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Micrornas And The Regulation Of Cellular Quiescence
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Book Synopsis Cellular Quiescence by : H. Daniel Lacorazza
Download or read book Cellular Quiescence written by H. Daniel Lacorazza and published by Humana Press. This book was released on 2017-10-18 with total page 303 pages. Available in PDF, EPUB and Kindle. Book excerpt: This detailed volume explores methods and protocols that aim to increase our understanding of how cells enter a quiescent state during homeostasis and how cells exit quiescence and re-enter differentiating cell divisions to restore damaged tissues, essential for developing new approaches in regenerative medicine in the future. The chapters in this book were designed to address cellular quiescence in prokaryote and eukaryote organisms, detection of quiescence (Hoechst/pyronin Y, FUCCI, CFSE, BrdU, H2B-GFP, CyTOF), quiescence in stem cells (skin, intestinal, neuronal, hematopoietic), genomic regulation (gene expression, transcription factors, lncRNA, RNA methylation), as well as analysis of the heterogeneity of quiescence by computer modeling. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Cellular Quiescence: Methods and Protocols offers a broad view of basic and cutting-edge technology to inspire research in this emerging field of cell biology.
Book Synopsis Hormones, Metabolism and the Benefits of Exercise by : Bruce Spiegelman
Download or read book Hormones, Metabolism and the Benefits of Exercise written by Bruce Spiegelman and published by Springer. This book was released on 2018-03-07 with total page 108 pages. Available in PDF, EPUB and Kindle. Book excerpt: The world is faced with an epidemic of metabolic diseases such as obesity and type 2 diabetes. This is due to changes in dietary habits and the decrease in physical activity. Exercise is usually part of the prescription, the first line of defense, to prevent or treat metabolic disorders. However, we are still learning how and why exercise provides metabolic benefits in human health. This open access volume focuses on the cellular and molecular pathways that link exercise, muscle biology, hormones and metabolism. This will include novel “myokines” that might act as new therapeutic agents in the future.
Book Synopsis MicroRNAs in Cancer by : Cesar Lopez-Camarillo
Download or read book MicroRNAs in Cancer written by Cesar Lopez-Camarillo and published by CRC Press. This book was released on 2013-02-22 with total page 426 pages. Available in PDF, EPUB and Kindle. Book excerpt: MicroRNA (miRNA) biology is a cutting-edge topic in basic as well as biomedical research. This is a specialized book focusing on the current understanding of the role of miRNAs in the development, progression, invasion, and metastasis of diverse types of cancer. It also reviews their potential for applications in cancer diagnosis, prognosis, and th
Book Synopsis Transcriptional and Translational Regulation of Stem Cells by : Gary Hime
Download or read book Transcriptional and Translational Regulation of Stem Cells written by Gary Hime and published by Springer Science & Business Media. This book was released on 2013-05-22 with total page 370 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume describes the latest findings on transcriptional and translational regulation of stem cells. Both transcriptional activators and repressors have been shown to be crucial for the maintenance of the stem cell state. A key element of stem cell maintenance is repression of differentiation factors or developmental genes – achieved transcriptionally, epigenetically by the Polycomb complex, and post-transcriptionally by RNA-binding proteins and microRNAs. This volume takes two approaches to this topic – (1) illustrating the general principles outlined above through a series of different stem cell examples – embryonic, iPS and adult stem cells, and (2) describing several molecular families that have been shown to have roles in regulation of multiple stem cell populations.
Book Synopsis Cell Cycle Regulation by : Philipp Kaldis
Download or read book Cell Cycle Regulation written by Philipp Kaldis and published by Results and Problems in Cell Differentiation. This book was released on 2006-06-26 with total page 400 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is a state-of-the-art summary of the latest achievements in cell cycle control research with an outlook on the effect of these findings on cancer research. The chapters are written by internationally leading experts in the field. They provide an updated view on how the cell cycle is regulated in vivo, and about the involvement of cell cycle regulators in cancer.
Book Synopsis Regulation of microRNAs by : Helge Großhans
Download or read book Regulation of microRNAs written by Helge Großhans and published by Springer. This book was released on 2011-08-25 with total page 160 pages. Available in PDF, EPUB and Kindle. Book excerpt: Given this pervasiveness and importance of miRNA-mediated gene regulation, it should come as little surprise that miRNAs themselves are also highly regulated. However, the recent explosion of knowledge on this topic has been remarkable, providing a primary motivation for publication of this book. As miRNAs are transcribed by RNA polymerase II, the enzyme that also generates mRNAs, it was perhaps not unexpected that miRNA transcription would be subject to regulation, and we have willfully mitted this aspect from this monograph. However, what has been unexpected is the extent of post-transcriptional regulation of miRNAs that is illustrated in this book.
Book Synopsis Insect Diapause by : David L. Denlinger
Download or read book Insect Diapause written by David L. Denlinger and published by Cambridge University Press. This book was released on 2022-02-03 with total page 465 pages. Available in PDF, EPUB and Kindle. Book excerpt: Our highly seasonal world restricts insect activity to brief portions of the year. This feature necessitates a sophisticated interpretation of seasonal changes and enactment of mechanisms for bringing development to a halt and then reinitiating it when the inimical season is past. The dormant state of diapause serves to bridge the unfavourable seasons, and its timing provides a powerful mechanism for synchronizing insect development. This book explores how seasonal signals are monitored and used by insects to enact specific molecular pathways that generate the diapause phenotype. The broad perspective offered here scales from the ecological to the molecular and thus provides a comprehensive view of this exciting and vibrant research field, offering insights on topics ranging from pest management, evolution, speciation, climate change and disease transmission, to human health, as well as analogies with other forms of invertebrate dormancy and mammalian hibernation.
Book Synopsis The Cell Biology of Stem Cells by : Eran Meshorer
Download or read book The Cell Biology of Stem Cells written by Eran Meshorer and published by Springer Science & Business Media. This book was released on 2011-01-11 with total page 246 pages. Available in PDF, EPUB and Kindle. Book excerpt: Stem cells have been gaining a lot of attention in recent years. Their unique potential to self-renew and differentiate has turned them into an attractive model for the study of basic biological questions such as cell division, replication, transcription, cell fate decisions, and more. With embryonic stem (ES) cells that can generate each cell type in the mammalian body and adult stem cells that are able to give rise to the cells within a given lineage, basic questions at different developmental stages can be addressed. Importantly, both adult and embryonic stem cells provide an excellent tool for cell therapy, making stem cell research ever more pertinent to regenerative medicine. As the title The Cell Biology of Stem Cells suggests, our book deals with multiple aspects of stem cell biology, ranging from their basic molecular characteristics to the in vivo stem cell trafficking of adult stem cells and the adult stem-cell niche, and ends with a visit to regeneration and cell fate reprogramming. In the first chapter, “Early embryonic cell fate decisions in the mouse”, Amy Ralson and Yojiro Yamanaka describe the mechanisms that support early developmental decisions in the mouse pre-implantation embryo and the current understanding of the source of the most immature stem cell types, which includes ES cells, trophoblast stem (TS) cells and extraembryonic endoderm stem (XEN) cells.
Book Synopsis Cell Engineering and Regeneration by : Heinz Redl
Download or read book Cell Engineering and Regeneration written by Heinz Redl and published by Springer. This book was released on 2017-02-16 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This reference work presents the origins of cells for tissue engineering and regeneration, including primary cells, tissue-specific stem cells, pluripotent stem cells and trans-differentiated or reprogrammed cells. There is particular emphasis on current understanding of tissue regeneration based on embryology and evolution studies, including mechanisms of amphibian regeneration. The book covers the use of autologous versus allogeneic cell sources, as well as various procedures used for cell isolation and cell pre-conditioning , such as cell sorting, biochemical and biophysical pre-conditioning, transfection and aggregation. It also presents cell modulation using growth factors, molecular factors, epigenetic approaches, changes in biophysical environment, cellular co-culture and other elements of the cellular microenvironment. The pathways of cell delivery are discussed with respect to specific clinical situations, including delivery of ex vivo manipulated cells via local and systemic routes, as well as activation and migration of endogenous reservoirs of reparative cells. The volume concludes with an in-depth discussion of the tracking of cells in vivo and their various regenerative activities inside the body, including differentiation, new tissue formation and actions on other cells by direct cell-to-cell communication and by secretion of biomolecules.
Download or read book Plant microRNAs written by Célia Miguel and published by Springer Nature. This book was released on 2020-02-01 with total page 254 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book summarizes the latest findings on the functions of microRNAs in the regulation of plant development and responses to the surrounding environment. MicroRNAs are an important class of molecules that can be found in diverse groups of organisms, including plants and animals, and the investigation of their roles is a highly dynamic and “hot” research topic. The respective chapters address four main aspects, namely: microRNA investigation and annotation, the regulatory roles of microRNAs in various developmental processes, in response to abiotic factors, and in the context of biotic stress response regulation. Systematically reviewing the most important findings in this field, the book offers an essential guide for undergraduate and graduate students, teachers, and plant science researchers. Due to the potential applications of microRNAs in crop breeding and plant protection, it also represents a valuable resource for scientists in academia and the private sector alike.
Book Synopsis Photosynthesis, Productivity, and Environmental Stress by : Parvaiz Ahmad
Download or read book Photosynthesis, Productivity, and Environmental Stress written by Parvaiz Ahmad and published by John Wiley & Sons. This book was released on 2019-11-04 with total page 365 pages. Available in PDF, EPUB and Kindle. Book excerpt: A guide to environmental fluctuations that examines photosynthesis under both controlled and stressed conditions Photosynthesis, Productivity and Environmental Stress is a much-needed guide that explores the topics related to photosynthesis (both terrestrial and aquatic) and puts the focus on the basic effect of environmental fluctuations. The authors—noted experts on the topic—discuss photosynthesis under both controlled and stressed conditions and review new techniques for mitigating stressors including methods such as transgeneics, proteomics, genomics, ionomics, metabolomics, micromics, and more. In order to feed our burgeoning world population, it is vital that we must increase food production. Photosynthesis is directly related to plant growth and crop production and any fluctuation in the photosynthetic activity imposes great threat to crop productivity. Due to the environmental fluctuations plants are often exposed to the different environmental stresses that cause decreased photosynthetic rate and problems in the plant growth and development. This important book addresses this topic and: Covers topics related to terrestrial and aquatic photosynthesis Highlights the basic effect of environmental fluctuations Explores common stressors such as drought, salinity, alkalinity, temperature, UV-radiations, oxygen deficiency, and more Contains methods and techniques for improving photosynthetic efficiency for greater crop yield Written for biologists and environmentalists, Photosynthesis, Productivity and Environmental Stress offers an overview of the stressors affecting photosynthesis and includes possible solutions for improved crop production.
Book Synopsis Novel Gene Therapy Approaches by : Ming Wei
Download or read book Novel Gene Therapy Approaches written by Ming Wei and published by BoD – Books on Demand. This book was released on 2013-02-13 with total page 408 pages. Available in PDF, EPUB and Kindle. Book excerpt: Gene therapy has the potential to be a tailor-made therapeutic with increased specificity and decreased side effects that can offer a "cure" for many disorders. The aim of this book is to provide up-to-date reviews of the rapidly growing field of gene therapy. Chapters cover a large range of topics including methods of gene delivery, and identification of targets with several papers on cancer gene therapy. If more people become aware of the true nature and potential of gene therapy, perhaps we can achieve the full benefit of such an innovative approach for the treatment of a range of diseases, including cancer.
Book Synopsis MicroRNA Cancer Regulation by : Ulf Schmitz
Download or read book MicroRNA Cancer Regulation written by Ulf Schmitz and published by Springer Science & Business Media. This book was released on 2013-02-03 with total page 352 pages. Available in PDF, EPUB and Kindle. Book excerpt: This edited reflects the current state of knowledge about the role of microRNAs in the formation and progression of solid tumours. The main focus lies on computational methods and applications, together with cutting edge experimental techniques that are used to approach all aspects of microRNA regulation in cancer. We are sure that the emergence of high-throughput quantitative techniques will make this integrative approach absolutely necessary in the near future. This book will be a resource for researchers starting out with cancer microRNA research, but is also intended for the experienced researcher who wants to incorporate concepts and tools from systems biology and bioinformatics into his work. Bioinformaticians and modellers are provided with a general perspective on microRNA biology in cancer, and the state-of-the-art in computational microRNA biology.
Book Synopsis Brain Neurotrauma by : Firas H. Kobeissy
Download or read book Brain Neurotrauma written by Firas H. Kobeissy and published by CRC Press. This book was released on 2015-02-25 with total page 718 pages. Available in PDF, EPUB and Kindle. Book excerpt: With the contribution from more than one hundred CNS neurotrauma experts, this book provides a comprehensive and up-to-date account on the latest developments in the area of neurotrauma including biomarker studies, experimental models, diagnostic methods, and neurotherapeutic intervention strategies in brain injury research. It discusses neurotrauma mechanisms, biomarker discovery, and neurocognitive and neurobehavioral deficits. Also included are medical interventions and recent neurotherapeutics used in the area of brain injury that have been translated to the area of rehabilitation research. In addition, a section is devoted to models of milder CNS injury, including sports injuries.
Book Synopsis CELL GEOMETRY. by : G. V. SHIVASHANKAR
Download or read book CELL GEOMETRY. written by G. V. SHIVASHANKAR and published by . This book was released on 2018 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Hematopoietic Differentiation of Human Pluripotent Stem Cells by : Tao Cheng
Download or read book Hematopoietic Differentiation of Human Pluripotent Stem Cells written by Tao Cheng and published by Springer. This book was released on 2015-08-25 with total page 131 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book features the most cutting-edge work from the world’s leading laboratories in this field and provides practical methods for differentiating pluripotent stem cells into hematopoietic lineages in the blood system. Pluripotent stem cells have attracted major interest from a fast-growing and multidisciplinary community of researchers who are developing new techniques for the derivation and differentiation of these cells into specific cell lineages. These direct differentiation methods hold great promise for the translational applications of these cells. This book is an essential reference work for researchers at all levels in the fields of hematology and stem cell biology, as well as clinical practitioners in regenerative medicine.
Download or read book HIV-1 Latency written by Guido Silvestri and published by Springer. This book was released on 2018-10-11 with total page 253 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume summarizes recent advances in understanding the mechanisms of HIV-1 latency, in characterizing residual viral reservoirs, and in developing targeted interventions to reduce HIV-1 persistence during antiretroviral therapy. Specific chapters address the molecular mechanisms that govern and regulate HIV-1 transcription and latency; assays and technical approaches to quantify viral reservoirs in humans and animal models; the complex interchange between viral reservoirs and the host immune system; computational strategies to model viral reservoir dynamics; and the development of therapeutic approaches that target viral reservoir cells. With contributions from an interdisciplinary group of investigators that cover a broad spectrum of subjects, from molecular virology to proof-of-principle clinical trials, this book is a valuable resource for basic scientists, translational investigators, infectious-disease physicians, individuals living with HIV/AIDS and the general public.
