Some Antiviral and Antineoplastic Drugs, and Other Pharmaceutical Agents

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Publisher : World Health Organization
ISBN 13 :
Total Pages : 536 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Some Antiviral and Antineoplastic Drugs, and Other Pharmaceutical Agents by : IARC Working Group on the Evaluation of Carcinogenic Risks to Humans

Download or read book Some Antiviral and Antineoplastic Drugs, and Other Pharmaceutical Agents written by IARC Working Group on the Evaluation of Carcinogenic Risks to Humans and published by World Health Organization. This book was released on 2000 with total page 536 pages. Available in PDF, EPUB and Kindle. Book excerpt: Evaluates the carcinogenic risks to humans posed by the use of four antiretroviral agents four DNA topoisomerase II inhibitors used in the treatment of cancer and an additional three pharmaceutical agents (hydroxyures phenolphthalein and vitamin K substances). The volume marks the first IARC evaluation of nucleoside analogs that act as antiviral agents. The evaluation responds in part to recent findings that zidovudine (AZT) an effective antiretroviral agent now being given to pregnant HIV-infected women to prevent maternal-to-fetal transmission of the virus is a transplacental carcinogen in mice. The opening monograph evaluates the carcinogenicity to humans of the antiretroviral nucleoside analogs zidovudine (AZT) zalcitabine (ddC) and didanosine (ddI) and the antiherpesvirus drug aciclovir. Of these aciclovir and didanosine could not be classified on the basis of available data. For zidovudine transplacental administration to mice resulted in an increased incidence and multiplicity of lung and liver tumours and in an increased incidence of female reproductive tract tumours in one study but not in another involving treatment at a lower dose. Despite observation of toxic effects in some studies of humans human carcinogenicity data were judged to provide inadequate evidence of carcinogenicity in humans. Zidovudine was classified as possibly carcinogenic to humans. Similar weaknesses in human carcinogenicity data for zalcitabine which consistently induces thymic lymphomas in mice resulted in its classification as possibly carcinogenic to humans. The second monograph evaluates four DNA topoisomerase II inhibitors: etoposide teniposide mitoxantrone and amsacrine. Of these etoposide - one of the most widely used and effective cytotoxic drugs in combination therapy - was classified as probably carcinogenic to humans and etoposide in combination with cisplatin and bleomycin was judged to be carcinogenic to humans. Teniposide was classified as probably carcinogenic to humans and mitoxantrone and amsacrine were classified as possibly carcinogenic to humans. Of the three pharmaceutical agents evaluated in the final monograph hydroxyurea which is widely used in cancer treatment and increasingly in combination with didanosine in HIV infection could not be classified. Phenolphthalein a widely used laxative now being withdrawn from the market in many countries because of toxicological concerns was classified as possibly carcinogenic. Vitamin K substances could not be classified on the basis of available evidence.

Closing the Gap in a Generation

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Publisher : World Health Organization
ISBN 13 : 9241563702
Total Pages : 257 pages
Book Rating : 4.2/5 (415 download)

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Book Synopsis Closing the Gap in a Generation by : WHO Commission on Social Determinants of Health

Download or read book Closing the Gap in a Generation written by WHO Commission on Social Determinants of Health and published by World Health Organization. This book was released on 2008 with total page 257 pages. Available in PDF, EPUB and Kindle. Book excerpt: Social justice is a matter of life and death. It affects the way people live, their consequent chance of illness, and their risk of premature death. We watch in wonder as life expectancy and good health continue to increase in parts of the world and in alarm as they fail to improve in others.

Compendium of Sanitation Systems and Technologies

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Publisher :
ISBN 13 : 9783906484570
Total Pages : 176 pages
Book Rating : 4.4/5 (845 download)

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Book Synopsis Compendium of Sanitation Systems and Technologies by : Elizabeth Tilley

Download or read book Compendium of Sanitation Systems and Technologies written by Elizabeth Tilley and published by . This book was released on 2014 with total page 176 pages. Available in PDF, EPUB and Kindle. Book excerpt:

State of World Aquaculture 2006

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Publisher : Food & Agriculture Org.
ISBN 13 : 9789251056318
Total Pages : 148 pages
Book Rating : 4.0/5 (563 download)

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Book Synopsis State of World Aquaculture 2006 by : Food and Agriculture Organization of the United Nations. Inland Water Resources and Aquaculture Service

Download or read book State of World Aquaculture 2006 written by Food and Agriculture Organization of the United Nations. Inland Water Resources and Aquaculture Service and published by Food & Agriculture Org.. This book was released on 2006 with total page 148 pages. Available in PDF, EPUB and Kindle. Book excerpt: Aquaculture is developing, expanding and intensifying in almost all regions of the world, except in sub-Saharan Africa. Although the sector appears to be capable of meeting the gap between future demand and supply for aquatic food, there are many constraints and challenges which must be addressed in order to at least maintain the present level of per capita consumption at the global level. Key issues are the need for enhanced enforcement of regulation and better governance of the sector, as well as greater producer participation in the decision-making and regulation process. This publication examines past trends in aquaculture development as well as the current global status, drawing on a number of national and regional reviews.

Terra 2008

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Publisher : Getty Publications
ISBN 13 : 1606060430
Total Pages : 438 pages
Book Rating : 4.6/5 (6 download)

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Book Synopsis Terra 2008 by : Leslie Rainer

Download or read book Terra 2008 written by Leslie Rainer and published by Getty Publications. This book was released on 2011-06-14 with total page 438 pages. Available in PDF, EPUB and Kindle. Book excerpt: Earthen architecture constitutes one of the most diverse forms of cultural heritage and one of the most challenging to preserve. It dates from all periods and is found on all continents but is particularly prevalent in Africa, where it has been a building tradition for centuries. Sites range from ancestral cities in Mali to the palaces of Abomey in Benin, from monuments and mosques in Iran and Buddhist temples on the Silk Road to Spanish missions in California. This volume's sixty-four papers address such themes as earthen architecture in Mali, the conservation of living sites, local knowledge systems and intangible aspects, seismic and other natural forces, the conservation and management of archaeological sites, research advances, and training.

Corpus

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Publisher : Fordham Univ Press
ISBN 13 : 0823229637
Total Pages : 311 pages
Book Rating : 4.8/5 (232 download)

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Book Synopsis Corpus by : Jean-Luc Nancy

Download or read book Corpus written by Jean-Luc Nancy and published by Fordham Univ Press. This book was released on 2009-08-25 with total page 311 pages. Available in PDF, EPUB and Kindle. Book excerpt: How have we thought “the body”? How can we think it anew? The body of mortal creatures, the body politic, the body of letters and of laws, the “mystical body of Christ”—all these (and others) are incorporated in the word Corpus, the title and topic of Jean-Luc Nancy’s masterwork. Corpus is a work of literary force at once phenomenological, sociological, theological, and philosophical in its multiple orientations and approaches. In thirty-six brief sections, Nancy offers us at once an encyclopedia and a polemical program—reviewing classical takes on the “corpus” from Plato, Aristotle, and Saint Paul to Descartes, Hegel, Husserl, and Freud, while demonstrating that the mutations (technological, biological, and political) of our own culture have given rise to the need for a new understanding of the body. He not only tells the story of this cultural change but also explores the promise and responsibilities that such a new understanding entails. The long-awaited English translation is a bold, bravura rendering. To the title essay are added five closely related recent pieces—including a commentary by Antonia Birnbaum—dedicated in large part to the legacy of the “mind-body problem” formulated by Descartes and the challenge it poses to rethinking the ancient problems of the corpus. The last and most poignant of these essays is “The Intruder,” Nancy’s philosophical meditation on his heart transplant. The book also serves as the opening move in Nancy’s larger project called “The deconstruction of Christianity.”

Knowing our lands and resources

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Publisher : UNESCO Publishing
ISBN 13 : 9231002104
Total Pages : 150 pages
Book Rating : 4.2/5 (31 download)

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Book Synopsis Knowing our lands and resources by : Roué, Marie

Download or read book Knowing our lands and resources written by Roué, Marie and published by UNESCO Publishing. This book was released on 2017-04-03 with total page 150 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Economic Fallacies

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Publisher : Simon Publications
ISBN 13 : 9781931541022
Total Pages : 0 pages
Book Rating : 4.5/5 (41 download)

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Book Synopsis Economic Fallacies by : Frederic Bastiat

Download or read book Economic Fallacies written by Frederic Bastiat and published by Simon Publications. This book was released on 2001-08-16 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book, written by the celebrated nineteenth century French economist propagating free trade, reads as it was written yesterday.

Disaster risk reduction in school curricula: case studies from thirty countries

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Author :
Publisher : UNESCO
ISBN 13 : 9230010871
Total Pages : 209 pages
Book Rating : 4.2/5 (3 download)

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Book Synopsis Disaster risk reduction in school curricula: case studies from thirty countries by :

Download or read book Disaster risk reduction in school curricula: case studies from thirty countries written by and published by UNESCO. This book was released on 2012 with total page 209 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Health System Performance Comparison: an Agenda for Policy, Information and Research

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Publisher : McGraw-Hill Education (UK)
ISBN 13 : 033524727X
Total Pages : 418 pages
Book Rating : 4.3/5 (352 download)

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Book Synopsis Health System Performance Comparison: an Agenda for Policy, Information and Research by : Irene Papanicolas

Download or read book Health System Performance Comparison: an Agenda for Policy, Information and Research written by Irene Papanicolas and published by McGraw-Hill Education (UK). This book was released on 2013-06-16 with total page 418 pages. Available in PDF, EPUB and Kindle. Book excerpt: International comparison of health system performance has become increasingly popular, made possible by the rapidly expanding availability of health data. It has become one of the most important levers for prompting health system reform. Yet, as the demand for transparency and accountability in healthcare increases, so too does the need to compare data from different health systems both accurately and meaningfully. This timely and authoritative book offers an important summary of the current developments in health system performance comparison. It summarises the current state of efforts to compare systems, and identifies and explores the practical and conceptual challenges that occur. It discusses data and methodological challenges, as well as broader issues such as the interface between evidence and practice. The book draws out the priorities for future work on performance comparison, in the development of data sources and measurement instruments, analytic methodology, and assessment of evidence on performance. It concludes by presenting the key lessons and future priorities, and in doing so offers a rich source of material for policy-makers, their analytic advisors, international agencies, academics and students of health systems.

The Cambridge Handbook of Age and Ageing

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Publisher :
ISBN 13 :
Total Pages : 784 pages
Book Rating : 4.F/5 ( download)

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Book Synopsis The Cambridge Handbook of Age and Ageing by : Malcolm L. Johnson

Download or read book The Cambridge Handbook of Age and Ageing written by Malcolm L. Johnson and published by . This book was released on 2005-12 with total page 784 pages. Available in PDF, EPUB and Kindle. Book excerpt: Publisher Description

Water & Heritage

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Publisher :
ISBN 13 : 9789088903861
Total Pages : 434 pages
Book Rating : 4.9/5 (38 download)

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Book Synopsis Water & Heritage by : Willem Willems

Download or read book Water & Heritage written by Willem Willems and published by . This book was released on 2017-01-15 with total page 434 pages. Available in PDF, EPUB and Kindle. Book excerpt: Water is vital for life, and its availability has been a concern for mankind throughout the ages. Its presence has always been ascertained in a variety of ways and the development of human society everywhere is connected with various forms of water management. Man also needed to manage water to find protection from its dangers and the need for that is increasing. In the coming decades, the impact of climate change is expected to intensify floods and droughts, affect groundwater resources, raise sea levels, increase pollution and enhance the frequency and magnitude of disasters. Societies around the world are challenged to adapt to these threats to ensure water security, economic prosperity and environmental and cultural sustainability. This book deals with the heritage of water management and the use that was made of water, as well as the impact of water management on heritage. An example of the former may be an ancient irrigation system in the Filipines or in the Middle East that still functions today, while the latter may reflect the importance of maintaining groundwater levels for the preservation of organic remains on archaeological sites or of wooden piles underneath standing buildings. In either case the papers in this book reflect the dynamic nature of water, and hence the equally dynamic relation between water management and heritage. This publication follows up on a Heritage and Water conference in Amsterdam, the first of its kind. Its main purpose is to credibly present the importance and value of heritage and historical experience for water and sustainable development, and vice versa, present the importance of water management for the protection of heritage. It presents evolving insights and concepts about Water and about Heritage from a variety of disciplines, policy and public perspectives illustrated with cases studies and aims to connect decision makers with experts such as engineers, archaeologists, historians, geographers, ecologist and landscape architects