Metallothioneins In Biochemistry And Pathology

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Metallothioneins in Biochemistry and Pathology

Author : Paolo Zatta
Publisher : World Scientific
ISBN 13 : 9812778934
Total Pages : 335 pages
Book Rating : 4.8/5 (127 download)

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Book Synopsis Metallothioneins in Biochemistry and Pathology by : Paolo Zatta

Download or read book Metallothioneins in Biochemistry and Pathology written by Paolo Zatta and published by World Scientific. This book was released on 2008 with total page 335 pages. Available in PDF, EPUB and Kindle. Book excerpt: Metallothioneins (MTs) represent a large family of proteins characterized by high heavy metal content (mainly CuII and ZnII) and by an unusual cysteine abundance. They have a powerful protective function in all animal tissues, due most likely to their properties as free radical scavengers protecting against oxidative damage. Moreover, the presence and overexpression of MTs in various pathological conditions, such as metal dyshomeostasis, cell proliferation, neurological disorders, and chemotherapy and radiotherapy resistance, could be used as an important prognostic marker, as a histopathological diagnostic tool, and to follow specific pharmacological treatments.This important book explores the role of MTs in the field of neurological disorders (brain inflammation, Alzheimer's and prion diseases, autism, ALS, etc.), cardiology (cardiomyopathy, atherosclerosis), and oncology (melanoma, prostate and breast cancer), through authoritative contributions and a description of basic biochemical information and paradigmatic pathological events.

Metallothionein IV

Author : C. Klaasen
Publisher : Birkhäuser
ISBN 13 : 3034888473
Total Pages : 641 pages
Book Rating : 4.0/5 (348 download)

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Book Synopsis Metallothionein IV by : C. Klaasen

Download or read book Metallothionein IV written by C. Klaasen and published by Birkhäuser. This book was released on 2012-12-06 with total page 641 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Proceedings of the Fourth International Metallothionein Meeting (MT-97) feature the latest research on metallothionein. The book covers a broad range of topics which provide important information for both basic and clinical investigators. The selected 94 articles in this book are written by the leading scientists in the field around the world. This is an increasingly important, multi-disciplinary area of study that has benefitted from recent advances in concepts and methodologies from other fields.

Metallothionein in Biology and Medicine

Author : Curtis D. Klaassen
Publisher : CRC Press
ISBN 13 : 9780849388323
Total Pages : 436 pages
Book Rating : 4.3/5 (883 download)

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Book Synopsis Metallothionein in Biology and Medicine by : Curtis D. Klaassen

Download or read book Metallothionein in Biology and Medicine written by Curtis D. Klaassen and published by CRC Press. This book was released on 1991-08-27 with total page 436 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book brings together work from leading researchers to present the most recent advances in research on metallothionein. This protein interests toxicologists because it is thought that metallothionein protects against metal toxicity and possibly against oxidative stress. It is of interest to pharmacologists because modification of metallothionein levels might have a role in cancer chemotherapy. Nutritionists have an interest in this protein because it appears to be a major storage protein for zinc. Biochemists and molecular biologists will be interested in the mechanisms of regulation of this protein because it is extremely inducible.

Metallothioneins and Related Chelators

Author : Astrid Sigel
Publisher : Walter de Gruyter GmbH & Co KG
ISBN 13 : 3110436272
Total Pages : 544 pages
Book Rating : 4.1/5 (14 download)

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Book Synopsis Metallothioneins and Related Chelators by : Astrid Sigel

Download or read book Metallothioneins and Related Chelators written by Astrid Sigel and published by Walter de Gruyter GmbH & Co KG. This book was released on 2015-07-24 with total page 544 pages. Available in PDF, EPUB and Kindle. Book excerpt: These sulfur-rich chelators, being important in metal ion homeostasis, find increasing attention. MILS-5, written by 30 internationally recognized experts, focuses on this hot topic. The reader is supported by about 20 tables, more than 80 illustrations and nearly 2000 references. This book is an essential resource for scientists working in a wide range of disciplines from environmental toxicology and inorganic biochemistry all the way through to physiology and medicine.

Metallothionein III

Author : Kazuo T. Suzuki
Publisher : Birkhauser
ISBN 13 :
Total Pages : 504 pages
Book Rating : 4.:/5 (318 download)

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Book Synopsis Metallothionein III by : Kazuo T. Suzuki

Download or read book Metallothionein III written by Kazuo T. Suzuki and published by Birkhauser. This book was released on 1993 with total page 504 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Metallothionein IV

Author : C Klaasen
Publisher :
ISBN 13 : 9783034888486
Total Pages : 700 pages
Book Rating : 4.8/5 (884 download)

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Book Synopsis Metallothionein IV by : C Klaasen

Download or read book Metallothionein IV written by C Klaasen and published by . This book was released on 1998-12-01 with total page 700 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Metallothioneins in Normal and Cancer Cells

Author : Piotr Dziegiel
Publisher : Springer
ISBN 13 : 3319274724
Total Pages : 126 pages
Book Rating : 4.3/5 (192 download)

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Book Synopsis Metallothioneins in Normal and Cancer Cells by : Piotr Dziegiel

Download or read book Metallothioneins in Normal and Cancer Cells written by Piotr Dziegiel and published by Springer. This book was released on 2016-02-04 with total page 126 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book describes the structures of Metallothionein (MT) family members and the cellular functions of MT-1, MT-2 and MT-4 isoforms, as well as provides insights into divergent biological roles of MT-3. The authors explain the involvement of MT molecules in various processes related to carcinogenesis, including an organ-specific presentation of current data concerning their potential impact on the progression of various tumors and the regulatory role of MT family members in the function of the immune system.

Metallothionin III

Author : K.T. Suzuki
Publisher : Birkhäuser
ISBN 13 : 9783764327699
Total Pages : 483 pages
Book Rating : 4.3/5 (276 download)

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Book Synopsis Metallothionin III by : K.T. Suzuki

Download or read book Metallothionin III written by K.T. Suzuki and published by Birkhäuser. This book was released on 1993-01-01 with total page 483 pages. Available in PDF, EPUB and Kindle. Book excerpt: Focuses on the biological roles and medical implications of metallothioneins, and related chemical and biochemical developments. The contributors present and discuss findings on the roles of metallothionein in various kinds of stress conditions, including exposure to heavy metals.

Hydrolith 2: Surrealist Research & Investigations

Author : Oyster Moon Press
Publisher : Lulu.com
ISBN 13 : 0578157926
Total Pages : 370 pages
Book Rating : 4.5/5 (781 download)

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Book Synopsis Hydrolith 2: Surrealist Research & Investigations by : Oyster Moon Press

Download or read book Hydrolith 2: Surrealist Research & Investigations written by Oyster Moon Press and published by Lulu.com. This book was released on 2013-08-12 with total page 370 pages. Available in PDF, EPUB and Kindle. Book excerpt: Magazine. Poetry. Fiction. Literary Nonfiction. Art. Translation. "This second issue of HYDROLITH is a continuation of what the first volume started, which was and is to assemble a stimulating selection of exclusively recent work by groups and individuals of the international Surrealist movement, to facilitate intellectual exchange and collaboration, enabling us to concentrate the echoes of our commonalities as well as the shadows of our differences. In so doing, this volume aspires to reduce all manner of distances that exist between us. All works in this book are in English, while many of them are translations from the Dutch, French, Greek, Portuguese, Romanian, Spanish and Turkish languages."--from the Preface

Genetics, Neurology, Behavior, and Diet in Dementia

Author : Colin R Martin
Publisher : Academic Press
ISBN 13 : 0128158697
Total Pages : 954 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis Genetics, Neurology, Behavior, and Diet in Dementia by : Colin R Martin

Download or read book Genetics, Neurology, Behavior, and Diet in Dementia written by Colin R Martin and published by Academic Press. This book was released on 2020-08-11 with total page 954 pages. Available in PDF, EPUB and Kindle. Book excerpt: Genetics, Neurology, Behavior, and Diet in Dementia: The Neuroscience of Dementia, Volume 2 consolidates different fields of dementia research into a single book, covering a range of subjects, including Alzheimer’s disease, Lewy body dementia, mixed dementia, vascular dementia, physical activity, risk factors, mortality, biomarkers, SPECT, CT, MRI, questionnaires, nutrition, sleep, delirium, hearing loss, agitation, aggression, delusions, anxiety, depression, hallucinations, psychosis, senile plaques, tau and amyloid-beta, neuroinflammation, and molecular biology. This foundational, comprehensive book assembles the latest understanding on all dementias and their common features in a single source. It is an invaluable resource for neuroscientists, neurologists, and anyone in the field. Offers comprehensive coverage of a broad range of topics related to dementia Serves as a foundational collection for neuroscientists and neurologists on the biology of dementia and brain dysfunction Contains in each chapter an abstract, key facts, mini dictionary of terms, and summary points to aid in understanding Provides unique sections on specific subareas, intellectual components, and knowledge-based niches that will help readers navigate key areas for research and further clinical recommendations Features preclinical and clinical studies to help researchers map out key areas for research and further clinical recommendations Serves as a "one-stop" source for everything you need to know about dementia

Research Communications in Molecular Pathology and Pharmacology

Author :
Publisher :
ISBN 13 :
Total Pages : 756 pages
Book Rating : 4.3/5 (555 download)

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Book Synopsis Research Communications in Molecular Pathology and Pharmacology by :

Download or read book Research Communications in Molecular Pathology and Pharmacology written by and published by . This book was released on 1998 with total page 756 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Molecular Biology and Toxicology of Metals

Author : Rudolfs K. Zalups
Publisher : CRC Press
ISBN 13 : 9780748407989
Total Pages : 608 pages
Book Rating : 4.4/5 (79 download)

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Book Synopsis Molecular Biology and Toxicology of Metals by : Rudolfs K. Zalups

Download or read book Molecular Biology and Toxicology of Metals written by Rudolfs K. Zalups and published by CRC Press. This book was released on 2000-02-24 with total page 608 pages. Available in PDF, EPUB and Kindle. Book excerpt: Molecular Biology and Toxicology of Metals provides a critical review and analysis of the current state of knowledge of metal ion transport and metabolism in prokaryotic and eukaryotic cellular systems. It covers the latest information on specific metals and the biological molecules with which metals interact. It also details mechanisms in the handling and toxicity of metals in specific organ systems, and the role of metals in cell signalling and gene transcription in target cells. This book is sure to prove a fertile meeting ground for the disciplines of molecular genetics and metal toxicology.

The Role of Glia in Neurotoxicity

Author : Michael Aschner
Publisher : CRC Press
ISBN 13 : 9780849347924
Total Pages : 380 pages
Book Rating : 4.3/5 (479 download)

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Book Synopsis The Role of Glia in Neurotoxicity by : Michael Aschner

Download or read book The Role of Glia in Neurotoxicity written by Michael Aschner and published by CRC Press. This book was released on 1996-03-27 with total page 380 pages. Available in PDF, EPUB and Kindle. Book excerpt: It is well established that glial cells represent more than mere passive cytoskeletal support elements of the central and peripheral nervous system. A reciprocal relationship exists between neurons and glia that is vital for mutual differentiation, development, and functioning of both cell types. It also has become apparent that perturbations in glial function may lead to deleterious consequences in juxtaposed neurons. It is therefore possible that neuronal damage induced by chemicals or neuropathic disease involves dissociation of glial-neuronal interactions. The Role of Glia in Neurotoxicity brings together experts in the neurosciences to provide a more complete understanding of the effects of chemicals on nervous system function. This book explores potential sites of glial-neuronal interactions both in the central and peripheral nervous system, focusing on potential sites of neurotoxicant actions. Text introduces basic aspects of neuroscience, the first step toward understanding the mechanisms at work in normal physiology. The ways in which these processes are disturbed in pathological conditions are discussed. Distinguished authors examine the functional interactions between glial cells and neurons during development, adulthood, and senescence. The roles of glia in the normal CNS and PNS are described. The book offers specific, in-depth examples of directly (via diffusive and cell surface signals) or indirectly (via effects on the extracellular fluid or the blood-brain barrier) mediated glial neurotoxicity. This reference includes different techniques, conceptual frameworks, and approaches that are currently used in the study of the role of glia in neurotoxicity. This timely review not only presents an excellent overview of the state of the science but also provides direction for future research into the consequences of an altered glial-neuronal unit.

Comprehensive Toxicology

Author :
Publisher : Elsevier
ISBN 13 : 0081006128
Total Pages : 8639 pages
Book Rating : 4.0/5 (81 download)

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Book Synopsis Comprehensive Toxicology by :

Download or read book Comprehensive Toxicology written by and published by Elsevier. This book was released on 2017-12-01 with total page 8639 pages. Available in PDF, EPUB and Kindle. Book excerpt: Comprehensive Toxicology, Third Edition, Fifteen Volume Set discusses chemical effects on biological systems, with a focus on understanding the mechanisms by which chemicals induce adverse health effects. Organized by organ system, this comprehensive reference work addresses the toxicological effects of chemicals on the immune system, the hematopoietic system, cardiovascular system, respiratory system, hepatic toxicology, renal toxicology, gastrointestinal toxicology, reproductive and endocrine toxicology, neuro and behavioral toxicology, developmental toxicology and carcinogenesis, also including critical sections that cover the general principles of toxicology, cellular and molecular toxicology, biotransformation and toxicology testing and evaluation. Each section is examined in state-of-the-art chapters written by domain experts, providing key information to support the investigations of researchers across the medical, veterinary, food, environment and chemical research industries, and national and international regulatory agencies. Thoroughly revised and expanded to 15 volumes that include the latest advances in research, and uniquely organized by organ system for ease of reference and diagnosis, this new edition is an essential reference for researchers of toxicology. Organized to cover both the fundamental principles of toxicology and unique aspects of major organ systems Thoroughly revised to include the latest advances in the toxicological effects of chemicals on the immune system Features additional coverage throughout and a new volume on toxicology of the hematopoietic system Presents in-depth, comprehensive coverage from an international author base of domain experts

Physiological Mechanisms Of Marine Pollutant Toxicity

Author : Winona Vernberg
Publisher : Elsevier
ISBN 13 : 032314540X
Total Pages : 579 pages
Book Rating : 4.3/5 (231 download)

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Book Synopsis Physiological Mechanisms Of Marine Pollutant Toxicity by : Winona Vernberg

Download or read book Physiological Mechanisms Of Marine Pollutant Toxicity written by Winona Vernberg and published by Elsevier. This book was released on 2012-12-02 with total page 579 pages. Available in PDF, EPUB and Kindle. Book excerpt: Physiological Mechanisms of Marine Pollutant Toxicity contains the proceedings of a symposium on ""Pollution and Marine Organisms"" held at the University of South Carolina in Columbia, South Carolina, on November 30 to December 3, 1981. It explores the effects of pollutants, such as petroleum hydrocarbons, heavy metals, and pesticides, on the physiology of marine organisms, along with the functional aspects of detoxification and the environmental health implications of pollution. Organized into three sections encompassing 24 chapters, this volume begins with a discussion of subcellular accumulation and detoxification of metals in aquatic animals such as fishes, crabs, and polychaetes. The reader is then introduced to the physiological mechanisms of pollutant toxicity, including the sublethal effects of pollutants on the gill morphology of the scallop, Placopecten magellanicus; mechanisms underlying the tolerance of killifish embryos to heavy metals; increased sensitivity of smolts in seawater to petroleum hydrocarbons, such as toluene and naphthalene; and physiological effects of sublethal concentrations of benzene and dimethylnaphthalene on blue crab juveniles. The book concludes by outlining research directions for linking cause and effect concerning pollution and marine organisms. This book will be a valuable resource for marine scientists, ecologists, and students.

New Approaches to Monitoring Aquatic Eco-systems

Author : Terence P. Boyle
Publisher : ASTM International
ISBN 13 : 0803109393
Total Pages : 222 pages
Book Rating : 4.8/5 (31 download)

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Book Synopsis New Approaches to Monitoring Aquatic Eco-systems by : Terence P. Boyle

Download or read book New Approaches to Monitoring Aquatic Eco-systems written by Terence P. Boyle and published by ASTM International. This book was released on 1987 with total page 222 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Phylogenetic Perspectives on the Vertebrate Immune System

Author : Gregory Becker
Publisher : Springer Science & Business Media
ISBN 13 : 1461512913
Total Pages : 380 pages
Book Rating : 4.4/5 (615 download)

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Book Synopsis Phylogenetic Perspectives on the Vertebrate Immune System by : Gregory Becker

Download or read book Phylogenetic Perspectives on the Vertebrate Immune System written by Gregory Becker and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 380 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book contains the proceedings of the first meeting on invertebrate immunity ever sponsored as a summer research conference by the Federation of American Societies for Experimental Biology (FASEB). The conference was held in Copper Mountain, CO from July 11-16, 1999. It was a an extension of a New York Academy of Sciences meeting entitled "Primordial Immunity: Foundations for the Vertebrate Immune System" held on May 2-5,1993 at the Marine Biological Laboratories in Woods Hole, MA. The proceedings of that meeting were published in The Annals of the New York Academy of Sciences (volume 712). At that meeting all the attendes agreed that this type of conference (a relatively small focused gathering) allowed for participation by investigators at all levels of their careers. We further agreed that we should search for a forum that would allow this meeting to continue. The FASEB Summer Research Conference was an excellent vehicle for this type of meeting. Furthermore, this year's participants decided to continue this meeting as a regularly scheduled FASEB sponsored event. This was a unique conference in the sense that it focused upon mechanisms of development and defense in protostome and deuterostome invertebrates and lower vertebrates. There was a strong emphasis on evolutionary cell biology, phylogenetic inferences and the evolution of recognition and regulatory systems.