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Modeling Evolution Of Heterogeneous Populations
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Book Synopsis Modeling Evolution of Heterogeneous Populations by : Irina Kareva
Download or read book Modeling Evolution of Heterogeneous Populations written by Irina Kareva and published by Academic Press. This book was released on 2019-10-16 with total page 354 pages. Available in PDF, EPUB and Kindle. Book excerpt: Modeling Evolution of Heterogeneous Populations: Theory and Applications describes, develops and provides applications of a method that allows incorporating population heterogeneity into systems of ordinary and discrete differential equations without significantly increasing system dimensionality. The method additionally allows making use of results of bifurcation analysis performed on simplified homogeneous systems, thereby building on the existing body of tools and knowledge and expanding applicability and predictive power of many mathematical models. - Introduces Hidden Keystone Variable (HKV) method, which allows modeling evolution of heterogenous populations, while reducing multi-dimensional selection systems to low-dimensional systems of differential equations - Demonstrates that replicator dynamics is governed by the principle of maximal relative entropy that can be derived from the dynamics of selection systems instead of being postulated - Discusses mechanisms behind models of both Darwinian and non-Darwinian selection - Provides examples of applications to various fields, including cancer growth, global demography, population extinction, tragedy of the commons and resource sustainability, among others - Helps inform differences in underlying mechanisms of population growth from experimental observations, taking one from experiment to theory and back
Book Synopsis Modeling and Parameter Estimation for Heterogeneous Cell Populations by : Jan Hasenauer
Download or read book Modeling and Parameter Estimation for Heterogeneous Cell Populations written by Jan Hasenauer and published by Logos Verlag Berlin GmbH. This book was released on 2013 with total page 143 pages. Available in PDF, EPUB and Kindle. Book excerpt: Most of the modeling performed in biology aims at achieving a quantitative description and understanding of the intracellular signaling pathways within a "typical cell". However, in many biologically important situations even genetically identical cell populations show a heterogeneous response. This means that individual members of the cell population behave differently. Such situations require the study of cell-to-cell variability and the development of models for heterogeneous cell populations. The main contribution of this thesis is the development of unifying modeling frameworks for signal transduction and proliferation processes in heterogeneous cell populations. These modeling frameworks allow for the detailed description of individual cells as well as differences between them. In contrast to many existing modeling approaches, the proposed frameworks allow for a direct comparison of model predictions with available data. Beyond this, the proposed population models can be simulated efficiently and, by exploiting the model structures, we are able to develop model-tailored Bayesian parameter estimation methods. These methods enable the calculation of the optimal parameter estimates, as well as the evaluation of the parameter and prediction uncertainties. The proposed tools allow for novel insights in population dynamics, in particular the model-based characterization of population heterogeneity and cellular subgroups. This is illustrated for two different application examples: pro- and anti-apoptotic signaling, which is interesting in the context of cancer therapy, and immune cell proliferation.
Book Synopsis Environmental Stress, Adaptation and Evolution by : K. Bijlsma
Download or read book Environmental Stress, Adaptation and Evolution written by K. Bijlsma and published by Birkhäuser. This book was released on 2013-03-08 with total page 328 pages. Available in PDF, EPUB and Kindle. Book excerpt: Most organisms and populations have to cope with hostile environments, threatening their existence. Their ability to respond phenotypically and genetically to these challenges and to evolve adaptive mechanisms is, therefore, crucial. The contributions to this book aim at understanding, from a evolutionary perspective, the impact of stress on biological systems. Scientists, applying different approaches spanning from the molecular and the protein level to individuals, populations and ecosystems, explore how organisms adapt to extreme environments, how stress changes genetic structure and affects life histories, how organisms cope with thermal stress through acclimation, and how environmental and genetic stress induce fluctuating asymmetry, shape selection pressure and cause extinction of populations. Finally, it discusses the role of stress in evolutionary change, from stress induced mutations and selection to speciation and evolution at the geological time scale. The book contains reviews and novel scientific results on the subject. It will be of interest to both researchers and graduate students and may serve as a text for graduate courses.
Book Synopsis Modeling Evolution by : Derek A. Roff
Download or read book Modeling Evolution written by Derek A. Roff and published by Oxford University Press. This book was released on 2010 with total page 464 pages. Available in PDF, EPUB and Kindle. Book excerpt: Computer modeling is now an integral part of research in evolutionary biology. This book outlines how evolutionary questions are formulated and how, in practice, they can be resolved by analytical and numerical methods.
Book Synopsis Population Genetics and Microevolutionary Theory by : Alan R. Templeton
Download or read book Population Genetics and Microevolutionary Theory written by Alan R. Templeton and published by John Wiley & Sons. This book was released on 2006-09-29 with total page 720 pages. Available in PDF, EPUB and Kindle. Book excerpt: The advances made possible by the development of molecular techniques have in recent years revolutionized quantitative genetics and its relevance for population genetics. Population Genetics and Microevolutionary Theory takes a modern approach to population genetics, incorporating modern molecular biology, species-level evolutionary biology, and a thorough acknowledgment of quantitative genetics as the theoretical basis for population genetics. Logically organized into three main sections on population structure and history, genotype-phenotype interactions, and selection/adaptation Extensive use of real examples to illustrate concepts Written in a clear and accessible manner and devoid of complex mathematical equations Includes the author's introduction to background material as well as a conclusion for a handy overview of the field and its modern applications Each chapter ends with a set of review questions and answers Offers helpful general references and Internet links
Book Synopsis Computational Modeling of Infectious Disease by : Chris von Csefalvay
Download or read book Computational Modeling of Infectious Disease written by Chris von Csefalvay and published by Elsevier. This book was released on 2023-02-14 with total page 478 pages. Available in PDF, EPUB and Kindle. Book excerpt: Computational Modeling of Infectious Disease: With Applications in Python provides an illustrated compendium of tools and tactics for analyzing infectious diseases using cutting-edge computational methods. From simple S(E)IR models, and through time series analysis and geospatial models, this book is both a guided tour through the computational analysis of infectious diseases and a quick-reference manual. Chapters are accompanied by extensive practical examples in Python, illustrating applications from start to finish. This book is designed for researchers and practicing infectious disease forecasters, modelers, data scientists, and those who wish to learn more about analysis of infectious disease processes in the real world. Connects computational infectious disease analysis to state-of-the-art data science Conveys ideas on epidemiology and infectious disease modeling in a clear, accessible way Provides code examples to elucidate best practices
Book Synopsis Computational Modeling of Biological Systems by : Nikolay V Dokholyan
Download or read book Computational Modeling of Biological Systems written by Nikolay V Dokholyan and published by Springer Science & Business Media. This book was released on 2012-02-10 with total page 360 pages. Available in PDF, EPUB and Kindle. Book excerpt: Computational modeling is emerging as a powerful new approach to study and manipulate biological systems. Multiple methods have been developed to model, visualize, and rationally alter systems at various length scales, starting from molecular modeling and design at atomic resolution to cellular pathways modeling and analysis. Higher time and length scale processes, such as molecular evolution, have also greatly benefited from new breeds of computational approaches. This book provides an overview of the established computational methods used for modeling biologically and medically relevant systems.
Book Synopsis Mathematical Ecology by : Thomas G. Hallam
Download or read book Mathematical Ecology written by Thomas G. Hallam and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 455 pages. Available in PDF, EPUB and Kindle. Book excerpt: There isprobably no more appropriate location to hold a course on mathematical ecology than Italy, the countryofVito Volterra, a founding father ofthe subject. The Trieste 1982Autumn Course on Mathematical Ecology consisted of four weeksofvery concentrated scholasticism and aestheticism. The first weeks were devoted to fundamentals and principles ofmathematicalecology. A nucleusofthe material from the lectures presented during this period constitutes this book. The final week and a half of the Course was apportioned to the Trieste Research Conference on Mathematical Ecology whose proceedings have been published as Volume 54, Lecture Notes in Biomathematics, Springer-Verlag. The objectivesofthe first portionofthe course wereambitious and, probably, unattainable. Basic principles of the areas of physiological, population, com munitY, and ecosystem ecology that have solid ecological and mathematical foundations were to be presented. Classical terminology was to be introduced, important fundamental topics were to be developed, some past and some current problems of interest were to be presented, and directions for possible research were to be provided. Due to time constraints, the coverage could not be encyclopedic;many areas covered already have merited treatises of book length. Consequently, preliminary foundation material was covered in some detail, but subject overviewsand area syntheseswerepresented when research frontiers were being discussed. These lecture notes reflect this course philosophy.
Book Synopsis Integrated Population Models by : Michael Schaub
Download or read book Integrated Population Models written by Michael Schaub and published by Academic Press. This book was released on 2021-11-12 with total page 640 pages. Available in PDF, EPUB and Kindle. Book excerpt: Integrated Population Models: Theory and Ecological Applications with R and JAGS is the first book on integrated population models, which constitute a powerful framework for combining multiple data sets from the population and the individual levels to estimate demographic parameters, and population size and trends. These models identify drivers of population dynamics and forecast the composition and trajectory of a population. Written by two population ecologists with expertise on integrated population modeling, this book provides a comprehensive synthesis of the relevant theory of integrated population models with an extensive overview of practical applications, using Bayesian methods by means of case studies. The book contains fully-documented, complete code for fitting all models in the free software, R and JAGS. It also includes all required code for pre- and post-model-fitting analysis. Integrated Population Models is an invaluable reference for researchers and practitioners involved in population analysis, and for graduate-level students in ecology, conservation biology, wildlife management, and related fields. The text is ideal for self-study and advanced graduate-level courses. - Offers practical and accessible ecological applications of IPMs (integrated population models) - Provides full documentation of analyzed code in the Bayesian framework - Written and structured for an easy approach to the subject, especially for non-statisticians
Book Synopsis Biological Control Systems and Disease Modelling by : Babatunde Ogunnaike
Download or read book Biological Control Systems and Disease Modelling written by Babatunde Ogunnaike and published by Frontiers Media SA. This book was released on 2021-06-04 with total page 342 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Applications Of Epidemiological Models To Public Health Policymaking: The Role Of Heterogeneity In Model Predictions by : Zhilan Feng
Download or read book Applications Of Epidemiological Models To Public Health Policymaking: The Role Of Heterogeneity In Model Predictions written by Zhilan Feng and published by World Scientific. This book was released on 2014-04-16 with total page 306 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mathematical models can be very helpful to understand the transmission dynamics of infectious diseases. This book presents examples of epidemiological models and modeling tools that can assist policymakers to assess and evaluate disease control strategies.
Book Synopsis Game-Theoretical Models in Biology by : Mark Broom
Download or read book Game-Theoretical Models in Biology written by Mark Broom and published by CRC Press. This book was released on 2013-03-27 with total page 522 pages. Available in PDF, EPUB and Kindle. Book excerpt: Covering the major topics of evolutionary game theory, Game-Theoretical Models in Biology presents both abstract and practical mathematical models of real biological situations. It discusses the static aspects of game theory in a mathematically rigorous way that is appealing to mathematicians. In addition, the authors explore many applications of game theory to biology, making the text useful to biologists as well. The book describes a wide range of topics in evolutionary games, including matrix games, replicator dynamics, the hawk-dove game, and the prisoner’s dilemma. It covers the evolutionarily stable strategy, a key concept in biological games, and offers in-depth details of the mathematical models. Most chapters illustrate how to use MATLAB® to solve various games. Important biological phenomena, such as the sex ratio of so many species being close to a half, the evolution of cooperative behavior, and the existence of adornments (for example, the peacock’s tail), have been explained using ideas underpinned by game theoretical modeling. Suitable for readers studying and working at the interface of mathematics and the life sciences, this book shows how evolutionary game theory is used in the modeling of these diverse biological phenomena.
Download or read book Disease Evolution written by Zhilan Feng and published by American Mathematical Soc.. This book was released on with total page 264 pages. Available in PDF, EPUB and Kindle. Book excerpt: Infectious diseases are continuing to threaten humankind. While some diseases have been controlled, new diseases are constantly appearing. Others are now reappearing in forms that are resistant to drug treatments. A capacity for continual re-adaptation furnishes pathogens with the power to escape our control efforts through evolution. This makes it imperative to understand the complex selection pressures that are shaping and reshaping diseases. Modern models of evolutionaryepidemiology provide powerful tools for creating, expressing, and testing such understanding. Bringing together international leaders in the field, this volume offers a panoramic tour of topical developments in understanding the mechanisms of disease evolution. The volume's first part elucidates the generalconcepts underlying models of disease evolution. Methodological challenges addressed include those posed by spatial structure, stochastic dynamics, disease phases and classes, single- and multi-drug resistance, the heterogeneity of host populations and tissues, and the intricate coupling of disease evolution with between-host and within-host dynamics. The book's second part shows how these methods are utilized for investigating the dynamics and evolution of specific diseases, includingHIV/AIDS, tuberculosis, SARS, malaria, and human rhinovirus infections. This volume is particularly suited for introducing young scientists and established researchers with backgrounds in mathematics, computer science, or biology to the current techniques and challenges of mathematical evolutionaryepidemiology.
Book Synopsis Guide to Simulation and Modeling for Biosciences by : David J. Barnes
Download or read book Guide to Simulation and Modeling for Biosciences written by David J. Barnes and published by Springer. This book was released on 2015-09-01 with total page 347 pages. Available in PDF, EPUB and Kindle. Book excerpt: This accessible text presents a detailed introduction to the use of a wide range of software tools and modeling environments for use in the biosciences, as well as the fundamental mathematical background. The practical constraints presented by each modeling technique are described in detail, enabling the researcher to determine which software package would be most useful for a particular problem. Features: introduces a basic array of techniques to formulate models of biological systems, and to solve them; discusses agent-based models, stochastic modeling techniques, differential equations, spatial simulations, and Gillespie’s stochastic simulation algorithm; provides exercises; describes such useful tools as the Maxima algebra system, the PRISM model checker, and the modeling environments Repast Simphony and Smoldyn; contains appendices on rules of differentiation and integration, Maxima and PRISM notation, and some additional mathematical concepts; offers supplementary material at an associated website.
Book Synopsis Agent-based Modeling of Tax Evasion by : Sascha Hokamp
Download or read book Agent-based Modeling of Tax Evasion written by Sascha Hokamp and published by John Wiley & Sons. This book was released on 2018-02-12 with total page 356 pages. Available in PDF, EPUB and Kindle. Book excerpt: The only single-source guide to understanding, using, adapting, and designing state-of-the-art agent-based modelling of tax evasion A computational method for simulating the behavior of individuals or groups and their effects on an entire system, agent-based modeling has proven itself to be a powerful new tool for detecting tax fraud. While interdisciplinary groups and individuals working in the tax domain have published numerous articles in diverse peer-reviewed journals and have presented their findings at international conferences, until Agent-based Modelling of Tax Evasion there was no authoritative, single-source guide to state-of-the-art agent-based tax evasion modeling techniques and technologies. Featuring contributions from distinguished experts in the field from around the globe, Agent-Based Modelling of Tax Evasion provides in-depth coverage of an array of field tested agent-based tax evasion models. Models are presented in a unified format so as to enable readers to systematically work their way through the various modeling alternatives available to them. Three main components of each agent-based model are explored in accordance with the Overview, Design Concepts, and Details (ODD) protocol, each section of which contains several sub elements that help to illustrate the model clearly and that assist readers in replicating the modeling results described. Presents models in a unified and structured manner to provide a point of reference for readers interested in agent-based modelling of tax evasion Explores the theoretical aspects and diversity of agent-based modeling through the example of tax evasion Provides an overview of the characteristics of more than thirty agent-based tax evasion frameworks Functions as a solid foundation for lectures and seminars on agent-based modelling of tax evasion The only comprehensive treatment of agent-based tax evasion models and their applications, this book is an indispensable working resource for practitioners and tax evasion modelers both in the agent-based computational domain and using other methodologies. It is also an excellent pedagogical resource for teaching tax evasion modeling and/or agent-based modeling generally.
Book Synopsis Dispersal Ecology and Evolution by : Michel Baguette
Download or read book Dispersal Ecology and Evolution written by Michel Baguette and published by Oxford University Press. This book was released on 2012-09-27 with total page 497 pages. Available in PDF, EPUB and Kindle. Book excerpt: Provides an overview of the fast expanding field of dispersal ecology. The causes, mechanisms, and consequences of dispersal at the individual, population, species, and community levels are all considered.
Book Synopsis Data-driven Modelling of Structured Populations by : Stephen P. Ellner
Download or read book Data-driven Modelling of Structured Populations written by Stephen P. Ellner and published by Springer. This book was released on 2016-05-13 with total page 339 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is a “How To” guide for modeling population dynamics using Integral Projection Models (IPM) starting from observational data. It is written by a leading research team in this area and includes code in the R language (in the text and online) to carry out all computations. The intended audience are ecologists, evolutionary biologists, and mathematical biologists interested in developing data-driven models for animal and plant populations. IPMs may seem hard as they involve integrals. The aim of this book is to demystify IPMs, so they become the model of choice for populations structured by size or other continuously varying traits. The book uses real examples of increasing complexity to show how the life-cycle of the study organism naturally leads to the appropriate statistical analysis, which leads directly to the IPM itself. A wide range of model types and analyses are presented, including model construction, computational methods, and the underlying theory, with the more technical material in Boxes and Appendices. Self-contained R code which replicates all of the figures and calculations within the text is available to readers on GitHub. Stephen P. Ellner is Horace White Professor of Ecology and Evolutionary Biology at Cornell University, USA; Dylan Z. Childs is Lecturer and NERC Postdoctoral Fellow in the Department of Animal and Plant Sciences at The University of Sheffield, UK; Mark Rees is Professor in the Department of Animal and Plant Sciences at The University of Sheffield, UK.
