Modern Avenues in Metal-Nucleic Acid Chemistry

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Author :
Publisher : CRC Press
ISBN 13 : 100084787X
Total Pages : 465 pages
Book Rating : 4.0/5 (8 download)

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Book Synopsis Modern Avenues in Metal-Nucleic Acid Chemistry by : Jens Müller

Download or read book Modern Avenues in Metal-Nucleic Acid Chemistry written by Jens Müller and published by CRC Press. This book was released on 2023-04-24 with total page 465 pages. Available in PDF, EPUB and Kindle. Book excerpt: Volume 25, entitled Modern Avenues in Metal-Nucleic Acid Chemistry, of the series Metal Ions in Life Sciences (MILS), provides a timely overview of selected relevant developments in a field which previously had a pronounced focus on fundamental chemistry aspects such as coordination principles, structural chemistry, and consequences for biological processes and disease-related medicinal issues. More recently, also as a consequence of the advent of supramolecular chemistry, advancements in nanochemistry, and new bio-analytical methods, novel aspects of this field have emerged. MILS-25 gives a state-of-the-art account on the present state of research in this field, addressing, among others, porous materials, non-covalent interactions, stimuli-responsive bioconjugates, DNA-templated metal arrays and nanoclusters, genotyping, guanine quadruplexes, and riboswitches. It consists of 15 comprehensive chapters with over 1600 citations, 160 figures (90 of them in color), with key contributions from 40 international experts from Europe, Asia, and America. It is an essential resource for scientists from numerous disciplines, ranging from materials science to biochemistry, by way of classical chemistry and physics. • It offers an update on nucleic acid – metal complex bioconjugates and their applications • It provides an insight into coordination polymers involving nucleic acid components • It covers a wide range of nucleic acids, from DNA duplexes, triplexes and quadruplexes to RNA

Interplay between Metal Ions and Nucleic Acids

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Author :
Publisher : Springer Science & Business Media
ISBN 13 : 9400721722
Total Pages : 386 pages
Book Rating : 4.4/5 (7 download)

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Book Synopsis Interplay between Metal Ions and Nucleic Acids by : Astrid Sigel

Download or read book Interplay between Metal Ions and Nucleic Acids written by Astrid Sigel and published by Springer Science & Business Media. This book was released on 2012-01-02 with total page 386 pages. Available in PDF, EPUB and Kindle. Book excerpt: Interplay between Metal Ions and Nucleic Acids provides in an authoritative and timely manner in 12 stimulating chapters, written by 24 internationally recognized experts from 8 nations, and supported by nearly 1500 references, about 20 tables, and 125 illustrations, many in color, a most up-to-date view on metal ion-nucleic acid interactions; the characterization of which is covered in solution and in the solid state. The volume concentrates on modern developments encompassing topics in the wide range from G-quadruplexes via DNAzymes, catalysis at the DNA scaffold, and metal-mediated base pairs to peptide nucleic acids (PNAs) being thus of relevance, e.g., for chemistry and nanotechnology but also for molecular biology and (genetic) diagnostics.

Metal Ions in Biological Systems

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Author :
Publisher : CRC Press
ISBN 13 : 9780824795498
Total Pages : 860 pages
Book Rating : 4.7/5 (954 download)

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Book Synopsis Metal Ions in Biological Systems by : Astrid Sigel

Download or read book Metal Ions in Biological Systems written by Astrid Sigel and published by CRC Press. This book was released on 1996-02-05 with total page 860 pages. Available in PDF, EPUB and Kindle. Book excerpt: Volume 32 covers metal ion bonding to phosphate, sugar and nucleobase residues; the ambidentate as well as the stacking properties of nucleotides; kinetic aspects as well as properties of nucleobase and nucleotide analogs; and the oligonucleotides and nucleic acids. It examines electron transfer reactions over a large number of base repairs in DNA, the role of metal ions in ribozymes, ternary metal-nucleic acid base-protein complexes, metal responsive gene regulation, and the structure-activity relationships of anticancer drugs and their action on DNA, including cisplatin and the role of proteins.

Metal Ions in Biological Systems

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Author :
Publisher : CRC Press
ISBN 13 : 9780824796884
Total Pages : 736 pages
Book Rating : 4.7/5 (968 download)

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Book Synopsis Metal Ions in Biological Systems by : Astrid Sigel

Download or read book Metal Ions in Biological Systems written by Astrid Sigel and published by CRC Press. This book was released on 1996-02-29 with total page 736 pages. Available in PDF, EPUB and Kindle. Book excerpt: "Volume 33 focuses on the vibrant research area of probing nucleic acids--the carriers of the genetic code--by metal ion complexes of small molecules providing an authoritative, timely account of this fascinating topic by over 50 distinguished experts."

Nucleic Acid-metal Ion Interactions

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Author :
Publisher : Royal Society of Chemistry
ISBN 13 : 0854041958
Total Pages : 449 pages
Book Rating : 4.8/5 (54 download)

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Book Synopsis Nucleic Acid-metal Ion Interactions by : Nicholas V. Hud

Download or read book Nucleic Acid-metal Ion Interactions written by Nicholas V. Hud and published by Royal Society of Chemistry. This book was released on 2009 with total page 449 pages. Available in PDF, EPUB and Kindle. Book excerpt: Provides a perspective on nucleic acid-metal ion interactions with an emphasis on experimental biophysical studies which will prove indispensable to biophysicists and molecular biologists.

Metal Complex - DNA Interactions

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Author :
Publisher : John Wiley & Sons
ISBN 13 : 9781405194105
Total Pages : 544 pages
Book Rating : 4.1/5 (941 download)

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Book Synopsis Metal Complex - DNA Interactions by : Nick Hadjiliadis

Download or read book Metal Complex - DNA Interactions written by Nick Hadjiliadis and published by John Wiley & Sons. This book was released on 2009-03-30 with total page 544 pages. Available in PDF, EPUB and Kindle. Book excerpt: Metal ions and metal complexes have long been recognized ascritically important components of nucleic acid chemistry, both inregulation of gene expression and as promising therapeutic agents.Understanding how metal complexes interact with DNA has become anactive research area at the interface between chemistry, molecularbiology and medicine. Metal Complex - DNA Interactions provides a comprehensiveoverview of this increasingly diverse field, presenting recentdevelopments and the latest research with particular emphasis onmetal-based drugs and metal ion toxicity. The text is divided intofour parts: Basic Structural and Kinetic Aspects: includes chapterson sequence-selective metal binding to DNA and thermodynamicmodels. Medical Applications: focuses on anticancer platinumdrugs, including discussions on DNA repair in antitumor effects ofplatinum drugs and photo-dynamic therapy. DNA-Recognition - Nucleases and Sensor: describesprobes for DNA recognition, artificial restriction agents,metallo-DNAzymes for metal sensing applications and metal iondependent catalysis in nucleic acid enzymes. Toxicological Aspects: deals with structural studies ofmercury–DNA interactions, chromium-induced DNA damage andrepair, and the effect of arsenic and nickel on DNAintegrity. This book will be a valuable resource for academic researchersand professionals from a range of pharmaceutical and chemicalindustries, particularly those involved in the development of newand less toxic anticancer metallo-drugs, and in the field ofenvironmental and toxicological chemistry.

Nucleic Acid Chemistry

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Author :
Publisher : Wiley-Interscience
ISBN 13 :
Total Pages : 442 pages
Book Rating : 4.F/5 ( download)

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Book Synopsis Nucleic Acid Chemistry by : Leroy B. Townsend

Download or read book Nucleic Acid Chemistry written by Leroy B. Townsend and published by Wiley-Interscience. This book was released on 1978 with total page 442 pages. Available in PDF, EPUB and Kindle. Book excerpt: This fourth part of a continuing series gives detailed information on up-to-date approaches that enable researchers to select suitable procedures. The descriptions provided are detailed so the novice, as well as those with experience, will be able to apply information in the laboratory.

Less Common Metals in Proteins and Nucleic Acid Probes

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Author :
Publisher : Springer
ISBN 13 : 9783662147504
Total Pages : 233 pages
Book Rating : 4.1/5 (475 download)

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Book Synopsis Less Common Metals in Proteins and Nucleic Acid Probes by : Michael J. Clarke

Download or read book Less Common Metals in Proteins and Nucleic Acid Probes written by Michael J. Clarke and published by Springer. This book was released on 2014-03-12 with total page 233 pages. Available in PDF, EPUB and Kindle. Book excerpt: Some of the more interesting elements in the chemistry of life are less commonly occuring ones such as nickel and molybdenum. This volume elucidates the chemistry of these elements in important enzymes and also explores the chemistry of elements that do not normally occur in biological molecules, but are useful in probing their structure and function. Topics include: Acquisition and transport of Ni. Mechanistic action of Ni in a wide variety of enzymes. Multielectron redox systems involving pterins in proteins. Chemistry of the pterin and flavin complexes of Mo, Fe, Cu and Ru ions. Replacement of iron in transferrin by a number of other metal ions. Use of polypyridyl complexes of ruthenium and other transition metals as probes of nucleic acid structure through photochemical reactions.

Nucleic Acid Chemistry

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Author :
Publisher :
ISBN 13 : 9780471880905
Total Pages : 0 pages
Book Rating : 4.8/5 (89 download)

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Book Synopsis Nucleic Acid Chemistry by : Leroy B. Townsend

Download or read book Nucleic Acid Chemistry written by Leroy B. Townsend and published by . This book was released on 1978 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:

The Nucleic Acid Protocols Handbook

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Author :
Publisher : Springer Science & Business Media
ISBN 13 : 1592590381
Total Pages : 997 pages
Book Rating : 4.5/5 (925 download)

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Book Synopsis The Nucleic Acid Protocols Handbook by : Ralph Rapley

Download or read book The Nucleic Acid Protocols Handbook written by Ralph Rapley and published by Springer Science & Business Media. This book was released on 2008-06-29 with total page 997 pages. Available in PDF, EPUB and Kindle. Book excerpt: A comprehensive treasury of all the key molecular biology methods-ranging from DNA extraction to gene localization in situ-needed to function effectively in the modern laboratory. Each of the 120 highly successful techniques follows the format of the much acclaimed Methods in Molecular BiologyOao series, providing an introduction to the scientific basis of each technique, a complete listing of all the necessary materials and reagents, and clear step-by-step instruction to permit error-free execution. Included for each technique are notes about pitfalls to avoid, troubleshooting tips, alternate methods, and explanations of the reasons for certain steps-all key elements contributing significantly to success or failure in the lab. The Nucleic Acid Protocols Handbook constitutes today's most comprehensive collection of all the key classic and cutting-edge techniques for the successful isolation, analysis, and manipulation of nucleic acids by both experienced researchers and those new to the field."

Perspectives in Nucleoside and Nucleic Acid Chemistry

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Author :
Publisher : John Wiley & Sons
ISBN 13 : 9783906390215
Total Pages : 440 pages
Book Rating : 4.3/5 (92 download)

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Book Synopsis Perspectives in Nucleoside and Nucleic Acid Chemistry by : M. Volkan Kisakürek

Download or read book Perspectives in Nucleoside and Nucleic Acid Chemistry written by M. Volkan Kisakürek and published by John Wiley & Sons. This book was released on 2000 with total page 440 pages. Available in PDF, EPUB and Kindle. Book excerpt: The chemistry of nucleosides and nucleic acids is a rapidly developing field. Many of the most important recent advances in medicinal chemistry have occured in this field with the development of novel nucleoside– and nucleotide–based antiviral and antitumor drugs. New synthesis strategies involving novel protecting groups have helped spur progress in drug–development and genome–sequencing research. This volume, comprised of contributions written by internationally recognized experts, covers cutting–edge developments in current nucleoside and nucleic acid research. The most recent synthesis innovations, including combinatorial approaches, spectroscopy and structural studies, thermodynamic and computational investigations, stability assessments, and medicinal applications are presented. Synthetic, physical, organic, bioorganic, and medicinal chemists working on all aspects of nucleoside and nucleic acid research will value this comprehensive state–of–the–art overview.

Nucleic Acids

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Author :
Publisher : Academic Press
ISBN 13 : 0128205040
Total Pages : 248 pages
Book Rating : 4.1/5 (282 download)

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Book Synopsis Nucleic Acids by : Irshad Ul Haq Bhat

Download or read book Nucleic Acids written by Irshad Ul Haq Bhat and published by Academic Press. This book was released on 2023-08-20 with total page 248 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nucleic Acids: A Natural Target for Newly Designed Metal Chelate Based Drugs discusses how human diseases are becoming more costly to treat, along with updates on the resistance offered by disease-causing agents. The abundance of drugs in the market has provided great relief to patients, but side effects can destroy the immune system of the body. Patients need to boost their immune system, and at the same time cover expenses incurred to cure disease. Thus, a paradigm shift is needed to design a drug molecule with low cost and easy availability. Metal complexes can be a great example of such a shift, as metal ions are components of biological molecules and can achieve good binding capability to specific targets while not allowing them to damage healthy cell system. Therefore, in this book, a comprehensive compilation of recent data is provided, including the structural elucidation of metal complexes by advanced techniques and the binding pattern of metal complexes with specific targets. Focuses on recent advances and methods adopted for generating new metal-based molecules and their interactions with biomolecules, especially nucleic acids Addresses challenges for developing new metal-based drugs Examines advances in optical techniques for the characterization of metal-based drugs

Current Protocols in Nucleic Acid Chemistry

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Author :
Publisher : Current Protocols
ISBN 13 : 9780471246626
Total Pages : pages
Book Rating : 4.2/5 (466 download)

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Book Synopsis Current Protocols in Nucleic Acid Chemistry by : Serge L. Beaucage

Download or read book Current Protocols in Nucleic Acid Chemistry written by Serge L. Beaucage and published by Current Protocols. This book was released on 2000 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Good methods must be reliable, well-tested, and honed to minimize the time and expense required to achieve the desired results. CPNC provides a continuously growing and evolving set of protocols that allows researchers to benefit from the experience of other researchers around the world. The core manual provides a comprehensive set of protocols that have been compiled, revised, and streamlined over the last 6 years. Quarterly updates provide new protocols in emerging areas of research as well as continued advances and new applications for fundamental methods. The book is designed to grow and change with the field of nucleic acid chemistry. Fundamental nucleoside chemistry methods include sugar-base condensation, phosphorylation, and nucleoside protection. Methods for oligonucleotide synthesis include H-phosphonate and phosphoramidite approaches, solid-phase and solution-phase synthesis, large-scale synthesis, synthesis for modified and unmodified oligonucleotides, conjugation of oligonucleotides, synthesis without base protection, and synthesis on microarrays. More specialized synthetic methods include synthesis of biologically active nucleosides and prodrugs. Purification and characterization methods are detailed. Advanced methods include biophysical analysis, combinatorial methods, and nanotechnology. Each protocol includes rationale for choosing appropriate methods, step-by-step procedures, complete recipes, anticipated results, characterization data, and troubleshooting, as well as background and recommended reading. The level of procedural detail is far beyond that found in the research literature, and tips and comments from authors are geared towards ensuring reliable duplication in the laboratory.

Metal--DNA Chemistry

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Author :
Publisher :
ISBN 13 :
Total Pages : 232 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Metal--DNA Chemistry by : Thomas D. Tullius

Download or read book Metal--DNA Chemistry written by Thomas D. Tullius and published by . This book was released on 1989 with total page 232 pages. Available in PDF, EPUB and Kindle. Book excerpt: The chemistry of metals is providing new insights into DNA chemistry, making it necessary for scientists in this emerging interdisciplinary research to be able to understand work in both fields. This new volume provides an examination of the application of metal chemistry to molecular biology as well as a review of recent research results. Its 11 chapters provide broad coverage of such topics as the development and use of metal complexes as tools in molecular biology, the involvement of metal ions in genetic regulation, and the importance of metal-based drugs in the treatment of cancer.

Mass Spectrometry of Nucleosides and Nucleic Acids

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Author :
Publisher : CRC Press
ISBN 13 : 9781420044027
Total Pages : 504 pages
Book Rating : 4.0/5 (44 download)

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Book Synopsis Mass Spectrometry of Nucleosides and Nucleic Acids by : Joseph H. Banoub

Download or read book Mass Spectrometry of Nucleosides and Nucleic Acids written by Joseph H. Banoub and published by CRC Press. This book was released on 2009-12-21 with total page 504 pages. Available in PDF, EPUB and Kindle. Book excerpt: Assembling the work of an international panel of researchers, Mass Spectrometry of Nucleosides and Nucleic Acids summarizes and reviews the latest developments in the field and provides a window on the next generation of analysis. Beginning with an overview of recent developments, the book highlights the most popular ionization methods and illustrates the diversity of strategies employed in the characterization and sequencing of DNA and RNA oligomers, nucleosides, nucleotides, and adducts. It describes studies performed on deoxyinosine and its analogues and provides an introduction to tandem mass spectrometry (MS/MS). Next, the contributors examine mass spectrometric application in the study of cyclic nucleotides in biochemical signal transduction. They analyze urinary modified nucleosides and explore DNA adducts. They discuss isotope labeling of DNA-mass spectrometry (ILD-MS) and examine various uses of electrospray ionization mass spectrometry (ESI-MS). The book reviews recent progress in the direct MS characterization of noncovalent nucleic acid-protein complexes, explores the interaction and ionization of guanidine-derived compounds with highly acidic biomolecules, and examines quantitative identification of nucleic acids via signature digestion products detected using mass spectrometry. The book describes a direct-infusion ESI-MS approach that can serve as a screening technique for the presence of modified nucleosides from small RNAs. Lastly, it discusses the LC-MS/MS method for the in vitro replication studies on damage-containing DNA substrates, and concludes with an examination of the influence of metal ions on the structure and reactivity of nucleic acids. The exciting developments in mass spectrometry technology have fueled incredible advances in our understanding of nucleic acids and their complexes. The contributions presented in this volume capture the range of these advances, helping to inspire new findings and avenues of research.

Frontiers in Nucleic Acid Chemistry

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Author :
Publisher : Mdpi AG
ISBN 13 : 9783036598987
Total Pages : 0 pages
Book Rating : 4.5/5 (989 download)

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Book Synopsis Frontiers in Nucleic Acid Chemistry by : Ramon Eritja

Download or read book Frontiers in Nucleic Acid Chemistry written by Ramon Eritja and published by Mdpi AG. This book was released on 2024-01-09 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This Reprint is dedicated to the memory of Enrique Pedroso, Professor Emeritus of Organic Chemistry at University of Barcelona, who passed away at the age of 72 on September 2020. Professor Enrique Pedroso has been one of the pioneers of Nucleic Acids Chemistry in Spain, significantly contributing to the development of this highly interdisciplinary field which combines organic chemistry, biochemistry, pharmacology, materials chemistry, and biophysics. His major research achievements were accomplished in the synthesis of modified oligonucleotides and especially conjugates and cyclic oligonucleotides, as well as their analogues, which opened up new avenues in the search for novel applications of oligonucleotides. This Reprint comprises a collection of research or review articles prepared by international experts in Nucleic Acids, including nucleoside and oligonucleotide synthesis, nucleic acids structural studies, DNA repair, and biophysical characterization of DNA-targeting ligands, especially G-quadruplex binding drugs.

Basic Principles in Nucleic Acid Chemistry

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Author :
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (112 download)

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Book Synopsis Basic Principles in Nucleic Acid Chemistry by : Paul On Pong TS'O

Download or read book Basic Principles in Nucleic Acid Chemistry written by Paul On Pong TS'O and published by . This book was released on 1976 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: