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Author : Karim Mekhail
Publisher : Frontiers Media SA
ISBN 13 : 288974504X
Total Pages : 139 pages
Book Rating : 4.8/5 (897 download)
Download or read book Spatial Genome Organization written by Karim Mekhail and published by Frontiers Media SA. This book was released on 2022-02-23 with total page 139 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Guido Tiana
Publisher : CRC Press
ISBN 13 : 1351387006
Total Pages : 387 pages
Book Rating : 4.3/5 (513 download)
Download or read book Modeling the 3D Conformation of Genomes written by Guido Tiana and published by CRC Press. This book was released on 2019-01-15 with total page 387 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides a timely summary of physical modeling approaches applied to biological datasets that describe conformational properties of chromosomes in the cell nucleus. Chapters explain how to convert raw experimental data into 3D conformations, and how to use models to better understand biophysical mechanisms that control chromosome conformation. The coverage ranges from introductory chapters to modeling aspects related to polymer physics, and data-driven models for genomic domains, the entire human genome, epigenome folding, chromosome structure and dynamics, and predicting 3D genome structure.
Author : G. Tiana
Publisher : CRC Press
ISBN 13 : 9780367780456
Total Pages : 370 pages
Book Rating : 4.7/5 (84 download)
Download or read book Modeling the 3D Conformation of Genomes written by G. Tiana and published by CRC Press. This book was released on 2021-03-31 with total page 370 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides a timely summary of physical modeling approaches applied to biological datasets that describe conformational properties of chromosomes in the cell nucleus. The coverage ranges from introductory chapters to modeling aspects related to polymer physics, and data-driven models for genomic domains, and predicting 3D genome structur
Author : Silvio Bicciato
Publisher : Humana
ISBN 13 : 9781071613924
Total Pages : 0 pages
Book Rating : 4.6/5 (139 download)
Download or read book Hi-C Data Analysis written by Silvio Bicciato and published by Humana. This book was released on 2022-09-04 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume details a comprehensive set of methods and tools for Hi-C data processing, analysis, and interpretation. Chapters cover applications of Hi-C to address a variety of biological problems, with a specific focus on state-of-the-art computational procedures adopted for the data analysis. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Hi-C Data Analysis: Methods and Protocols aims to help computational and molecular biologists working in the field of chromatin 3D architecture and transcription regulation.
Author : Scott Camazine
Publisher : Princeton University Press
ISBN 13 : 0691212929
Total Pages : 548 pages
Book Rating : 4.6/5 (912 download)
Download or read book Self-Organization in Biological Systems written by Scott Camazine and published by Princeton University Press. This book was released on 2020-05-05 with total page 548 pages. Available in PDF, EPUB and Kindle. Book excerpt: The synchronized flashing of fireflies at night. The spiraling patterns of an aggregating slime mold. The anastomosing network of army-ant trails. The coordinated movements of a school of fish. Researchers are finding in such patterns--phenomena that have fascinated naturalists for centuries--a fertile new approach to understanding biological systems: the study of self-organization. This book, a primer on self-organization in biological systems for students and other enthusiasts, introduces readers to the basic concepts and tools for studying self-organization and then examines numerous examples of self-organization in the natural world. Self-organization refers to diverse pattern formation processes in the physical and biological world, from sand grains assembling into rippled dunes to cells combining to create highly structured tissues to individual insects working to create sophisticated societies. What these diverse systems hold in common is the proximate means by which they acquire order and structure. In self-organizing systems, pattern at the global level emerges solely from interactions among lower-level components. Remarkably, even very complex structures result from the iteration of surprisingly simple behaviors performed by individuals relying on only local information. This striking conclusion suggests important lines of inquiry: To what degree is environmental rather than individual complexity responsible for group complexity? To what extent have widely differing organisms adopted similar, convergent strategies of pattern formation? How, specifically, has natural selection determined the rules governing interactions within biological systems? Broad in scope, thorough yet accessible, this book is a self-contained introduction to self-organization and complexity in biology--a field of study at the forefront of life sciences research.
Author : Oldenburg Oldenburg Press
Publisher :
ISBN 13 : 9781523764426
Total Pages : 40 pages
Book Rating : 4.7/5 (644 download)
Download or read book HiC-Pro: an Optimized and Flexible Pipeline for Hi-C Data Processing written by Oldenburg Oldenburg Press and published by . This book was released on 2016-01-29 with total page 40 pages. Available in PDF, EPUB and Kindle. Book excerpt: HiC-Pro is an optimized and flexible pipeline for processing Hi-C data from raw reads to normalized contact maps. HiC-Pro maps reads, detects valid ligation products, performs quality controls and generates intra- and inter-chromosomal contact maps. It includes a fast implementation of the iterative correction method and is based on a memory-efficient data format for Hi-C contact maps. In addition, HiC-Pro can use phased genotype data to build allele-specific contact maps. We applied HiC-Pro to different Hi-C datasets, demonstrating its ability to easily process large data in a reasonable time. Source code and documentation are available at http://github.com/nservant/HiC-Pro.
Author : National Research Council
Publisher : National Academies Press
ISBN 13 : 0309038405
Total Pages : 128 pages
Book Rating : 4.3/5 (9 download)
Download or read book Mapping and Sequencing the Human Genome written by National Research Council and published by National Academies Press. This book was released on 1988-01-01 with total page 128 pages. Available in PDF, EPUB and Kindle. Book excerpt: There is growing enthusiasm in the scientific community about the prospect of mapping and sequencing the human genome, a monumental project that will have far-reaching consequences for medicine, biology, technology, and other fields. But how will such an effort be organized and funded? How will we develop the new technologies that are needed? What new legal, social, and ethical questions will be raised? Mapping and Sequencing the Human Genome is a blueprint for this proposed project. The authors offer a highly readable explanation of the technical aspects of genetic mapping and sequencing, and they recommend specific interim and long-range research goals, organizational strategies, and funding levels. They also outline some of the legal and social questions that might arise and urge their early consideration by policymakers.
Author : Vincent D. Blondel
Publisher : Springer Science & Business Media
ISBN 13 : 1848001541
Total Pages : 283 pages
Book Rating : 4.8/5 (48 download)
Download or read book Recent Advances in Learning and Control written by Vincent D. Blondel and published by Springer Science & Business Media. This book was released on 2008-01-11 with total page 283 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume is composed of invited papers on learning and control. The contents form the proceedings of a workshop held in January 2008, in Hyderabad that honored the 60th birthday of Doctor Mathukumalli Vidyasagar. The 14 papers, written by international specialists in the field, cover a variety of interests within the broader field of learning and control. The diversity of the research provides a comprehensive overview of a field of great interest to control and system theorists.
Author : Li Chunling
Publisher : Brookings Institution Press
ISBN 13 : 0815739370
Total Pages : 403 pages
Book Rating : 4.8/5 (157 download)
Download or read book China's Youth written by Li Chunling and published by Brookings Institution Press. This book was released on 2021-09-28 with total page 403 pages. Available in PDF, EPUB and Kindle. Book excerpt: Understanding the young adults who came of age during the rise of China's economic and global power This book by a prominent Chinese sociologist explores how China's youth will influence the country's future. Focusing on millennials—those born between the early 1980s and the mid-1990s—the book examines the status, lifestyles, attitudes, values, and behaviors of this key segment of the country's population. Li Chunling's study presents a native Chinese perspective on the increasingly diverse generation that at some point will assume leadership of the country. Among the key questions addressed in the book are: How do Chinese millennials differ both from preceding generations in China and from their counterparts around the world? How can current and future relations between Chinese millennials and the Chinese government be assessed? And, what are the factors or fault lines that have shaped the intra-generational differences among China's young people? Members of this age cohort are extraordinary, and in some respects unique, in contemporary China. Their ascent has accompanied five historic and far-reaching developments. These include China's rapid economic rise, the adoption of the one-child-per-family policy, the largest domestic rural-to-urban migration in Chinese history, the opening of extensive educational opportunities abroad, and the arrival of the digital era. Young Chinese citizens have developed a comprehensive understanding of the world much faster than previous generations; millennials see themselves not as extensions of the past, but rather as the innovators of the country's future. Through expansive and in-depth empirical research on Chinese millennials and younger age cohorts (people in their late teens and early 20s), Dr. Li's book illustrates how China's younger adults reflect the growing diversity and persistent inequality in society. The book also explores how their distinct characteristics and views will shape the country's trajectory. For the outside world, developing a better understanding of this unique generation is an urgent task, given that China now has more influence on the global economy and regional security than at any other point in modern history.
Author : Beatrice Bodega
Publisher : Humana
ISBN 13 : 9781071606636
Total Pages : 322 pages
Book Rating : 4.6/5 (66 download)
Download or read book Capturing Chromosome Conformation written by Beatrice Bodega and published by Humana. This book was released on 2020-10-29 with total page 322 pages. Available in PDF, EPUB and Kindle. Book excerpt: This detailed book collects methods based on the evolution of the chromosome conformation capture (3C) technique and other complementary approaches to dissect chromatin conformation with an emphasis on dissection of nuclear compartmentalization and visualization in imaging. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Capturing Chromosome Conformation: Methods and Protocols serves as an ideal guide for researchers working to further understand 3D genome organization.
Author : National Academies of Sciences, Engineering, and Medicine
Publisher : National Academies Press
ISBN 13 : 0309458390
Total Pages : 133 pages
Book Rating : 4.3/5 (94 download)
Download or read book The Chemistry of Microbiomes written by National Academies of Sciences, Engineering, and Medicine and published by National Academies Press. This book was released on 2017-07-19 with total page 133 pages. Available in PDF, EPUB and Kindle. Book excerpt: The 21st century has witnessed a complete revolution in the understanding and description of bacteria in eco- systems and microbial assemblages, and how they are regulated by complex interactions among microbes, hosts, and environments. The human organism is no longer considered a monolithic assembly of tissues, but is instead a true ecosystem composed of human cells, bacteria, fungi, algae, and viruses. As such, humans are not unlike other complex ecosystems containing microbial assemblages observed in the marine and earth environments. They all share a basic functional principle: Chemical communication is the universal language that allows such groups to properly function together. These chemical networks regulate interactions like metabolic exchange, antibiosis and symbiosis, and communication. The National Academies of Sciences, Engineering, and Medicine's Chemical Sciences Roundtable organized a series of four seminars in the autumn of 2016 to explore the current advances, opportunities, and challenges toward unveiling this "chemical dark matter" and its role in the regulation and function of different ecosystems. The first three focused on specific ecosystemsâ€"earth, marine, and humanâ€"and the last on all microbiome systems. This publication summarizes the presentations and discussions from the seminars.
Author : Sudipto Banerjee
Publisher : CRC Press
ISBN 13 : 020348780X
Total Pages : 470 pages
Book Rating : 4.2/5 (34 download)
Download or read book Hierarchical Modeling and Analysis for Spatial Data written by Sudipto Banerjee and published by CRC Press. This book was released on 2003-12-17 with total page 470 pages. Available in PDF, EPUB and Kindle. Book excerpt: Among the many uses of hierarchical modeling, their application to the statistical analysis of spatial and spatio-temporal data from areas such as epidemiology And environmental science has proven particularly fruitful. Yet to date, the few books that address the subject have been either too narrowly focused on specific aspects of spatial analysis,
Author : National Academies of Sciences, Engineering, and Medicine
Publisher : National Academies Press
ISBN 13 : 0309676738
Total Pages : 201 pages
Book Rating : 4.3/5 (96 download)
Download or read book Next Steps for Functional Genomics written by National Academies of Sciences, Engineering, and Medicine and published by National Academies Press. This book was released on 2020-12-18 with total page 201 pages. Available in PDF, EPUB and Kindle. Book excerpt: One of the holy grails in biology is the ability to predict functional characteristics from an organism's genetic sequence. Despite decades of research since the first sequencing of an organism in 1995, scientists still do not understand exactly how the information in genes is converted into an organism's phenotype, its physical characteristics. Functional genomics attempts to make use of the vast wealth of data from "-omics" screens and projects to describe gene and protein functions and interactions. A February 2020 workshop was held to determine research needs to advance the field of functional genomics over the next 10-20 years. Speakers and participants discussed goals, strategies, and technical needs to allow functional genomics to contribute to the advancement of basic knowledge and its applications that would benefit society. This publication summarizes the presentations and discussions from the workshop.
Author : Mark C. Leake
Publisher : Humana
ISBN 13 : 9781493936298
Total Pages : 0 pages
Book Rating : 4.9/5 (362 download)
Download or read book Chromosome Architecture written by Mark C. Leake and published by Humana. This book was released on 2016-06-10 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume details a valuable collection of protocols and reviews, such as emerging experimental and theoretical approaches. These approaches have resulted in a substantial improvement in the understanding of chromosome architecture. Chromosome Architecture: Methods and Protocols guides readers through cutting-edge interdisciplinary methods which allow for an understanding of architecture of chromosomes with exceptionally enhanced resolution, both in terms of space and time. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Chromosome Architecture: Methods and Protocols aims to ensure successful results in the further study of this vital field.
Author : National Academies of Sciences, Engineering, and Medicine
Publisher : National Academies Press
ISBN 13 : 0309437873
Total Pages : 231 pages
Book Rating : 4.3/5 (94 download)
Download or read book Gene Drives on the Horizon written by National Academies of Sciences, Engineering, and Medicine and published by National Academies Press. This book was released on 2016-08-28 with total page 231 pages. Available in PDF, EPUB and Kindle. Book excerpt: Research on gene drive systems is rapidly advancing. Many proposed applications of gene drive research aim to solve environmental and public health challenges, including the reduction of poverty and the burden of vector-borne diseases, such as malaria and dengue, which disproportionately impact low and middle income countries. However, due to their intrinsic qualities of rapid spread and irreversibility, gene drive systems raise many questions with respect to their safety relative to public and environmental health. Because gene drive systems are designed to alter the environments we share in ways that will be hard to anticipate and impossible to completely roll back, questions about the ethics surrounding use of this research are complex and will require very careful exploration. Gene Drives on the Horizon outlines the state of knowledge relative to the science, ethics, public engagement, and risk assessment as they pertain to research directions of gene drive systems and governance of the research process. This report offers principles for responsible practices of gene drive research and related applications for use by investigators, their institutions, the research funders, and regulators.
Author : Michael L. Stein
Publisher : Springer Science & Business Media
ISBN 13 : 1461214947
Total Pages : 263 pages
Book Rating : 4.4/5 (612 download)
Download or read book Interpolation of Spatial Data written by Michael L. Stein and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 263 pages. Available in PDF, EPUB and Kindle. Book excerpt: A summary of past work and a description of new approaches to thinking about kriging, commonly used in the prediction of a random field based on observations at some set of locations in mining, hydrology, atmospheric sciences, and geography.
Author : Yi-Ping Phoebe Chen
Publisher : Springer Science & Business Media
ISBN 13 : 9783540208730
Total Pages : 420 pages
Book Rating : 4.2/5 (87 download)
Download or read book Bioinformatics Technologies written by Yi-Ping Phoebe Chen and published by Springer Science & Business Media. This book was released on 2005-01-18 with total page 420 pages. Available in PDF, EPUB and Kindle. Book excerpt: Introductio to bioinformatics. Overview of structural bioinformatics. Database warehousing in bioinformatics. Modeling for bioinformatics. Pattern matching for motifs. Visualization and fractal analysis of biological sequences. Microarray data analysis.
