Microbial Subversion Of Immunity

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Microbial Subversion of Immunity

Author : Peter Julius Lachmann
Publisher : Caister Academic Press Limited
ISBN 13 : 9781904455059
Total Pages : 0 pages
Book Rating : 4.4/5 (55 download)

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Book Synopsis Microbial Subversion of Immunity by : Peter Julius Lachmann

Download or read book Microbial Subversion of Immunity written by Peter Julius Lachmann and published by Caister Academic Press Limited. This book was released on 2006 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Microbes have evolved in an impressive and diverse range of strategies to subvert the host immune system. Two major types of strategies exist. The first is the evasion of recognition by the host, for example by using antigenic variation, masking of epitopes, the use of decoys, molecular mimicry, etc. The second is the modulation and/or suppression of the innate (e.g. complement, NK cells) and adaptive (e.g. antibodies) immune responses. A better understanding of the underlying mechanisms involved is critical for the rational design of novel therapeutic agents and vaccines to treat and/or prevent infectious diseases. Another area of active research is the application of microbial immunomodulatory factors in the treatment of human immunological disorders (e.g. inflammatory bowel disease and asthma) and as sources of pharmacologically active agents. In this book, internationally renown scientists critically review the current cutting-edge research in this area. Topics covered include the subversion of complement, NK cell function, mucosal innate immune response, evasion/subversion mechanisms used by bacteria, helminths, viruses, and the measles model system. Containing over 1,700 references, this book is an essential resource book for researchers in the fields of microbiology, immunology, pharmacology, and molecular medicine.

Janeway's Immunobiology

Author : Kenneth Murphy
Publisher : Garland Science
ISBN 13 : 9780815344575
Total Pages : pages
Book Rating : 4.3/5 (445 download)

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Book Synopsis Janeway's Immunobiology by : Kenneth Murphy

Download or read book Janeway's Immunobiology written by Kenneth Murphy and published by Garland Science. This book was released on 2010-06-22 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: The Janeway's Immunobiology CD-ROM, Immunobiology Interactive, is included with each book, and can be purchased separately. It contains animations and videos with voiceover narration, as well as the figures from the text for presentation purposes.

Bacterial Evasion of the Host Immune System

Author : Pedro Escoll
Publisher : Caister Academic Press Limited
ISBN 13 : 9781910190692
Total Pages : 0 pages
Book Rating : 4.1/5 (96 download)

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Book Synopsis Bacterial Evasion of the Host Immune System by : Pedro Escoll

Download or read book Bacterial Evasion of the Host Immune System written by Pedro Escoll and published by Caister Academic Press Limited. This book was released on 2017 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Expert international authors critically review the most important current research in bacterial evasion of the host immune response. Topics range from an overview of the seven most important bacterial secretion systems to a thorough review of evsaion by mycobacteria. Essential reading for everyone involved in bacterial pathogenesis research.

Pathogenesis of Bacterial Infections in Animals

Author : Carlton L. Gyles
Publisher : John Wiley & Sons
ISBN 13 : 0470344830
Total Pages : 456 pages
Book Rating : 4.4/5 (73 download)

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Book Synopsis Pathogenesis of Bacterial Infections in Animals by : Carlton L. Gyles

Download or read book Pathogenesis of Bacterial Infections in Animals written by Carlton L. Gyles and published by John Wiley & Sons. This book was released on 2008-02-28 with total page 456 pages. Available in PDF, EPUB and Kindle. Book excerpt: This much-anticipated third edition again consolidates the knowledge of more than twenty experts on pathogenesis of animal disease caused by various species or groups of bacteria. Emphasizing pathogenic events at the molecular and cellular levels, the editors and contributors place these developments in the context of the overall picture of disease. Pathogenesis of Bacterial Infections in Animals, Third edition, updates and expands the content of the second edition and includes cutting-edge information from the most current research. Comments on previous editions: "...highly recommended." --The Veterinary Record "...a comprehensive, complete and easy-to-use source of information." --Veterinary Microbiology "...recommended for graduate students and specialists in microbiology, pathology and infectious disease." --U.S. Animal Health Association Newsletter "...a wonderful book." --Journal of the American Veterinary Medical Association "...highly recommended." --The Cornell Veterinarian Graduate students, faculty, researchers, and specialists in microbiology, pathology, and infectious diseases will benefit from this highly-detailed and expanded edition of a popular and well-read veterinary text.

The Immune Response

Author : Tak W. Mak
Publisher : Academic Press
ISBN 13 : 0080534481
Total Pages : 1217 pages
Book Rating : 4.0/5 (85 download)

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Book Synopsis The Immune Response by : Tak W. Mak

Download or read book The Immune Response written by Tak W. Mak and published by Academic Press. This book was released on 2005-11-11 with total page 1217 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Immune Response is a unique reference work covering the basic and clinical principles of immunology in a modern and comprehensive fashion. Written in an engaging conversational style, the book conveys the broad scope and fascinating appeal of immunology. The book is beautifully illustrated with superb figures as well as many full color plates. This extraordinary work will be an invaluable resource for lecturers and graduate students in immunology, as well as a vital reference for research scientists and clinicians studying related areas in the life and medical sciences. - Current and thorough 30 chapter reference reviewed by luminaries in the field - Unique 'single voice' ensures consistency of definitions and concepts - Comprehensive and elegant illustrations bring key concepts to life - Provides historical context to allow fuller understanding of key issues - Introductory chapters 1-4 serve as an 'Immunology Primer' before topics are discussed in more detail

Cytosolic Bacterial Subversions of Mucosal Immunity

Author : Camille Rey
Publisher :
ISBN 13 :
Total Pages : 0 pages
Book Rating : 4.:/5 (115 download)

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Book Synopsis Cytosolic Bacterial Subversions of Mucosal Immunity by : Camille Rey

Download or read book Cytosolic Bacterial Subversions of Mucosal Immunity written by Camille Rey and published by . This book was released on 2018 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cytosolic bacterial pathogens S. flexneri and L. monocytogenes subvert extracellular mucosal immunity by inducing their uptake and intracellular lifestyle in the intestinal epithelium. Within the host, they are able to rapidly escape their internalization vacuole, invade the cytosol and escape cellular degradation by spreading from cell-to-cell. Antigen sampling M cells overlying immune induction sites are targeted by these pathogens to initiate intestinal invasion. However, the intracellular lifestyle of these pathogens within M cells, the mechanism of spread of the infection toneigh boring enterocytes from this entry point and the mechanism of S. flexneri evasion of adaptive immunity is poorly characterized. We present a novel physiologic model of apical S. flexneri infection of human in vitro M cells which recapitulates the early steps of epithelial invasion. We show that a subset of S. flexneri is rapidly transcytosed, within 15 minutes, through M cells. We establish a newtime-lapse imaging approach of M cell infections, which reveals that another subset of bacteriainduces apical ruffling upon entry, vacuolar rupture and replicates within the M cells at later timepoints. Remarkably, these bacteria are able to spread from M cells to neighboring cells by actinbased-motility, which we show constitutes the main route of basolateral spreading of the infection.As we extend our study to L. monocytogenes, we observe that unlike S. flexneri, the bacterium diverts M cell transcytosis via the virulence factor ActA. However, we discover that L. monocytogenes spreads within the epithelium exclusively by actin-based motility, similar to S. flexneri. We propose that subversion of M cell transcytosis and avoidance of underlying immune tissues are features shared by cytosolic pathogens, allowing their escape from induction of adaptive immunity.In addition, we submit a pipeline of fluorescence-based single cell sorting of enterocytes atsuccessive stages of infection combined with transcriptional analysis by multiplex qPCR. This methodreveals the production of distinct responses in host enterocytes according to subcellular pathogen localizations. We observe the production of a strong bystander response involving multiplecorrelated host pathways in non-infected enterocytes. Moreover, we detect the output of distinct host response patterns according to vacuolar or cytosolic bacterial localizations in infectedenterocytes. We further show that the virulence effector OspF contributes to dampen infected host responses and disrupt otherwise correlated host signaling pathways. To conclude, our studies expose new immune subversion strategies linked to the intracellular life styles of cytosolic enteric bacteria, highlighting the importance of M cells in initial bacterial dissemination and diversion of adaptive immunity, and the organization and disruption of innate immune responses provoked in enterocytes during infection.

Cell Signaling in Host–Pathogen Interactions: The Host Point of View

Author : Diana Bahia
Publisher : Frontiers Media SA
ISBN 13 : 288945455X
Total Pages : 414 pages
Book Rating : 4.8/5 (894 download)

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Book Synopsis Cell Signaling in Host–Pathogen Interactions: The Host Point of View by : Diana Bahia

Download or read book Cell Signaling in Host–Pathogen Interactions: The Host Point of View written by Diana Bahia and published by Frontiers Media SA. This book was released on 2018-03-23 with total page 414 pages. Available in PDF, EPUB and Kindle. Book excerpt: The ability of pathogens, such as parasites, bacteria, fungi and viruses to invade, persist and adapt in both invertebrate and vertebrate hosts is multifactorial and depends on both pathogen and host fitness. Communication between a pathogen and its host relies on a wide and dynamic array of molecular interactions. Through this constant communication most pathogens evolved to be relatively benign, whereas killing of its host by a pathogen represents a failure to adapt. Pathogens are lethal to their host when their interaction has not been long enough for adaptation. Evolution has selected conserved immune receptors that recognize signature patterns of pathogens as non-self elements and initiate host innate responses aimed at eradicating infection. Conversely, pathogens evolved mechanisms to evade immune recognition and subvert cytokine secretion in order to survive, replicate and cause disease. The cell signaling machinery is a critical component of the immune system that relays information from the receptors to the nucleus where transcription of key immune genes is activated. Host cells have developed signal transduction systems to maintain homeostasis with pathogens. Most cellular processes and cell signaling pathways are tightly regulated by protein phosphorylation in which protein kinases are key protagonists. Pathogens have developed multiple mechanisms to subvert important signal transduction pathways such as the mitogen activated protein kinase (MAPK) and the nuclear factor kB (NF-kB) pathways. Pathogens also secrete effectors that manipulate actin cytoskeleton and its regulators, hijack cell cycle machinery and alter vesicular trafficking. This research topic focuses on the cellular signaling mechanisms that are essential for host immunity and their subversion by pathogens.

Trained Immunity-based Vaccines

Author : Jose Luis Subiza
Publisher : Frontiers Media SA
ISBN 13 : 2889712311
Total Pages : 195 pages
Book Rating : 4.8/5 (897 download)

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Book Synopsis Trained Immunity-based Vaccines by : Jose Luis Subiza

Download or read book Trained Immunity-based Vaccines written by Jose Luis Subiza and published by Frontiers Media SA. This book was released on 2021-08-25 with total page 195 pages. Available in PDF, EPUB and Kindle. Book excerpt: Dr. Jose Luis Subiza is the founder and CEO of Inmunotek SL. The other Topic Editors declare no competing interests with regard to the Research Topic subject.

Pathogenesis of Bacterial Infections in Animals

Author : John F. Prescott
Publisher : John Wiley & Sons
ISBN 13 : 1119754852
Total Pages : 820 pages
Book Rating : 4.1/5 (197 download)

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Book Synopsis Pathogenesis of Bacterial Infections in Animals by : John F. Prescott

Download or read book Pathogenesis of Bacterial Infections in Animals written by John F. Prescott and published by John Wiley & Sons. This book was released on 2022-08-15 with total page 820 pages. Available in PDF, EPUB and Kindle. Book excerpt: PATHOGENESIS OF BACTERIAL INFECTIONS IN ANIMALS Comprehensive review of the major bacterial pathogens of animals, focusing on the current understanding of how they cause disease Pathogenesis of Bacterial Infections in Animals, Fifth Edition is a specialist reference that provides a comprehensive review of bacterial pathogens in animals and their complex interplay with disease processes, offering a complete understanding of how bacteria cause disease in animals. It covers the many recent advances in the field including the newest taxonomies. In this revised and long anticipated fifth edition, additional introductory chapters have been added to set the material in context, and more figures added to integrate and improve understanding and comprehension throughout the text. A companion website presents the figures from the book in PowerPoint and references. This detailed reference includes novel approaches to controlling bacterial pathogens in the light of growing concerns about antimicrobial resistance, with more than 70 expert authors sharing their wisdom on the topic. While molecular pathogenesis is a major aspect in almost every chapter, the authors have been careful to place pathogens in their broader context. Pathogenesis of Bacterial Infections in Animals, Fifth Edition also contains information on: Themes in bacterial pathogenesis, covering the basic elements of pathogenesis, concepts of virulence, host-pathogen interactions and communication, and pathogenesis in the post-genomic era Evolution of bacterial pathogens, covering what they are and how they emerge, along with sources of genetic diversity, population structure, and genome plasticity Understanding of pathogenesis through pathogenomics and bioinformatics, including how mutations generate pathogen diversity, and an overview of genome sequencing technologies Subversion of the immune response by bacterial pathogens, covering subversion of both innate responses and adaptive immunity Pathogenesis of Bacterial Infections in Animals, Fifth Edition is an essential resource for graduate students in veterinary medicine and animal science, and for veterinary microbiologists, pathologists, infectious disease experts, and others interested in bacterial disease. It is the only book to cover this topic to this depth through the wealth of insight of dozens of qualified and practicing professionals.

Human Herpesviruses

Author : Ann Arvin
Publisher : Cambridge University Press
ISBN 13 : 1139461648
Total Pages : 1325 pages
Book Rating : 4.1/5 (394 download)

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Book Synopsis Human Herpesviruses by : Ann Arvin

Download or read book Human Herpesviruses written by Ann Arvin and published by Cambridge University Press. This book was released on 2007-08-16 with total page 1325 pages. Available in PDF, EPUB and Kindle. Book excerpt: This comprehensive account of the human herpesviruses provides an encyclopedic overview of their basic virology and clinical manifestations. This group of viruses includes human simplex type 1 and 2, Epstein–Barr virus, Kaposi's Sarcoma-associated herpesvirus, cytomegalovirus, HHV6A, 6B and 7, and varicella-zoster virus. The viral diseases and cancers they cause are significant and often recurrent. Their prevalence in the developed world accounts for a major burden of disease, and as a result there is a great deal of research into the pathophysiology of infection and immunobiology. Another important area covered within this volume concerns antiviral therapy and the development of vaccines. All these aspects are covered in depth, both scientifically and in terms of clinical guidelines for patient care. The text is illustrated generously throughout and is fully referenced to the latest research and developments.

Bacterial Pathogenesis

Author :
Publisher : Academic Press
ISBN 13 : 0080860567
Total Pages : 643 pages
Book Rating : 4.0/5 (88 download)

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Book Synopsis Bacterial Pathogenesis by :

Download or read book Bacterial Pathogenesis written by and published by Academic Press. This book was released on 1998-07-01 with total page 643 pages. Available in PDF, EPUB and Kindle. Book excerpt: Established almost 30 years ago, Methods in Microbiology is the most prestigious series devoted to techniques and methodology in the field. Now totally revamped, revitalized, with a new format and expanded scope, Methods in Microbiology will continue to provide you with tried and tested, cutting-edge protocols to directly benefit your research. - Focuses on the methods most useful for the microbiologist interested in the way in which bacteria cause disease - Includes section devoted to 'Approaches to characterising pathogenic mechanisms' by Stanley Falkow - Covers safety aspects, detection, identification and speciation - Includes techniques for the study of host interactions and reactions in animals and plants - Describes biochemical and molecular genetic approaches - Essential methods for gene expression and analysis - Covers strategies and problems for disease control

Unifying Microbial Mechanisms

Author : Michael F. Cole
Publisher : Garland Science
ISBN 13 : 0429557833
Total Pages : 346 pages
Book Rating : 4.4/5 (295 download)

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Book Synopsis Unifying Microbial Mechanisms by : Michael F. Cole

Download or read book Unifying Microbial Mechanisms written by Michael F. Cole and published by Garland Science. This book was released on 2019-09-09 with total page 346 pages. Available in PDF, EPUB and Kindle. Book excerpt: Microbial pathogenesis is the study of the mechanisms by which microbes (bacteria, viruses, protozoa, and multicellular parasites) cause infectious disease and make their hosts (humans) ill. Bacterial infections we thought were easily treatable are again a huge cause for concern with the well-publicized rise of antibiotic resistance. There are very few effective antiviral drugs and we live with the threat of epidemics such as bird flu and the outbreaks of viruses such the recent (and ongoing) Ebola crisis. Parasitic diseases such as malaria continue to pose a heavy burden in the developing world and with climate change could spread into the developed world. There is therefore an urgent need to understand microbial mechanisms, with research programmes and university courses dedicated to the subject

Microbial Toxins

Author : P. Gopalakrishnakone
Publisher : Springer
ISBN 13 : 9789400764484
Total Pages : 502 pages
Book Rating : 4.7/5 (644 download)

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Book Synopsis Microbial Toxins by : P. Gopalakrishnakone

Download or read book Microbial Toxins written by P. Gopalakrishnakone and published by Springer. This book was released on 2018-03-14 with total page 502 pages. Available in PDF, EPUB and Kindle. Book excerpt: In recent years, the field of Toxinology has expanded substantially. On the one hand it studies venomous animals, plants and micro organisms in detail to understand their mode of action on targets. While on the other, it explores the biochemical composition, genomics and proteomics of toxins and venoms to understand their three interaction with life forms (especially humans), development of antidotes and exploring their pharmacological potential. Therefore, Toxinology has deep linkages with biochemistry, molecular biology, anatomy and pharmacology. In addition, there is a fast developing applied subfield, clinical toxinology, which deals with understanding and managing medical effects of toxins on human body. Given the huge impact of toxin-based deaths globally, and the potential of venom in generation of drugs for so-far incurable diseases (for example, Diabetes, Chronic Pain), the continued research and growth of the field is imminent. This has led to the growth of research in the area and the consequent scholarly output by way of publications in journals and books. Despite this ever growing body of literature within biomedical sciences, there is still no all-inclusive reference work available that collects all of the important biochemical, biomedical and clinical insights relating to Toxinology. The Handbook of Toxinology aims to address this gap and cover the field of Toxinology comprehensively.

Immunology and Evolution of Infectious Disease

Author : Steven A. Frank
Publisher : Princeton University Press
ISBN 13 : 9780691095950
Total Pages : 364 pages
Book Rating : 4.0/5 (959 download)

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Book Synopsis Immunology and Evolution of Infectious Disease by : Steven A. Frank

Download or read book Immunology and Evolution of Infectious Disease written by Steven A. Frank and published by Princeton University Press. This book was released on 2002-07-21 with total page 364 pages. Available in PDF, EPUB and Kindle. Book excerpt: Publisher Description

Subversion of Innate Immunity by Blastomyces Dermatitidis

Author :
Publisher :
ISBN 13 :
Total Pages : 160 pages
Book Rating : 4.:/5 (888 download)

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Book Synopsis Subversion of Innate Immunity by Blastomyces Dermatitidis by :

Download or read book Subversion of Innate Immunity by Blastomyces Dermatitidis written by and published by . This book was released on 2014 with total page 160 pages. Available in PDF, EPUB and Kindle. Book excerpt: Our understanding of the innate immune response to the dimorphic fungus, Blastomyces dermatitidis, is very limited. Blastomycosis is a challenging disease from a clinical perspective due to the long incubation time and difficulty in diagnosis. B. dermatitidis is widely believed to be an extracellular pathogen. We found that pulmonary instillation of spores (the infectious particle) leads to rapid and efficient internalization within leukocytes, particularly alveolar macrophages. The harsh intracellular environment of alveolar macrophages is normally fatal to microorganisms. However, using live imaging we found that B. dermatitidis is able to survive this attack, transition from spores to the pathogenic yeast form, and replicate within alveolar macrophages. We found that depleting alveolar macrophages curtailed infection and delayed phase transition. Additionally, spores cultured in vitro converted to yeast faster in the presence of macrophages than in medium alone. This research reveals B. dermatitidis as facultative intracellular pathogen of alveolar macrophages able to respond to host factors to establish disease. B. dermatitidis also subverts the innate immune response through the production of the aminopeptidase DppIV. Gene silencing in B. dermatitidis revealed that DppIV is essential for virulence, and acts in part by blunting recruitment of Ly6ChiCCR2+ inflammatory monocytes to the lung, and their differentiation into TipDCs as well as impairing activation of neutrophils and killing of yeast mediated by these cells and macrophages. Mammalian DppIV regulates the immune response through cleavage and inactivation of cytokines and chemokines. B. dermatitidis likewise dampens innate immunity by producing DppIV. This serves as an example of a pathogen exploiting molecular mimicry. Collectively, this work identifies early mechanisms of pathogenesis through innate immune evasion and alteration by B. dermatitidis.

Pathogenesis of Bacterial Infections in Animals

Author : Carlton L. Gyles
Publisher : John Wiley & Sons
ISBN 13 : 0470961724
Total Pages : 674 pages
Book Rating : 4.4/5 (79 download)

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Book Synopsis Pathogenesis of Bacterial Infections in Animals by : Carlton L. Gyles

Download or read book Pathogenesis of Bacterial Infections in Animals written by Carlton L. Gyles and published by John Wiley & Sons. This book was released on 2011-06-09 with total page 674 pages. Available in PDF, EPUB and Kindle. Book excerpt: Pathogenesis of Bacterial Infections in Animals, Fourth Edition captures the rapid developments in understanding the mechanisms of virulence of the major bacterial pathogens of animals. Now including a color plate section, the book presents an overview of pathogenesis, including relevant events that occur in the herd or flock and its environment, and activities that take place at the cellular and molecular levels. With contributions from 64 experts in the field, this book serves as a great reference for graduate students in veterinary medicine and animal science, microbiologists, virologists and pathologists.

Cytoskeleton

Author : Jose C. Jimenez-Lopez
Publisher : BoD – Books on Demand
ISBN 13 : 9535131699
Total Pages : 344 pages
Book Rating : 4.5/5 (351 download)

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Book Synopsis Cytoskeleton by : Jose C. Jimenez-Lopez

Download or read book Cytoskeleton written by Jose C. Jimenez-Lopez and published by BoD – Books on Demand. This book was released on 2017-05-17 with total page 344 pages. Available in PDF, EPUB and Kindle. Book excerpt: The cytoskeleton is a highly dynamic intracellular platform constituted by a three-dimensional network of proteins responsible for key cellular roles as structure and shape, cell growth and development, and offering to the cell with "motility" that being the ability of the entire cell to move and for material to be moved within the cell in a regulated fashion (vesicle trafficking). The present edition of Cytoskeleton provides new insights into the structure-functional features, dynamics, and cytoskeleton's relationship to diseases. The authors' contribution in this book will be of substantial importance to a wide audience such as clinicians, researches, educators, and students interested in getting updated knowledge about molecular basis of cytoskeleton, such as regulation of cell vital processes by actin-binding proteins as cell morphogenesis, motility, their implications in cell signaling, as well as strategies for clinical trial and alternative therapies based in multitargeting molecules to tackle diseases, that is, cancer.