Mitochondrial Metabolism

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The Therapeutic Use of N-Acetylcysteine (NAC) in Medicine

Author : Richard Eugene Frye
Publisher : Springer
ISBN 13 : 9811053111
Total Pages : 392 pages
Book Rating : 4.8/5 (11 download)

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Book Synopsis The Therapeutic Use of N-Acetylcysteine (NAC) in Medicine by : Richard Eugene Frye

Download or read book The Therapeutic Use of N-Acetylcysteine (NAC) in Medicine written by Richard Eugene Frye and published by Springer. This book was released on 2018-09-20 with total page 392 pages. Available in PDF, EPUB and Kindle. Book excerpt: Focusing on the practical use of N-Acetyl-Cysteine (NAC) in medicine, this book provides a comprehensive review of the basic biological and clinical studies documenting its benefits in treating medical disease. NAC is perhaps best known as an antidote for acetaminophen, but its therapeutic effect in a wide range of medical diseases has recently been realized. In addition to its well recognized use in radiological contrast prophylaxis for renal disease and pulmonary disorders, studies have suggested significant promise in psychiatric and neurological disorders such as addiction, Alzheimer’s disease, ataxia, autism, bipolar disorder, depression, epilepsy, neuropathy, obsessive-compulsive disorder, schizophrenia, traumatic brain injury and trichotillomania in addition to promising studies in audiology, cardiology, exercise physiology, gastroenterology, hematology, infectious disease, infertility and ophthalmology. Given the promising studies for a wide range of medical conditions, coupled with a excellent safety profile, the potential for NAC in the treatment of human disease appears considerable. Dr Leonore A Herzenberg from Stanford University, a pioneer of redox physiology and the use of NAC, provides a succinct history of the development of the therapeutic use of NAC for medical disease. This is followed by a series of basic science chapters outlining the role of NAC in important physiological processes, including modulation of dopamine and glutamate neurotransmitter systems, redox and mitochondrial metabolism, apoptosis and inflammation. The last section of the book is dedicated to clinically oriented chapters that comprehensively review the literature on medical disorders in which NAC has been found to be effective, including toxicity and cardiovascular, gastrointestinal, neurological, psychiatric, pulmonary and renal disorders. Each chapter reviews the theoretical biological mechanisms of NAC for the specific diseases reviewed, rates the clinical studies using a standardized criteria in order to provide an objective level of evidence and grade of recommendation for the use of NAC for specific medical conditions and outlines the ongoing clinical trials examining NAC for the treatment of specific diseases. Final chapters review the clinical evidence verifying that specific theoretical biological mechanisms are actually being targeted by NAC in medical disease. Studies on the pharmacology, formulation and potential adverse effects of NAC are also reviewed. A final chapter synthesizes the clinical studies to suggest that the effectiveness of NAC may signal a new basic physiological disorder, glutathione deficiency, which may be an important pathophysiological mechanism of many diseases.

Mitochondria and Anaerobic Energy Metabolism in Eukaryotes

Author : William F. Martin
Publisher : Walter de Gruyter GmbH & Co KG
ISBN 13 : 3110612410
Total Pages : 269 pages
Book Rating : 4.1/5 (16 download)

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Book Synopsis Mitochondria and Anaerobic Energy Metabolism in Eukaryotes by : William F. Martin

Download or read book Mitochondria and Anaerobic Energy Metabolism in Eukaryotes written by William F. Martin and published by Walter de Gruyter GmbH & Co KG. This book was released on 2020-12-07 with total page 269 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mitochondria are sometimes called the powerhouses of eukaryotic cells, because mitochondria are the site of ATP synthesis in the cell. ATP is the universal energy currency, it provides the power that runs all other life processes. Humans need oxygen to survive because of ATP synthesis in mitochondria. The sugars from our diet are converted to carbon dioxide in mitochondria in a process that requires oxygen. Just like a fire needs oxygen to burn, our mitochondria need oxygen to make ATP. From textbooks and popular literature one can easily get the impression that all mitochondria require oxygen. But that is not the case. There are many groups of organismsm known that make ATP in mitochondria without the help of oxygen. They have preserved biochemical relicts from the early evolution of eukaryotic cells, which took place during times in Earth history when there was hardly any oxygen avaiable, certainly not enough to breathe. How the anaerobic forms of mitochondria work, in which organisms they occur, and how the eukaryotic anaerobes that possess them fit into the larger picture of rising atmospheric oxygen during Earth history are the topic of this book.

Mitochondria and Cancer

Author : Keshav Singh
Publisher : Springer Science & Business Media
ISBN 13 : 0387848355
Total Pages : 294 pages
Book Rating : 4.3/5 (878 download)

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Book Synopsis Mitochondria and Cancer by : Keshav Singh

Download or read book Mitochondria and Cancer written by Keshav Singh and published by Springer Science & Business Media. This book was released on 2009-04-05 with total page 294 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nearly a century of scientific research has revealed that mitochondrial dysfunction is one of the most common and consistent phenotypes of cancer cells. A number of notable differences in the mitochondria of normal and cancer cells have been described. These include differences in mitochondrial metabolic activity, molecular composition of mitochondria and mtDNA sequence, as well as in alteration of nuclear genes encoding mitochondrial proteins. This book, Mitochondria and Cancer, edited by Keshav K. Singh and Leslie C. Costello, presents thorough analyses of mitochondrial dysfunction as one of the hallmarks of cancer, discusses the clinical implications of mitochondrial defects in cancer, and as unique cellular targets for novel and selective anti-cancer therapy.

Mitochondrial Dysfunction

Author : Lawrence H. Lash
Publisher : Elsevier
ISBN 13 : 1483218619
Total Pages : 527 pages
Book Rating : 4.4/5 (832 download)

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Book Synopsis Mitochondrial Dysfunction by : Lawrence H. Lash

Download or read book Mitochondrial Dysfunction written by Lawrence H. Lash and published by Elsevier. This book was released on 2013-10-22 with total page 527 pages. Available in PDF, EPUB and Kindle. Book excerpt: Methods in Toxicology, Volume 2: Mitochondrial Dysfunction provides a source of methods, techniques, and experimental approaches for studying the role of abnormal mitochondrial function in cell injury. The book discusses the methods for the preparation and basic functional assessment of mitochondria from liver, kidney, muscle, and brain; the methods for assessing mitochondrial dysfunction in vivo and in intact organs; and the structural aspects of mitochondrial dysfunction are addressed. The text also describes chemical detoxification and metabolism as well as specific metabolic reactions that are especially important targets or indicators of damage. The methods for measurement of alterations in fatty acid and phospholipid metabolism and for the analysis and manipulation of oxidative injury and antioxidant systems are also considered. The book further tackles additional methods on mitochondrial energetics and transport processes; approaches for assessing impaired function of mitochondria; and genetic and developmental aspects of mitochondrial disease and toxicology. The text also looks into mitochondrial DNA synthesis, covalent binding to mitochondrial DNA, DNA repair, and mitochondrial dysfunction in the context of developing individuals and cellular differentiation. Microbiologists, toxicologists, biochemists, and molecular pharmacologists will find the book invaluable.

Mitochondrial Medicine

Author : Anna Gvozdjáková
Publisher : Springer Science & Business Media
ISBN 13 : 1402067143
Total Pages : 446 pages
Book Rating : 4.4/5 (2 download)

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Book Synopsis Mitochondrial Medicine by : Anna Gvozdjáková

Download or read book Mitochondrial Medicine written by Anna Gvozdjáková and published by Springer Science & Business Media. This book was released on 2008-02-01 with total page 446 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mitochondrial medicine deals with diseases that are related to mitochondrial dysfunction due to a number of causes from free radical damage to genetic mutation. This book is based on extensive data gathered over 30 years of clinical and experimental research. In it, internationally recognized authors share their experience in various fields of their expertise and guide readers through the disease process, from basic biochemical mechanisms to diagnosis to therapeutic aspects.

Mitochondrial Function and Biogenesis

Author : Carla Koehler
Publisher : Springer Science & Business Media
ISBN 13 : 9783540214892
Total Pages : 362 pages
Book Rating : 4.2/5 (148 download)

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Book Synopsis Mitochondrial Function and Biogenesis by : Carla Koehler

Download or read book Mitochondrial Function and Biogenesis written by Carla Koehler and published by Springer Science & Business Media. This book was released on 2004-05-13 with total page 362 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides the first modern and truly comprehensive coverage of the biochemistry, genetics, and pathology of mitochondria in different organisms. It particularly focuses on the recent advances in our understanding of basic mitochondrial research to the consequences of dysfunction at the molecular level. (Cover)

Metabolism in Cancer

Author : Thorsten Cramer
Publisher : Springer
ISBN 13 : 3319421182
Total Pages : 272 pages
Book Rating : 4.3/5 (194 download)

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Book Synopsis Metabolism in Cancer by : Thorsten Cramer

Download or read book Metabolism in Cancer written by Thorsten Cramer and published by Springer. This book was released on 2016-08-24 with total page 272 pages. Available in PDF, EPUB and Kindle. Book excerpt: This textbook presents concise chapters written by internationally respected experts on various important aspects of cancer-associated metabolism, offering a comprehensive overview of the central features of this exciting research field. The discovery that tumor cells display characteristic alterations of metabolic pathways has significantly changed our understanding of cancer: while the first description of tumor-specific changes in cellular energetics was published more than 90 years ago, the causal significance of this observation for the pathogenesis of cancer was only discovered in the post-genome era. The first 10 years of the twenty-first century were characterized by rapid advances in our grasp of the functional role of cancer-specific metabolism as well as the underlying molecular pathways. Various unanticipated interrelations between metabolic alterations and cancer-driving pathways were identified and currently await translation into diagnostic and therapeutic applications. Yet the speed, quantity, and complexity of these new discoveries make it difficult for researchers to keep up to date with the latest developments, an issue this book helps to remedy.

Mitochondria and Cell Death

Author : Guy C. Brown
Publisher :
ISBN 13 :
Total Pages : 248 pages
Book Rating : 4.4/5 (91 download)

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Book Synopsis Mitochondria and Cell Death by : Guy C. Brown

Download or read book Mitochondria and Cell Death written by Guy C. Brown and published by . This book was released on 1999 with total page 248 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Mitochondrial Metabolism

Author : Jalal Pourahmad
Publisher : Academic Press
ISBN 13 : 0128224096
Total Pages : 318 pages
Book Rating : 4.1/5 (282 download)

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Book Synopsis Mitochondrial Metabolism by : Jalal Pourahmad

Download or read book Mitochondrial Metabolism written by Jalal Pourahmad and published by Academic Press. This book was released on 2021-07-28 with total page 318 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mitochondrial Metabolism: An Approach for Disease Management covers mitotherapy from three combined perspectives, Pharmacology, Toxicology and Biochemistry. After an introduction from world-renowned experts, the book's chapters cover the balancing role in reduction/oxidation mitochondria play, mitochondria as targets for therapeutics through its metabolism, mitochondrial contributions to the cell death process, mitochondrial response to environmental toxicants, the mitochondrial role in aging, the impact of calorie restrictive diets, new advances in the identification of altered mitochondria associated signaling pathways in carcinogenesis, and much more. This book provides bioscientists new horizons to realize the importance of mitochondria in present-day research on therapies dealing with mitochondria associated chronic diseases, including diabetes, cancer and neurodegenerative disorders. - Details the significant role of mitochondria in chronic diseases - Presents new insights on the targeting of mitochondria for therapeutic purposes - Includes updated results on mitotherapy and other mitochondria-oriented therapies

Cancer as a Metabolic Disease

Author : Thomas Seyfried
Publisher : John Wiley & Sons
ISBN 13 : 1118310306
Total Pages : 482 pages
Book Rating : 4.1/5 (183 download)

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Book Synopsis Cancer as a Metabolic Disease by : Thomas Seyfried

Download or read book Cancer as a Metabolic Disease written by Thomas Seyfried and published by John Wiley & Sons. This book was released on 2012-05-18 with total page 482 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book addresses controversies related to the origins of cancer and provides solutions to cancer management and prevention. It expands upon Otto Warburg's well-known theory that all cancer is a disease of energy metabolism. However, Warburg did not link his theory to the "hallmarks of cancer" and thus his theory was discredited. This book aims to provide evidence, through case studies, that cancer is primarily a metabolic disease requring metabolic solutions for its management and prevention. Support for this position is derived from critical assessment of current cancer theories. Brain cancer case studies are presented as a proof of principle for metabolic solutions to disease management, but similarities are drawn to other types of cancer, including breast and colon, due to the same cellular mutations that they demonstrate.

Mitochondria in Obesity and Type 2 Diabetes

Author : Beatrice Morio
Publisher : Academic Press
ISBN 13 : 0128117524
Total Pages : 460 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis Mitochondria in Obesity and Type 2 Diabetes by : Beatrice Morio

Download or read book Mitochondria in Obesity and Type 2 Diabetes written by Beatrice Morio and published by Academic Press. This book was released on 2019-04-12 with total page 460 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mitochondria in Obesity and Type 2 Diabetes: Comprehensive Review on Mitochondrial Functioning and Involvement in Metabolic Diseases synthesizes discoveries from laboratories around the world, enhancing our understanding of the involvement of mitochondria in the etiology of diseases, such as obesity and type 2 diabetes. Chapters illustrate and provide an overview of key concepts on topics such as the role of mitochondria in adipose tissue, cancer, cardiovascular comorbidities, skeletal muscle, the liver, kidney, and more. This book is a must-have reference for students and educational teams in biology, physiology and medicine, and researchers.

Mitochondria in Health and Diseases

Author : Sabzali Javadov
Publisher :
ISBN 13 : 9783039363841
Total Pages : 434 pages
Book Rating : 4.3/5 (638 download)

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Book Synopsis Mitochondria in Health and Diseases by : Sabzali Javadov

Download or read book Mitochondria in Health and Diseases written by Sabzali Javadov and published by . This book was released on 2020-09-04 with total page 434 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mitochondria are subcellular organelles evolved by the endosymbiosis of bacteria with eukaryotic cells. They are the main source of ATP in the cell and engaged in other aspects of cell metabolism and cell function, including the regulation of ion homeostasis, cell growth, redox status, and cell signaling. Due to their central role in cell life and death, mitochondria are also involved in the pathogenesis and progression of human diseases/conditions, including neurodegenerative and cardiovascular disorders, cancer, diabetes, inflammation, and aging. However, despite the increasing number of studies, precise mechanisms whereby mitochondria are involved in the regulation of basic physiological functions, as well as their role in the cell under pathophysiological conditions, remain unknown. A lack of in-depth knowledge of the regulatory mechanisms of mitochondrial metabolism and function, as well as interplay between the factors that transform the organelle from its role in pro-survival to pro-death, have hindered the development of new mitochondria-targeted pharmacological and conditional approaches for the treatment of human diseases. This book highlights the latest achievements in elucidating the role of mitochondria under physiological conditions, in various cell/animal models of human diseases, and in patients.

Mitochondrial Metabolism in Ischemic Heart Disease

Author : Shijun Wang
Publisher : Frontiers Media SA
ISBN 13 : 2889766209
Total Pages : 245 pages
Book Rating : 4.8/5 (897 download)

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Book Synopsis Mitochondrial Metabolism in Ischemic Heart Disease by : Shijun Wang

Download or read book Mitochondrial Metabolism in Ischemic Heart Disease written by Shijun Wang and published by Frontiers Media SA. This book was released on 2022-07-27 with total page 245 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Molecular Biology of the Cell

Author :
Publisher :
ISBN 13 : 9780815332183
Total Pages : 0 pages
Book Rating : 4.3/5 (321 download)

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Book Synopsis Molecular Biology of the Cell by :

Download or read book Molecular Biology of the Cell written by and published by . This book was released on 2002 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Mitochondria: The Anti- cancer Target for the Third Millennium

Author : Jiri Neuzil
Publisher : Springer
ISBN 13 : 9401789843
Total Pages : 387 pages
Book Rating : 4.4/5 (17 download)

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Book Synopsis Mitochondria: The Anti- cancer Target for the Third Millennium by : Jiri Neuzil

Download or read book Mitochondria: The Anti- cancer Target for the Third Millennium written by Jiri Neuzil and published by Springer. This book was released on 2014-05-26 with total page 387 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book will be focused on mitochondria as very promising targets for anti-cancer drugs, yet to be fully exploited. It will contain chapters focused on aspects of basic research as well as on clinical relevance, which will be written by specialists in the field. That the role of mitochondria in human pathologies goes beyond the neoplastic diseases will be documented by a chapter of the role of mitochondria in Friedreich's ataxia.

Plant Mitochondria: From Genome to Function

Author : David Day
Publisher : Springer Science & Business Media
ISBN 13 : 1402024002
Total Pages : 347 pages
Book Rating : 4.4/5 (2 download)

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Book Synopsis Plant Mitochondria: From Genome to Function by : David Day

Download or read book Plant Mitochondria: From Genome to Function written by David Day and published by Springer Science & Business Media. This book was released on 2013-11-09 with total page 347 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mitochondria in plants, as in other eukaryotes, play an essential role in the cell as the major producers of ATP via oxidative phosphorylation. However, mitochondria also play crucial roles in many other aspects of plant development and performance, and possess an array of unique properties which allow them to interact with the specialized features of plant cell metabolism. The two main themes running through the book are the interconnection between gene regulation and protein function, and the integration of mitochondria with other components of plant cells. The book begins with an overview of the dynamics of mitochondrial structure, morphology and inheritance. It then discusses the biogenesis of mitochondria, the regulation of gene expression, the mitochondrial genome and its interaction with the nucleus, and the targeting of proteins to the organelle. This is followed by a discussion of the contributions that mutations, involving mitochondrial proteins, have made to our understanding of the way the organelle interacts with the rest of the plant cell, and the new field of proteomics and the discovery of new functions. Also covered are the pathways of electron transport, with special attention to the non-phosphorylating bypasses, metabolite transport, and specialized mitochondrial metabolism. In the end, the impact of oxidative stress on mitochondria and the defense mechanisms, that are employed to allow survival, are discussed. This book is for the use of advanced undergraduates, graduates, postgraduates, and beginning researchers in the areas of molecular and cellular biology, integrative biology, biochemistry, bioenergetics, proteomics and plant and agricultural sciences.

Mitochondrial Dysfunction Caused by Drugs and Environmental Toxicants

Author : Yvonne Will
Publisher : John Wiley & Sons
ISBN 13 : 1119329744
Total Pages : 816 pages
Book Rating : 4.1/5 (193 download)

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Book Synopsis Mitochondrial Dysfunction Caused by Drugs and Environmental Toxicants by : Yvonne Will

Download or read book Mitochondrial Dysfunction Caused by Drugs and Environmental Toxicants written by Yvonne Will and published by John Wiley & Sons. This book was released on 2018-03-23 with total page 816 pages. Available in PDF, EPUB and Kindle. Book excerpt: Developed as a one-stop reference source for drug safety and toxicology professionals, this book explains why mitochondrial failure is a crucial step in drug toxicity and how it can be avoided. • Covers both basic science and applied technology / methods • Allows readers to understand the basis of mitochondrial function, the preclinical assessments used, and what they reveal about drug effects • Contains both in vitro and in vivo methods for analysis, including practical screening approaches for drug discovery and development • Adds coverage about mitochondrial toxicity underlying organ injury, clinical reports on drug classes, and discussion of environmental toxicants affecting mitochondria