Author : Steffen Witte
Publisher :
ISBN 13 :
Total Pages : 0 pages
Book Rating : 4.:/5 (14 download)
Book Synopsis Molecular Basis of Mitochondrial Diseases Exemplified by Mutation of the Translation Factor Cox14 by : Steffen Witte
Download or read book Molecular Basis of Mitochondrial Diseases Exemplified by Mutation of the Translation Factor Cox14 written by Steffen Witte and published by . This book was released on 2023 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mitochondrial oxidative phosphorylation (OXPHOS) fuels cellular ATP demands. OXPHOS defects lead to severe human disorders with unexplained tissue specific pathologies. More and more evidence shows that mitochondrial dysfunction is an important pathomechanism in the development of many common human diseases. Mitochondrial gene expression is essential for OXPHOS biogenesis since core subunits of the complexes are mitochondrial-encoded. COX14 is required for translation of COX1, the central mitochondrial-encoded subunit of complex IV. In this study, a COX14 mouse mutant corresponding to a pat...