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Methods In Mammary Gland Biology And Breast Cancer Research
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Book Synopsis Methods in Mammary Gland Biology and Breast Cancer Research by : Margot M. Ip
Download or read book Methods in Mammary Gland Biology and Breast Cancer Research written by Margot M. Ip and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 350 pages. Available in PDF, EPUB and Kindle. Book excerpt: approaches to the experimental problems that still face us in understanding this most fascinating of organs. Too many people contributed to the completion of this volume to allow acknowledg ment of all the individual efforts, but we particularly thank the reviewers whose input into the editorial process was invaluable and the authors of these chapters who revised their text, sometimes more than once, to bring it to the high standards set by the Editors. The Com mittee gratefully acknowledges the support ofVysis, Inc. , in the publication of a color figure in Chapter 19, by S. Weber-Hall and Trevor Dale. Finally, we wish to express our heartfelt appreciation to Margot Ip and Bonnie Asch, who worked long and hard to bring this volume to fruition. Margaret C. Neville for the Committee on Mammary Gland Biology Preface One of the most exciting and beneficial developments in research on mammary gland biology and breast cancer has been the influx of increased funding to support this work. This influx, which has been due primarily to the tireless efforts of breast cancer activists to gamer addi tional money from various federal and state sources, has led to a rapid expansion of research efforts by attracting numerous new investigators into the field. These new investigators include students, postdoctoral fellows, and scientists from other fields.
Book Synopsis Perspectives in Mammary Gland Development and Breast Cancer Research by : Zuzana Koledova
Download or read book Perspectives in Mammary Gland Development and Breast Cancer Research written by Zuzana Koledova and published by Frontiers Media SA. This book was released on 2020-10-27 with total page 158 pages. Available in PDF, EPUB and Kindle. Book excerpt: This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.
Download or read book Breast Cancer written by Anne M. Bowcock and published by Springer Science & Business Media. This book was released on 1999-01-11 with total page 593 pages. Available in PDF, EPUB and Kindle. Book excerpt: A comprehensive state-of-the-art summary of breast cancer research and treatment by leading authorities. The book's many distinguished contributors illuminate the biology and genetics of breast cancer, including what is known about the hereditary breast cancer genes, BRCA1 and 2, the cutting-edge cytogenic approaches, and the biology of breast cancer metastasis. In addition, the authors describe current and future methods of breast cancer treatment in depth, and discuss environment and diet as risk factors for the disease. Breast Cancer: Molecular Genetics, Pathogenesis, and Therapeutics constitutes an excellent reference and resource for all those clinical and experimental oncologists, as well as genetic counselors nurses, who need to understand the latest developments in breast cancer biology, risk, and treatment.
Book Synopsis Techniques and Methodological Approaches in Breast Cancer Research by : Jose Russo
Download or read book Techniques and Methodological Approaches in Breast Cancer Research written by Jose Russo and published by Springer. This book was released on 2014-05-14 with total page 301 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume explores the myriad of techniques and methodological approaches that are being used in breast cancer research. The authors critically evaluate of the advantages and disadvantages of current methodologies, starting with the tools available for understanding the architecture of the human breast, including its tissue and cellular composition. The volume discusses the importance of functional studies in breast cancer research, especially with the help of laser capture microdissection, which allows the separation of small amounts of tissue, as well as specific cells, for biochemical analysis. In addition, the authors address methodologies including stem cell separation, which has helped in significantly understanding their role in normal breast development, but also further the understanding of breast cancer and its therapeutic management. The use of in vitro techniques and established cell lines for mechanistic studies in chemotherapeutic approaches have been invaluable will be discussed. Imaging techniques for evaluating in vitro and in vivo behavior of normal and cancerous breast tissue will be explored, as it provides a better understanding of the physiopathology of cancer. The volume will also discuss the molecular analysis of gene function in breast cancer through the transcriptomic and epigenomic profile. More importantly, the advancement of more refined techniques in sequencing will be covered. This monograph will be a comprehensive, authoritative and timely, as it addresses the emerging approaches used in breast cancer research.
Book Synopsis Undergraduate Training in Mammary Gland Biology and Breast Cancer by :
Download or read book Undergraduate Training in Mammary Gland Biology and Breast Cancer written by and published by . This book was released on 2006 with total page 45 pages. Available in PDF, EPUB and Kindle. Book excerpt: This research report describes the third and final year of the BCRT undergraduate research training program in breast cancer. The goal of this project was to provide undergraduate trainees with exposure to areas of breast cancer research that focus on the role of microenvironment in mammary gland biology and in the development of neoplasia. Trainees in this project benefited from working in a program that investigates the intersection of hormones, growth factors, and extracellular matrix (ECM) signaling and remodeling during mammary gland morphogenesis, differentiation, and carcinogenesis. The program was advertised through several undergraduate research forums on the UC Berkeley campus, and more than forty applications were received. From these, eight applicants were selected to represent a balance of interests and approaches, with broad levels of expertise ranging from laboratory novices to students with many years of laboratory experience. During the research portion of the program, undergraduate trainees had frequent interaction with mentors and with advanced postdoctoral fellows, and reports were presented in organized, biweekly meetings structured to reflect the organization of a research paper. At the first meeting, the students presented the introduction to their research project; at the second, the materials and methods; at the third, the results. For the final meeting of the program, the students presented their work in complete form, including conclusions and interpretations. While the success at obtaining experimental results within the allotted time of the research program varies, all the participants (both students and preceptors) agreed that the overall experience was successful.
Book Synopsis Current Advances in Breast Cancer Research: A Molecular Approach by : Shankar Suman
Download or read book Current Advances in Breast Cancer Research: A Molecular Approach written by Shankar Suman and published by Bentham Science Publishers. This book was released on 2020-04-30 with total page 401 pages. Available in PDF, EPUB and Kindle. Book excerpt: Breast cancer is a recognized disease around the world with varying patient outcomes based on the type of breast cancer, access to healthcare and other factors. Survival rates for breast cancer are significantly lower in metastatic cases than localized cases. Early diagnosis and effective treatments for the efficient management of breast cancer are now in demand , as they help to prolong patient life. There have been many breakthrough developments in the molecular biology of breast cancer research in recent times. Advancements in diagnostic techniques (imaging and biomarker detection) for breast cancer have improved the screening of the disease and have improved patient outcomes. Despite these enhancements, the disease is still lethal for patients and the search for a cure requires a complete understanding of the disease. Current Advances in Breast Cancer Research: A Molecular Approach presents a comprehensive overview of current basic and translational research on the subject. The 14 chapters of the book give emphasis to current knowledge about breast cancer, ongoing challenges, and innovative research findings by different research groups. Readers will find detailed information about breast cancer biology, genetics, clinical diagnostics and treatments. Additional information for advanced readers in life sciences, such as techniques relevant to genomics (including genetic fingerprinting), proteomics, metabolomics and medicine (such as imaging and molecular diagnostics) is also provided. The combination of both basic and advanced information makes this book a useful reference to the student and researcher, alike, seeking an understanding about breast cancer at a molecular level.
Book Synopsis Training in Mammary Gland Biology and Breast Cancer by :
Download or read book Training in Mammary Gland Biology and Breast Cancer written by and published by . This book was released on 2005 with total page 19 pages. Available in PDF, EPUB and Kindle. Book excerpt: The goal of the present proposal is to provide post-doctoral training opportunities in breast cancer research that focus on the role of microenvironmental in mammary gland biology. Trainees will benefit from working in a dynamic interactive program under the guidance of the LBNL mentors to investigate the intersection of hormone action, growth factor activity, and extracellular matrix remodeling during mammary gland development and carcinogenesis. In addition, trainees will be exposed to a variety of other topics related to breast cancer, as well as research ranging from molecular medicine to genomics, by their participation in working groups, lectures and scientific meetings with other Berkeley Lab and Bay Area researchers.
Book Synopsis Breast Cancer: Cellular and Molecular Biology by : Marc E. Lippman
Download or read book Breast Cancer: Cellular and Molecular Biology written by Marc E. Lippman and published by Springer Science & Business Media. This book was released on 1988-08-31 with total page 424 pages. Available in PDF, EPUB and Kindle. Book excerpt: Where do you begin to look for a recent, authoritative article on the diagnosis or management of particular malignancy? The few general oncology text books are generally out of date. Single papers in specialized journals are informative but seldom comprehensive; these are more often preliminary reports on a very limited number of patients. Certain general journals fre quently publish good in-depth reviews of cancer topics, and published sym posium lectures are often the best overviews available. Unfortunately, these reviews and supplements appear sporadically, and the reader can never be sure when a topic of special interest will be covered. Cancer Treatment and Research is a series of authoritative volumes which aim to meet this need. It is an attempt to establish a critical mass of oncology literature covering virtually all oncology topics, revised frequently to keep the coverage up to date, easily available on a single library shelf or by a single personal subscription. We have approached the problem in the following fashion. First, by divid ing the oncology literature into specific subdivisions such as lung cancer, genitourinary cancer, pediatric oncology, etc. Second, by asking eminent authorities in each of these areas to edit a volume on the specific topic on an annual or biannual basis. Each topic and tumor type is covered in a volume appearing frequently and predictably, discussing current diagnosis, staging, markers, all forms of treatment modalities, basic biology, and more.
Book Synopsis Mammary Gland Development: Methods and Protocols by : Finian Martin
Download or read book Mammary Gland Development: Methods and Protocols written by Finian Martin and published by Methods in Molecular Biology. This book was released on 2018-11-12 with total page 372 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Breast Cancer Biology by : Dil Afroze
Download or read book Breast Cancer Biology written by Dil Afroze and published by BoD – Books on Demand. This book was released on 2020-07-08 with total page 127 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book offers a comprehensive overview of recent developments in the field of breast cancer biology. It is a complete and descriptive reference on motioning pathways and new treatment options for the future transnational scientists and clinicians working on cancer research and treatment. We greatly appreciate the work of all the contributors to this book. They have brought with them tremendous diversity of perspectives and fields, which is truly reflective of the complexity of the topic, and they have come together in this project to serve as the node of multidisciplinary collaboration in this field. Finally, we must acknowledge the thousands of cancer patients who have participated in the studies, and who have inspired us to gather information to significantly progress knowledge in the field in recent years.
Book Synopsis Breast Cancer Research Protocols by : Susan A. Brooks
Download or read book Breast Cancer Research Protocols written by Susan A. Brooks and published by Springer Science & Business Media. This book was released on 2008-02-02 with total page 507 pages. Available in PDF, EPUB and Kindle. Book excerpt: A collection of both well-established and cutting-edge methods for investigating breast cancer biology not only in the laboratory, but also in clinical settings. These readily reproducible techniques solve a variety of problems, ranging from how to collect, store, and prepare human breast tumor samples for analysis, to analyzing cells in vivo and in vitro. Additional chapters address the technology of handling biopsies, new methods for analyzing genes and gene expression, markers of clinical outcome and progress, analysis of tumor-derived proteins and antigens, validating targets, and investigating the biology of newly discovered genes.
Book Synopsis Breast Cancer: Origins, Detection, and Treatment by : Marvin A. Rich
Download or read book Breast Cancer: Origins, Detection, and Treatment written by Marvin A. Rich and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 360 pages. Available in PDF, EPUB and Kindle. Book excerpt: The control of breast cancer, a leading cause of cancer death in women, will depend ultimately on our understanding of the disease--its origin, and progression which in turn will permit the effective management of its treatment, its detection, and perhaps even its prevention. It is for a better understanding of this spectrum of biological processes crossing back and forth across scientific and clinical disciplines that this volume strives. Several broad topics have been addressed in organizing a large mass of work representing state of the art updates from many of the major breast cancer research groups around the world. The chapters in the first section speak to the factors affecting the growth and development of normal and malignant mammary epithelium. Special emphasis is placed on insights drawn from developmental biology, the cellular interactions that occur in the mammary gland during growth and differentiation; and the study of hormones and growth factors in the regulation of growth and differentiation of normal and malignant breast tissues. In the section on the biology of breast cancer, there is a characterization of relevant model systems for the study of breast cancer and their contribution to our understanding of preneoplasia and progression in mammary cancer. Included as well is the current status of major studies on the immunological aspects of breast cancer and the latest efforts in the development of markers for metastasis in breast cancer.
Book Synopsis Cellular and Molecular Biology of Mammary Cancer by : E. Anderson
Download or read book Cellular and Molecular Biology of Mammary Cancer written by E. Anderson and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 519 pages. Available in PDF, EPUB and Kindle. Book excerpt: The idea for this book arose during the 1985 Gordon Conference on "Mammary Gland Biology". New developments in the methodology of cell biology and the explosive growth of molecular biology had begun to impact upon our understanding of mammary gland growth and function. It seemed a propitious time for summarizing the current status of knowledge of the cell and molecular biology of mammary cancer and for attempting to outline future areas of concern and interest. The reviews presented here were completed by the Fall of 1986. Although new insights will surely continue to emerge, it is hoped that the material in this volume will form not only a current update but a basic core of information for future experiments. We have not attempted to cover all areas of mammary gland transformation. Those areas where recent detailed reviews are already available have been omitted. Also, the areas of normal gland development, cell ultrastructure, hormone responsiveness, chemotherapy and clinical aspects of mammary cancer have not been included. Instead, we have selected those areas where the development of new methodology, reagents and results have led to new ideas about mammary gland function and development as they are related to neoplasia.
Book Synopsis Biology of the Mammary Gland by : John A. Mol
Download or read book Biology of the Mammary Gland written by John A. Mol and published by Springer Science & Business Media. This book was released on 2006-04-11 with total page 309 pages. Available in PDF, EPUB and Kindle. Book excerpt: Proceedings of the European Cooperation in the Field of Scientific and Technical Research (COST 825) Symposium on Mammary Gland Biology, held September 16-18, 1999, in Tours, France. It is difficult to overstate the evolutionary and functional significance of mammary tissue in biology. Substantial progress has been made by researchers in various disciplines, particularly over the last fifteen years, towards realizing the potential of this tissue to yield powerful experimental models for morphogenesis and tissue development; for cellular differentiation; for the biosynthesis and secretion of proteins, lipids, small molecules and inorganic salts; and for the coordination and regulation of these processes. More recently, the possibility of exploiting the secretory epithelial cells of mammary tissue as `cell factories' has become a reality and the recombinant production by lactating animals of an increasing number of proteins, valuable both in the pharmaceutical and `nutraceutical' fields, is in progress or under development. Also in this sphere of agricultural production, genetic as well as nutritional technologies are under investigation and exploitation to optimize milk composition for various end-uses - for instance in food process and manufacture. The possibilities of deriving health benefit from the bioactive properties of some of the minor constituents of milk are emerging to counter the highly-publicized negative health impact of excessive consumption of saturated animal fats. In human nutrition and medicine, the mammary gland is both a source of nutrition to the neonate and a potential health threat to the adult female - breast cancer remains the major single cause of female mortality in most developed countries. This volume provides a unique glimpse into our understanding, at the cutting edge of a variety of disciplines, of this versatile and extraordinary tissue, at the birth of the twenty-first century.
Book Synopsis Translational Research in Breast Cancer by : Dong-Young Noh
Download or read book Translational Research in Breast Cancer written by Dong-Young Noh and published by Springer Nature. This book was released on 2021-05-13 with total page 630 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book describes recent advances in translational research in breast cancer and presents emerging applications of this research that promise to have meaningful impacts on diagnosis and treatment. It introduces ideas and materials derived from the clinic that have been brought to "the bench" for basic research, as well as findings that have been applied back to "the bedside". Detailed attention is devoted to breast cancer biology and cell signaling pathways and to cancer stem cell and tumor heterogeneity in breast cancer. Various patient-derived research models are discussed, and a further focus is the role of biomarkers in precision medicine for breast cancer patients. Next-generation clinical research receives detailed attention, addressing the increasingly important role of big data in breast cancer research and a wide range of other emerging developments. An entire section is also devoted to the management of women with high-risk breast cancer. Translational Research in Breast Cancer will help clinicians and scientists to optimize their collaboration in order to achieve the common goal of conquering breast cancer.
Book Synopsis New Methods to Study Human Mammary Development and Breast Cancer by : Ethan Samuel Sokol
Download or read book New Methods to Study Human Mammary Development and Breast Cancer written by Ethan Samuel Sokol and published by . This book was released on 2017 with total page 153 pages. Available in PDF, EPUB and Kindle. Book excerpt: Breast cancer is fundamentally a disease of aberrant differentiation. Breast cancers arise from within the normal architecture of the mammary gland and resemble normal mammary epithelial cell types on a molecular and gene expression level. Many tumors become dependent on the signaling pathways that guide mammary differentiation and proliferation, and may be driven by transcription factors and signaling pathways that enforce cell state. It's no wonder then that many fundamental insights into breast cancer biology derive from study of the normal mammary gland. Mouse models of mammary gland development have helped identify many of the key genetic and hormonal drivers of mammary differentiation. However, these systems have some limitations. First, study of stem and progenitor cell differentiation decisions has been hampered by a lack of definitive markers of cell state. Second, validation of these pathways in human mammary tissue has been challenging due to a paucity of human model systems. This thesis describes work to overcome these limitations. Here I describe a computational method to identify regulators of cell state transitions without the need for definitive markers of cell state. Using this method, we identified RUNXI as a regulator of mammary stem cell differentiation, and demonstrated that RUNX1 is required for exit from the stem/progenitor state. RUNX1 inhibition expanded the pool of stem cells and blocked mammary morphogenesis. This thesis also describes the development of a 3D hydrogel culture system that supports the growth of primary human mammary epithelial tissues. The tissues exhibit all major cell types found in the mammary gland and are hormone responsive. We further adapted the culture system to study the early stages of breast cancer progression by injecting tumor cells into the tissues. Tumor cells interacted and intercalated with normal mammary epithelial cells before invading out of the tissues. We utilized this system to validate SMARCE1 as a regulator of human breast cancer progression. SMARCE1 expression is predictive of progression in early-stage epithelial tumors, and SMARCE1 is functionally required for basement membrane degradation. In our tissue model of tumor progression SMARCE1 was dispensable for cell growth and in situ spreading but was required for invasion.
Book Synopsis The Mammary Gland as an Experimental Model by : Mina Bissell
Download or read book The Mammary Gland as an Experimental Model written by Mina Bissell and published by . This book was released on 2011 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Studies of mammary gland biology are critically important given the prevalence of breast cancer in the population. There are many other reasons to study this organ, however. It represents an excellent model system for research into developmental mechanisms, gene regulation, tissue organization, hormonal action, secretion, and stem cell biology, revealing general principles that can be extended to other organs and tissues. This book provides valuable lessons for all cell, developmental, and cancer biologists.
