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Author : Rubén Emilio Diaz
Publisher :
ISBN 13 :
Total Pages : 574 pages
Book Rating : 4.:/5 (35 download)
Download or read book Micro and Nano Scale Bioelectronics in Cell Micro-electroporation written by Rubén Emilio Diaz and published by . This book was released on 2005 with total page 574 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Victor V. Zhirnov
Publisher : William Andrew
ISBN 13 : 1437778410
Total Pages : 209 pages
Book Rating : 4.4/5 (377 download)
Download or read book Microsystems for Bioelectronics written by Victor V. Zhirnov and published by William Andrew. This book was released on 2010-11-23 with total page 209 pages. Available in PDF, EPUB and Kindle. Book excerpt: Microsystems for Bioelectronics is the ultimate guide in the biomedical application industry. It provides a physics-based assessment of the limitless potential of miniaturization technologies. This book goes far beyond the complete design of the final systems. It also discusses the developments of computation and communication subsystems. The future of this technology lies in understanding the scaling limits for the individual systems. This includes all of its components and the fundamental energy source that powers all autonomous microsystems. Rapid advances in microfabrication technologies are offering new opportunities and capabilities to develop systems for biomedical applications. These applications include the diagnostics community and those that are active in therapy services. Microsystems for Bioelectronics is one of the only books on the market today that goes into the comprehensive treatment of integrated microsystems.
Author : Gregory David Troszak
Publisher :
ISBN 13 :
Total Pages : 174 pages
Book Rating : 4.:/5 (769 download)
Download or read book A Theoretical Analysis of Singularity-induced Micro-electroporation and Its Applications written by Gregory David Troszak and published by . This book was released on 2011 with total page 174 pages. Available in PDF, EPUB and Kindle. Book excerpt: Electroporation - the permeabilization of the cell membrane lipid bilayer due to a pulsed electric field - has important implications in the biotechnology, medicine, and food industries. Although the physical mechanism that causes electroporation is not entirely understood, it is believed that pulsed electric fields significantly increase the potential difference across the cell membrane, resulting in the formation of pores. Depending on the magnitude and duration of a pulsed electric field, membrane permeabilization is either reversible or irreversible. Reversible electroporation is commonly used to transfer macromolecules such as proteins, DNA, or drugs into cells, and the destructive nature of irreversible electroporation makes it suitable for cell ablation and sterilization. Most electroporation devices have facing electrodes that generate uniform electric fields. Consequently, the magnitudes of these electric fields are inversely proportional to the distance between the electrodes. Since reversible and irreversible electroporation require electric field magnitudes on the order of 1 and 10 kV/cm, respectively, large potential differences are required to induce electroporation. Reducing the potential difference required to perform electroporation eliminates the need for a power supply, making electroporation cheaper and more accessible. Singularity-induced micro-electroporation - an electroporation configuration composed of two adjacent electrodes separated by a nanoscale insulator - aims to reduce the potential difference required to perform electroporation. Application of a small potential difference between the electrodes creates a radially varying electric field emanating from the insulator. Secondary current distribution models of singularity-induced micro-electroporation show that applying a potential difference as low as 2.9 V creates an electric field that is capable of inducing reversible and irreversible electroporation. To date, the lowest potential difference used to perform irreversible electroporation is 2̃0 V. More impressively, these models demonstrate that the ohmic drops in galvanic electrochemical cells can generate electroporation-inducing electric fields, enabling the creation of a self-powered micro-electroporation device.
Author : Cherry Gupta
Publisher :
ISBN 13 :
Total Pages : 197 pages
Book Rating : 4.:/5 (945 download)
Download or read book DNA Translocation and Cell Electroporation in Micro and Nanofluidic Devices written by Cherry Gupta and published by . This book was released on 2015 with total page 197 pages. Available in PDF, EPUB and Kindle. Book excerpt: Besides maintaining high cell viability and achieving dose control, an important feature of NEP is the delivery of large molecules such as plasmids and quantum dots directly into the cell cytosol. In contrast, delivery of large plasmids during bulk electroporation, wherein cells and genes/plasmids are mixed in a buffered medium and an external electric field is applied across the mixture which electroporates the cells, is via formation of cell membrane bound aggregates which get endocytosed post pulsation. Various mechanisms of DNA transport across the membrane have been proposed including passive diffusion of DNA through pores formed during electroporation, electrophoretic transfer of DNA into the cytosol through membrane pores, and electrically induced trapping of DNA in the endosome-like vesicles. In this study we visualized the transport of DNA molecules during NEP to understand the associated delivery mechanism.
Author : HyunChul Jung
Publisher :
ISBN 13 :
Total Pages : 157 pages
Book Rating : 4.:/5 (759 download)
Download or read book Design, Fabrication and Characterization of Micro/nano Electroporation Devices for Drug/gene Delivery written by HyunChul Jung and published by . This book was released on 2011 with total page 157 pages. Available in PDF, EPUB and Kindle. Book excerpt: Abstract: In current traditional electroporation methods, each cell experience different local process conditions due to non uniform electric fields, and high voltage. This leads to a degree of cell death and untransfected cells in every process. We designed and developed a novel micro/nanoscaled devices to apply relatively low and uniform electric field for well-controlled in vitro gene delivery and improved cell survival rate and overall transfection efficiency.
Author : Xinyu Liu
Publisher : Academic Press
ISBN 13 : 0128242434
Total Pages : 406 pages
Book Rating : 4.1/5 (282 download)
Download or read book Micro and Nano Systems for Biophysical Studies of Cells and Small Organisms written by Xinyu Liu and published by Academic Press. This book was released on 2021-08-14 with total page 406 pages. Available in PDF, EPUB and Kindle. Book excerpt: Micro and Nano Systems for Biophysical Studies of Cells and Small Organisms provides a comprehensive introduction to the state-of-the-art micro and nano systems that have recently been developed and applied to biophysical studies of cells and small organisms. These micro and nano systems span from microelectromechanical systems (MEMS) and microfluidic devices to robotic micro-nanomanipulation systems. These biophysical studies range from cell mechanics to the neural science of worms and Drosophila. This book will help readers understand the fundamentals surrounding the development of these tools and teach them the most recent advances in cellular and organismal biophysics enabled by these technologies. Comprehensive coverage of micro and nano-system technology and application to biophysical studies of cells and small organisms. Highlights the most recent advances in cellular and organismal biophysics enabled by micro and nano systems. Insightful outlook on future directions and trends in each chapter covering a sub-area of the book topic.
Author : J. Christopher Love
Publisher : John Wiley & Sons
ISBN 13 : 3527801294
Total Pages : 302 pages
Book Rating : 4.5/5 (278 download)
Download or read book Micro- and Nanosystems for Biotechnology written by J. Christopher Love and published by John Wiley & Sons. This book was released on 2016-03-07 with total page 302 pages. Available in PDF, EPUB and Kindle. Book excerpt: Emphasizing their emerging capabilities, this volume provides a strong foundation for an understanding of how micro- and nanotechnologies used in biomedical research have evolved from concepts to working platforms. Volume editor Christopher Love has assembled here a highly interdisciplinary group of authors with backgrounds ranging from chemical engineering right up to materials science to reflect how the intersection of ideas from biology with engineering disciplines has spurred on innovations. In fact, a number of the basic technologies described are reaching the market to advance the discovery and development of biopharmaceuticals. The first part of the book focuses on microsystems for single-cell analysis, examining tools and techniques used to isolate cells from a range of biological samples, while the second part is dedicated to tiny technologies for modulating biological systems at the scale of individual cells, tissues or whole organisms. New tools are described which have a great potential for (pre)clinical development of interventions in a range of illnesses, such as cancer and neurological diseases. Besides describing the promising applications, the authors also highlight the ongoing challenges and opportunities in the field.
Author :
Publisher :
ISBN 13 :
Total Pages : 774 pages
Book Rating : 4.F/5 ( download)
Download or read book Dissertation Abstracts International written by and published by . This book was released on 2006 with total page 774 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Jaime Castillo-León
Publisher : CRC Press
ISBN 13 : 1439827435
Total Pages : 258 pages
Book Rating : 4.4/5 (398 download)
Download or read book Micro and Nano Techniques for the Handling of Biological Samples written by Jaime Castillo-León and published by CRC Press. This book was released on 2011-08-25 with total page 258 pages. Available in PDF, EPUB and Kindle. Book excerpt: Several micro- and nanomanipulation techniques have emerged in recent decades thanks to advances in micro- and nanofabrication. For instance, the atomic force microscope (AFM) uses a nano-sized tip to image, push, pull, cut, and indent biological material in air, liquid, or vacuum. Using micro- and nanofabrication techniques, scientists can make manipulation tools, such as microgrippers and nanotweezers, on the same length scale as the biological samples. Micro and Nano Techniques for the Handling of Biological Samples reviews the different techniques available to manipulate and integrate biological materials in a controlled manner, either by sliding them along a surface (2-D manipulation), or by gripping and moving them to a new position (3-D manipulation). The advantages and drawbacks are mentioned together with examples that reflect the state-of-the-art in manipulation techniques for biological samples. Thanks to the advances in micro- and nanomanipulation techniques, the integration of biomaterials with physical transducers has been possible, giving rise to new and highly sensitive biosensing devices. Although great progress has been made, challenges are still present. To understand the complex interactions between and inside biological samples, scientists will always be working on improving technologies to manipulate, transport, sort, and integrate samples in different environments. Balanced between simplicity for the beginner and hardcore theory for the more advanced readers, this book is the ideal launching point for sharpening the scientific tools required to address these challenges.
Author : Andre M. Goffinet
Publisher : Springer Science & Business Media
ISBN 13 : 3540480021
Total Pages : 347 pages
Book Rating : 4.5/5 (44 download)
Download or read book Mouse Brain Development written by Andre M. Goffinet and published by Springer Science & Business Media. This book was released on 2012-08-10 with total page 347 pages. Available in PDF, EPUB and Kindle. Book excerpt: Our understanding of the molecular mechanisms involved in mammalian brain development remains limited. However, the last few years have wit nessed a quantum leap in our knowledge, due to technological improve ments, particularly in molecular genetics. Despite this progress, the available body of data remains mostly phenomenological and reveals very little about the grammar that organizes the molecular dictionary to articulate a pheno type. Nevertheless, the recent progress in genetics will allow us to contem plate, for the first time, the integration of observation into a coherent view of brain development. Clearly, this may be a major challenge for the next century, and arguably is the most important task of contemporary develop mental biology. The purpose of the present book is to provide an overview that syn thesizes up-to-date information on selected aspects of mouse brain devel opment. Given the format, it was not possible to cover all aspects of brain development, and many important subjects are missing. The selected themes are, to a certain extent, subjective and reflect the interests of the contributing authors. Examples of major themes that are not covered are peripheral nervous system development, including myelination, the development of the hippocampus and several other CNS structures, as well as the developmental function of some important morphoregulatory molecules.
Author : Devashish Shrivastava
Publisher : John Wiley & Sons
ISBN 13 : 1119127300
Total Pages : 897 pages
Book Rating : 4.1/5 (191 download)
Download or read book Theory and Applications of Heat Transfer in Humans, 2 Volume Set written by Devashish Shrivastava and published by John Wiley & Sons. This book was released on 2018-07-02 with total page 897 pages. Available in PDF, EPUB and Kindle. Book excerpt: An authoritative guide to theory and applications of heat transfer in humans Theory and Applications of Heat Transfer in Humans 2V Set offers a reference to the field of heating and cooling of tissue, and associated damage. The author—a noted expert in the field—presents, in this book, the fundamental physics and physiology related to the field, along with some of the recent applications, all in one place, in such a way as to enable and enrich both beginner and advanced readers. The book provides a basic framework that can be used to obtain ‘decent’ estimates of tissue temperatures for various applications involving tissue heating and/or cooling, and also presents ways to further develop more complex methods, if needed, to obtain more accurate results. The book is arranged in three sections: The first section, named ‘Physics’, presents fundamental mathematical frameworks that can be used as is or combined together forming more complex tools to determine tissue temperatures; the second section, named ‘Physiology’, presents ideas and data that provide the basis for the physiological assumptions needed to develop successful mathematical tools; and finally, the third section, named ‘Applications’, presents examples of how the marriage of the first two sections are used to solve problems of today and tomorrow. This important text is the vital resource that: Offers a reference book in the field of heating and cooling of tissue, and associated damage. Provides a comprehensive theoretical and experimental basis with biomedical applications Shows how to develop and implement both, simple and complex mathematical models to predict tissue temperatures Includes simple examples and results so readers can use those results directly or adapt them for their applications Designed for students, engineers, and other professionals, a comprehensive text to the field of heating and cooling of tissue that includes proven theories with applications. The author reveals how to develop simple and complex mathematical models, to predict tissue heating and/or cooling, and associated damage.
Author : Aleš Prokop
Publisher : Springer Science & Business Media
ISBN 13 : 9400712480
Total Pages : 871 pages
Book Rating : 4.4/5 (7 download)
Download or read book Intracellular Delivery written by Aleš Prokop and published by Springer Science & Business Media. This book was released on 2011-05-26 with total page 871 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book features a special subsection of Nanomedicine, an application of nanotechnology to achieve breakthroughs in healthcare. It exploits the improved and often novel physical, chemical and biological properties of materials only existent at the nanometer scale. As a consequence of small scale, nanosystems in most cases are efficiently uptaken by cells and appear to act at the intracellular level. Nanotechnology has the potential to improve diagnosis, treatment and follow-up of diseases, and includes targeted drug delivery and regenerative medicine; it creates new tools and methods that impact significantly upon existing conservative practices. This volume is a collection of authoritative reviews. In the introductory section we define the field (intracellular delivery). Then, the fundamental routes of nanodelivery devices, cellular uptake, types of delivery devices, particularly in terms of localized cellular delivery, both for small drug molecules, macromolecular drugs and genes; at the academic and applied levels, are covered. The following section is dedicated to enhancing delivery via special targeting motifs followed by the introduction of different types of intracellular nanodelivery devices (e.g. a brief description of their chemistry) and ways of producing these different devices. Finally, we put special emphasis on particular disease states and on other biomedical applications, whilst diagnostic and sensing issues are also included. Intracellular delivery / therapy is a highly topical which will stir great interest. Intracellular delivery enables much more efficient drug delivery since the impact (on different organelles and sites) is intracellular as the drug is not supplied externally within the blood stream. There is great potential for targeted delivery with improved localized delivery and efficacy.
Author : Krzysztof Iniewski
Publisher : Artech House
ISBN 13 : 1596933186
Total Pages : 453 pages
Book Rating : 4.5/5 (969 download)
Download or read book VLSI Circuits for Biomedical Applications written by Krzysztof Iniewski and published by Artech House. This book was released on 2008 with total page 453 pages. Available in PDF, EPUB and Kindle. Book excerpt: Supported with over 280 illustrations and over 160 equations, the book offers cutting-edge guidance on designing integrated circuits for wireless biosensing, body implants, biosensing interfaces, and molecular biology. You discover innovative design techniques and novel materials to help you achieve higher levels circuit and system performance.
Author : Areles Molleman
Publisher : John Wiley & Sons
ISBN 13 : 0470856513
Total Pages : 186 pages
Book Rating : 4.4/5 (78 download)
Download or read book Patch Clamping written by Areles Molleman and published by John Wiley & Sons. This book was released on 2003-06-13 with total page 186 pages. Available in PDF, EPUB and Kindle. Book excerpt: Patch clamping is a widely applied electrophysiological technique for the study of ion channels; membrane proteins that regulate the flow of ions across cellular membranes and therefore influence the physiology of all cells. Patch Clamping aims to cover the basic principles and practical applications of this important technique. Starting with a review of the history of patch clamping, the text then goes on to cover the basic principles, platforms, equipment and environmental control, and will also include coverage of preparation types, recording modes and analysis of results. This book will explain the basic principles and practical application of patch clamp electrophysiology Written in a non-technical style to ensure its broad appeal to novice users Takes a practical approach This self-contained guide provides everything a practising patch clamp electrophysiologist needs to know to master this technique, including an overview of membrane biophysics, standard experimental design, data analysis, and technical concerns
Author : Christopher Spicer
Publisher : Royal Society of Chemistry
ISBN 13 : 1788017536
Total Pages : 323 pages
Book Rating : 4.7/5 (88 download)
Download or read book The Chemistry of Inorganic Biomaterials written by Christopher Spicer and published by Royal Society of Chemistry. This book was released on 2021-08-18 with total page 323 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book overviews the underlying chemistry behind the most common and cutting-edge inorganic materials in current use, or approaching use, in vivo.
Author : Steven J. Luck
Publisher : MIT Press
ISBN 13 : 0262525852
Total Pages : 417 pages
Book Rating : 4.2/5 (625 download)
Download or read book An Introduction to the Event-Related Potential Technique, second edition written by Steven J. Luck and published by MIT Press. This book was released on 2014-05-30 with total page 417 pages. Available in PDF, EPUB and Kindle. Book excerpt: An essential guide to designing, conducting, and analyzing event-related potential (ERP) experiments, completely updated for this edition. The event-related potential (ERP) technique, in which neural responses to specific events are extracted from the EEG, provides a powerful noninvasive tool for exploring the human brain. This volume describes practical methods for ERP research along with the underlying theoretical rationale. It offers researchers and students an essential guide to designing, conducting, and analyzing ERP experiments. This second edition has been completely updated, with additional material, new chapters, and more accessible explanations. Freely available supplementary material, including several online-only chapters, offer expanded or advanced treatment of selected topics. The first half of the book presents essential background information, describing the origins of ERPs, the nature of ERP components, and the design of ERP experiments. The second half of the book offers a detailed treatment of the main steps involved in conducting ERP experiments, covering such topics as recording the EEG, filtering the EEG and ERP waveforms, and quantifying amplitudes and latencies. Throughout, the emphasis is on rigorous experimental design and relatively simple analyses. New material in the second edition includes entire chapters devoted to components, artifacts, measuring amplitudes and latencies, and statistical analysis; updated coverage of recording technologies; concrete examples of experimental design; and many more figures. Online chapters cover such topics as overlap, localization, writing and reviewing ERP papers, and setting up and running an ERP lab.
Author : Horacio D. Espinosa
Publisher : John Wiley & Sons
ISBN 13 : 111848259X
Total Pages : 519 pages
Book Rating : 4.1/5 (184 download)
Download or read book Nano and Cell Mechanics written by Horacio D. Espinosa and published by John Wiley & Sons. This book was released on 2012-12-12 with total page 519 pages. Available in PDF, EPUB and Kindle. Book excerpt: Research in nano and cell mechanics has received much attention from the scientific community as a result of society needs and government initiatives to accelerate developments in materials, manufacturing, electronics, medicine and healthcare, energy, and the environment. Engineers and scientists are currently engaging in increasingly complex scientific problems that require interdisciplinary approaches. In this regard, studies in this field draw from fundamentals in atomistic scale phenomena, biology, statistical and continuum mechanics, and multiscale modeling and experimentation. As a result, contributions in these areas are spread over a large number of specialized journals, which prompted the Editors to assemble this book. Nano and Cell Mechanics: Fundamentals and Frontiers brings together many of the new developments in the field for the first time, and covers fundamentals and frontiers in mechanics to accelerate developments in nano- and bio-technologies. Key features: • Provides an overview of recent advances in nano and cell mechanics. • Covers experimental, analytical, and computational tools used to investigate biological and nanoscale phenomena. • Covers fundamentals and frontiers in mechanics to accelerate developments in nano- and bio-technologies. • Presents multiscale-multiphysics modeling and experimentation techniques. • Examines applications in materials, manufacturing, electronics, medicine and healthcare. Nano and Cell Mechanics: Fundamentals and Frontiers is written by internationally recognized experts in theoretical and applied mechanics, applied physics, chemistry, and biology. It is an invaluable reference for graduate students of nano- and bio-technologies, researchers in academia and industry who are working in nano and cell mechanics, and practitioners who are interested in learning about the latest analysis tools. The book can also serve as a text for graduate courses in theoretical and applied mechanics, mechanical engineering, materials science, and applied physics.
