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Modulation Of Epidermal Growth Factor Induced Cell Signaling In Mammary Epithelium By Prolactin
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Book Synopsis Modulation of Epidermal Growth Factor-induced Cell Signaling in Mammary Epithelium by Prolactin by : Suzanne E. Fenton
Download or read book Modulation of Epidermal Growth Factor-induced Cell Signaling in Mammary Epithelium by Prolactin written by Suzanne E. Fenton and published by . This book was released on 1993 with total page 482 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Prolactin Inhibits Epidermal Growth Factor Induced Cellular Signaling in Mouse Mammary Epithelial Cells by : Julie Lynn Johnson
Download or read book Prolactin Inhibits Epidermal Growth Factor Induced Cellular Signaling in Mouse Mammary Epithelial Cells written by Julie Lynn Johnson and published by . This book was released on 1996 with total page 186 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Prolactin Regulation of Epidermal Growth Factor Receptor Kinase in Mammary Epithelial Cells by : Victor J. Quijano
Download or read book Prolactin Regulation of Epidermal Growth Factor Receptor Kinase in Mammary Epithelial Cells written by Victor J. Quijano and published by . This book was released on 1998 with total page 428 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Characterizing the Role of Prolactin-induced Tyrosine Phosphorylation of Grb2 in the Regulation of Epidermal Growth Factor Signalling in Mammary Epithelial and Breast Cancer Cells by : Eric Haines
Download or read book Characterizing the Role of Prolactin-induced Tyrosine Phosphorylation of Grb2 in the Regulation of Epidermal Growth Factor Signalling in Mammary Epithelial and Breast Cancer Cells written by Eric Haines and published by . This book was released on 2009 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Characterizing the Role of Prolactin-induced Grb2 Tyrosine Phosphorylation in the Regulation of Epidermal Growth Factor Signalling in Mammary Epithelial and Breast Cancer Cells by : Eric Haines
Download or read book Characterizing the Role of Prolactin-induced Grb2 Tyrosine Phosphorylation in the Regulation of Epidermal Growth Factor Signalling in Mammary Epithelial and Breast Cancer Cells written by Eric Haines and published by . This book was released on 2009 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Modulation of Epidermal Growth Factor Receptor Expression by Chemotherapeutic Agents in Breast Cancer Cell Lines by :
Download or read book Modulation of Epidermal Growth Factor Receptor Expression by Chemotherapeutic Agents in Breast Cancer Cell Lines written by and published by . This book was released on 2001 with total page 17 pages. Available in PDF, EPUB and Kindle. Book excerpt: The epidermal growth factor receptor (EOFR) is a cell-surface protein that relays signals from the extracellular environment into the cell by binding specific polypeptide hormones followed by activation of intracellular signal transduction pathways. Although rarely an oncogene, the ability of EGFR-mediated signaling to generate diverse responses including growth, differentiation, stress response, apoptosis suppression, and altered mobility makes this protein a potentially powerful tumor promoter. The association between higher EOFR expression and poorer prognosis in breast cancer and the frequency of higher EGFR levels in more aggressive/metastatic breast tumors reinforce this possibility. Our research aims to uncover a link between chemotherapeutic exposure and increased expression of EOFR in breast cancer cells with the hope of explaining why higher levels of EGFR are common to more advanced breast tumors. We have shown that exposure of MCF-7, T-47D, and ZR-75-1 breast cancer cells to the anti-metabolite compound methotrexate causes an up-regulation of EGFR receptor expression. Our work demonstrates that the EGFR up-regulation usually occurs at both the niRNA level and protein level (with increased expression on the cell surface) and that this may be accompanied by changes in the expression of EGFR ligands. We also demonstrate that the methotrexate-induced EOFR expression in these cells alters EGF-mediated phosphorylation of ERK and AKT (causing changes in the specificity, timing and intensity of EOFR signaling through these pathways in a cell specific manner). ERK and AKT signaling pathways have been shown to mediate anti-apoptotic effects. We therefore hypothesize that increased EOFR expression and signaling in these cells provides a survival advantage by suppression of chemotherapy induced apoptosis, possibly explaining the prevalence of EGFR over-expression in drug resistant cell lines and more aggressive breast tumors.
Book Synopsis Investigation of the Link Between Prolactin, Mammary Gland Development and Carcinogenesis by Transcript Profiling by :
Download or read book Investigation of the Link Between Prolactin, Mammary Gland Development and Carcinogenesis by Transcript Profiling written by and published by . This book was released on 2002 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mammary lobuloalveolar development during pregnancy is controlled by the endocrine action of prolactin, estrogen and progesterone, but currently little is known of the transcriptional events that occur in response to these hormones. This study examines the transcriptional response of the mammary gland to the direct action of prolactin. Mammary tissue recombination experiments demonstrated that lobuloalveolar development is dependent upon the presence of prolactin receptors in mammary epithelium but not the stroma. Comparison of transcript profiles derived from recombined glands with and without epithelial prolactin receptors, from glands without epithelium, and from SCp2 cells treated with and without prolactin, allowed a small set of epithelial-specific prolactin-modulated transcripts to be identified. This included the epithelial specific Ets transcription factor Elf5. Elf5 expression decreased in Prlr(+/- ) mammary glands but there was no change in Prlr expression in Elf5(+/- ) mammary glands, indicate that ElfS acts downstream of prolactin. The expression of milk protein genes decreased in both Prlr(+/- ) and Elf5(+/- ) mammary glands, consistent with a role for Elf5 in mediating prolactin-induced epithelial differentiation, however, the expression of a number of growth factors decreased in Prlr(+/- ) mammary glands but increased in Elf5(+/- ) mammary glands. Thus prolactin induces the expression of Elf5, which performs a pivotal role in mediating the switch from prolactin induced epithelial cell proliferation to differentiation within the mammary gland during pregnancy.
Book Synopsis Modulation of Epidermal Growth Factor Receptor Expression and Its Role in Cell Survival in Methotrexate-Treated Breast Cancer Cell Lines by : James Nicholas Welch
Download or read book Modulation of Epidermal Growth Factor Receptor Expression and Its Role in Cell Survival in Methotrexate-Treated Breast Cancer Cell Lines written by James Nicholas Welch and published by . This book was released on 2002 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book FOXA1 written by Mounira Ibrahim and published by . This book was released on 2019 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: "Triple Negative Breast Cancer (TNBC) is the most resistant subtype of breast cancer. The lack of expression of estrogen, progesterone, and human epidermal growth factor 2 receptors in TNBC leads to the limited use of targeted therapy. Therefore, treatment with chemotherapy remains the main approach for treating TNBC with low therapeutic benefits and increased risk of resistance. Pro-differentiation based therapies by reversing breast cancer cells into an epithelial phenotype have recently been studied as a promising therapeutic approach for TNBC. Indeed, the laboratory of Dr. Ali showed that restoring prolactin pro-differentiation pathway reversed the mesenchymal aggressive phenotype of TNBC into the epithelial form with less aggressive behavior, less invasiveness, and lower metastasis. In addition, they identified a TNBC subgroup of patients that preserved prolactin receptor (PRLR) expression to show better overall survival and better prognosis. By metagenes cluster analysis, the TNBC-PRLR subtype is characterized by the up regulation of luminal-like differentiation genes which are Forkhead Box A1 (FOXA1) and androgen receptor (AR). Our aim is to determine the effect of FOXA1 on the epithelial mesenchymal transition (EMT) of breast cancer cells and how it may modulate the antitumorigenic role of prolactin and its signaling pathway in breast cancer. To achieve our objectives, we measured the expression of FOXA1 at the mRNA and protein levels after treating TNBC-PRLR cell lines with prolactin. We also produced CRISPR knock out of FOXA1 in these cell lines and measured the protein level of both E-cadherin, an epithelial marker and vimentin as a mesenchymal marker. As expected, the knock-out cells showed a decrease in the level of E-cadherin and an increase in vimentin compared to the parental cells. Finally, we conclude that FOXA1 can be a potential pro-differentiation marker in breast cancer cells. Further studies are needed to investigate this role of FOXA1 and its use as a target for personalized medicine in triple negative breast cancer"--
Book Synopsis Extracellular Matrix: Pathobiology and Signaling by : Nikos Karamanos
Download or read book Extracellular Matrix: Pathobiology and Signaling written by Nikos Karamanos and published by Walter de Gruyter. This book was released on 2012-08-31 with total page 940 pages. Available in PDF, EPUB and Kindle. Book excerpt: Over the last decades cell biology and biological chemistry have increasingly turned their attention to the space between cells and revealed an elaborate network of macromolecules essential for structural support, cell adhesion and signaling. This comprehensive handbook of the extracellular matrix will give an overview of the current state of knowledge of matrix components (structure and function), their role in heath and disease (matrix pathobiology) and new aspects related to pharmacological targeting. It will provide an introduction to the extracellular matrix and detailed sections and chapters on: Importance of extracellular matrix in health and disease Matrix proteoglycans (aggrecan, versican, perlecan, SLRPs, syndecans, glypicans, serglycin) Matrix proteinases (remodeling, would healing, regulatory roles in health and disease, metalloproteinases, cystein proteases, plasmin and plasminogen activator system) Glycobiology (hyaluronan and sulfated glycosaminoglycans in cancer, inflammation and metabolic control) Collagens (supramolecular assembly, proteins binding collagen, scaffolds, bacterial and mutated collagens, procollagen proteinases) Cell surface receptors (integrins, syndecans, mechanical strain and TGFb, CD44 and DDR). Biotechnological and pharmacological outlook (matrix regulation by growth factors, hyaluronidases, pathobiology, disease targeting, delivery systems, EMT and proteomics). "The book Extracellular Matrix: Pathobiology and Signaling provides a comprehensive and up to date collection of very relevant topics for understanding the various facets of extracellular matrix and its interactions with cells in normal tissue as well as in disease. It represents the current front-line and will serve as a reference for extracellular matrix and posttranslational modifications." Dick Heinegård, Department of Clinical Sciences Lund, Section Rheumatology, Lund University, Sweden
Download or read book Cumulated Index Medicus written by and published by . This book was released on 2000 with total page 1844 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Free Energy Calculations by : Christophe Chipot
Download or read book Free Energy Calculations written by Christophe Chipot and published by Springer Science & Business Media. This book was released on 2007-01-08 with total page 528 pages. Available in PDF, EPUB and Kindle. Book excerpt: Free energy constitutes the most important thermodynamic quantity to understand how chemical species recognize each other, associate or react. Examples of problems in which knowledge of the underlying free energy behaviour is required, include conformational equilibria and molecular association, partitioning between immiscible liquids, receptor-drug interaction, protein-protein and protein-DNA association, and protein stability. This volume sets out to present a coherent and comprehensive account of the concepts that underlie different approaches devised for the determination of free energies. The reader will gain the necessary insight into the theoretical and computational foundations of the subject and will be presented with relevant applications from molecular-level modelling and simulations of chemical and biological systems. Both formally accurate and approximate methods are covered using both classical and quantum mechanical descriptions. A central theme of the book is that the wide variety of free energy calculation techniques available today can be understood as different implementations of a few basic principles. The book is aimed at a broad readership of graduate students and researchers having a background in chemistry, physics, engineering and physical biology.
Book Synopsis Biology of the Mammary Gland by : John A. Mol
Download or read book Biology of the Mammary Gland written by John A. Mol and published by Springer Science & Business Media. This book was released on 2006-04-11 with total page 309 pages. Available in PDF, EPUB and Kindle. Book excerpt: Proceedings of the European Cooperation in the Field of Scientific and Technical Research (COST 825) Symposium on Mammary Gland Biology, held September 16-18, 1999, in Tours, France. It is difficult to overstate the evolutionary and functional significance of mammary tissue in biology. Substantial progress has been made by researchers in various disciplines, particularly over the last fifteen years, towards realizing the potential of this tissue to yield powerful experimental models for morphogenesis and tissue development; for cellular differentiation; for the biosynthesis and secretion of proteins, lipids, small molecules and inorganic salts; and for the coordination and regulation of these processes. More recently, the possibility of exploiting the secretory epithelial cells of mammary tissue as `cell factories' has become a reality and the recombinant production by lactating animals of an increasing number of proteins, valuable both in the pharmaceutical and `nutraceutical' fields, is in progress or under development. Also in this sphere of agricultural production, genetic as well as nutritional technologies are under investigation and exploitation to optimize milk composition for various end-uses - for instance in food process and manufacture. The possibilities of deriving health benefit from the bioactive properties of some of the minor constituents of milk are emerging to counter the highly-publicized negative health impact of excessive consumption of saturated animal fats. In human nutrition and medicine, the mammary gland is both a source of nutrition to the neonate and a potential health threat to the adult female - breast cancer remains the major single cause of female mortality in most developed countries. This volume provides a unique glimpse into our understanding, at the cutting edge of a variety of disciplines, of this versatile and extraordinary tissue, at the birth of the twenty-first century.
Download or read book The Pituitary written by Shlomo Melmed and published by Academic Press. This book was released on 2010-12-09 with total page 745 pages. Available in PDF, EPUB and Kindle. Book excerpt: The pituitary, albeit a small gland, is known as the "master gland" of the endocrine system and contributes to a wide spectrum of disorders, diseases, and syndromes. Since the publication of the second edition of The Pituitary, in 2002, there have been major advances in the molecular biology research of pituitary hormone production and action and there is now a better understanding of the pathogenesis of pituitary tumors and clinical syndromes resulting in perturbation of pituitary function. There have also been major advances in the clinical management of pituitary disorders. Medical researchers and practitioners now better understand the morbidity and mortality associated with pituitary hormone hyposecretion and hypersecretion. Newly developed drugs, and improved methods of delivering established drugs, are allowing better medical management of acromegaly and prolactinoma. These developments have improved the worldwide consensus around the definition of a "cure" for pituitary disease, especially hormone hypersecretion, and hence will improve the success or lack of success of various forms of therapy. It is therefore time for a new edition of The Pituitary. The third edition will continue to be divided into sections that summarize normal hypothalamic-pituitary development and function, hypothalamic-pituitary failure, and pituitary tumors; additional sections will describe pituitary disease in systemic disorders and diagnostic procedures, including imaging, assessment of the eyes, and biochemical testing. The first chapter will be completely new – placing a much greater emphasis on physiology and pathogenesis. Two new chapters will be added on the Radiation and Non-surgical Management of the Pituitary and Other Pituitary Lesions. Other chapters will be completely updated and many new author teams will be invited. The second edition published in 2002 and there have been incredible changes in both the research and clinical aspects of the pituitary over the past 8 years – from new advances in growth hormones to pituitary tumor therapy. Presents a comprehensive, translational source of information about the pituitary in one reference work Pituitary experts (from all areas of research and practice) take readers from the bench research (cellular and molecular mechanism), through genomic and proteomic analysis, all the way to clinical analysis (histopathology and imaging) and new therapeutic approaches Clear presentation by endocrine researchers of the cellular and molecular mechanisms underlying pituitary hormones and growth factors as well as new techniques used in detecting lesions (within the organ) and other systemic disorders Clear presentation by endocrinologists and neuroendocrine surgeons of how imaging, assessment of the eyes, and biochemical testing can lead to new therapeutic approaches
Book Synopsis Cell Growth Processes by : Daiki Kimura
Download or read book Cell Growth Processes written by Daiki Kimura and published by Nova Publishers. This book was released on 2008 with total page 254 pages. Available in PDF, EPUB and Kindle. Book excerpt: The basis for cell proliferation entails the control of key signalling and cell cycle regulators through transcriptional, translational, post-translational, genetic and epigenetic mechanisms. Many conceptual breakthroughs in cell regulation have derived from analyses of basic cell cycle mechanisms. This book presents research in the field.
Book Synopsis Yen & Jaffe's Reproductive Endocrinology - E-Book by : Jerome F. Strauss
Download or read book Yen & Jaffe's Reproductive Endocrinology - E-Book written by Jerome F. Strauss and published by Elsevier Health Sciences. This book was released on 2023-03-24 with total page 1393 pages. Available in PDF, EPUB and Kindle. Book excerpt: For over 40 years, Yen & Jaffe's Reproductive Endocrinology has been the gold standard text of both basic science and clinical practice of the full range of female and male reproductive disorders. The fully revised 9th Edition continues this tradition of excellence with complete coverage, including up-to-date information on impaired fertility, infertility, recurrent pregnancy loss, problems of sexual development, menstrual disturbances, fibroids, endometriosis, female and male reproductive aging, fertility preservation, assisted reproduction technologies including ovarian stimulation and ovulation induction, transgender hormonal treatment, contraception, and more. An outstanding editorial board and other global experts in the field share their knowledge and expertise to keep you abreast of current science and practice in endocrinology. Includes new chapters on Meiosis, Fertilization and Embryo Development; Recurrent Pregnancy Loss; Uterus Transplantation; Mitochondrial Transplantation and Gene Editing; and Germs Cells Developed In Vitro. Provides extensively revised information on contemporary practices in assisted reproduction, fertility preservation, and ovulation induction. Provides an online video library that highlights surgical procedures, diagnostic imaging, and functional ultrasound imaging. Adds three new members to the exceptional editorial team: Drs. Anuja Dokras, Carmen J. Williams, and Zev Williams. Features full-color, high-quality illustrations that clearly depict basic anatomic structures, endocrine processes, and cell function and dysfunction. Includes bulleted lists under major headings in each chapter for quick, at-a-glance summaries of every section. Lists Top References at the end of each chapter that distill the most important references for research underpinnings, to complement the complete online reference list.
Book Synopsis Hormonally Active Agents in the Environment by : National Research Council
Download or read book Hormonally Active Agents in the Environment written by National Research Council and published by National Academies Press. This book was released on 2000-02-03 with total page 453 pages. Available in PDF, EPUB and Kindle. Book excerpt: Some investigators have hypothesized that estrogens and other hormonally active agents found in the environment might be involved in breast cancer increases and sperm count declines in humans as well as deformities and reproductive problems seen in wildlife. This book looks in detail at the science behind the ominous prospect of "estrogen mimics" threatening health and well-being, from the level of ecosystems and populations to individual people and animals. The committee identifies research needs and offers specific recommendations to decision-makers. This authoritative volume: Critically evaluates the literature on hormonally active agents in the environment and identifies known and suspected toxicologic mechanisms and effects of fish, wildlife, and humans. Examines whether and how exposure to hormonally active agents occursâ€"in diet, in pharmaceuticals, from industrial releases into the environmentâ€"and why the debate centers on estrogens. Identifies significant uncertainties, limitations of knowledge, and weaknesses in the scientific literature. The book presents a wealth of information and investigates a wide range of examples across the spectrum of life that might be related to these agents.
