Organelle Contact Sites

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Publisher : Springer
ISBN 13 : 9811045674
Total Pages : 254 pages
Book Rating : 4.8/5 (11 download)

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Book Synopsis Organelle Contact Sites by : Mitsuo Tagaya

Download or read book Organelle Contact Sites written by Mitsuo Tagaya and published by Springer. This book was released on 2017-08-16 with total page 254 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides the first comprehensive coverage of the quickly evolving research field of membrane contact sites (MCS). A total of 16 chapters explain their organization and role and unveil the significance of MCS for various diseases. MCS, the intracellular structures where organellar membranes come in close contact with one another, mediate the exchange of proteins, lipids, and ions. Via these functions, MCS are critical for the survival and the growth of the cell. Owing to that central role in the functioning of cells, MCS dysfunctions lead to important defects of human physiology, influence viral and bacterial infection, and cause disease such as inflammation, type II diabetes, neurodegenerative disorders, and cancer. To approach such a multifaceted topic, this volume assembles a series of chapters dealing with the full array of research about MCS and their respective roles for diseases. Most chapters also introduce the history and the state of the art of MCS research, which will initiate discussion points for the respective types of MCS for years to come. This work will appeal to all cell biologists as well as researchers on diseases that are impacted by MCS dysfunction. Additionally, it will stimulate graduate students and postdocs who will energize, drive, and develop the research field in the near future.

Molecular Biology of The Cell

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Publisher :
ISBN 13 : 9780815332183
Total Pages : 0 pages
Book Rating : 4.3/5 (321 download)

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Book Synopsis Molecular Biology of The Cell by : Bruce Alberts

Download or read book Molecular Biology of The Cell written by Bruce Alberts and published by . This book was released on 2002 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Mitochondria-endoplasmic Reticulum Contact Sites

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Publisher :
ISBN 13 :
Total Pages : 0 pages
Book Rating : 4.:/5 (135 download)

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Book Synopsis Mitochondria-endoplasmic Reticulum Contact Sites by : Jordan Luke Morris

Download or read book Mitochondria-endoplasmic Reticulum Contact Sites written by Jordan Luke Morris and published by . This book was released on 2021 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Mitochondria and Endoplasmic Reticulum Dysfunction in Parkinson’s Disease

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Publisher : Frontiers Media SA
ISBN 13 : 2889633349
Total Pages : 132 pages
Book Rating : 4.8/5 (896 download)

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Book Synopsis Mitochondria and Endoplasmic Reticulum Dysfunction in Parkinson’s Disease by : Sandeep Kumar Barodia

Download or read book Mitochondria and Endoplasmic Reticulum Dysfunction in Parkinson’s Disease written by Sandeep Kumar Barodia and published by Frontiers Media SA. This book was released on 2020-01-23 with total page 132 pages. Available in PDF, EPUB and Kindle. Book excerpt: Several pathogenic mechanisms are involved in the pathogenesis of Parkinson’s Disease (PD), a neurodegenerative disease characterized by the loss of substantial nigra (SN) dopamine (DA) neurons. Alterations in calcium (Ca2+) homeostasis, cellular proteostasis, axonal transport, mitochondrial function, and neuroinflammation are linked to PD. However, research involving inter-organelle communication and their significance as precise mechanisms underlying neuronal death in PD remain to be elucidated. Evidence showed that perturbations in the mitochondria-endoplasmic reticulum (ER) network play an important role in the pathogenesis of PD. Alterations in the mitochondria-ER interface have been reported in PARK2 knockout mice and patients harboring PARK2 mutations. Enhanced parkin levels maintain mitochondria-ER cross-talk and assure regulated Ca2+ transfer to sustain cell bioenergetics. Several familial PD-related proteins, including Parkin and PINK1, may lead to modifications in the mitochondria-ER signaling. Interestingly, mitochondria-ER tethering suppresses mitophagy and parkin/PINK1-dependent mechanism regulates the destruction of mitochondria-ER contact sites by catalyzing a rapid burst of Mfn2 phospho-ubiquitination to trigger p97-dependent disassembly of Mfn2 complexes from the outer mitochondrial membrane. Mitofusin-mediated ER stress elicited neurodegeneration in Pink1/Parkin models of PD. α-Synuclein, a presynaptic protein, can bind to the ER-mitochondria tethering protein vesicle-associated membrane protein-associated protein B (VAPB) to disrupt Ca2+ homeostasis and mitochondrial ATP production. It has been reported that ER stress and mitochondrial cell death pathways might mediate A53T mutant α-synuclein-induced toxicity. Mitochondria-ER signaling mechanism is poorly characterized in neurons and its association in neuronal pathophysiology remains uncertain. The presence of mitochondria-ER contacts in neurons, preferentially at synapses, suggests a potential role in regulating synaptic activity. Alterations in mitochondria-ER associations are expected to be potentially detrimental to neurons, especially to SN DA neurons. Compounds from an unbiased chemical screen reverse both ER-to-Golgi trafficking defects and associated mitochondrial dysfunction in different PD models. In addition, a dibenzoylmethane derivative protects DA neurons against ER stress. Thus, mitochondria-ER signaling may represent a possible upstream drug target as potential therapeutic strategy for PD. In this Research Topic, we bring together knowledge that emphasizes the importance of mitochondria-ER communication and its impact to further dissect the pathogenic mechanisms in PD.

The Inflammasomes

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Publisher : Springer Science & Business Media
ISBN 13 : 3034801483
Total Pages : 233 pages
Book Rating : 4.0/5 (348 download)

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Book Synopsis The Inflammasomes by : Isabelle Couillin

Download or read book The Inflammasomes written by Isabelle Couillin and published by Springer Science & Business Media. This book was released on 2011-07-02 with total page 233 pages. Available in PDF, EPUB and Kindle. Book excerpt: The inflammasome was first described in 2002 as a molecular complex activating proinflammatory caspases and therefore regulating the maturation and biological activities of cytokines such as IL-1 and IL-18. This finding was substantiated by the identification of several mutations in the cias1 gene, encoding the human NLRP3 protein, responsible for several autoinflammatory disorders such as the Muckle Wells syndrome. Since, the interest for this complex has constantly increased and several inflammasome complexes with different specificities have been described. These inflammasomes sense a wide variety of pathogens and danger signals and are key players in the inflammatory response. With the contributions of leading international experts in the field, this book provides an extensive overview of the current knowledge of inflammasome biology and their role in health and disease.

The Role of ER-mitochondria Contact Sites in the Regulation of Glucose Metabolism

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Publisher :
ISBN 13 :
Total Pages : 0 pages
Book Rating : 4.:/5 (137 download)

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Book Synopsis The Role of ER-mitochondria Contact Sites in the Regulation of Glucose Metabolism by : Kirstin Arianna Tamucci

Download or read book The Role of ER-mitochondria Contact Sites in the Regulation of Glucose Metabolism written by Kirstin Arianna Tamucci and published by . This book was released on 2023 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: The mechanisms by which mitochondria convert nutrients into cellular energy have been described in intricate detail, and yet, the regulation and compartmentalization of such metabolic pathways are poorly understood. As a result, the underlying causes of mitochondrial dysfunction and bioenergetic deficiency in diseases such as amyotrophic lateral sclerosis (ALS) remain elusive. To address this longstanding gap in the field, we first sought to understand how the metabolism of glucose and glucose-derived pyruvate are regulated in the cell. Previous research has suggested that this metabolic regulation is mediated by specialized lipid raft domains of the endoplasmic reticulum (ER) in close contact with mitochondria, referred to as mitochondria-associated ER membranes (MAM). Using density gradient ultracentrifugation and immunoblotting techniques, we found that MAM domains play a role in the compartmentalization of glycolysis by recruiting and promoting the interaction of specific glycolytic enzymes.

Cell Biology by the Numbers

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Publisher : Garland Science
ISBN 13 : 1317230698
Total Pages : 400 pages
Book Rating : 4.3/5 (172 download)

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Book Synopsis Cell Biology by the Numbers by : Ron Milo

Download or read book Cell Biology by the Numbers written by Ron Milo and published by Garland Science. This book was released on 2015-12-07 with total page 400 pages. Available in PDF, EPUB and Kindle. Book excerpt: A Top 25 CHOICE 2016 Title, and recipient of the CHOICE Outstanding Academic Title (OAT) Award. How much energy is released in ATP hydrolysis? How many mRNAs are in a cell? How genetically similar are two random people? What is faster, transcription or translation?Cell Biology by the Numbers explores these questions and dozens of others provid

The Liver

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Publisher : John Wiley & Sons
ISBN 13 : 1119436826
Total Pages : 1156 pages
Book Rating : 4.1/5 (194 download)

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Book Synopsis The Liver by : Irwin M. Arias

Download or read book The Liver written by Irwin M. Arias and published by John Wiley & Sons. This book was released on 2020-03-09 with total page 1156 pages. Available in PDF, EPUB and Kindle. Book excerpt: Bridging the gap between basic scientific advances and the understanding of liver disease — the extensively revised new edition of the premier text in the field. The latest edition of The Liver: Biology and Pathobiology remains a definitive volume in the field of hepatology, relating advances in biomedical sciences and engineering to understanding of liver structure, function, and disease pathology and treatment. Contributions from leading researchers examine the cell biology of the liver, the pathobiology of liver disease, the liver’s growth, regeneration, metabolic functions, and more. Now in its sixth edition, this classic text has been exhaustively revised to reflect new discoveries in biology and their influence on diagnosing, managing, and preventing liver disease. Seventy new chapters — including substantial original sections on liver cancer and groundbreaking advances that will have significant impact on hepatology — provide comprehensive, fully up-to-date coverage of both the current state and future direction of hepatology. Topics include liver RNA structure and function, gene editing, single-cell and single-molecule genomic analyses, the molecular biology of hepatitis, drug interactions and engineered drug design, and liver disease mechanisms and therapies. Edited by globally-recognized experts in the field, this authoritative volume: Relates molecular physiology to understanding disease pathology and treatment Links the science and pathology of the liver to practical clinical applications Features 16 new “Horizons” chapters that explore new and emerging science and technology Includes plentiful full-color illustrations and figures The Liver: Biology and Pathobiology, Sixth Edition is an indispensable resource for practicing and trainee hepatologists, gastroenterologists, hepatobiliary and liver transplant surgeons, and researchers and scientists in areas including hepatology, cell and molecular biology, virology, and drug metabolism.

Correlative Light and Electron MIcroscopy

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Publisher : Academic Press
ISBN 13 : 0124160263
Total Pages : 466 pages
Book Rating : 4.1/5 (241 download)

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Book Synopsis Correlative Light and Electron MIcroscopy by : Thomas Muller-Reichert

Download or read book Correlative Light and Electron MIcroscopy written by Thomas Muller-Reichert and published by Academic Press. This book was released on 2012-08-10 with total page 466 pages. Available in PDF, EPUB and Kindle. Book excerpt: The combination of electron microscopy with transmitted light microscopy (termed correlative light and electron microscopy; CLEM) has been employed for decades to generate molecular identification that can be visualized by a dark, electron-dense precipitate. This new volume of Methods in Cell Biology covers many areas of CLEM, including a brief history and overview on CLEM methods, imaging of intermediate stages of meiotic spindle assembly in C. elegans embryos using CLEM, and capturing endocytic segregation events with HPF-CLEM. Covers many areas of CLEM by the best international scientists in the field Includes a brief history and overview on CLEM methods

Mechanisms of Regulation of Mitochondria-endoplasmic Reticulum Contact Sites

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Publisher :
ISBN 13 :
Total Pages : 0 pages
Book Rating : 4.:/5 (116 download)

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Book Synopsis Mechanisms of Regulation of Mitochondria-endoplasmic Reticulum Contact Sites by : Renata Lopes Familiar Couto

Download or read book Mechanisms of Regulation of Mitochondria-endoplasmic Reticulum Contact Sites written by Renata Lopes Familiar Couto and published by . This book was released on 2019 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: In eukaryotic cells, inter-organelle communication is crucial for several cellular functions, as well as for several cell signaling mechanisms. Mitochondria and the endoplasmic reticulum (ER), for example, form tight contact sites that are implicated in many aspects of cell physiology, and whose disruption has been associated with pathology, particularly neurodegenerative diseases. Although the contacts between these organelles are one of the most studied and most stable, the basic understanding of their regulation, as well as the communication of these two organelles via signaling pathways ...

Scanning Electron Microscopy for the Life Sciences

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Publisher : Cambridge University Press
ISBN 13 : 0521195993
Total Pages : 275 pages
Book Rating : 4.5/5 (211 download)

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Book Synopsis Scanning Electron Microscopy for the Life Sciences by : Heide Schatten

Download or read book Scanning Electron Microscopy for the Life Sciences written by Heide Schatten and published by Cambridge University Press. This book was released on 2013 with total page 275 pages. Available in PDF, EPUB and Kindle. Book excerpt: A guide to modern scanning electron microscopy instrumentation, methodology and techniques, highlighting novel applications to cell and molecular biology.

Regulation of Endoplasmic Reticulum and Mitochondria in Cellular Homeostasis

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Publisher : Frontiers Media SA
ISBN 13 : 2832501893
Total Pages : 183 pages
Book Rating : 4.8/5 (325 download)

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Book Synopsis Regulation of Endoplasmic Reticulum and Mitochondria in Cellular Homeostasis by : Yongye Huang

Download or read book Regulation of Endoplasmic Reticulum and Mitochondria in Cellular Homeostasis written by Yongye Huang and published by Frontiers Media SA. This book was released on 2022-10-07 with total page 183 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Store-Operated Calcium Channels

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Publisher : Academic Press
ISBN 13 : 0124079385
Total Pages : 307 pages
Book Rating : 4.1/5 (24 download)

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Book Synopsis Store-Operated Calcium Channels by :

Download or read book Store-Operated Calcium Channels written by and published by Academic Press. This book was released on 2013-07-24 with total page 307 pages. Available in PDF, EPUB and Kindle. Book excerpt: Store-operated calcium channels are found in most animal cells and regulate many cellular functions including cell division, growth, differentiation, and cell death. This volume provides a concise and informative overview of the principles of store-operated calcium entry and the key developments in the field from researchers who have led these advances. The overall goal of the volume is to provide interested students and investigators with sufficient information to enable a broad understanding of the progress and current excitement in the field. The volume contains a wealth of information that even experienced investigators in the field will find useful. The volume provides a comprehensive overview of the mechanisms and functions of store-operated calcium channels Contributors are authoritative researchers who have produced important advances in the field The volume is well-illustrated with cartoons and data to facilitate easy comprehension of the subject

Live Cell Proximity Biotinylation Enables Proteomic Analysis of Mitochondria-endoplasmic Reticulum Contact Sites

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Publisher :
ISBN 13 :
Total Pages : 128 pages
Book Rating : 4.:/5 (959 download)

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Book Synopsis Live Cell Proximity Biotinylation Enables Proteomic Analysis of Mitochondria-endoplasmic Reticulum Contact Sites by : Victoria Hung

Download or read book Live Cell Proximity Biotinylation Enables Proteomic Analysis of Mitochondria-endoplasmic Reticulum Contact Sites written by Victoria Hung and published by . This book was released on 2016 with total page 128 pages. Available in PDF, EPUB and Kindle. Book excerpt: The cell is able to carry out an astounding number of biological functions in part due to its ability to compartmentalize chemical reactions to different cellular regions and organelles. In order to understand the biological pathways that occur in a specific cellular region, one needs to know the identity of the protein players and how they behave spatially and temporally in the context of a living cell. Obtaining complete protein inventories is a recurring challenge in cell biology, and although mass spectrometry-based proteomics has made great strides in cataloging all proteins, traditional protocols are limited because they rely on a purification of the cellular entity of interest. This purification step is imperfect, and furthermore, many cellular regions cannot be purified. Prior work in the Ting lab developed a methodology to bypass organelle and complex purification by using an engineered ascorbate peroxidase (APEX) to tag proximal endogenous proteins with biotin for subsequent purification and identification by mass spectrometry. Although this method worked well in membrane-enclosed compartments, it was insufficiently specific when applied to unbounded or partially bounded regions such as the mitochondrial intermembrane space. This thesis presents a ratiometric tagging strategy that can achieve high spatial specificity in unbounded cellular regions. We use this strategy to map the proteomes of mitochondrial subcompartments to understand how the mitochondrion communicates with the rest of the cell, and in particular, with the endoplasmic reticulum. These proteomes led to the identification of a protein that may be a component of a tethering complex between mitochondria and the endoplasmic reticulum.

Mitochondrial Communication in Physiology, Disease and Aging

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Publisher : Frontiers Media SA
ISBN 13 : 2889459632
Total Pages : 135 pages
Book Rating : 4.8/5 (894 download)

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Book Synopsis Mitochondrial Communication in Physiology, Disease and Aging by : Nuno Raimundo

Download or read book Mitochondrial Communication in Physiology, Disease and Aging written by Nuno Raimundo and published by Frontiers Media SA. This book was released on 2019-08-20 with total page 135 pages. Available in PDF, EPUB and Kindle. Book excerpt: This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.

Endoplasmic Reticulum Stress in Health and Disease

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Publisher : Springer Science & Business Media
ISBN 13 : 9400743513
Total Pages : 448 pages
Book Rating : 4.4/5 (7 download)

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Book Synopsis Endoplasmic Reticulum Stress in Health and Disease by : Patrizia Agostinis

Download or read book Endoplasmic Reticulum Stress in Health and Disease written by Patrizia Agostinis and published by Springer Science & Business Media. This book was released on 2012-08-13 with total page 448 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Endoplasmic Reticulum (ER) is an organelle with extraordinary signaling and homeostatic functions. It is the organelle responsible for protein folding, maturation, quality control and trafficking of proteins destined for the plasma membrane or for secretion into the extracellular environment. Failure, overloading or malfunctioning of any of the signaling or quality control mechanisms occurring in the ER may provoke a stress condition known as ‘ER stress’. Accumulating evidence indicates that ER stress may dramatically perturb interactions between the cell and its environment, and contribute to the development of human diseases, ranging from metabolic diseases and cancer to neurodegenerative diseases, or impact therapeutic outcome. This book primarily focuses on the pathophysiology of ER stress. It introduces the molecular bases of ER stress, the emerging relevance of the ER-mitochondria cross-talk, the signaling pathways engaged and cellular responses to ER stress, including the adaptive Unfolded Protein Response (UPR), autophagy as well as cell death. Next the book addresses the role of ER stress in physiology and in the etiology of relevant pathological conditions, like carcinogenesis and inflammation, neurodegeneration and metabolic disease. The last chapter describes how ER stress pathways can be targeted for therapeutic benefit. Altogether, this book will provide the reader with an exhaustive view of ER stress biology and the latest insights in the role of ER stress in relevant human diseases.

Mitochondria and Cell Death

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Publisher :
ISBN 13 :
Total Pages : 248 pages
Book Rating : 4.4/5 (91 download)

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Book Synopsis Mitochondria and Cell Death by : Guy C. Brown

Download or read book Mitochondria and Cell Death written by Guy C. Brown and published by . This book was released on 1999 with total page 248 pages. Available in PDF, EPUB and Kindle. Book excerpt: