Modern Issues And Methods In Biostatistics

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Modern Issues and Methods in Biostatistics

Author : Mark Chang
Publisher : Springer Science & Business Media
ISBN 13 : 144199842X
Total Pages : 316 pages
Book Rating : 4.4/5 (419 download)

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Book Synopsis Modern Issues and Methods in Biostatistics by : Mark Chang

Download or read book Modern Issues and Methods in Biostatistics written by Mark Chang and published by Springer Science & Business Media. This book was released on 2011-07-15 with total page 316 pages. Available in PDF, EPUB and Kindle. Book excerpt: Classic biostatistics, a branch of statistical science, has as its main focus the applications of statistics in public health, the life sciences, and the pharmaceutical industry. Modern biostatistics, beyond just a simple application of statistics, is a confluence of statistics and knowledge of multiple intertwined fields. The application demands, the advancements in computer technology, and the rapid growth of life science data (e.g., genomics data) have promoted the formation of modern biostatistics. There are at least three characteristics of modern biostatistics: (1) in-depth engagement in the application fields that require penetration of knowledge across several fields, (2) high-level complexity of data because they are longitudinal, incomplete, or latent because they are heterogeneous due to a mixture of data or experiment types, because of high-dimensionality, which may make meaningful reduction impossible, or because of extremely small or large size; and (3) dynamics, the speed of development in methodology and analyses, has to match the fast growth of data with a constantly changing face. This book is written for researchers, biostatisticians/statisticians, and scientists who are interested in quantitative analyses. The goal is to introduce modern methods in biostatistics and help researchers and students quickly grasp key concepts and methods. Many methods can solve the same problem and many problems can be solved by the same method, which becomes apparent when those topics are discussed in this single volume.

Modern Statistical Methods for Health Research

Author : Yichuan Zhao
Publisher : Springer Nature
ISBN 13 : 3030724379
Total Pages : 506 pages
Book Rating : 4.0/5 (37 download)

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Book Synopsis Modern Statistical Methods for Health Research by : Yichuan Zhao

Download or read book Modern Statistical Methods for Health Research written by Yichuan Zhao and published by Springer Nature. This book was released on 2021-10-14 with total page 506 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book brings together the voices of leading experts in the frontiers of biostatistics, biomedicine, and the health sciences to discuss the statistical procedures, useful methods, and novel applications in biostatistics research. It also includes discussions of potential future directions of biomedicine and new statistical developments for health research, with the intent of stimulating research and fostering the interactions of scholars across health research related disciplines. Topics covered include: Health data analysis and applications to EHR data Clinical trials, FDR, and applications in health science Big network analytics and its applications in GWAS Survival analysis and functional data analysis Graphical modelling in genomic studies The book will be valuable to data scientists and statisticians who are working in biomedicine and health, other practitioners in the health sciences, and graduate students and researchers in biostatistics and health.

Modern Biostatistical Methods for Evidence-Based Global Health Research

Author : Ding-Geng (Din) Chen
Publisher : Springer Nature
ISBN 13 : 3031110129
Total Pages : 489 pages
Book Rating : 4.0/5 (311 download)

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Book Synopsis Modern Biostatistical Methods for Evidence-Based Global Health Research by : Ding-Geng (Din) Chen

Download or read book Modern Biostatistical Methods for Evidence-Based Global Health Research written by Ding-Geng (Din) Chen and published by Springer Nature. This book was released on 2022-11-25 with total page 489 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides an overview of the emerging topics in biostatistical theories and methods through their applications to evidence-based global health research and decision-making. It brings together some of the top scholars engaged in biostatistical method development on global health to highlight and describe recent advances in evidence-based global health applications. The volume is composed of five main parts: data harmonization and analysis; systematic review and statistical meta-analysis; spatial-temporal modeling and disease mapping; Bayesian statistical modeling; and statistical methods for longitudinal data or survival data. It is designed to be illuminating and valuable to both expert biostatisticians and to health researchers engaged in methodological applications in evidence-based global health research. It is particularly relevant to countries where global health research is being rigorously conducted.

Modern Clinical Trial Analysis

Author : Wan Tang
Publisher : Springer Science & Business Media
ISBN 13 : 1461443229
Total Pages : 256 pages
Book Rating : 4.4/5 (614 download)

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Book Synopsis Modern Clinical Trial Analysis by : Wan Tang

Download or read book Modern Clinical Trial Analysis written by Wan Tang and published by Springer Science & Business Media. This book was released on 2012-09-05 with total page 256 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume covers classic as well as cutting-edge topics on the analysis of clinical trial data in biomedical and psychosocial research and discusses each topic in an expository and user-friendly fashion. The intent of the book is to provide an overview of the primary statistical and data analytic issues associated with each of the selected topics, followed by a discussion of approaches for tackling such issues and available software packages for carrying out analyses. While classic topics such as survival data analysis, analysis of diagnostic test data and assessment of measurement reliability are well known and covered in depth by available topic-specific texts, this volume serves a different purpose: it provides a quick introduction to each topic for self-learning, particularly for those who have not done any formal coursework on a given topic but must learn it due to its relevance to their multidisciplinary research. In addition, the chapters on these classic topics will reflect issues particularly relevant to modern clinical trials such as longitudinal designs and new methods for analyzing data from such study designs. The coverage of these topics provides a quick introduction to these important statistical issues and methods for addressing them. As with the classic topics, this part of the volume on modern topics will enable researchers to grasp the statistical methods for addressing these emerging issues underlying modern clinical trials and to apply them to their research studies.

Modern Statistics with R

Author : Måns Thulin
Publisher : BoD - Books on Demand
ISBN 13 : 9152701514
Total Pages : 598 pages
Book Rating : 4.1/5 (527 download)

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Book Synopsis Modern Statistics with R by : Måns Thulin

Download or read book Modern Statistics with R written by Måns Thulin and published by BoD - Books on Demand. This book was released on 2021-07-28 with total page 598 pages. Available in PDF, EPUB and Kindle. Book excerpt: The past decades have transformed the world of statistical data analysis, with new methods, new types of data, and new computational tools. The aim of Modern Statistics with R is to introduce you to key parts of the modern statistical toolkit. It teaches you: - Data wrangling - importing, formatting, reshaping, merging, and filtering data in R. - Exploratory data analysis - using visualisation and multivariate techniques to explore datasets. - Statistical inference - modern methods for testing hypotheses and computing confidence intervals. - Predictive modelling - regression models and machine learning methods for prediction, classification, and forecasting. - Simulation - using simulation techniques for sample size computations and evaluations of statistical methods. - Ethics in statistics - ethical issues and good statistical practice. - R programming - writing code that is fast, readable, and free from bugs. Starting from the very basics, Modern Statistics with R helps you learn R by working with R. Topics covered range from plotting data and writing simple R code to using cross-validation for evaluating complex predictive models and using simulation for sample size determination. The book includes more than 200 exercises with fully worked solutions. Some familiarity with basic statistical concepts, such as linear regression, is assumed. No previous programming experience is needed.

Topics in Biostatistics

Author : Walter T. Ambrosius
Publisher : Springer Science & Business Media
ISBN 13 : 1588295311
Total Pages : 530 pages
Book Rating : 4.5/5 (882 download)

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Book Synopsis Topics in Biostatistics by : Walter T. Ambrosius

Download or read book Topics in Biostatistics written by Walter T. Ambrosius and published by Springer Science & Business Media. This book was released on 2007-07-06 with total page 530 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents a multidisciplinary survey of biostatics methods, each illustrated with hands-on examples. It introduces advanced methods in statistics, including how to choose and work with statistical packages. Specific topics of interest include microarray analysis, missing data techniques, power and sample size, statistical methods in genetics. The book is an essential resource for researchers at every level of their career.

Development of Modern Statistics and Related Topics

Author : Heping Zhang
Publisher : World Scientific
ISBN 13 : 9812383956
Total Pages : 301 pages
Book Rating : 4.8/5 (123 download)

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Book Synopsis Development of Modern Statistics and Related Topics by : Heping Zhang

Download or read book Development of Modern Statistics and Related Topics written by Heping Zhang and published by World Scientific. This book was released on 2003 with total page 301 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book encompasses a wide range of important topics. The articles cover the following areas: asymptotic theory and inference, biostatistics, economics and finance, statistical computing and Bayesian statistics, and statistical genetics. Specifically, the issues that are studied include large deviation, deviation inequalities, local sensitivity of model misspecification in likelihood inference, empirical likelihood confidence intervals, uniform convergence rates in density estimation, randomized designs in clinical trials, MCMC and EM algorithms, approximation of p-values in multipoint linkage analysis, use of mixture models in genetic studies, and design and analysis of quantitative traits.

Biostatistics

Author : Gerald van Belle
Publisher : John Wiley & Sons
ISBN 13 : 0471602353
Total Pages : 894 pages
Book Rating : 4.4/5 (716 download)

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Book Synopsis Biostatistics by : Gerald van Belle

Download or read book Biostatistics written by Gerald van Belle and published by John Wiley & Sons. This book was released on 2004-10-06 with total page 894 pages. Available in PDF, EPUB and Kindle. Book excerpt: A respected introduction to biostatistics, thoroughly updated and revised The first edition of Biostatistics: A Methodology for the Health Sciences has served professionals and students alike as a leading resource for learning how to apply statistical methods to the biomedical sciences. This substantially revised Second Edition brings the book into the twenty-first century for today’s aspiring and practicing medical scientist. This versatile reference provides a wide-ranging look at basic and advanced biostatistical concepts and methods in a format calibrated to individual interests and levels of proficiency. Written with an eye toward the use of computer applications, the book examines the design of medical studies, descriptive statistics, and introductory ideas of probability theory and statistical inference; explores more advanced statistical methods; and illustrates important current uses of biostatistics. New to this edition are discussions of Longitudinal data analysis Randomized clinical trials Bayesian statistics GEE The bootstrap method Enhanced by a companion Web site providing data sets, selected problems and solutions, and examples from such current topics as HIV/AIDS, this is a thoroughly current, comprehensive introduction to the field.

Methods and Applications of Statistics in the Life and Health Sciences

Author : Narayanaswamy Balakrishnan
Publisher : John Wiley & Sons
ISBN 13 : 0470405090
Total Pages : 1027 pages
Book Rating : 4.4/5 (74 download)

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Book Synopsis Methods and Applications of Statistics in the Life and Health Sciences by : Narayanaswamy Balakrishnan

Download or read book Methods and Applications of Statistics in the Life and Health Sciences written by Narayanaswamy Balakrishnan and published by John Wiley & Sons. This book was released on 2009-12-02 with total page 1027 pages. Available in PDF, EPUB and Kindle. Book excerpt: Inspired by the Encyclopedia of Statistical Sciences, Second Edition, this volume outlines the statistical tools for successfully working with modern life and health sciences research Data collection holds an essential part in dictating the future of health sciences and public health, as the compilation of statistics allows researchers and medical practitioners to monitor trends in health status, identify health problems, and evaluate the impact of health policies and programs. Methods and Applications of Statistics in the Life and Health Sciences serves as a single, one-of-a-kind resource on the wide range of statistical methods, techniques, and applications that are applied in modern life and health sciences in research. Specially designed to present encyclopedic content in an accessible and self-contained format, this book outlines thorough coverage of the underlying theory and standard applications to research in related disciplines such as biology, epidemiology, clinical trials, and public health. Uniquely combining established literature with cutting-edge research, this book contains classical works and more than twenty-five new articles and completely revised contributions from the acclaimed Encyclopedia of Statistical Sciences, Second Edition. The result is a compilation of more than eighty articles that explores classic methodology and new topics, including: Sequential methods in biomedical research Statistical measures of human quality of life Change-point methods in genetics Sample size determination for clinical trials Mixed-effects regression models for predicting pre-clinical disease Probabilistic and statistical models for conception Statistical methods are explored and applied to population growth, disease detection and treatment, genetic and genomic research, drug development, clinical trials, screening and prevention, and the assessment of rehabilitation, recovery, and quality of life. These topics are explored in contributions written by more than 100 leading academics, researchers, and practitioners who utilize various statistical practices, such as election bias, survival analysis, missing data techniques, and cluster analysis for handling the wide array of modern issues in the life and health sciences. With its combination of traditional methodology and newly developed research, Methods and Applications of Statistics in the Life and Health Sciences has everything students, academics, and researchers in the life and health sciences need to build and apply their knowledge of statistical methods and applications.

Innovative Strategies, Statistical Solutions and Simulations for Modern Clinical Trials

Author : Mark Chang
Publisher : CRC Press
ISBN 13 : 1351214527
Total Pages : 218 pages
Book Rating : 4.3/5 (512 download)

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Book Synopsis Innovative Strategies, Statistical Solutions and Simulations for Modern Clinical Trials by : Mark Chang

Download or read book Innovative Strategies, Statistical Solutions and Simulations for Modern Clinical Trials written by Mark Chang and published by CRC Press. This book was released on 2019-03-20 with total page 218 pages. Available in PDF, EPUB and Kindle. Book excerpt: "This is truly an outstanding book. [It] brings together all of the latest research in clinical trials methodology and how it can be applied to drug development.... Chang et al provide applications to industry-supported trials. This will allow statisticians in the industry community to take these methods seriously." Jay Herson, Johns Hopkins University The pharmaceutical industry's approach to drug discovery and development has rapidly transformed in the last decade from the more traditional Research and Development (R & D) approach to a more innovative approach in which strategies are employed to compress and optimize the clinical development plan and associated timelines. However, these strategies are generally being considered on an individual trial basis and not as part of a fully integrated overall development program. Such optimization at the trial level is somewhat near-sighted and does not ensure cost, time, or development efficiency of the overall program. This book seeks to address this imbalance by establishing a statistical framework for overall/global clinical development optimization and providing tactics and techniques to support such optimization, including clinical trial simulations. Provides a statistical framework for achieve global optimization in each phase of the drug development process. Describes specific techniques to support optimization including adaptive designs, precision medicine, survival-endpoints, dose finding and multiple testing. Gives practical approaches to handling missing data in clinical trials using SAS. Looks at key controversial issues from both a clinical and statistical perspective. Presents a generous number of case studies from multiple therapeutic areas that help motivate and illustrate the statistical methods introduced in the book. Puts great emphasis on software implementation of the statistical methods with multiple examples of software code (both SAS and R). It is important for statisticians to possess a deep knowledge of the drug development process beyond statistical considerations. For these reasons, this book incorporates both statistical and "clinical/medical" perspectives.

Regression Methods in Biostatistics

Author : Eric Vittinghoff
Publisher : Springer Science & Business Media
ISBN 13 : 1461413524
Total Pages : 526 pages
Book Rating : 4.4/5 (614 download)

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Book Synopsis Regression Methods in Biostatistics by : Eric Vittinghoff

Download or read book Regression Methods in Biostatistics written by Eric Vittinghoff and published by Springer Science & Business Media. This book was released on 2012 with total page 526 pages. Available in PDF, EPUB and Kindle. Book excerpt: This fresh edition, substantially revised and augmented, provides a unified, in-depth, readable introduction to the multipredictor regression methods most widely used in biostatistics. The examples used, analyzed using Stata, can be applied to other areas.

Advanced Medical Statistics (2nd Edition)

Author : Lu Ying
Publisher : World Scientific
ISBN 13 : 9814583324
Total Pages : 1472 pages
Book Rating : 4.8/5 (145 download)

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Book Synopsis Advanced Medical Statistics (2nd Edition) by : Lu Ying

Download or read book Advanced Medical Statistics (2nd Edition) written by Lu Ying and published by World Scientific. This book was released on 2015-06-29 with total page 1472 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book aims to provide both comprehensive reviews of the classical methods and an introduction to new developments in medical statistics. The topics range from meta analysis, clinical trial design, causal inference, personalized medicine to machine learning and next generation sequence analysis. Since the publication of the first edition, there have been tremendous advances in biostatistics and bioinformatics. The new edition tries to cover as many important emerging areas and reflect as much progress as possible. Many distinguished scholars, who greatly advanced their research areas in statistical methodology as well as practical applications, also have revised several chapters with relevant updates and written new ones from scratch.The new edition has been divided into four sections, including, Statistical Methods in Medicine and Epidemiology, Statistical Methods in Clinical Trials, Statistical Genetics, and General Methods. To reflect the rise of modern statistical genetics as one of the most fertile research areas since the publication of the first edition, the brand new section on Statistical Genetics includes entirely new chapters reflecting the state of the art in the field.Although tightly related, all the book chapters are self-contained and can be read independently. The book chapters intend to provide a convenient launch pad for readers interested in learning a specific topic, applying the related statistical methods in their scientific research and seeking the newest references for in-depth research.

Modern Applied U-Statistics

Author : Jeanne Kowalski
Publisher : John Wiley & Sons
ISBN 13 : 0470186453
Total Pages : 402 pages
Book Rating : 4.4/5 (71 download)

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Book Synopsis Modern Applied U-Statistics by : Jeanne Kowalski

Download or read book Modern Applied U-Statistics written by Jeanne Kowalski and published by John Wiley & Sons. This book was released on 2008-01-28 with total page 402 pages. Available in PDF, EPUB and Kindle. Book excerpt: A timely and applied approach to the newly discovered methods and applications of U-statistics Built on years of collaborative research and academic experience, Modern Applied U-Statistics successfully presents a thorough introduction to the theory of U-statistics using in-depth examples and applications that address contemporary areas of study including biomedical and psychosocial research. Utilizing a "learn by example" approach, this book provides an accessible, yet in-depth, treatment of U-statistics, as well as addresses key concepts in asymptotic theory by integrating translational and cross-disciplinary research. The authors begin with an introduction of the essential and theoretical foundations of U-statistics such as the notion of convergence in probability and distribution, basic convergence results, stochastic Os, inference theory, generalized estimating equations, as well as the definition and asymptotic properties of U-statistics. With an emphasis on nonparametric applications when and where applicable, the authors then build upon this established foundation in order to equip readers with the knowledge needed to understand the modern-day extensions of U-statistics that are explored in subsequent chapters. Additional topical coverage includes: Longitudinal data modeling with missing data Parametric and distribution-free mixed-effect and structural equation models A new multi-response based regression framework for non-parametric statistics such as the product moment correlation, Kendall's tau, and Mann-Whitney-Wilcoxon rank tests A new class of U-statistic-based estimating equations (UBEE) for dependent responses Motivating examples, in-depth illustrations of statistical and model-building concepts, and an extensive discussion of longitudinal study designs strengthen the real-world utility and comprehension of this book. An accompanying Web site features SAS? and S-Plus? program codes, software applications, and additional study data. Modern Applied U-Statistics accommodates second- and third-year students of biostatistics at the graduate level and also serves as an excellent self-study for practitioners in the fields of bioinformatics and psychosocial research.

Modern Methods for Epidemiology

Author : Yu-Kang Tu
Publisher : Springer Science & Business Media
ISBN 13 : 9400730241
Total Pages : 315 pages
Book Rating : 4.4/5 (7 download)

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Book Synopsis Modern Methods for Epidemiology by : Yu-Kang Tu

Download or read book Modern Methods for Epidemiology written by Yu-Kang Tu and published by Springer Science & Business Media. This book was released on 2012-05-22 with total page 315 pages. Available in PDF, EPUB and Kindle. Book excerpt: Routine applications of advanced statistical methods on real data have become possible in the last ten years because desktop computers have become much more powerful and cheaper. However, proper understanding of the challenging statistical theory behind those methods remains essential for correct application and interpretation, and rarely seen in the medical literature. Modern Methods for Epidemiology provides a concise introduction to recent development in statistical methodologies for epidemiological and biomedical researchers. Many of these methods have become indispensible tools for researchers working in epidemiology and medicine but are rarely discussed in details by standard textbooks of biostatistics or epidemiology. Contributors of this book are experienced researchers and experts in their respective fields. This textbook provides a solid starting point for those who are new to epidemiology, and for those looking for guidance in more modern statistical approaches to observational epidemiology. Epidemiological and biomedical researchers who wish to overcome the mathematical barrier of applying those methods to their research will find this book an accessible and helpful reference for self-learning and research. This book is also a good source for teaching postgraduate students in medical statistics or epidemiology.

Elementary Bayesian Biostatistics

Author : Lemuel A. Moye
Publisher : CRC Press
ISBN 13 : 1584887257
Total Pages : 400 pages
Book Rating : 4.5/5 (848 download)

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Book Synopsis Elementary Bayesian Biostatistics by : Lemuel A. Moye

Download or read book Elementary Bayesian Biostatistics written by Lemuel A. Moye and published by CRC Press. This book was released on 2016-04-19 with total page 400 pages. Available in PDF, EPUB and Kindle. Book excerpt: Bayesian analyses have made important inroads in modern clinical research due, in part, to the incorporation of the traditional tools of noninformative priors as well as the modern innovations of adaptive randomization and predictive power. Presenting an introductory perspective to modern Bayesian procedures, Elementary Bayesian Biostatistics explo

Fundamentals of Modern Statistical Methods

Author : Rand R. Wilcox
Publisher : Springer Science & Business Media
ISBN 13 : 1475735227
Total Pages : 263 pages
Book Rating : 4.4/5 (757 download)

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Book Synopsis Fundamentals of Modern Statistical Methods by : Rand R. Wilcox

Download or read book Fundamentals of Modern Statistical Methods written by Rand R. Wilcox and published by Springer Science & Business Media. This book was released on 2013-11-21 with total page 263 pages. Available in PDF, EPUB and Kindle. Book excerpt: Conventional statistical methods routinely miss differences among groups or associations among variables. These differences are detected by more modern techniques. Hundreds of journal articles have described the reasons why standard techniques are unsatisfactory. Nonetheless, simple and intuitive explanations are generally unavailable. Without assuming any prior training in statistics, Part I of this book describes basic statistical principles from a point of view that makes their shortcomings easy to understand. Part II describes modern methods that address the problems covered in Part I. Using data from actual studies, many examples are included.

Applying Contemporary Statistical Techniques

Author : Rand R. Wilcox
Publisher : Gulf Professional Publishing
ISBN 13 : 9780127515410
Total Pages : 688 pages
Book Rating : 4.5/5 (154 download)

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Book Synopsis Applying Contemporary Statistical Techniques by : Rand R. Wilcox

Download or read book Applying Contemporary Statistical Techniques written by Rand R. Wilcox and published by Gulf Professional Publishing. This book was released on 2003-01-06 with total page 688 pages. Available in PDF, EPUB and Kindle. Book excerpt: Applying Contemporary Statistical Techniques explains why traditional statistical methods are often inadequate or outdated when applied to modern problems. Wilcox demonstrates how new and more powerful techniques address these problems far more effectively, making these modern robust methods understandable, practical, and easily accessible. Highlights: * Assumes no previous training in statistics * Explains when and why modern methods provide more accurate results * Provides simple descriptions of when and why conventional methods can be highly unsatisfactory * Covers the latest developments on multiple comparisons * Includes recent advances in risk-based methods * Features many illustrations and examples using data from real studies * Describes and illustrates easy-to-use s-plus functions for applying cutting-edge techniques "The book is quite unique in that it offers a lot of up-to-date statistical tools. No other book at this level comes close in this aspect." Xuming He -University of Illinois, Urbana