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Mobilizing Mutations
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Book Synopsis Mobilizing Mutations by : Daniel Navon
Download or read book Mobilizing Mutations written by Daniel Navon and published by University of Chicago Press. This book was released on 2019-09-20 with total page 409 pages. Available in PDF, EPUB and Kindle. Book excerpt: With every passing year, more and more people learn that they or their young or unborn child carries a genetic mutation. But what does this mean for the way we understand a person? Today, genetic mutations are being used to diagnose novel conditions like the XYY, Fragile X, NGLY1 mutation, and 22q11.2 Deletion syndromes, carving out rich new categories of human disease and difference. Daniel Navon calls this form of categorization “genomic designation,” and in Mobilizing Mutations he shows how mutations, and the social factors that surround them, are reshaping human classification. Drawing on a wealth of fieldwork and historical material, Navon presents a sociological account of the ways genetic mutations have been mobilized and transformed in the sixty years since it became possible to see abnormal human genomes, providing a new vista onto the myriad ways contemporary genetic testing can transform people’s lives. Taking us inside these shifting worlds of research and advocacy over the last half century, Navon reveals the ways in which knowledge about genetic mutations can redefine what it means to be ill, different, and ultimately, human.
Book Synopsis Mobilizing Mutations by : Daniel Navon
Download or read book Mobilizing Mutations written by Daniel Navon and published by University of Chicago Press. This book was released on 2019-09-20 with total page 409 pages. Available in PDF, EPUB and Kindle. Book excerpt: With every passing year, more and more people learn that they or their young or unborn child carries a genetic mutation. But what does this mean for the way we understand a person? Today, genetic mutations are being used to diagnose novel conditions like the XYY, Fragile X, NGLY1 mutation, and 22q11.2 Deletion syndromes, carving out rich new categories of human disease and difference. Daniel Navon calls this form of categorization “genomic designation,” and in Mobilizing Mutations he shows how mutations, and the social factors that surround them, are reshaping human classification. Drawing on a wealth of fieldwork and historical material, Navon presents a sociological account of the ways genetic mutations have been mobilized and transformed in the sixty years since it became possible to see abnormal human genomes, providing a new vista onto the myriad ways contemporary genetic testing can transform people’s lives. Taking us inside these shifting worlds of research and advocacy over the last half century, Navon reveals the ways in which knowledge about genetic mutations can redefine what it means to be ill, different, and ultimately, human.
Book Synopsis Genetic Analysis of Complex Disease by : William K. Scott
Download or read book Genetic Analysis of Complex Disease written by William K. Scott and published by John Wiley & Sons. This book was released on 2021-11-11 with total page 340 pages. Available in PDF, EPUB and Kindle. Book excerpt: Genetic Analysis of Complex Diseases An up-to-date and complete treatment of the strategies, designs and analysis methods for studying complex genetic disease in human beings In the newly revised Third Edition of Genetic Analysis of Complex Diseases, a team of distinguished geneticists delivers a comprehensive introduction to the most relevant strategies, designs and methods of analysis for the study of complex genetic disease in humans. The book focuses on concepts and designs, thereby offering readers a broad understanding of common problems and solutions in the field based on successful applications in the design and execution of genetic studies. This edited volume contains contributions from some of the leading voices in the area and presents new chapters on high-throughput genomic sequencing, copy-number variant analysis and epigenetic studies. Providing clear and easily referenced overviews of the considerations involved in genetic analysis of complex human genetic disease, including sampling, design, data collection, linkage and association studies and social, legal and ethical issues. Genetic Analysis of Complex Diseases also provides: A thorough introduction to study design for the identification of genes in complex traits Comprehensive explorations of basic concepts in genetics, disease phenotype definition and the determination of the genetic components of disease Practical discussions of modern bioinformatics tools for analysis of genetic data Reflecting on responsible conduct of research in genetic studies, as well as linkage analysis and data management New expanded chapter on complex genetic interactions This latest edition of Genetic Analysis of Complex Diseases is a must-read resource for molecular biologists, human geneticists, genetic epidemiologists and pharmaceutical researchers. It is also invaluable for graduate students taking courses in statistical genetics or genetic epidemiology.
Download or read book Human Geopolitics written by Alan Gamlen and published by Oxford University Press. This book was released on 2019-05-02 with total page 304 pages. Available in PDF, EPUB and Kindle. Book excerpt: Human geopolitics, the competition for population rather than territory, is an essential but weakly understood dimension of world politics today. Such competition has preceded violent conflict throughout history, but has been muted since the Treaties of Westphalia laid the territorial foundations of the modern international system in the mid-seventeenth century. Today, however, human geopolitics is being resurrected in unanticipated ways, as governments are enabled and encouraged to engage their emigrant diasporas. How and why is this happening? Until now these questions have been difficult to answer. The majority of research attention has focused on questions of immigration policy in a handful of wealthy migrant destination countries, largely ignoring the emigration policies that preoccupy the worlds many migrant origin states. This book addresses that research imbalance, by focusing on the overlooked sending side of migration policy. Drawing on data covering all UN members across the post-WWII period, and fieldwork with high-level policy makers across 60 states and a dozen international organisations, the book charts the re-emergence of human geopolitics through the global spread of diaspora institutions government ministries and offices dedicated to emigrants and their descendants. It calls for the development of stronger guiding principles and evaluation frameworks to govern these new state-diaspora relations in an era of unprecedented global interdependence.
Download or read book Mutations in Man written by G. Obe and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 338 pages. Available in PDF, EPUB and Kindle. Book excerpt: This year we remember the 39th anniversary of the atomic bomb explo sions in Hiroshima and Nagasaki, which led to the exposure of thou sands of people to high doses of ionizing radiations. Nearly 18 years earlier, on the 15th of September, 1927, H. J. Muller presented his paper The Problem of Genic Modification at the Fifth International Congress of Genetics in Berlin, in which he brilliantly demonstrated the muta genic activity of X-rays. In 1928, K. H. Bauer formulated his mutation theory of the origin of cancer, and already in 1914, Th. Boveri speculat ed that tumor cells originate from an abnormal chromosomal comple ment. In the meantime we have learned that also nonionizing radiation and an immense number of environmental chemicals, both, man-made and naturally occurring, are mutagenic in a variety of test systems, in cluding human cells. In no case has it been shown unequivocally that physical or chemical mutagens have led to an elevation of the mutation rate in the germ cells of man, but in view of the huge body of experi mental data this seems to be a problem of detection. It can be expect ed that germ cell mutations are induced as a consequence of exposure to mutagens in man, as yet undetectable with the methods at hand. An uncontrolled addition of mutations to the human gene pool may well have unforeseen and catastrophic consequences in future genera tions for whom we should feel responsible.
Book Synopsis The Oxford Handbook of Expertise and Democratic Politics by : Gil Eyal
Download or read book The Oxford Handbook of Expertise and Democratic Politics written by Gil Eyal and published by Oxford University Press. This book was released on 2023 with total page 593 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the last several decades, there has been a surge of interest in expertise in the social scientific, philosophical, and legal literatures. While it is tempting to attribute this surge of interest in expertise to the emergence and consolidation of a "knowledge society," "post-industrial society," or "network society," it is more likely that the debates about expertise are symptomatic of significant change and upheaval. As the number of contenders for expert status has increased, as the bases for their claims have become more diverse, and as the struggles between these would-be experts intensified, expertise became problematic and contested. In The Oxford Handbook of Expertise and Democratic Politics, Gil Eyal and Thomas Medvetz have brought together a broad group of scholars who have engaged substantively and theoretically with debates regarding the nature of expertise and the social roles of experts to examine these areas within sociology and allied disciplines. The analyses take an historical and relational approach to the topic and are motivated by the sense that growing mistrust in experts represents a danger to democratic politics today. The chapters will be organized into three general parts: key theoretical and historical debates, the politics of expertise, and expertise within and across professional, disciplinary, legal, and intellectual spheres. Among the topics considered here are the value and relevance of the boundary between experts and laypeople; the causes and consequences of mistrust in experts; the meanings and social uses of objectivity; and the significance of recent transformations in the organization of the professions. Bringing together investigations from social scientists, philosophers, and legal scholars into the political dimensions of expertise, this Handbook connects interdisciplinary work done in science and technology studies with the more classic concerns, topics, and concepts of sociologists of professions and intellectuals.
Book Synopsis Disability Dialogues by : Andrew J. Hogan
Download or read book Disability Dialogues written by Andrew J. Hogan and published by JHU Press. This book was released on 2022-11-29 with total page 263 pages. Available in PDF, EPUB and Kindle. Book excerpt: "The author argues that postwar clinical professionals resisted adopting more positive, accepting, and sociopolitical perspectives on people with disabilities, as were espoused by self-advocates and family advocates, primarily owing to concerns about professional role, identity, and prestige"--
Book Synopsis Heredity under the Microscope by : Soraya de Chadarevian
Download or read book Heredity under the Microscope written by Soraya de Chadarevian and published by University of Chicago Press. This book was released on 2020-07-02 with total page 318 pages. Available in PDF, EPUB and Kindle. Book excerpt: By focusing on chromosomes, Heredity under the Microscope offers a new history of postwar human genetics. Today chromosomes are understood as macromolecular assemblies and are analyzed with a variety of molecular techniques. Yet for much of the twentieth century, researchers studied chromosomes by looking through a microscope. Unlike any other technique, chromosome analysis offered a direct glimpse of the complete human genome, opening up seemingly endless possibilities for observation and intervention. Critics, however, countered that visual evidence was not enough and pointed to the need to understand the molecular mechanisms. Telling this history in full for the first time, Soraya de Chadarevian argues that the often bewildering variety of observations made under the microscope were central to the study of human genetics. Making space for microscope-based practices alongside molecular approaches, de Chadarevian analyzes the close connections between genetics and an array of scientific, medical, ethical, legal, and policy concerns in the atomic age. By exploring the visual evidence provided by chromosome research in the context of postwar biology and medicine, Heredity under the Microscope sheds new light on the cultural history of the human genome.
Book Synopsis Entanglements of Rare Diseases in the Baltic Sea Region by : Malgorzata Rajtar
Download or read book Entanglements of Rare Diseases in the Baltic Sea Region written by Malgorzata Rajtar and published by Lexington Books. This book was released on 2023-10-16 with total page 225 pages. Available in PDF, EPUB and Kindle. Book excerpt: Drawing on ethnographic studies of the lived experiences of people with rare diseases, this volume critically examines rare, chronic diseases in the context of care, kinship, and technologies, providing in-depth analyses of local worlds that usually remain at the peripheries of medical anthropological inquiry.
Book Synopsis Autistic Intelligence by : Douglas W. Maynard
Download or read book Autistic Intelligence written by Douglas W. Maynard and published by University of Chicago Press. This book was released on 2022-05-25 with total page 282 pages. Available in PDF, EPUB and Kindle. Book excerpt: Examines the diagnostic process to question how we understand autism as a category and to better recognize its intelligence and uncommon sense. As autism has become a widely prevalent diagnosis, we have grown increasingly desperate to understand it. Whether by placing baseless blame on vaccinations or seeking a genetic cause, Americans have struggled to understand what autism is and where it comes from. In Autistic Intelligence, Douglas Maynard and Jason Turowetz focus on a different origin of autism: the diagnostic process. By looking at how autism is diagnosed, they ask us to question the norms we use to measure autistic behavior against, why we understand autistic behavior as disordered, and how we go about assigning that disorder to particular people. To do so, the authors take a close look at a clinic in which children are assessed for and diagnosed with autism. Their research draws on hours observing assessment evaluations among psychologists, pediatricians, parents, and children in order to make plain the systems, language, and categories that clinicians rely upon when making their assessments. Those diagnostic tools determine the kind of information doctors can gather about children, and indeed, those assessments affect how children act. Autistic Intelligence shows that autism is not a stable category, but the result of an interpretive act, and in the process of diagnosing children with autism, we often miss all of the unique contributions they make to the world around them.
Book Synopsis The Routledge Handbook of Anthropology and Global Health by : Tsitsi B. Masvawure
Download or read book The Routledge Handbook of Anthropology and Global Health written by Tsitsi B. Masvawure and published by Taylor & Francis. This book was released on 2024-03-20 with total page 449 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Routledge Handbook of Anthropology and Global Health provides an overview of the complex relationship between anthropology and global health. The book brings together a diverse group of scholars who consider the intersection of anthropological concerns with health and disease as understood and intervened upon by the field of global health. The book is structured around five sections: (1) social, cultural, and political determinants of health; (2) knowledge production in anthropology and global health; (3) persistent invisibilities in global health; (4) reimagining a critical global health; and (5) new horizons in anthropology and global health. Over these five themes a range of topics is explored, including: rare diseases medical pluralism universal global health protocols HIV health security indigenous communities (non)communicable diseases decolonizing global health The Routledge Handbook of Anthropology and Global Health is an essential resource for upper-level students and researchers in anthropology, global health, sociology, international development, health studies, and politics.
Book Synopsis The Western Disease by : Claire Laurier Decoteau
Download or read book The Western Disease written by Claire Laurier Decoteau and published by University of Chicago Press. This book was released on 2021-05-31 with total page 278 pages. Available in PDF, EPUB and Kindle. Book excerpt: Because autism is an increasingly common diagnosis, North Americans are familiar with its symptoms and treatments. But what we know and think about autism is shaped by our social relationship to health, disease, and the medical system. In The Western Disease Claire Laurier Decoteau explores the ways that recent immigrants from Somalia to Canada and the US make sense of their children’s diagnosis of autism. Having never heard of autism before migrating to North America, they often determine that it must be a Western disease. Given its apparent absence in Somalia, they view it as Western in nature, caused by environmental and health conditions unique to life in North America. Following Somali parents as they struggle to make sense of their children's illness and advocate for alternative care, Decoteau unfolds how complex interacting factors of immigration, race, and class affect Somalis’ relationship to the disease. Somalis’ engagement with autism challenges the prevailing presumption among Western doctors that their approach to healing is universal. Decoteau argues that centering an analysis on autism within the Somali diaspora exposes how autism has been defined and institutionalized as a white, middle-class disorder, leading to health disparities based on race, class, age, and ability. The Western Disease asks us to consider the social causes of disease and the role environmental changes and structural inequalities play in health vulnerability.
Book Synopsis The Oxford Handbook of Expertise and Democratic Politics by :
Download or read book The Oxford Handbook of Expertise and Democratic Politics written by and published by Oxford University Press. This book was released on 2023-05-05 with total page 593 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the last several decades, there has been a surge of interest in expertise in the social scientific, philosophical, and legal literatures. While it is tempting to attribute this surge of interest in expertise to the emergence and consolidation of a "knowledge society," "post-industrial society," or "network society," it is more likely that the debates about expertise are symptomatic of significant change and upheaval. As the number of contenders for expert status has increased, as the bases for their claims have become more diverse, and as the struggles between these would-be experts intensified, expertise became problematic and contested. In The Oxford Handbook of Expertise and Democratic Politics, Gil Eyal and Thomas Medvetz have brought together a broad group of scholars who have engaged substantively and theoretically with debates regarding the nature of expertise and the social roles of experts to examine these areas within sociology and allied disciplines. The analyses take an historical and relational approach to the topic and are motivated by the sense that growing mistrust in experts represents a danger to democratic politics today. Among the topics considered here are the value and relevance of the boundary between experts and laypeople; the causes and consequences of mistrust in experts; the meanings and social uses of objectivity; and the significance of recent transformations in the organization of the professions. Bringing together investigations from social scientists, philosophers, and legal scholars into the political dimensions of expertise, this Handbook connects interdisciplinary work done in science and technology studies with the more classic concerns, topics, and concepts of sociologists of professions and intellectuals.
Book Synopsis From Skepticism to Competence by : Mariana Craciun
Download or read book From Skepticism to Competence written by Mariana Craciun and published by University of Chicago Press. This book was released on 2024 with total page 252 pages. Available in PDF, EPUB and Kindle. Book excerpt: "While many doctors can examine the body for cut-and-dry data-a cardiologist can take a scan of the heart, an endocrinologist can measure the hormones in your blood, an oncologist can locate a tumor--psychiatrists are in a unique position: the only way to know someone's mind is through their own account of it. In this ethnography, sociologist Mariana Craciun follows a group of young medical students studying psychiatry as they go through training in psychotherapy. Their instructors, experienced psychotherapists, introduce approaches designed to uncover the inner workings of the mind of each patient, a dramatic departure from the students' earlier focus on the brain's chemical functions and the drugs that treat them. Despite the uncertainty endemic to psychotherapeutic approaches, Craciun shows us how students transform from psychotherapy skeptics into believers. Ultimately, Craciun illuminates widespread conflicts at the intersection of professional authority, uncertainty, and expertise, as we see how professionals come to rethink the goals and purpose of their jobs when they acknowledge the uncertain outcomes of their work"--
Book Synopsis The Quest for Sexual Health by : Steven Epstein
Download or read book The Quest for Sexual Health written by Steven Epstein and published by University of Chicago Press. This book was released on 2022-03-23 with total page 462 pages. Available in PDF, EPUB and Kindle. Book excerpt: "Since the 1970s, health professionals, researchers, governments, advocacy groups, and commercial interests have invested in the pursuit of something called 'sexual health'. Programs were launched, organizations founded, initiatives funded, products sold-and yet, no book before this one asks: What does it mean to be sexually healthy? When did people conceive of a form of health called sexual health? And how did it become the gateway to addressing a host of social harms and the reimagining of private desires and public dreams? Offering an entryway into the distinctive worlds of sexual health, this book traverses the distance from the research and treatment domains where sexual health is assessed, measured, and improved to the "sex expos" that invite attendees to "leave their inhibitions at the door and explore today's top intimacy products" and beyond. Sexual health encompasses wildly disparate agendas and speaks to innumerable concerns-from sexual dysfunction to sexual violence, from HIV prevention to reproductive freedom, to the practicalities of sexual contact during a global pandemic. Rather than a thing apart, sexual health is intertwined with nearly every conceivable topical debate-and more of them every day. Through his wide-ranging exploration, Steven Epstein provides the critical tools needed to bring into focus the different faces of sexual health and parse the debates that swirl around it"--
Download or read book GUYnecology written by Rene Almeling and published by University of California Press. This book was released on 2020-08-25 with total page 303 pages. Available in PDF, EPUB and Kindle. Book excerpt: For more than a century, the medical profession has made enormous efforts to understand and treat women’s reproductive bodies. But only recently have researchers begun to ask basic questions about how men’s health matters for reproductive outcomes, from miscarriage to childhood illness. What explains this gap in knowledge, and what are its consequences? Rene Almeling examines the production, circulation, and reception of biomedical knowledge about men’s reproductive health. From a failed nineteenth-century effort to launch a medical specialty called andrology to the contemporary science of paternal effects, there has been a lack of attention to the importance of men’s age, health, and exposures. Analyzing historical documents, media messages, and qualitative interviews, GUYnecology demonstrates how this non-knowledge shapes reproductive politics today.
Book Synopsis After Positivism by : Nicholas Hoover Wilson
Download or read book After Positivism written by Nicholas Hoover Wilson and published by Columbia University Press. This book was released on 2024-04-21 with total page 612 pages. Available in PDF, EPUB and Kindle. Book excerpt: What is the value of comparison for research in historical sociology? Today, social scientists regularly express doubt about the positivist premises that have long justified comparison’s use: that cases can be unproblematically compared as though they are independent of one another, that comparison can reliably yield valid causal inference, and that comparative methods can grapple with questions of meaning, sequence, and process that are central to historical explanation. Yet they remain reluctant to abandon comparison altogether, not least because comparisons are still manifestly useful in the research process. After Positivism presents a bold new set of warrants and methodologies for comparison that takes these criticisms fully into account. The contributors to this book marshal a wide array of postpositivist approaches to knowledge to reconstruct the analytic potential of comparison for a new generation of social scientists. In addition to providing fresh answers to classic questions about case selection and causal inference, authors ponder the role comparison plays in a world where social phenomena are demonstrably time-, space-, and concept-dependent; where causation is typically conjunctural; where social structures and groups emerge and die; and where important objects of inquiry can be understood only in terms of relationships, emergent properties, or contingent and irregular effects. Engaging and timely, this book will be of interest to all those who seek to improve our explanations of historical change in social-scientific research.
