Metabotropic Glutamate Receptors In Psychiatric And Neurological Disorders

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Metabotropic Glutamate Receptors in Psychiatric and Neurological Disorders

Author :
Publisher : Elsevier
ISBN 13 : 0323993958
Total Pages : 432 pages
Book Rating : 4.3/5 (239 download)

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Book Synopsis Metabotropic Glutamate Receptors in Psychiatric and Neurological Disorders by :

Download or read book Metabotropic Glutamate Receptors in Psychiatric and Neurological Disorders written by and published by Elsevier. This book was released on 2023-03-01 with total page 432 pages. Available in PDF, EPUB and Kindle. Book excerpt: Metabotropic Glutamate Receptors in Psychiatric and Neurological Disorders, Volume 168 in the International Review of Neurobiology series, highlights advances in the field, with this new volume presenting interesting chapters on topics such as mGlu receptors in Parkinson's disease, Metabotropic glutamate receptors in estradiol-mediated motivated behaviors in females, mGlu regulation of sleep, Implications for sleep disruptions in psychiatric disorders, Mechanisms of mGlu receptor trafficking; alterations by methamphetamine, Group I mGlu and cocaine seeking, The role of mGlu receptors in fear and anxiety, Regulation of Alcohol Consumption, Reward, Dependence, and Perception by Metabotropic Glutamate Receptor Signaling, and mGlu5 as a biomarker for psychiatric disorders. - Provides the authority and expertise of leading contributors from an international board of authors - Presents the latest release in the International Review of Neurobiology serials - Updated release includes the latest information on metabotropic glutamate receptors in psychiatric and neurological disorders

Magnesium in the Central Nervous System

Author : Robert Vink
Publisher : University of Adelaide Press
ISBN 13 : 0987073052
Total Pages : 354 pages
Book Rating : 4.9/5 (87 download)

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Book Synopsis Magnesium in the Central Nervous System by : Robert Vink

Download or read book Magnesium in the Central Nervous System written by Robert Vink and published by University of Adelaide Press. This book was released on 2011 with total page 354 pages. Available in PDF, EPUB and Kindle. Book excerpt: The brain is the most complex organ in our body. Indeed, it is perhaps the most complex structure we have ever encountered in nature. Both structurally and functionally, there are many peculiarities that differentiate the brain from all other organs. The brain is our connection to the world around us and by governing nervous system and higher function, any disturbance induces severe neurological and psychiatric disorders that can have a devastating effect on quality of life. Our understanding of the physiology and biochemistry of the brain has improved dramatically in the last two decades. In particular, the critical role of cations, including magnesium, has become evident, even if incompletely understood at a mechanistic level. The exact role and regulation of magnesium, in particular, remains elusive, largely because intracellular levels are so difficult to routinely quantify. Nonetheless, the importance of magnesium to normal central nervous system activity is self-evident given the complicated homeostatic mechanisms that maintain the concentration of this cation within strict limits essential for normal physiology and metabolism. There is also considerable accumulating evidence to suggest alterations to some brain functions in both normal and pathological conditions may be linked to alterations in local magnesium concentration. This book, containing chapters written by some of the foremost experts in the field of magnesium research, brings together the latest in experimental and clinical magnesium research as it relates to the central nervous system. It offers a complete and updated view of magnesiums involvement in central nervous system function and in so doing, brings together two main pillars of contemporary neuroscience research, namely providing an explanation for the molecular mechanisms involved in brain function, and emphasizing the connections between the molecular changes and behavior. It is the untiring efforts of those magnesium researchers who have dedicated their lives to unraveling the mysteries of magnesiums role in biological systems that has inspired the collation of this volume of work.

Metabotropic Glutamate Receptors and Neurological/Psychiatric Disorders

Author : Enza Palazzo
Publisher : Frontiers Media SA
ISBN 13 : 2889458628
Total Pages : 139 pages
Book Rating : 4.8/5 (894 download)

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Book Synopsis Metabotropic Glutamate Receptors and Neurological/Psychiatric Disorders by : Enza Palazzo

Download or read book Metabotropic Glutamate Receptors and Neurological/Psychiatric Disorders written by Enza Palazzo and published by Frontiers Media SA. This book was released on 2019-06-19 with total page 139 pages. Available in PDF, EPUB and Kindle. Book excerpt: Considering that neurological and psychiatric illnesses do not still have efficient therapies and are becoming increasingly widespread, the search for novel targets appears fundamental. Neuroinflammation, alterations in adult neurogenesis and excitotoxicity, all associated with glutamate transmission dysfunction, are key components of the pathogenetic mechanisms underlying neuropsychiatric illnesses. Counteracting the neurotoxic actions of glutamate through the modulatory actions of metabotropic glutamate receptors (mGluRs), represents a rational intervention that offers tolerability compatible with clinical therapy. Their suitability as targets for developing novel therapies is also based on the fact that mGluRs are found abundantly expressed in synapses of the central nervous system (CNS) that are considered critical in certain neurological and psychiatric disorders. Moreover, recently there has been an exponential development of selective ligands, especially positive and negative allosteric modulators, which by binding to less conserved transmembrane domain sequences ensure, besides a good permeability in the CNS, an adequate selectivity for each mGluR subtype. The eBook “Metabotropic Glutamate Receptors and Neurological/Psychiatric Disorders”, collects contributes (original and review articles) on the beneficial effects of positive and negative allosteric modulators of mGluRs in animal models of neurological and psychiatric diseases from renown experts in the field. The hope is that the effort of both Editors and Contributors of this eBook confirms the unlimited potential of mGluRs in CNS diseases and generate a collaborative discussion on the state of art, overall trends, novel strategies, and future direction of this attractive field of research.

The Heterogeneity of Cancer Metabolism

Author : Anne Le
Publisher : Springer
ISBN 13 : 331977736X
Total Pages : 186 pages
Book Rating : 4.3/5 (197 download)

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Book Synopsis The Heterogeneity of Cancer Metabolism by : Anne Le

Download or read book The Heterogeneity of Cancer Metabolism written by Anne Le and published by Springer. This book was released on 2018-06-26 with total page 186 pages. Available in PDF, EPUB and Kindle. Book excerpt: Genetic alterations in cancer, in addition to being the fundamental drivers of tumorigenesis, can give rise to a variety of metabolic adaptations that allow cancer cells to survive and proliferate in diverse tumor microenvironments. This metabolic flexibility is different from normal cellular metabolic processes and leads to heterogeneity in cancer metabolism within the same cancer type or even within the same tumor. In this book, we delve into the complexity and diversity of cancer metabolism, and highlight how understanding the heterogeneity of cancer metabolism is fundamental to the development of effective metabolism-based therapeutic strategies. Deciphering how cancer cells utilize various nutrient resources will enable clinicians and researchers to pair specific chemotherapeutic agents with patients who are most likely to respond with positive outcomes, allowing for more cost-effective and personalized cancer therapeutic strategies.

Glial ⇔ Neuronal Signaling

Author : Glenn I. Hatton
Publisher : Springer Science & Business Media
ISBN 13 : 9781402079368
Total Pages : 460 pages
Book Rating : 4.0/5 (793 download)

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Book Synopsis Glial ⇔ Neuronal Signaling by : Glenn I. Hatton

Download or read book Glial ⇔ Neuronal Signaling written by Glenn I. Hatton and published by Springer Science & Business Media. This book was released on 2004-05-31 with total page 460 pages. Available in PDF, EPUB and Kindle. Book excerpt: Glial Neuronal Signaling fills a need for a monograph/textbook to be used in advanced courses or graduate seminars aimed at exploring glial-neuronal interactions. Even experts in the field will find useful the authoritative summaries of evidence on ion channels and transporters in glia, genes involved in signaling during development, metabolic cross talk and cooperation between astrocytes and neurons, to mention but a few of the timely summaries of a wide range of glial-neuronal interactions. The chapters are written by the top researchers in the field of glial-neuronal signaling, and cover the most current advances in this field. The book will also be of value to the workers in the field of cell biology in general. When we think about the brain we usually think about neurons. Although there are 100 billion neurons in mammalian brain, these cells do not constitute a majority. Quite the contrary, glial cells and other non-neuronal cells are 10-50 times more numerous than neurons. This book is meant to integrate the emerging body of information that has been accumulating, revealing the interactive nature of the brain's two major neural cell types, neurons and glia, in brain function.

Neurobiology of Mental Illness

Author : Dennis S. Charney
Publisher : Oxford University Press, USA
ISBN 13 : 0199934959
Total Pages : 1259 pages
Book Rating : 4.1/5 (999 download)

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Book Synopsis Neurobiology of Mental Illness by : Dennis S. Charney

Download or read book Neurobiology of Mental Illness written by Dennis S. Charney and published by Oxford University Press, USA. This book was released on 2013-07-04 with total page 1259 pages. Available in PDF, EPUB and Kindle. Book excerpt: Our understanding of the neurobiological basis of psychiatric disease has accelerated in the past five years. The fourth edition of Neurobiology of Mental Illness has been completely revamped given these advances and discoveries on the neurobiologic foundations of psychiatry. Like its predecessors the book begins with an overview of the basic science. The emerging technologies in Section 2 have been extensively redone to match the progress in the field including new chapters on the applications of stem cells, optogenetics, and image guided stimulation to our understanding and treatment of psychiatric disorders. Sections' 3 through 8 pertain to the major psychiatric syndromes-the psychoses, mood disorders, anxiety disorders, substance use disorders, dementias, and disorders of childhood-onset. Each of these sections includes our knowledge of their etiology, pathophysiology, and treatment. The final section discusses special topic areas including the neurobiology of sleep, resilience, social attachment, aggression, personality disorders and eating disorders. In all, there are 32 new chapters in this volume including unique insights on DSM-5, the Research Domain Criteria (RDoC) from NIMH, and a perspective on the continuing challenges of diagnosis given what we know of the brain and the mechanisms pertaining to mental illness. This book provides information from numerous levels of analysis including molecular biology and genetics, cellular physiology, neuroanatomy, neuropharmacology, epidemiology, and behavior. In doing so it translates information from the basic laboratory to the clinical laboratory and finally to clinical treatment. No other book distills the basic science and underpinnings of mental disorders and explains the clinical significance to the scope and breadth of this classic text. The result is an excellent and cutting-edge resource for psychiatric residents, psychiatric researchers and doctoral students in neurochemistry and the neurosciences.

The Neurobiological Basis of Suicide

Author : Yogesh Dwivedi
Publisher : CRC Press
ISBN 13 : 143983881X
Total Pages : 485 pages
Book Rating : 4.4/5 (398 download)

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Book Synopsis The Neurobiological Basis of Suicide by : Yogesh Dwivedi

Download or read book The Neurobiological Basis of Suicide written by Yogesh Dwivedi and published by CRC Press. This book was released on 2012-06-25 with total page 485 pages. Available in PDF, EPUB and Kindle. Book excerpt: With recent studies using genetic, epigenetic, and other molecular and neurochemical approaches, a new era has begun in understanding pathophysiology of suicide. Emerging evidence suggests that neurobiological factors are not only critical in providing potential risk factors but also provide a promising approach to develop more effective treatment and prevention strategies. The Neurobiological Basis of Suicide discusses the most recent findings in suicide neurobiology. Psychological, psychosocial, and cultural factors are important in determining the risk factors for suicide; however, they offer weak prediction and can be of little clinical use. Interestingly, cognitive characteristics are different among depressed suicidal and depressed nonsuicidal subjects, and could be involved in the development of suicidal behavior. The characterization of the neurobiological basis of suicide is in delineating the risk factors associated with suicide. The Neurobiological Basis of Suicide focuses on how and why these neurobiological factors are crucial in the pathogenic mechanisms of suicidal behavior and how these findings can be transformed into potential therapeutic applications.

Biology of the NMDA Receptor

Author : Antonius M. VanDongen
Publisher : CRC Press
ISBN 13 : 142004415X
Total Pages : 368 pages
Book Rating : 4.4/5 (2 download)

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Book Synopsis Biology of the NMDA Receptor by : Antonius M. VanDongen

Download or read book Biology of the NMDA Receptor written by Antonius M. VanDongen and published by CRC Press. This book was released on 2008-10-29 with total page 368 pages. Available in PDF, EPUB and Kindle. Book excerpt: The NMDA receptor plays a critical role in the development of the central nervous system and in adult neuroplasticity, learning, and memory. Therefore, it is not surprising that this receptor has been widely studied. However, despite the importance of rhythms for the sustenance of life, this aspect of NMDAR function remains poorly studied. Written

Neural Mechanisms of Addiction

Author : Mary Torregrossa
Publisher : Academic Press
ISBN 13 : 0128123311
Total Pages : 308 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis Neural Mechanisms of Addiction by : Mary Torregrossa

Download or read book Neural Mechanisms of Addiction written by Mary Torregrossa and published by Academic Press. This book was released on 2018-08-24 with total page 308 pages. Available in PDF, EPUB and Kindle. Book excerpt: Neural Mechanisms of Addiction is the only book available that synthesizes the latest research in the field into a single, accessible resource covering all aspects of how addiction develops and persists in the brain. The book summarizes our most recent understanding on the neural mechanisms underlying addiction. It also examines numerous biobehavioral aspects of addiction disorders, such as reinforcement learning, reward, cognitive dysfunction, stress, and sleep and circadian rhythms that are not covered in any other publication. Readers with find the most up-to-date information on which to build a foundation for their future research in this expanding field. Combining chapters from leading researchers and thought leaders, this book is an indispensable guide for students and investigators engaged in addiction research. - Transcends multiple neural, neurochemical and behavioral domains - Summarizes advances in the field of addiction research since the advent of optogenetics - Discusses the most current, leading theories of addiction, including molecular mechanisms and dopamine mechanisms

Glutamate-Related Biomarkers in Drug Development for Disorders of the Nervous System

Author : Institute of Medicine
Publisher : National Academies Press
ISBN 13 : 0309212219
Total Pages : 74 pages
Book Rating : 4.3/5 (92 download)

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Book Synopsis Glutamate-Related Biomarkers in Drug Development for Disorders of the Nervous System by : Institute of Medicine

Download or read book Glutamate-Related Biomarkers in Drug Development for Disorders of the Nervous System written by Institute of Medicine and published by National Academies Press. This book was released on 2011-08-05 with total page 74 pages. Available in PDF, EPUB and Kindle. Book excerpt: Glutamate is the most pervasive neurotransmitter in the central nervous system (CNS). Despite this fact, no validated biological markers, or biomarkers, currently exist for measuring glutamate pathology in CNS disorders or injuries. Glutamate dysfunction has been associated with an extensive range of nervous system diseases and disorders. Problems with how the neurotransmitter glutamate functions in the brain have been linked to a wide variety of disorders, including schizophrenia, Alzheimer's, substance abuse, and traumatic brain injury. These conditions are widespread, affecting a large portion of the United States population, and remain difficult to treat. Efforts to understand, treat, and prevent glutamate-related disorders can be aided by the identification of valid biomarkers. The Institute of Medicine's Forum on Neuroscience and Nervous System Disorders held a workshop on June 21-22, 2010, to explore ways to accelerate the development, validation, and implementation of such biomarkers. Glutamate-Related Biomarkers in Drug Development for Disorders of the Nervous System: Workshop Summary investigates promising current and emerging technologies, and outlines strategies to procure resources and tools to advance drug development for associated nervous system disorders. Moreover, this report highlights presentations by expert panelists, and the open panel discussions that occurred during the workshop.

From Structure to Clinical Development: Allosteric Modulation of G Protein-Coupled Receptors

Author :
Publisher : Academic Press
ISBN 13 : 0128201886
Total Pages : 330 pages
Book Rating : 4.1/5 (282 download)

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Book Synopsis From Structure to Clinical Development: Allosteric Modulation of G Protein-Coupled Receptors by :

Download or read book From Structure to Clinical Development: Allosteric Modulation of G Protein-Coupled Receptors written by and published by Academic Press. This book was released on 2020-05-13 with total page 330 pages. Available in PDF, EPUB and Kindle. Book excerpt: From Structure to Clinical Development: Allosteric Modulation of G Protein-Coupled Receptors, Volume 88, the latest release in the Advances in Pharmacology series, presents a variety of chapters from the best authors in the field. Chapters in this updated edition include Targeting muscarinic M1 receptor in neurodegeneration, Photo-switchable allosteric ligands, Computational approaches for the design of mGlu receptor allosteric modulators, Allosteric modulation of GLP-1 receptor in metabolic disorders, Group II mGluR roles in the nervous system and their roles in addiction, RAMPs as allosteric modulators of Class B GPCRs, Structure-based discovery and development of mGlu5 NAMs, and much more. - Includes the authority and expertise of leading contributors in pharmacology - Presents the latest release in the Advances in Pharmacology series

Cognitive Plasticity in Neurologic Disorders

Author : Joseph I. Tracy
Publisher : Oxford University Press, USA
ISBN 13 : 0199965242
Total Pages : 433 pages
Book Rating : 4.1/5 (999 download)

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Book Synopsis Cognitive Plasticity in Neurologic Disorders by : Joseph I. Tracy

Download or read book Cognitive Plasticity in Neurologic Disorders written by Joseph I. Tracy and published by Oxford University Press, USA. This book was released on 2014-12-02 with total page 433 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume makes clear that the cognitive and behavioural symptoms of neurologic disorders and syndromes are dynamic and changing. Each chapter describes the neuroplastic processes at work in a particular condition, giving rise to these ongoing cognitive changes.

Pain in Psychiatric Disorders

Author : D.P. Finn
Publisher : Karger Medical and Scientific Publishers
ISBN 13 : 3318055743
Total Pages : 192 pages
Book Rating : 4.3/5 (18 download)

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Book Synopsis Pain in Psychiatric Disorders by : D.P. Finn

Download or read book Pain in Psychiatric Disorders written by D.P. Finn and published by Karger Medical and Scientific Publishers. This book was released on 2015-09-28 with total page 192 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book offers a series of authoritative reviews on pain in psychiatric disorders written by leading experts. They discuss the complex interplay between pain and psychiatric disorders such as anxiety, depression and borderline personality disorder, as well as neurosteroids, epigenetic mechanisms and TRPV1, with a strong focus on neurobiological mechanisms and current and future therapeutic targets. Special attention is given to the importance of inflammation and the immune system as a common substrate in both pain and psychiatric disorders. The state-of-the-art reviews present both preclinical and clinical research, providing the reader with sound knowledge that provides a basis for further research and clinical practice. Pain in Psychiatric Disorders is of special interest to psychiatrists, neurologists, neuroscientists, pharmacologists and other healthcare professionals treating pain in psychiatric patients, as well as research students with an interest in this field.

Oxford Textbook of Cognitive Neurology and Dementia

Author : Masud Husain
Publisher : Oxford University Press
ISBN 13 : 0198831080
Total Pages : 513 pages
Book Rating : 4.1/5 (988 download)

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Book Synopsis Oxford Textbook of Cognitive Neurology and Dementia by : Masud Husain

Download or read book Oxford Textbook of Cognitive Neurology and Dementia written by Masud Husain and published by Oxford University Press. This book was released on 2018-10-29 with total page 513 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume covers the dramatic developments that have occurred in basic neuroscience and clinical research in cognitive neurology and dementia. It is based on the clinical approach to the patient, and provides essential knowledge that is fundamental to clinical practice.

The Science and Practice of Lithium Therapy

Author : Gin S. Malhi
Publisher : Springer
ISBN 13 : 3319459236
Total Pages : 345 pages
Book Rating : 4.3/5 (194 download)

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Book Synopsis The Science and Practice of Lithium Therapy by : Gin S. Malhi

Download or read book The Science and Practice of Lithium Therapy written by Gin S. Malhi and published by Springer. This book was released on 2016-11-24 with total page 345 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides a clear and comprehensive guide to the clinical prescription of lithium that draws upon evidence-based knowledge of its mechanisms of action. The book is divided into two parts, on the science of lithium and the practice of lithium therapy. The former covers aspects such as the properties of the lithium ion, pharmacokinetics and pharmacodynamics, impact on neurotransmission, and gene expression modulation. The section on practice includes discussion of variability in response to lithium, use of lithium in the treatment of bipolar disorders, its value in suicide prevention, administration during pregnancy and in the pediatric age group, and side effects. Lithium is arguably the only true mood stabilizer, and its multifaceted effects across many clinical domains have given rise to a resurgence of interest in recent years, fuelled by both researchers and clinicians. Nevertheless, its use remains constrained by exaggerated concerns about potential side-effects. In reality, lithium is a simple molecule that is relatively straightforward to administer and monitor and has potentially profound benefits at a fraction of the cost of contemporary agents. This book dispels the many myths and concerns that surround its use and will be of interest for clinicians and researchers worldwide, and those that are recipients of lithium therapy.

GABA And Glutamate

Author : Janko Samardzic
Publisher : BoD – Books on Demand
ISBN 13 : 9535138219
Total Pages : 139 pages
Book Rating : 4.5/5 (351 download)

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Book Synopsis GABA And Glutamate by : Janko Samardzic

Download or read book GABA And Glutamate written by Janko Samardzic and published by BoD – Books on Demand. This book was released on 2018-03-21 with total page 139 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book collates the contributions of a selected number of neuroscientists that are interested in the molecular, preclinical, and clinical aspects of neurotransmission research. The seven chapters in this book address the latest research/review data related to GABA/glutamate system's organization and function, the structure of receptors, subtypes and their ligands, as well as the translational approach and clinical implications. The book offers readers a rich collection of data regarding current and future applications of GABA and glutamate neurotransmission, including promising research strategies and potential clinical benefits.

The Neurobiology of Schizophrenia

Author : Ted Abel
Publisher : Academic Press
ISBN 13 : 0128018771
Total Pages : 470 pages
Book Rating : 4.1/5 (28 download)

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Book Synopsis The Neurobiology of Schizophrenia by : Ted Abel

Download or read book The Neurobiology of Schizophrenia written by Ted Abel and published by Academic Press. This book was released on 2016-07-08 with total page 470 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Neurobiology of Schizophrenia begins with an overview of the various facets and levels of schizophrenia pathophysiology, ranging systematically from its genetic basis over changes in neurochemistry and electrophysiology to a systemic neural circuits level. When possible, the editors point out connections between the various systems. The editors also depict methods and research strategies used in the respective field. The individual backgrounds of the two editors promote a synthesis between basic neuroscience and clinical relevance. - Provides a comprehensive overview of neurobiological aspects of schizophrenia - Discusses schizophrenia at behavioral, cognitive, clinical, electrophysiological, molecular, and genetic levels - Edited by a translational researcher and a psychiatrist to promote synthesis between basic neuroscience and clinical relevance - Elucidates connections between the various systems depicted, when possible