Microarray Analysis Of The Physical Genome

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Microarray Analysis of the Physical Genome

Author : Jonathan R. Pollack
Publisher : Humana Press
ISBN 13 : 9781617794902
Total Pages : 0 pages
Book Rating : 4.7/5 (949 download)

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Book Synopsis Microarray Analysis of the Physical Genome by : Jonathan R. Pollack

Download or read book Microarray Analysis of the Physical Genome written by Jonathan R. Pollack and published by Humana Press. This book was released on 2011-12-06 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the early years of microarray technology, efforts were directed mainly at profiling expressed genes, while recently the microarray platform has been adapted into diverse applications directed toward the investigation of the physical genome. In Microarray Analysis of the Physical Genome: Methods and Protocols, experts in the field cover DNA microarray applications for the detection and characterization of genomic DNA-associated copy number alteration, loss of heterozygosity (LOH), cytosine methylation, protein binding sites, regulatory elements, and replication timing, with an emphasis on higher eukaryote (animal) and cancer genomes. Written in the highly successful Methods in Molecular BiologyTM series format, chapters include a brief introduction to their respective subjects, lists of the necessary materials and reagents, step-by-step protocols, and time-saving notes on troubleshooting and avoiding known pitfalls. Authoritative and easy-to-use, Microarray Analysis of the Physical Genome: Methods and Protocols is of great value to the molecular biologist or computational biologist interested in understanding the principles of these analyses or in planning future experiments using microarrays to characterize the physical genome.

Statistical Analysis of Gene Expression Microarray Data

Author : Terry Speed
Publisher : CRC Press
ISBN 13 : 0203011236
Total Pages : 237 pages
Book Rating : 4.2/5 (3 download)

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Book Synopsis Statistical Analysis of Gene Expression Microarray Data by : Terry Speed

Download or read book Statistical Analysis of Gene Expression Microarray Data written by Terry Speed and published by CRC Press. This book was released on 2003-03-26 with total page 237 pages. Available in PDF, EPUB and Kindle. Book excerpt: Although less than a decade old, the field of microarray data analysis is now thriving and growing at a remarkable pace. Biologists, geneticists, and computer scientists as well as statisticians all need an accessible, systematic treatment of the techniques used for analyzing the vast amounts of data generated by large-scale gene expression studies

Microarray Data Analysis

Author : Michael J. Korenberg
Publisher : Springer Science & Business Media
ISBN 13 : 1597453900
Total Pages : 569 pages
Book Rating : 4.5/5 (974 download)

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Book Synopsis Microarray Data Analysis by : Michael J. Korenberg

Download or read book Microarray Data Analysis written by Michael J. Korenberg and published by Springer Science & Business Media. This book was released on 2008-02-03 with total page 569 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this new volume, renowned authors contribute fascinating, cutting-edge insights into microarray data analysis. Information on an array of topics is included in this innovative book including in-depth insights into presentations of genomic signal processing. Also detailed is the use of tiling arrays for large genomes analysis. The protocols follow the successful Methods in Molecular BiologyTM series format, offering step-by-step instructions, an introduction outlining the principles behind the technique, lists of the necessary equipment and reagents, and tips on troubleshooting and avoiding pitfalls.

Microarray Gene Expression Data Analysis

Author : Helen Causton
Publisher : John Wiley & Sons
ISBN 13 : 1444311565
Total Pages : 176 pages
Book Rating : 4.4/5 (443 download)

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Book Synopsis Microarray Gene Expression Data Analysis by : Helen Causton

Download or read book Microarray Gene Expression Data Analysis written by Helen Causton and published by John Wiley & Sons. This book was released on 2009-04-01 with total page 176 pages. Available in PDF, EPUB and Kindle. Book excerpt: This guide covers aspects of designing microarray experiments and analysing the data generated, including information on some of the tools that are available from non-commercial sources. Concepts and principles underpinning gene expression analysis are emphasised and wherever possible, the mathematics has been simplified. The guide is intended for use by graduates and researchers in bioinformatics and the life sciences and is also suitable for statisticians who are interested in the approaches currently used to study gene expression. Microarrays are an automated way of carrying out thousands of experiments at once, and allows scientists to obtain huge amounts of information very quickly Short, concise text on this difficult topic area Clear illustrations throughout Written by well-known teachers in the subject Provides insight into how to analyse the data produced from microarrays

Molecular Biology of The Cell

Author : Bruce Alberts
Publisher :
ISBN 13 : 9780815332183
Total Pages : 0 pages
Book Rating : 4.3/5 (321 download)

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Book Synopsis Molecular Biology of The Cell by : Bruce Alberts

Download or read book Molecular Biology of The Cell written by Bruce Alberts and published by . This book was released on 2002 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:

A Practical Approach to Microarray Data Analysis

Author : Daniel P. Berrar
Publisher : Springer Science & Business Media
ISBN 13 : 0306478153
Total Pages : 382 pages
Book Rating : 4.3/5 (64 download)

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Book Synopsis A Practical Approach to Microarray Data Analysis by : Daniel P. Berrar

Download or read book A Practical Approach to Microarray Data Analysis written by Daniel P. Berrar and published by Springer Science & Business Media. This book was released on 2007-05-08 with total page 382 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the past several years, DNA microarray technology has attracted tremendous interest in both the scientific community and in industry. With its ability to simultaneously measure the activity and interactions of thousands of genes, this modern technology promises unprecedented new insights into mechanisms of living systems. Currently, the primary applications of microarrays include gene discovery, disease diagnosis and prognosis, drug discovery (pharmacogenomics), and toxicological research (toxicogenomics). Typical scientific tasks addressed by microarray experiments include the identification of coexpressed genes, discovery of sample or gene groups with similar expression patterns, identification of genes whose expression patterns are highly differentiating with respect to a set of discerned biological entities (e.g., tumor types), and the study of gene activity patterns under various stress conditions (e.g., chemical treatment). More recently, the discovery, modeling, and simulation of regulatory gene networks, and the mapping of expression data to metabolic pathways and chromosome locations have been added to the list of scientific tasks that are being tackled by microarray technology. Each scientific task corresponds to one or more so-called data analysis tasks. Different types of scientific questions require different sets of data analytical techniques. Broadly speaking, there are two classes of elementary data analysis tasks, predictive modeling and pattern-detection. Predictive modeling tasks are concerned with learning a classification or estimation function, whereas pattern-detection methods screen the available data for interesting, previously unknown regularities or relationships.

Analysis of Microarray Gene Expression Data

Author : Mei-Ling Ting Lee
Publisher : Springer Science & Business Media
ISBN 13 : 0792370872
Total Pages : 378 pages
Book Rating : 4.7/5 (923 download)

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Book Synopsis Analysis of Microarray Gene Expression Data by : Mei-Ling Ting Lee

Download or read book Analysis of Microarray Gene Expression Data written by Mei-Ling Ting Lee and published by Springer Science & Business Media. This book was released on 2004-04-30 with total page 378 pages. Available in PDF, EPUB and Kindle. Book excerpt: After genomic sequencing, microarray technology has emerged as a widely used platform for genomic studies in the life sciences. Microarray technology provides a systematic way to survey DNA and RNA variation. With the abundance of data produced from microarray studies, however, the ultimate impact of the studies on biology will depend heavily on data mining and statistical analysis. The contribution of this book is to provide readers with an integrated presentation of various topics on analyzing microarray data.

DNA Microarrays and Gene Expression

Author : Pierre Baldi
Publisher : Cambridge University Press
ISBN 13 : 9781139437608
Total Pages : 238 pages
Book Rating : 4.4/5 (376 download)

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Book Synopsis DNA Microarrays and Gene Expression by : Pierre Baldi

Download or read book DNA Microarrays and Gene Expression written by Pierre Baldi and published by Cambridge University Press. This book was released on 2011-04-28 with total page 238 pages. Available in PDF, EPUB and Kindle. Book excerpt: Massive data acquisition technologies, such as genome sequencing, high-throughput drug screening, and DNA arrays are in the process of revolutionizing biology and medicine. Using the mRNA of a given cell, at a given time, under a given set of conditions, DNA microarrays can provide a snapshot of the level of expression of all the genes in the cell. Such snapshots can be used to study fundamental biological phenomena such as development or evolution, to determine the function of new genes, to infer the role individual genes or groups of genes may play in diseases, and to monitor the effect of drugs and other compounds on gene expression. Originally published in 2002, this inter-disciplinary introduction to DNA arrays will be of value to anyone with an a interest in this powerful technology.

Functional Genomics

Author : Michael J. Brownstein
Publisher : Springer Science & Business Media
ISBN 13 : 159259364X
Total Pages : 264 pages
Book Rating : 4.5/5 (925 download)

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Book Synopsis Functional Genomics by : Michael J. Brownstein

Download or read book Functional Genomics written by Michael J. Brownstein and published by Springer Science & Business Media. This book was released on 2008-02-03 with total page 264 pages. Available in PDF, EPUB and Kindle. Book excerpt: This collection of robust, readily reproducible methods for microarray-based studies includes expert guidance in the optimal data analysis and informatics. On the methods side are proven techniques for monitoring subcellular RNA localization en masse, for mapping chromosomes at the resolution of a single gene, and for surveying the steady-state genome-wide distribution of DNA binding proteins in vivo. For those workers dealing with massive data sets, the book discusses the methodological aspects of data analysis and informatics in the design of microarray experiments, the choice of test statistic, and the assessment of observational significance, data reduction, and clustering.

Scientific Frontiers in Developmental Toxicology and Risk Assessment

Author : National Research Council
Publisher : National Academies Press
ISBN 13 : 0309070864
Total Pages : 348 pages
Book Rating : 4.3/5 (9 download)

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Book Synopsis Scientific Frontiers in Developmental Toxicology and Risk Assessment by : National Research Council

Download or read book Scientific Frontiers in Developmental Toxicology and Risk Assessment written by National Research Council and published by National Academies Press. This book was released on 2000-12-21 with total page 348 pages. Available in PDF, EPUB and Kindle. Book excerpt: Scientific Frontiers in Developmental Toxicology and Risk Assessment reviews advances made during the last 10-15 years in fields such as developmental biology, molecular biology, and genetics. It describes a novel approach for how these advances might be used in combination with existing methodologies to further the understanding of mechanisms of developmental toxicity, to improve the assessment of chemicals for their ability to cause developmental toxicity, and to improve risk assessment for developmental defects. For example, based on the recent advances, even the smallest, simplest laboratory animals such as the fruit fly, roundworm, and zebrafish might be able to serve as developmental toxicological models for human biological systems. Use of such organisms might allow for rapid and inexpensive testing of large numbers of chemicals for their potential to cause developmental toxicity; presently, there are little or no developmental toxicity data available for the majority of natural and manufactured chemicals in use. This new approach to developmental toxicology and risk assessment will require simultaneous research on several fronts by experts from multiple scientific disciplines, including developmental toxicologists, developmental biologists, geneticists, epidemiologists, and biostatisticians.

Computational Genome Analysis

Author : Richard C. Deonier
Publisher : Springer Science & Business Media
ISBN 13 : 0387288074
Total Pages : 542 pages
Book Rating : 4.3/5 (872 download)

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Book Synopsis Computational Genome Analysis by : Richard C. Deonier

Download or read book Computational Genome Analysis written by Richard C. Deonier and published by Springer Science & Business Media. This book was released on 2005-12-27 with total page 542 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents the foundations of key problems in computational molecular biology and bioinformatics. It focuses on computational and statistical principles applied to genomes, and introduces the mathematics and statistics that are crucial for understanding these applications. The book features a free download of the R software statistics package and the text provides great crossover material that is interesting and accessible to students in biology, mathematics, statistics and computer science. More than 100 illustrations and diagrams reinforce concepts and present key results from the primary literature. Exercises are given at the end of chapters.

Microarray Analysis

Author : Mark Schena
Publisher : Wiley-Liss
ISBN 13 : 9780471414438
Total Pages : 664 pages
Book Rating : 4.4/5 (144 download)

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Book Synopsis Microarray Analysis by : Mark Schena

Download or read book Microarray Analysis written by Mark Schena and published by Wiley-Liss. This book was released on 2002-11-11 with total page 664 pages. Available in PDF, EPUB and Kindle. Book excerpt: This authoritative text begins with an introduction to basic microarray technology. The author then provides clear explanations of the conceptual and theoretical basis of this technology, followed by thorough and multi-disciplinary coverage of modern and emerging applications. The coverageincludes chapters on microarray informatics, gene expression profiling, genetic diagnostics, and novel microarray technologies.

Exploration and Analysis of DNA Microarray and Other High-Dimensional Data

Author : Dhammika Amaratunga
Publisher : Wiley
ISBN 13 : 9781118364543
Total Pages : 344 pages
Book Rating : 4.3/5 (645 download)

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Book Synopsis Exploration and Analysis of DNA Microarray and Other High-Dimensional Data by : Dhammika Amaratunga

Download or read book Exploration and Analysis of DNA Microarray and Other High-Dimensional Data written by Dhammika Amaratunga and published by Wiley. This book was released on 2014-01-31 with total page 344 pages. Available in PDF, EPUB and Kindle. Book excerpt: Praise for the First Edition " ... extremely well written ... a comprehensive and up-to-date overview of this important field."--Journal of Environmental Quality Exploration and Analysis of DNA Microarray and Other High-Dimensional Data, Second Edition provides comprehensive coverage of recent advancements in microarray data analysis. A cutting-edge guide, the Second Edition demonstrates various methodologies for analyzing data in biomedical research and offers an overview of the modern techniques used in microarray technology to.

Classification Analysis of DNA Microarrays

Author : Leif E. Peterson
Publisher : John Wiley & Sons
ISBN 13 : 0470170816
Total Pages : 752 pages
Book Rating : 4.4/5 (71 download)

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Book Synopsis Classification Analysis of DNA Microarrays by : Leif E. Peterson

Download or read book Classification Analysis of DNA Microarrays written by Leif E. Peterson and published by John Wiley & Sons. This book was released on 2013-06-24 with total page 752 pages. Available in PDF, EPUB and Kindle. Book excerpt: Wiley Series in Bioinformatics: Computational Techniques and Engineering Yi Pan and Albert Y. Zomaya, Series Editors Wide coverage of traditional unsupervised and supervised methods and newer contemporary approaches that help researchers handle the rapid growth of classification methods in DNA microarray studies Proliferating classification methods in DNA microarray studies have resulted in a body of information scattered throughout literature, conference proceedings, and elsewhere. This book unites many of these classification methods in a single volume. In addition to traditional statistical methods, it covers newer machine-learning approaches such as fuzzy methods, artificial neural networks, evolutionary-based genetic algorithms, support vector machines, swarm intelligence involving particle swarm optimization, and more. Classification Analysis of DNA Microarrays provides highly detailed pseudo-code and rich, graphical programming features, plus ready-to-run source code. Along with primary methods that include traditional and contemporary classification, it offers supplementary tools and data preparation routines for standardization and fuzzification; dimensional reduction via crisp and fuzzy c-means, PCA, and non-linear manifold learning; and computational linguistics via text analytics and n-gram analysis, recursive feature extraction during ANN, kernel-based methods, ensemble classifier fusion. This powerful new resource: Provides information on the use of classification analysis for DNA microarrays used for large-scale high-throughput transcriptional studies Serves as a historical repository of general use supervised classification methods as well as newer contemporary methods Brings the reader quickly up to speed on the various classification methods by implementing the programming pseudo-code and source code provided in the book Describes implementation methods that help shorten discovery times Classification Analysis of DNA Microarrays is useful for professionals and graduate students in computer science, bioinformatics, biostatistics, systems biology, and many related fields.

Evolution of Translational Omics

Author : Institute of Medicine
Publisher : National Academies Press
ISBN 13 : 0309224187
Total Pages : 354 pages
Book Rating : 4.3/5 (92 download)

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Book Synopsis Evolution of Translational Omics by : Institute of Medicine

Download or read book Evolution of Translational Omics written by Institute of Medicine and published by National Academies Press. This book was released on 2012-09-13 with total page 354 pages. Available in PDF, EPUB and Kindle. Book excerpt: Technologies collectively called omics enable simultaneous measurement of an enormous number of biomolecules; for example, genomics investigates thousands of DNA sequences, and proteomics examines large numbers of proteins. Scientists are using these technologies to develop innovative tests to detect disease and to predict a patient's likelihood of responding to specific drugs. Following a recent case involving premature use of omics-based tests in cancer clinical trials at Duke University, the NCI requested that the IOM establish a committee to recommend ways to strengthen omics-based test development and evaluation. This report identifies best practices to enhance development, evaluation, and translation of omics-based tests while simultaneously reinforcing steps to ensure that these tests are appropriately assessed for scientific validity before they are used to guide patient treatment in clinical trials.

The Barley Genome

Author : Nils Stein
Publisher : Springer
ISBN 13 : 3319925288
Total Pages : 394 pages
Book Rating : 4.3/5 (199 download)

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Book Synopsis The Barley Genome by : Nils Stein

Download or read book The Barley Genome written by Nils Stein and published by Springer. This book was released on 2018-08-18 with total page 394 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents an overview of the state-of-the-art in barley genome analysis, covering all aspects of sequencing the genome and translating this important information into new knowledge in basic and applied crop plant biology and new tools for research and crop improvement. Unlimited access to a high-quality reference sequence is removing one of the major constraints in basic and applied research. This book summarizes the advanced knowledge of the composition of the barley genome, its genes and the much larger non-coding part of the genome, and how this information facilitates studying the specific characteristics of barley. One of the oldest domesticated crops, barley is the small grain cereal species that is best adapted to the highest altitudes and latitudes, and it exhibits the greatest tolerance to most abiotic stresses. With comprehensive access to the genome sequence, barley’s importance as a genetic model in comparative studies on crop species like wheat, rye, oats and even rice is likely to increase.

Gene Mapping, Discovery, and Expression

Author : Minou Bina
Publisher : Springer Science & Business Media
ISBN 13 : 1597450979
Total Pages : 335 pages
Book Rating : 4.5/5 (974 download)

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Book Synopsis Gene Mapping, Discovery, and Expression by : Minou Bina

Download or read book Gene Mapping, Discovery, and Expression written by Minou Bina and published by Springer Science & Business Media. This book was released on 2008-02-04 with total page 335 pages. Available in PDF, EPUB and Kindle. Book excerpt: Completion of the sequence of the human genome represents an unpar- leled achievement in the history of biology. The project has produced nearly complete, highly accurate, and comprehensive sequences of genomes of s- eral organisms including human, mouse, drosophila, and yeast. Furthermore, the development of high-throughput technologies has led to an explosion of projects to sequence the genomes of additional organisms including rat, chimp, dog, bee, chicken, and the list is expanding. The nearly completed draft of genomic sequences from numerous species has opened a new era of research in biology and in biomedical sciences. In keeping with the interdisciplinary nature of the new scientific era, the chapters in Gene Mapping, Discovery, and Expression: Methods and Protocols recapitulate the necessity of integration of experimental and computational tools for solving - portant research problems. The general underlying theme of this volume is DNA sequence-based technologies. At one level, the book highlights the importance of databases, genome-browsers, and web-based tools for data access and ana- sis. More specifically, sequencing projects routinely deposit their data in p- licly available databases including GenBank, at the National Center of Biotechnology (NCBI) in the United States; EMBL, maintained by the European Bioinformatics Institute; and DDBJ, the DNA Data Bank of Japan. Currently, several browsers offer facile access to numerous genomic DNA sequences for gene mapping and data retrieval.