Modifiers Of Chemical Carcinogenesis

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Mechanisms of Chemical Carcinogenesis

Author : D. E. Hathway
Publisher : Butterworth-Heinemann
ISBN 13 : 1483192466
Total Pages : 145 pages
Book Rating : 4.4/5 (831 download)

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Book Synopsis Mechanisms of Chemical Carcinogenesis by : D. E. Hathway

Download or read book Mechanisms of Chemical Carcinogenesis written by D. E. Hathway and published by Butterworth-Heinemann. This book was released on 2013-10-22 with total page 145 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mechanisms of Chemical Carcinogenesis provides information pertinent to the fundamental mechanisms of chemical carcinogenesis. This book surveys the interactions of chemical carcinogens with native DNA, the activation of normal cellular sequences, and the transforming role of the activated genes. Organized into seven chapters, this book begins with an overview of the relationship between the incidence of lung cancer and the frequency and duration of cigarette smoking. This text then examines the concept that carcinogens may require metabolic activation before they initiate carcinogenesis. Other chapters consider the structure of the nucleoside adducts resulting from the hydrolysis of salmon-sperm DNA and rat-liver ribosomal RNA. This book discusses as well the persistence of nucleoside analogues in target-tissue nucleic acid. The final chapter deals with mutational theory. This book is a valuable resource for workers involved with cancer research, toxicology, and molecular biology. Specialists in drug development, industrial hygiene and occupational medicine will also find this book useful.

Carcinogens, Dna Damage And Cancer Risk: Mechanisms Of Chemical Carcinogenesis

Author : Miriam Christine Poirier
Publisher : World Scientific
ISBN 13 : 981323721X
Total Pages : 391 pages
Book Rating : 4.8/5 (132 download)

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Book Synopsis Carcinogens, Dna Damage And Cancer Risk: Mechanisms Of Chemical Carcinogenesis by : Miriam Christine Poirier

Download or read book Carcinogens, Dna Damage And Cancer Risk: Mechanisms Of Chemical Carcinogenesis written by Miriam Christine Poirier and published by World Scientific. This book was released on 2018-09-28 with total page 391 pages. Available in PDF, EPUB and Kindle. Book excerpt: As chemical exposures and cancer rates increase worldwide, there is a need for students, researchers, public health professionals, and physicians to understand the mechanisms connecting exposure with human cancer risk. This new book is an essential reference, as well as introduction to the field of chemical carcinogenesis, with particular focus on DNA damage as a critical link between exposure and disease, and emphasis on biomarkers associated with cancer risk in humans. In addition to DNA damage, related topics covered include metabolism of selected chemical carcinogens, exposure-induced epigenetic changes, cancer-associated mutations and reduction of DNA damage and cancer risk by chemoprevention. The book is designed to be a comprehensive guide to basic principles, a teaching tool for academics, and a map for the development of protective mechanisms to reduce human cancer risk.

Chemical Induction of Cancer

Author : Joseph C. Arcos
Publisher : Springer Science & Business Media
ISBN 13 : 9780817637668
Total Pages : 748 pages
Book Rating : 4.6/5 (376 download)

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Book Synopsis Chemical Induction of Cancer by : Joseph C. Arcos

Download or read book Chemical Induction of Cancer written by Joseph C. Arcos and published by Springer Science & Business Media. This book was released on 1996-02-29 with total page 748 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the approach to the analysis of disease, including, of course, cancer, two major thrusts may be distinguished. These may be referred to, in shorthand, as agents and processes: the causative agents (chemical, microbial, physical, environmental, and psychosocial) and the organismic processes, initiated and furthered by the agents, culminating in observable pathology (at the macromolecular, cytological, histological, organ function, locomotor, and behavioral levels). The past 25 years, since the appearance of the first volume of the predecessor series (1) authored by the Editors of this present volume, have seen an impressive number of studies on chemicals (and other agents) as etiologic factors in the induction of cancer. The major emphasis has been on the discovery of many chemical carcinogens of widely different structures, their metabolism by various tissues and cells, and, in turn, their molecular-biochemical effects on the cells. This rapidly expanded body of information, as effectively covered in the predecessor volumes, is an excellent entree to the second half of the overall problem of chemical carcinogenesis, the processes. The active agents trigger a large array of molecular-biochemical alterations to which the target cells, target tissues, and target organisms respond in many select and common ways. This second major aspect of the induction of cancer by chemicals (and by other agents)- the sequence of cellular and tissue changes clearly relevant to cancer-remains the challenge for the future.

Chemical Carcinogenesis

Author : Francisco Feo
Publisher : Springer Science & Business Media
ISBN 13 : 1475796404
Total Pages : 646 pages
Book Rating : 4.4/5 (757 download)

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Book Synopsis Chemical Carcinogenesis by : Francisco Feo

Download or read book Chemical Carcinogenesis written by Francisco Feo and published by Springer Science & Business Media. This book was released on 2013-11-11 with total page 646 pages. Available in PDF, EPUB and Kindle. Book excerpt: About two centuries after the communication by Sir Percival Pott that the "chimney sweeper disease" was a cancer and its suggestion that active compounds of soot were the causative agents, and about one century after the description of urinary bladder cancer in dye workers, an enormous number of substances have been synthesized and have probably come into contact with man. Research in cancer prevention is of primary importance, and may receive continuous support from new discoveries on cancer etiology and pathogenesis. If one accepts the multistage model of chemical carcinogenesis, one has also to accept that many events occur between the contact of carcino genic compounds and their specific targets and the development of a clinically recognizable neoplasm. Thus, animal studies become essential to elucidate the different steps by which chemical carcinogens induce neoplasia. The analysis of these steps and the comparative evaluation of experimental models is essential to an understanding of pathogenesis.

Modifiers of Chemical Carcinogenesis

Author :
Publisher :
ISBN 13 : 9780890042328
Total Pages : 275 pages
Book Rating : 4.0/5 (423 download)

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Book Synopsis Modifiers of Chemical Carcinogenesis by :

Download or read book Modifiers of Chemical Carcinogenesis written by and published by . This book was released on 1980 with total page 275 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Combination Effects in Chemical Carcinogenesis

Author : Dietrich Schmähl
Publisher : John Wiley & Sons
ISBN 13 :
Total Pages : 300 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Combination Effects in Chemical Carcinogenesis by : Dietrich Schmähl

Download or read book Combination Effects in Chemical Carcinogenesis written by Dietrich Schmähl and published by John Wiley & Sons. This book was released on 1988 with total page 300 pages. Available in PDF, EPUB and Kindle. Book excerpt:

GENETIC DIFFERENCES IN CHEMICAL CARCINOGENESIS

Author : Richard E. Kouri
Publisher : Springer
ISBN 13 :
Total Pages : 240 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis GENETIC DIFFERENCES IN CHEMICAL CARCINOGENESIS by : Richard E. Kouri

Download or read book GENETIC DIFFERENCES IN CHEMICAL CARCINOGENESIS written by Richard E. Kouri and published by Springer. This book was released on 1980-07-29 with total page 240 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Carcinogenesis

Author : Thomas J. Slaga
Publisher :
ISBN 13 : 9780890042328
Total Pages : 275 pages
Book Rating : 4.0/5 (423 download)

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Book Synopsis Carcinogenesis by : Thomas J. Slaga

Download or read book Carcinogenesis written by Thomas J. Slaga and published by . This book was released on 1980 with total page 275 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Chemical Carcinogenesis

Author : David Barringer Clayson
Publisher :
ISBN 13 :
Total Pages : 496 pages
Book Rating : 4.:/5 (2 download)

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Book Synopsis Chemical Carcinogenesis by : David Barringer Clayson

Download or read book Chemical Carcinogenesis written by David Barringer Clayson and published by . This book was released on 1962 with total page 496 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Chemical Carcinogenesis and Mutagenesis II

Author : Colin S. Cooper
Publisher : Springer Science & Business Media
ISBN 13 : 3642747787
Total Pages : 482 pages
Book Rating : 4.6/5 (427 download)

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Book Synopsis Chemical Carcinogenesis and Mutagenesis II by : Colin S. Cooper

Download or read book Chemical Carcinogenesis and Mutagenesis II written by Colin S. Cooper and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 482 pages. Available in PDF, EPUB and Kindle. Book excerpt: I have been privileged to witness and participate in the great growth of knowledge on chemical carcinogenesis and mutagenesis since 1939 when I entered graduate school in biochemistry at the University of Wisconsin Madison. I immediately started to work with the carcinogenic aminoazo dyes un der the direction of Professor CARL BAUMANN. In 1942 I joined a fellow graduate student, ELIZABETH CA VERT, in marriage and we soon commenced a joyous part nership in research on chemical carcinogenesis at the McArdle Laboratory for Cancer Research in the University of Wisconsin Medical School in Madison. This collaboration lasted 45 years. I am very grateful that this volume is dedi cated to the memory of Elizabeth. The important and varied topics that are reviewed here attest to the continued growth of the fields of chemical car cinogenesis and mutagenesis, including their recent and fruitful union with viral oncology. I feel very optimistic about the application of knowledge in these fields to the eventual solution of numerous problems, including the detection and estimation of the risks to humans of environmental chemical carcinogens and re lated factors.

Chemical Carcinogenesis

Author : Claudio Nicolini
Publisher : Springer
ISBN 13 :
Total Pages : 520 pages
Book Rating : 4.:/5 (45 download)

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Book Synopsis Chemical Carcinogenesis by : Claudio Nicolini

Download or read book Chemical Carcinogenesis written by Claudio Nicolini and published by Springer. This book was released on 1982-10 with total page 520 pages. Available in PDF, EPUB and Kindle. Book excerpt: During October 18-30, 1981, the second course of the International School of Pure and Applied Biostructure, a NATO Advanced Study Institute, was held at the Ettore Majorana Center for Scientific Culture in Erice, Italy, co-sponsored by the International Union Against Cancer, the Italian League Against Cancer, the Italian Ministry of Public Education, the Italian Ministry of Scientific and Technological Research, the North Atlantic Treaty Organization, the Italian National Research Council, the Sicilian Regional Government and two pharmaceutical Companies (Zambeletti and Farmitalia). The subject of the course was "Chemical Carcino genesis" with participants selected world-wide from 18 different countries. It is now eminently clear that.the bulk of human cancers are related to one of several types of environmental exposure. Of the environmental hazards, chemicals are among the best characterized carcinogens. However, how chemicals induce cancer is still poorly understood. Because of the magnitude of the problem and the ob vious need for a much more critical scientific analysis of the process by which cancer is induced (carcinogenesis), it was highly desirable to expose a greater number of scientists with varying background to some of the latest thinking in chemical carcino genesis. The course had this as its major objective and the re sulting book does reflect it.

CARCINOGENESIS, A COMPREHENSIVE SURVEY, VOLUME 5: MODIFIERS OF CHEMICAL CARCINOGENESIS: AN APPROACH TO THE BIOCHEMICAL MECHANISM AND CANCER PREVENTION.

Download CARCINOGENESIS, A COMPREHENSIVE SURVEY, VOLUME 5: MODIFIERS OF CHEMICAL CARCINOGENESIS: AN APPROACH TO THE BIOCHEMICAL MECHANISM AND CANCER PREVENTION. PDF Online Free

Author : TJ SLAGA (Ed)
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (985 download)

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Book Synopsis CARCINOGENESIS, A COMPREHENSIVE SURVEY, VOLUME 5: MODIFIERS OF CHEMICAL CARCINOGENESIS: AN APPROACH TO THE BIOCHEMICAL MECHANISM AND CANCER PREVENTION. by : TJ SLAGA (Ed)

Download or read book CARCINOGENESIS, A COMPREHENSIVE SURVEY, VOLUME 5: MODIFIERS OF CHEMICAL CARCINOGENESIS: AN APPROACH TO THE BIOCHEMICAL MECHANISM AND CANCER PREVENTION. written by TJ SLAGA (Ed) and published by . This book was released on 1980 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Natural, Metal, Fiber, and Macromolecular Carcinogens

Author : Yin-Tak Woo
Publisher : Academic Press
ISBN 13 : 1483216020
Total Pages : 898 pages
Book Rating : 4.4/5 (832 download)

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Book Synopsis Natural, Metal, Fiber, and Macromolecular Carcinogens by : Yin-Tak Woo

Download or read book Natural, Metal, Fiber, and Macromolecular Carcinogens written by Yin-Tak Woo and published by Academic Press. This book was released on 2013-10-22 with total page 898 pages. Available in PDF, EPUB and Kindle. Book excerpt: Chemical Induction of Cancer: Structural Bases and Biological Mechanisms, Volume IIIC: Natural, Metal, Fiber, and Macromolecular Carcinogens covers structure-carcinogenicity relationships of carcinogenic mycotoxins, carcinogenic substances generated by plants, carcinogenic metals and metalloids, and foreign-body carcinogens. The book discusses the metabolism and mechanism of carcinogenic action, physicochemical properties, other biological activities (principally mutagenicity and teratogenicity), modification of carcinogenic activity, formation and environmental significance. The text also describes the carcinogenic water-soluble high polymers and explores the intriguing problems of the carcinogenic effect of osmotic imbalance in tissue microenvironment, as well as of spontaneous malignant transformation occurring in cell cultures in vitro. Studies on tumor induction and carcinogenesis modification by nonviral nucleic acids, by nucleases, proteases, histones, and by antigenic stimulation as well as by antibodies are also considered. The book further tackles tumor-released factors as possible modifiers of carcinogenesis. The text will prove invaluable to chemists and people involved in cancer research.

Chemical Carcinogens & Dna

Author : Philip L. Grover
Publisher : CRC Press
ISBN 13 : 0429536291
Total Pages : 344 pages
Book Rating : 4.4/5 (295 download)

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Book Synopsis Chemical Carcinogens & Dna by : Philip L. Grover

Download or read book Chemical Carcinogens & Dna written by Philip L. Grover and published by CRC Press. This book was released on 2019-06-04 with total page 344 pages. Available in PDF, EPUB and Kindle. Book excerpt: First published in 1979, Chemical Carcinogenesis and DNA is an essential guide to the relationship between mutagens, carcinogens and our own genetic makeup. Covering a range of associated topics, this volume provides information that would prove most beneficial for practitioners of medicine and students alike.

Chemical Carcinogenesis and Cancers

Author : Wilhelm C. Hueper
Publisher :
ISBN 13 :
Total Pages : 780 pages
Book Rating : 4.:/5 (43 download)

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Book Synopsis Chemical Carcinogenesis and Cancers by : Wilhelm C. Hueper

Download or read book Chemical Carcinogenesis and Cancers written by Wilhelm C. Hueper and published by . This book was released on 1964 with total page 780 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Chemical Induction of Cancer

Author : Joseph C. Arcos
Publisher : Birkhäuser
ISBN 13 : 9781461240778
Total Pages : 712 pages
Book Rating : 4.2/5 (47 download)

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Book Synopsis Chemical Induction of Cancer by : Joseph C. Arcos

Download or read book Chemical Induction of Cancer written by Joseph C. Arcos and published by Birkhäuser. This book was released on 2011-10-14 with total page 712 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the approach to the analysis of disease, including, of course, cancer, two major thrusts may be distinguished. These may be referred to, in shorthand, as agents and processes: the causative agents (chemical, microbial, physical, environmental, and psychosocial) and the organismic processes, initiated and furthered by the agents, culminating in observable pathology (at the macromolecular, cytological, histological, organ function, locomotor, and behavioral levels). The past 25 years, since the appearance of the first volume of the predecessor series (1) authored by the Editors of this present volume, have seen an impressive number of studies on chemicals (and other agents) as etiologic factors in the induction of cancer. The major emphasis has been on the discovery of many chemical carcinogens of widely different structures, their metabolism by various tissues and cells, and, in turn, their molecular-biochemical effects on the cells. This rapidly expanded body of information, as effectively covered in the predecessor volumes, is an excellent entree to the second half of the overall problem of chemical carcinogenesis, the processes. The active agents trigger a large array of molecular-biochemical alterations to which the target cells, target tissues, and target organisms respond in many select and common ways. This second major aspect of the induction of cancer by chemicals (and by other agents)- the sequence of cellular and tissue changes clearly relevant to cancer-remains the challenge for the future.

Chemical Carcinogenesis and Mutagenesis I

Author :
Publisher : Springer Science & Business Media
ISBN 13 : 3642747752
Total Pages : 617 pages
Book Rating : 4.6/5 (427 download)

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Book Synopsis Chemical Carcinogenesis and Mutagenesis I by :

Download or read book Chemical Carcinogenesis and Mutagenesis I written by and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 617 pages. Available in PDF, EPUB and Kindle. Book excerpt: I have been privileged to witness and participate in the great growth of knowledge on chemical carcinogenesis and mutagenesis since 1939 when I entered graduate school in biochemistry at the University of Wisconsin Madison. I immediately started to work with the carcinogenic aminoazo dyes un der the direction of Professor CARL BAUMANN. In 1942 I joined a fellow graduate student, ELIZABE1H CAVERT, in marriage and we soon commenced a joyous part nership in research on chemical carcinogenesis at the McArdle Laboratory for Cancer Research in the University of Wisconsin Medical School in Madison. This collaboration lasted 45 years. I am very grateful that this volume is dedi cated to the memory of Elizabeth. The important and varied topics that are reviewed here attest to the continued growth of the fields of chemical car cinogenesis and mutagenesis, including their recent and fruitful union with viral oncology. I feel very optimistic about the application of knowledge in these fields to the eventual solution of numerous problems, including the detection and estimation of the risks to humans of environmental chemical carcinogens and re lated factors.