Mitochondria In Health And In Sickness

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Mitochondria in Health and in Sickness

Author : Andrea Urbani
Publisher : Springer Nature
ISBN 13 : 9811383677
Total Pages : 277 pages
Book Rating : 4.8/5 (113 download)

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Book Synopsis Mitochondria in Health and in Sickness by : Andrea Urbani

Download or read book Mitochondria in Health and in Sickness written by Andrea Urbani and published by Springer Nature. This book was released on 2019-08-26 with total page 277 pages. Available in PDF, EPUB and Kindle. Book excerpt: Besides bringing together researchers and clinicians from various disciplines to share their scope of research on the seminal role of mitochondria in human disease, this original volume of the book has a broader appeal by exploring the health and disease of mitochondria, with specific emphasis on how mitochondrial dysfunction contributes to the development of various neurodegeneration, cancer, and metabolic disorders. The book also provides a foundational overview of the mitochondrial pathogenic or genetic variants and highlights various analytical tools used in the field of mitochondrial genetics; mitochondrial replacement therapy and strategies geared towards shifting heteroplasmy in individuals with mitochondrial disease; how state-of-the-art omics technologies (proteomics, functional genomics) have been employed to study mitochondrial biology in healthy and disease states; post-translational modifications in the regulation of mitochondrial proteins; and the role of mitochondria in host-pathogen interactions. Current approaches taken to study steady-state characteristics of mitochondrial structure and function in live mammalian cells in the contexts of normal and diseased states, and most recent research efforts to develop compounds with anti-cancer potential by targeting mitochondrial proteases or advances in therapeutic approaches towards mitochondrial disease were also explored. By covering this broad range of topics, our hope is to disseminate a wealth of knowledge on the critical role of mitochondria, and how to probe its function in health and in sickness.

The Mitochondrion in Health and Disease

Author : David D. Tyler
Publisher :
ISBN 13 :
Total Pages : 584 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis The Mitochondrion in Health and Disease by : David D. Tyler

Download or read book The Mitochondrion in Health and Disease written by David D. Tyler and published by . This book was released on 1992 with total page 584 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Mitochondria in Health and Disease

Author : Carolyn D. Berdanier
Publisher : CRC Press
ISBN 13 : 9780824754426
Total Pages : 640 pages
Book Rating : 4.7/5 (544 download)

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Book Synopsis Mitochondria in Health and Disease by : Carolyn D. Berdanier

Download or read book Mitochondria in Health and Disease written by Carolyn D. Berdanier and published by CRC Press. This book was released on 2005-06-09 with total page 640 pages. Available in PDF, EPUB and Kindle. Book excerpt: It was once assumed that mitochondrial diseases were rare and that few people were affected. As knowledge has grown about these organelles and their function, it became clear that mitochondrial malfunction could be linked to several chronic diseases. Diabetes has been associated with DNA mutation and can cause mutation itself. This text discusses findings involving the effects of disease on mitochondrial number, mitogenesis, and the base sequence of mitochondrial DNA. Experts discuss their study of mitochondria and what happens when it malfunctions. This book also explores the idea that mutated mitochondrial DNA can result in disease, and vice versa.

Mitochondrial Dysfunction

Author : Lawrence H. Lash
Publisher : Elsevier
ISBN 13 : 1483218619
Total Pages : 527 pages
Book Rating : 4.4/5 (832 download)

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Book Synopsis Mitochondrial Dysfunction by : Lawrence H. Lash

Download or read book Mitochondrial Dysfunction written by Lawrence H. Lash and published by Elsevier. This book was released on 2013-10-22 with total page 527 pages. Available in PDF, EPUB and Kindle. Book excerpt: Methods in Toxicology, Volume 2: Mitochondrial Dysfunction provides a source of methods, techniques, and experimental approaches for studying the role of abnormal mitochondrial function in cell injury. The book discusses the methods for the preparation and basic functional assessment of mitochondria from liver, kidney, muscle, and brain; the methods for assessing mitochondrial dysfunction in vivo and in intact organs; and the structural aspects of mitochondrial dysfunction are addressed. The text also describes chemical detoxification and metabolism as well as specific metabolic reactions that are especially important targets or indicators of damage. The methods for measurement of alterations in fatty acid and phospholipid metabolism and for the analysis and manipulation of oxidative injury and antioxidant systems are also considered. The book further tackles additional methods on mitochondrial energetics and transport processes; approaches for assessing impaired function of mitochondria; and genetic and developmental aspects of mitochondrial disease and toxicology. The text also looks into mitochondrial DNA synthesis, covalent binding to mitochondrial DNA, DNA repair, and mitochondrial dysfunction in the context of developing individuals and cellular differentiation. Microbiologists, toxicologists, biochemists, and molecular pharmacologists will find the book invaluable.

Ion Channels in Health and Sickness

Author : Fatima Shad Kaneez
Publisher : BoD – Books on Demand
ISBN 13 : 1789842271
Total Pages : 204 pages
Book Rating : 4.7/5 (898 download)

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Book Synopsis Ion Channels in Health and Sickness by : Fatima Shad Kaneez

Download or read book Ion Channels in Health and Sickness written by Fatima Shad Kaneez and published by BoD – Books on Demand. This book was released on 2018-10-10 with total page 204 pages. Available in PDF, EPUB and Kindle. Book excerpt: Ion channels are proteins that make pores in the membranes of excitable cells present both in the brain and the body. These cells are not only responsible for converting chemical and mechanical stimuli into the electrical signals but are also liable for monitoring vital functions. All our activities, from the blinking of our eyes to the beating of our heart and all our senses from smell to sight, touch, taste and hearing are regulated by the ion channels. This book will take us on an expedition describing the role of ion channels in congenital and acquired diseases and the challenges and limitations scientist are facing in the development of drugs targeting these membrane proteins.

Mitochondria and the Future of Medicine

Author : Lee Know
Publisher : Chelsea Green Publishing
ISBN 13 : 1603587675
Total Pages : 274 pages
Book Rating : 4.6/5 (35 download)

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Book Synopsis Mitochondria and the Future of Medicine by : Lee Know

Download or read book Mitochondria and the Future of Medicine written by Lee Know and published by Chelsea Green Publishing. This book was released on 2018 with total page 274 pages. Available in PDF, EPUB and Kindle. Book excerpt: With information for patients and practitioners on optimizing mitochondrial function for greater health and longevity Why do we age? Why does cancer develop? What's the connection between heart failure and Alzheimer's disease, or infertility and hearing loss? Can we extend lifespan, and if so, how? What is the Exercise Paradox? Why do antioxidant supplements sometimes do more harm than good? Many will be amazed to learn that all these questions, and many more, can be answered by a single point of discussion: mitochondria and bioenergetics. In Mitochondria and the Future of Medicine, Naturopathic Doctor Lee Know tells the epic story of mitochondria, the widely misunderstood and often-overlooked powerhouses of our cells. The legendary saga began over two billion years ago, when one bacterium entered another without being digested, which would evolve to create the first mitochondrion. Since then, for life to exist beyond single-celled bacteria, it's the mitochondria that have been responsible for this life-giving energy. By understanding how our mitochondria work, in fact, it is possible to add years to our lives, and life to our years. Current research, however, has revealed a dark side: many seemingly disconnected degenerative diseases have tangled roots in dysfunctional mitochondria. However, modern research has also endowed us with the knowledge on how to optimize its function, which is of critical importance to our health and longevity. Lee Know offers cutting-edge information on supplementation and lifestyle changes for mitochondrial optimization, such as CoQ10, D-Ribose, cannabinoids, and ketogenic dietary therapy, and how to implement their use successfully. Mitochondria and the Future of Medicine is an invaluable resource for practitioners interested in mitochondrial medicine and the true roots of chronic illness and disease, as well as anyone interested in optimizing their health.

Cancer as a Metabolic Disease

Author : Thomas Seyfried
Publisher : John Wiley & Sons
ISBN 13 : 1118310306
Total Pages : 482 pages
Book Rating : 4.1/5 (183 download)

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Book Synopsis Cancer as a Metabolic Disease by : Thomas Seyfried

Download or read book Cancer as a Metabolic Disease written by Thomas Seyfried and published by John Wiley & Sons. This book was released on 2012-05-18 with total page 482 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book addresses controversies related to the origins of cancer and provides solutions to cancer management and prevention. It expands upon Otto Warburg's well-known theory that all cancer is a disease of energy metabolism. However, Warburg did not link his theory to the "hallmarks of cancer" and thus his theory was discredited. This book aims to provide evidence, through case studies, that cancer is primarily a metabolic disease requring metabolic solutions for its management and prevention. Support for this position is derived from critical assessment of current cancer theories. Brain cancer case studies are presented as a proof of principle for metabolic solutions to disease management, but similarities are drawn to other types of cancer, including breast and colon, due to the same cellular mutations that they demonstrate.

Minding My Mitochondria

Author : Terry L. Wahls
Publisher : Tz Press
ISBN 13 : 9780982175088
Total Pages : 235 pages
Book Rating : 4.1/5 (75 download)

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Book Synopsis Minding My Mitochondria by : Terry L. Wahls

Download or read book Minding My Mitochondria written by Terry L. Wahls and published by Tz Press. This book was released on 2010 with total page 235 pages. Available in PDF, EPUB and Kindle. Book excerpt: A practical guide to understanding mitochondrial health and the steps you can take to improve your brain's function and health.

Autophagy in Health and Disease

Author : Roberta A. Gottlieb
Publisher : Academic Press
ISBN 13 : 0123851025
Total Pages : 241 pages
Book Rating : 4.1/5 (238 download)

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Book Synopsis Autophagy in Health and Disease by : Roberta A. Gottlieb

Download or read book Autophagy in Health and Disease written by Roberta A. Gottlieb and published by Academic Press. This book was released on 2012-12-31 with total page 241 pages. Available in PDF, EPUB and Kindle. Book excerpt: Autophagy in Health and Disease offers an overview of the latest research in autophagy with a translational emphasis. This publication takes scientific research in autophagy a step further and offers integrated content with advancements in autophagy from cell biology and biochemical research to clinical treatments. A necessary reference for the bookshelf of medical and scientific researchers and students, Autophagy in Health and Disease presents high quality, reputable information on autophagy, allowing the reader quick access to the most applicable information. Discusses current understanding of the roles of autophagy in health and disease Covers the background of autophagy, the development of tools and therapeutics to measure and modulate autophagy, and autophagy in tissues and disease processes

Ross & Wilson Anatomy and Physiology in Health and Illness E-Book

Author : Anne Waugh
Publisher : Elsevier Health Sciences
ISBN 13 : 0702072842
Total Pages : 584 pages
Book Rating : 4.7/5 (2 download)

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Book Synopsis Ross & Wilson Anatomy and Physiology in Health and Illness E-Book by : Anne Waugh

Download or read book Ross & Wilson Anatomy and Physiology in Health and Illness E-Book written by Anne Waugh and published by Elsevier Health Sciences. This book was released on 2018-07-12 with total page 584 pages. Available in PDF, EPUB and Kindle. Book excerpt: The new edition of the hugely successful Ross and Wilson Anatomy & Physiology in Health and Illness continues to bring its readers the core essentials of human biology presented in a clear and straightforward manner. Fully updated throughout, the book now comes with enhanced learning features including helpful revision questions and an all new art programme to help make learning even easier. The 13th edition retains its popular website, which contains a wide range of ‘critical thinking’ exercises as well as new animations, an audio-glossary, the unique Body Spectrum© online colouring and self-test program, and helpful weblinks. Ross and Wilson Anatomy & Physiology in Health and Illness will be of particular help to readers new to the subject area, those returning to study after a period of absence, and for anyone whose first language isn’t English. Latest edition of the world’s most popular textbook on basic human anatomy and physiology with over 1.5 million copies sold worldwide Clear, no nonsense writing style helps make learning easy Accompanying website contains animations, audio-glossary, case studies and other self-assessment material, the unique Body Spectrum© online colouring and self-test software, and helpful weblinks Includes basic pathology and pathophysiology of important diseases and disorders Contains helpful learning features such as Learning Outcomes boxes, colour coding and design icons together with a stunning illustration and photography collection Contains clear explanations of common prefixes, suffixes and roots, with helpful examples from the text, plus a glossary and an appendix of normal biological values. Particularly valuable for students who are completely new to the subject, or returning to study after a period of absence, and for anyone whose first language is not English All new illustration programme brings the book right up-to-date for today’s student Helpful ‘Spot Check’ questions at the end of each topic to monitor progress Fully updated throughout with the latest information on common and/or life threatening diseases and disorders Review and Revise end-of-chapter exercises assist with reader understanding and recall Over 150 animations – many of them newly created – help clarify underlying scientific and physiological principles and make learning fun

Mitochondrial Function in Lung Health and Disease

Author : Viswanathan Natarajan
Publisher : Springer
ISBN 13 : 1493908294
Total Pages : 230 pages
Book Rating : 4.4/5 (939 download)

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Book Synopsis Mitochondrial Function in Lung Health and Disease by : Viswanathan Natarajan

Download or read book Mitochondrial Function in Lung Health and Disease written by Viswanathan Natarajan and published by Springer. This book was released on 2014-07-26 with total page 230 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mitochondria, often referred to as the “powerhouses” of the cell, generate adenosine triphosphate (ATP) by oxidative phosphorylation or OXPHOS, and maintain cellular homeostasis. In addition to generating ATP, mitochondria are involved in regulation of cell cycle, proliferation, free radical production, innate immune responses and apoptosis. Mitochondrial Function in Lung Health and Disease fills the current gap in the literature and outlines the growing clinical relevance of mitochondrial dysfunction. Currently, there is no overview on the role of mitochondria in pulmonary diseases and this volume focuses on the mitochondrial metabolism, redox signaling, and mechanisms of mitochondrial pathways in lung injury, inflammation, repair and remodeling. Furthermore, in addition to their well-recognized role in cellular energy production and apoptosis, mitochondria appear to play a role in many respiratory diseases and lung cancer. Chapters are written by top notch researchers and clinicians and outline the evidence for mitochondrial biogenesis in inhalational lung injury, COPD and asthma.

Children and Environmental Toxins

Author : Philip J. Landrigan
Publisher : Oxford University Press
ISBN 13 : 0190662646
Total Pages : 241 pages
Book Rating : 4.1/5 (96 download)

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Book Synopsis Children and Environmental Toxins by : Philip J. Landrigan

Download or read book Children and Environmental Toxins written by Philip J. Landrigan and published by Oxford University Press. This book was released on 2018 with total page 241 pages. Available in PDF, EPUB and Kindle. Book excerpt: More than 80,000 new chemicals have been developed and released into the global environment during the last four decades. Today the World Health Organization attributes more than one-third of all childhood deaths to environmental causes, and as rates of childhood disease skyrocket -- autism, asthma, ADHD, obesity, diabetes, and even birth defects -- it raises serious, difficult questions around how the chemical environment is impacting children's health. Children and Environmental Toxins: What Everyone Needs to Know(R) offers an accessible guide to understanding and identifying the potential sources of harm in a child's environment. Written by experts in pediatrics and environmental health and formatted in an easy to follow question-and-answer format, it offers parents, care providers, and activists a reliable introduction to a hotly debated topic. As the burdens of environmental toxins and disease continue to defy borders, this book provides a new benchmark to understanding the potential threats in our environment and food. No parent or care provider should be without it.

The Lives of a Cell

Author : Lewis Thomas
Publisher : Penguin
ISBN 13 : 1101667052
Total Pages : 162 pages
Book Rating : 4.1/5 (16 download)

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Book Synopsis The Lives of a Cell by : Lewis Thomas

Download or read book The Lives of a Cell written by Lewis Thomas and published by Penguin. This book was released on 1978-02-23 with total page 162 pages. Available in PDF, EPUB and Kindle. Book excerpt: Elegant, suggestive, and clarifying, Lewis Thomas's profoundly humane vision explores the world around us and examines the complex interdependence of all things. Extending beyond the usual limitations of biological science and into a vast and wondrous world of hidden relationships, this provocative book explores in personal, poetic essays to topics such as computers, germs, language, music, death, insects, and medicine. Lewis Thomas writes, "Once you have become permanently startled, as I am, by the realization that we are a social species, you tend to keep an eye out for the pieces of evidence that this is, by and large, good for us."

Manganese in Health and Disease

Author : Lucio G Costa
Publisher : Royal Society of Chemistry
ISBN 13 : 1782622381
Total Pages : 655 pages
Book Rating : 4.7/5 (826 download)

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Book Synopsis Manganese in Health and Disease by : Lucio G Costa

Download or read book Manganese in Health and Disease written by Lucio G Costa and published by Royal Society of Chemistry. This book was released on 2014-11-27 with total page 655 pages. Available in PDF, EPUB and Kindle. Book excerpt: Manganese in the diet is nutritionally essential for normal physiologic functioning. However, excessive exposure to manganese has been associated with developmental, neurodegenerative and other disorders. The book comprehensively covers the toxicology of manganese. Leading investigators provide perspectives from toxicology, neuroscience, nutrition, molecular biology and risk assessment disciplines and chapters cover the toxicokinetics, toxicodynamic interactions and health effects of manganese, as well as its potential role in neurodegenerative diseases. A large section devoted to health effects presents the latest research that associates manganese exposure to potential human diseases. Any scientists, health professional or regulator involved with metal exposure and toxicology should find this volume essential reading. Students and researchers in neurotoxicology will also find this book a useful reference.

Role of Physical Exercise in Preventing Disease and Improving the Quality of Life

Author : Vilberto Stocchi
Publisher : Springer Science & Business Media
ISBN 13 : 8847003768
Total Pages : 225 pages
Book Rating : 4.8/5 (47 download)

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Book Synopsis Role of Physical Exercise in Preventing Disease and Improving the Quality of Life by : Vilberto Stocchi

Download or read book Role of Physical Exercise in Preventing Disease and Improving the Quality of Life written by Vilberto Stocchi and published by Springer Science & Business Media. This book was released on 2007-10-10 with total page 225 pages. Available in PDF, EPUB and Kindle. Book excerpt: The aim of this volume is to underline that promoting physical activity is crucial to preventing illness and maintaining our health, thus leading to a reduction in healthcare costs. Over the last decade studies have shown that physical exercise plays an important role in maintaining an individual's psycho-physical balance. Physical activity therefore helps in tackling today's major health challenges, including diabetes, high blood pressure, and cardiorespiratory diseases.

The Biopsychosocial Model of Health and Disease

Author : Derek Bolton
Publisher : Springer
ISBN 13 : 3030118991
Total Pages : 149 pages
Book Rating : 4.0/5 (31 download)

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Book Synopsis The Biopsychosocial Model of Health and Disease by : Derek Bolton

Download or read book The Biopsychosocial Model of Health and Disease written by Derek Bolton and published by Springer. This book was released on 2019-03-28 with total page 149 pages. Available in PDF, EPUB and Kindle. Book excerpt: This open access book is a systematic update of the philosophical and scientific foundations of the biopsychosocial model of health, disease and healthcare. First proposed by George Engel 40 years ago, the Biopsychosocial Model is much cited in healthcare settings worldwide, but has been increasingly criticised for being vague, lacking in content, and in need of reworking in the light of recent developments. The book confronts the rapid changes to psychological science, neuroscience, healthcare, and philosophy that have occurred since the model was first proposed and addresses key issues such as the model’s scientific basis, clinical utility, and philosophical coherence. The authors conceptualise biology and the psychosocial as in the same ontological space, interlinked by systems of communication-based regulatory control which constitute a new kind of causation. These are distinguished from physical and chemical laws, most clearly because they can break down, thus providing the basis for difference between health and disease. This work offers an urgent update to the model’s scientific and philosophical foundations, providing a new and coherent account of causal interactions between the biological, the psychological and social.

The Myth of Normal

Author : Gabor Maté, MD
Publisher : Penguin
ISBN 13 : 059308389X
Total Pages : 560 pages
Book Rating : 4.5/5 (93 download)

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Book Synopsis The Myth of Normal by : Gabor Maté, MD

Download or read book The Myth of Normal written by Gabor Maté, MD and published by Penguin. This book was released on 2022-09-13 with total page 560 pages. Available in PDF, EPUB and Kindle. Book excerpt: The instant New York Times bestseller By the acclaimed author of In the Realm of Hungry Ghosts, a groundbreaking investigation into the causes of illness, a bracing critique of how our society breeds disease, and a pathway to health and healing. In this revolutionary book, renowned physician Gabor Maté eloquently dissects how in Western countries that pride themselves on their healthcare systems, chronic illness and general ill health are on the rise. Nearly 70 percent of Americans are on at least one prescription drug; more than half take two. In Canada, every fifth person has high blood pressure. In Europe, hypertension is diagnosed in more than 30 percent of the population. And everywhere, adolescent mental illness is on the rise. So what is really “normal” when it comes to health? Over four decades of clinical experience, Maté has come to recognize the prevailing understanding of “normal” as false, neglecting the roles that trauma and stress, and the pressures of modern-day living, exert on our bodies and our minds at the expense of good health. For all our expertise and technological sophistication, Western medicine often fails to treat the whole person, ignoring how today’s culture stresses the body, burdens the immune system, and undermines emotional balance. Now Maté brings his perspective to the great untangling of common myths about what makes us sick, connects the dots between the maladies of individuals and the declining soundness of society—and offers a compassionate guide for health and healing. Cowritten with his son Daniel, The Myth Of Normal is Maté’s most ambitious and urgent book yet.