is reviewed. Detailed attention is devoted to targeted therapies, including novel drugs, and to potential targets for future drug development. In addition, readers find in-depth discussion of cellular and antibody-based immunotherapies as well as the role of hematopoietic stem cell transplantation in the treatment of leukemias and bone marrow malignancies. The book is of special interest for hematologists, oncologists, and cancer researchers; it is also of value for hematology trainees and medical students.

11th Symposium on Molecular Biology of Hematopoiesis and Treatment of Myeloproliferative Diseases

Author :
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (641 download)

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Book Synopsis 11th Symposium on Molecular Biology of Hematopoiesis and Treatment of Myeloproliferative Diseases by :

Download or read book 11th Symposium on Molecular Biology of Hematopoiesis and Treatment of Myeloproliferative Diseases written by and published by . This book was released on 1998 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Molecular Biology of Hematopoiesis and Treatment of Myeloproliferative Diseases

Author : Nader G. Abraham
Publisher : S Karger Ag
ISBN 13 : 9783805568234
Total Pages : 111 pages
Book Rating : 4.5/5 (682 download)

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Book Synopsis Molecular Biology of Hematopoiesis and Treatment of Myeloproliferative Diseases by : Nader G. Abraham

Download or read book Molecular Biology of Hematopoiesis and Treatment of Myeloproliferative Diseases written by Nader G. Abraham and published by S Karger Ag. This book was released on 1999-01-01 with total page 111 pages. Available in PDF, EPUB and Kindle. Book excerpt: This special issue of Acta Haematologica contains selected papers presented at the 11th International Symposium on Molecular Biology of Hematopoiesis, held in Bormio, Italy in June 1998. The following topics are considered: - the use of BMT for organ transplantation and autoimmune disease - new methods for stable gene transfer with increased transduction rate into pluripotent human stem cells - the state of the art in retrovirus gene transfer - the use of adenoviral- and retroviral-mediated interferon gene transfer for a possible treatment of patients with chronic myelogenous leukemia and colon cancer Bringing together the experience of leading specialists, this publication will be appreciated by hematologists, oncologists, and scientists working on gene therapy.

Molecular Biology of Hematopoiesis and Treatment of Myeloproliferative Diseases

Author : Nader G. Abraham
Publisher : S. Karger AG (Switzerland)
ISBN 13 : 9783805567299
Total Pages : 72 pages
Book Rating : 4.5/5 (672 download)

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Book Synopsis Molecular Biology of Hematopoiesis and Treatment of Myeloproliferative Diseases by : Nader G. Abraham

Download or read book Molecular Biology of Hematopoiesis and Treatment of Myeloproliferative Diseases written by Nader G. Abraham and published by S. Karger AG (Switzerland). This book was released on 1998 with total page 72 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Hematopoietic Stem Cell Biology

Author : Motonari Kondo
Publisher : Springer Science & Business Media
ISBN 13 : 1603273476
Total Pages : 260 pages
Book Rating : 4.6/5 (32 download)

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Book Synopsis Hematopoietic Stem Cell Biology by : Motonari Kondo

Download or read book Hematopoietic Stem Cell Biology written by Motonari Kondo and published by Springer Science & Business Media. This book was released on 2009-12-04 with total page 260 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the summer of 1988, my developmental biology professor announced to the class that hematopoietic stem cells (HSCs) had finally been purified. Somehow, I never forgot the professor’s words. When I started working in Dr. Irv Weissman’s labo- tory at Stanford as a postdoctoral fellow, I realized that the findings mentioned by the professor were from Weissman’s laboratory and had been published in a 1988 edition of the journal Science. It has been over 20 years since the publication of that seminal paper, and since then tremendous advances in understanding the biology and maturation of HSCs, namely the process of hematopoiesis, which includes lymphocyte development, have been made. These discoveries were made possible in part by advancements in technology. For example, recent availability of user friendly fluorescence activated cell sorting (FACS) machines and monoclonal an- bodies with a variety of fluorescent labels has allowed more scientists to sort and analyze rare populations in the bone marrow, such as HSCs. All classes of hematopoietic cells are derived from HSCs. Stem cell biology draws enormous attention not only from scientists, but also from ordinary people because of the tremendous potential for development of new therapeutic application to diseases that currently lack any type of effective therapy. Thus, this type of “regenerative medicine” is a relatively new and attractive field in both basic science and clinical medicine.

Molecular Hematology

Author : Drew Provan
Publisher : John Wiley & Sons
ISBN 13 : 1394180454
Total Pages : 452 pages
Book Rating : 4.3/5 (941 download)

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Book Synopsis Molecular Hematology by : Drew Provan

Download or read book Molecular Hematology written by Drew Provan and published by John Wiley & Sons. This book was released on 2024-05-28 with total page 452 pages. Available in PDF, EPUB and Kindle. Book excerpt: Provides a core knowledgebase for those with minimal exposure to hematologic molecular biology, fully revised and updated Molecular Hematology brings together the most up-to-date and reliable information on the molecular basis of major hematologic diseases. Edited and authored by leading experts in the field, this volume demonstrates the clinical relevance of molecular biology in the diagnosis and treatment of blood disorders. Concise, accessible chapters address key topics in modern hematology, such as lymphoma genetics, molecular coagulation, thrombophilia, pharmacogenomics, platelet disorders, hemophilia, anemia, and multiple myeloma. Chapters introduce and summarize specific hematologic diseases, explore the pathogenesis of the disorder, highlight new and emerging molecular strategies, and more. Now in its fifth edition, Molecular Hematology is fully revised to incorporate contemporary hematology research and practice. Entirely new chapters cover topics such as CAR-T cell technology, COVID, cancer cell biology, gene therapy and gene editing in clinical practice, as well as the impact of molecular research on the diagnosis and treatment of various malignant hematologic diseases. This edition includes updated suggested readings and a wealth of new full-color charts, graphs, and illustrations throughout. Covers the molecular biology of different blood diseases, their pathogeneses, and current molecular research and therapies Illustrates the impact of molecular research on hematologic investigations and therapeutics Discusses how progress in basic science and therapeutics has improved the diagnosis and care of patients with various hematologic disorders Surveys recent developments in cancer-cell biology, with an emphasis on leukemia and lymphoma Includes access to a companion Digital Edition providing search across the book, downloadable illustrations, and notation tools Molecular Hematology is a must-have resource for established and trainee clinicians, clinical scientists and researchers, medical students, and upper-level undergraduates in the fields of hematology, oncology, and molecular biology.

Myeloproliferative Disorders

Author : Richard T. Silver
Publisher : CRC Press
ISBN 13 : 1000687309
Total Pages : 240 pages
Book Rating : 4.0/5 (6 download)

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Book Synopsis Myeloproliferative Disorders by : Richard T. Silver

Download or read book Myeloproliferative Disorders written by Richard T. Silver and published by CRC Press. This book was released on 2007-10-11 with total page 240 pages. Available in PDF, EPUB and Kindle. Book excerpt: With the recent discovery of JAK2 mutations in myeloproliferative disorders, medical science has taken a revolutionary stride forward toward understanding the pathogenesis of these diseases. This new advancement translates not only to a more rapid and reliable diagnosis, but also allows groundbreaking research into the development of new therapeuti

Hematopoietic Stem Cells

Author : Louis M. Pelus
Publisher : Springer Nature
ISBN 13 : 1071626795
Total Pages : 284 pages
Book Rating : 4.0/5 (716 download)

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Book Synopsis Hematopoietic Stem Cells by : Louis M. Pelus

Download or read book Hematopoietic Stem Cells written by Louis M. Pelus and published by Springer Nature. This book was released on 2022-10-18 with total page 284 pages. Available in PDF, EPUB and Kindle. Book excerpt: This detailed volume collects updates on the technical advances in hematopoietic stem cell research and incorporates new techniques focused on the molecular/genetic, cellular, and whole organism levels. Exploring methods that apply stress to hematopoiesis, the book also contains chapters focused on better understanding the role of hematopoietic niches and their cellular components, as well as in vivo models that test and quantitate stem cell function and are key to further development of therapeutic applications. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step and readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and up-to-date, Hematopoietic Stem Cells: Methods and Protocols serves as a valued addition to laboratories focused on understanding hematopoietic stem cell biology and the therapeutic advances that can be derived from it.

Molecular Biology of Hematopoiesis and Treatment of Leukemias and Lymphomas

Author : Nader G. Abraham
Publisher : S. Karger AG (Switzerland)
ISBN 13 : 9783805566810
Total Pages : 76 pages
Book Rating : 4.5/5 (668 download)

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Book Synopsis Molecular Biology of Hematopoiesis and Treatment of Leukemias and Lymphomas by : Nader G. Abraham

Download or read book Molecular Biology of Hematopoiesis and Treatment of Leukemias and Lymphomas written by Nader G. Abraham and published by S. Karger AG (Switzerland). This book was released on 1998 with total page 76 pages. Available in PDF, EPUB and Kindle. Book excerpt: Hematopoietic stem cells give rise to all the differentiated elements of the blood, and much progress has been made in recent years in understanding the intricate network of cytokines that regulate the survival, self-renewal and differentiation of these cells. This special issue of Acta Haematologica contains selected contributions from the 10th Symposium on 'Molecular Biology of Hematopoiesis', held in Hamburg in 1997. Leading specialists in the field discuss the roles of cytokines and report preclinical and clinical experience with growth factors and chemotherapy in the treatment of leukemia and lymphoma. Revealing the mechanisms responsible for normal and abnormal cell proliferation and differentiation, and presenting innovative approaches for blood and marrow transplantation, this publication is recommended reading for all oncologists and hematologists.

Myeloproliferative Neoplasms

Author : Srdan Verstovsek
Publisher : Humana Press
ISBN 13 : 9781607612650
Total Pages : 230 pages
Book Rating : 4.6/5 (126 download)

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Book Synopsis Myeloproliferative Neoplasms by : Srdan Verstovsek

Download or read book Myeloproliferative Neoplasms written by Srdan Verstovsek and published by Humana Press. This book was released on 2010-10-21 with total page 230 pages. Available in PDF, EPUB and Kindle. Book excerpt: This succinct resource provides an ideal balance of the biology and practical therapeutic strategies for classic and non-classic BCR-ABL-negative myeloproliferative neoplasms. Utilizing current World Health Organization nomenclature, classification, and diagnostic criteria, international experts have assembled to convey the most up-to-date knowledge in this rapidly evolving field. The opening chapters cover the diagnosis and classification, genetics, cytogenetic findings, and prognostic factors of MPNs. Further chapters explore therapies specific to the different disease entities, including polycythemia vera, essential thrombocytopenia, myelofibrosis, and eosinophilic disorders, and mastocytosis. Unique areas of discussion include JAK2 inhibitor therapy, hematopoietic stem cell transplantation, and blastic transformation. A valuable reference for practicing hematologists, this forefront book enriches our understanding of recent discoveries and their impact on conventional and investigational treatments.

Fast Facts: Myelofibrosis

Author : Donal McLornan
Publisher : Karger Medical and Scientific Publishers
ISBN 13 : 3318070807
Total Pages : 102 pages
Book Rating : 4.3/5 (18 download)

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Book Synopsis Fast Facts: Myelofibrosis by : Donal McLornan

Download or read book Fast Facts: Myelofibrosis written by Donal McLornan and published by Karger Medical and Scientific Publishers. This book was released on 2022-04-25 with total page 102 pages. Available in PDF, EPUB and Kindle. Book excerpt: Myelofibrosis is a myeloproliferative neoplasm that has markedly heterogeneous features. The clinical phenotype can range from initial indolent presentation, which may be stable for many years, through to marked cytopenias, debilitating constitutional symptoms, massive splenomegaly and an inherent risk of leukemic transformation. Despite many advances regarding molecular classification, prognostication models and rapeutic options over the last few decades, allogeneic stem cell transplantation remains the only curative option, yet is suitable only for a minority of patients. ‘Fast Facts: Myelofibrosis’ is written for health professionals by two leading experts in the field, and provides up-to-date guidance on its accurate diagnosis, risk stratification and management. It also provides key insights into the molecular biology underpinning the disease. This concise handbook is an indispensable read for anyone wanting to get up to speed with best practice in the diagnosis and care of people with myelofibrosis. Table of Contents: • Presentation, classification and epidemiology • Molecular biology and pathogenesis • Clinical assessment and diagnosis • Prognostic models • Treatment approaches • Allogeneic stem cell transplantation • Management of blast-phase myelofibrosis • Therapies in development

Cellular and Molecular Aspects of Myeloproliferative Neoplasms - Part B

Author :
Publisher : Academic Press
ISBN 13 : 0323899420
Total Pages : 242 pages
Book Rating : 4.3/5 (238 download)

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Book Synopsis Cellular and Molecular Aspects of Myeloproliferative Neoplasms - Part B by :

Download or read book Cellular and Molecular Aspects of Myeloproliferative Neoplasms - Part B written by and published by Academic Press. This book was released on 2022-02-11 with total page 242 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cellular and Molecular Aspects of Myeloproliferative Neoplasms - Part B, Volume 366 in the International Review of Cell and Molecular Biology series, highlights new advances in the field, with this new volume presenting interesting chapters written by an international board of authors. Sections cover Genetic and Sex predisposition to MPN, Transcriptional configurations of Myeloproliferative Neoplasms, Inhibitors and therapeutic targets of MPN, Mutational landscape of blast-phase myeloproliferative neoplasm (MPN-BP) and antecedent MPN, and Lessons from Mouse model of MPN, Lab tests for MPN. Publishes only invited review articles on selected topics Authored by established and active cell and molecular biologists from international sources Offers a wide range of perspectives on specific subjects