Drug Metabolism in Drug Design and Development

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Publisher : John Wiley & Sons
ISBN 13 : 9780470191682
Total Pages : 448 pages
Book Rating : 4.1/5 (916 download)

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Book Synopsis Drug Metabolism in Drug Design and Development by : Donglu Zhang

Download or read book Drug Metabolism in Drug Design and Development written by Donglu Zhang and published by John Wiley & Sons. This book was released on 2007-11-16 with total page 448 pages. Available in PDF, EPUB and Kindle. Book excerpt: The essentials of drug metabolism vital to developing new therapeutic entities Information on the metabolism and disposition of candidate drugs is a critical part of all aspects of the drug discovery and development process. Drug metabolism, as practiced in the pharmaceutical industry today, is a complex, multidisciplinary field that requires knowledge of sophisticated analytical technologies and expertise in mechanistic and kinetic enzymology, organic reaction mechanism, pharmacokinetic analysis, animal physiology, basic chemical toxicology, preclinical pharmacology, and molecular biology. With chapters contributed by experts in their specific areas, this reference covers: * Basic concepts of drug metabolism * The role of drug metabolism in the pharmaceutical industry * Analytical techniques in drug metabolism * Common experimental approaches and protocols Drug Metabolism in Drug Design and Development emphasizes practical considerations such as the data needed, the experiments and analytical methods typically employed, and the interpretation and application of data. Chapters highlight facts, common protocols, detailed experimental designs, applications, and limitations of techniques. This is a comprehensive, hands-on reference for drug metabolism researchers as well as other professionals involved in pre-clinical drug discovery and development.

Metabolism and Medicine

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Publisher : CRC Press
ISBN 13 : 1000472132
Total Pages : 369 pages
Book Rating : 4.0/5 (4 download)

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Book Synopsis Metabolism and Medicine by : Brian Fertig

Download or read book Metabolism and Medicine written by Brian Fertig and published by CRC Press. This book was released on 2022-01-25 with total page 369 pages. Available in PDF, EPUB and Kindle. Book excerpt: Chronic disease states of aging should be viewed through the prism of metabolism and biophysical processes at all levels of physiological organization present in the human body. This book describes the building blocks of understanding from a reasonable but not high-level technical language viewpoint, employing the perspective of a clinical physician. It brings together concepts from five specific branches of physics relevant to biology and medicine, namely, biophysics, classical electromagnetism, thermodynamics, systems biology and quantum mechanics. Key Features: Broad and up-to-date overview of the field of metabolism, especially connecting the spectrum of topics that range from modern physical underpinnings with cell biology to clinical practice. Provides a deeper basic science and interdisciplinary understanding of biological systems that broaden the perspectives and therapeutic problem solving. Introduces the concept of the Physiological Fitness Landscape, which is inspired by the physics of phase transitions This first volume in a two-volume set, primarily targets an audience of clinical and science students, biomedical researchers and physicians who would benefit from understanding each other’s language.

Metabolic Medicine and Surgery

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Publisher : CRC Press
ISBN 13 : 1466567112
Total Pages : 660 pages
Book Rating : 4.4/5 (665 download)

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Book Synopsis Metabolic Medicine and Surgery by : Michael M. Rothkopf

Download or read book Metabolic Medicine and Surgery written by Michael M. Rothkopf and published by CRC Press. This book was released on 2014-11-07 with total page 660 pages. Available in PDF, EPUB and Kindle. Book excerpt: The first comprehensive overview of an emerging field, Metabolic Medicine and Surgery introduces a new paradigm in patient management that crosses existing subspecialty boundaries. This approach is necessitated by the challenges of treating patients with obesity, metabolic syndrome, cardiovascular disease and prediabetes, as well as those with maldigestion, malabsorption, malnutrition and nutritional deficiencies. This book teaches physicians and surgeons what they need to know about clinical nutrition, metabolism and the metabolic effects of bariatric surgery. It is also applicable to those in primary care, including physicians, residents, medical students, nurses and nurse practitioners, physician assistants and dietitians who are on the front lines of treating patients with obesity, diabetes and cardiovascular disease. The book is presented in four sections: 1. An Overview of Metabolic Medicine and Surgery; 2. Metabolic Syndrome, Insulin Resistance and Obesity; 3. Diseases of Undernutrition and Absorption; 4. A Nutritional Relationship to Neurological Diseases. It contains chapters from world-renowned experts who are widely published in major medical journals. The book also benefits from the contributions of clinicians with extensive experience and perspective in the field, including many who have been witness to its major developments. This book’s strength lies in the cross-specialty consensus created by the collaboration of the editors and further developed by their renowned contributors. It demonstrates how medicine, surgery, therapeutics, and nutrition can be combined synergistically to impact patient outcomes. It crystallizes the efforts of a multitude of physicians and scientists trying to control the linked pandemics of obesity, type-2 diabetes and cardiovascular disease. This book helps you develop comprehensive solutions to diseases afflicting vast numbers of patients worldwide.

Emery and Rimoin's Principles and Practice of Medical Genetics and Genomics

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Publisher : Elsevier
ISBN 13 : 0128152354
Total Pages : 1227 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis Emery and Rimoin's Principles and Practice of Medical Genetics and Genomics by : Reed E. Pyeritz

Download or read book Emery and Rimoin's Principles and Practice of Medical Genetics and Genomics written by Reed E. Pyeritz and published by Elsevier. This book was released on 2024-10-23 with total page 1227 pages. Available in PDF, EPUB and Kindle. Book excerpt: For decades, Emery and Rimoin's Principles and Practice of Medical Genetics and Genomics has served as the ultimate resource for clinicians integrating genetics and genomics into medical practice. With detailed coverage in contributions from more than 250 of the world's most trusted authorities in medical genetics and a series of 11 volumes available for individual sale, the Seventh Edition of this classic reference includes the latest information on seminal topics such as prenatal diagnosis, genome sequencing, public health genetics, genetic counseling, and management and treatment strategies to complete its coverage of this growing field for students, health providers, and researchers involved in the care of patients with genetic conditions, and increasingly, all areas of health and disease. This comprehensive yet practical resource emphasizes theory and research fundamentals related to the applications of medical genetics and genomics across the full spectrum of inherited disorders and applications to medicine more broadly. In this volume, leading physicians and researchers thoroughly examine medical genetics and genomics as applied to developmental disorders, as well as genetic conditions that affect hearing and vision. Here genetic researchers, students, and health professionals will find new and fully revised chapters on human developmental genetics, disorders affecting craniofacial development, chromosomal abnormalities, including aneuploidies and structural abnormalities, hereditary hearing impairment, and various genetic conditions of the eye. With regular advances in genomic technologies propelling precision medicine into the clinic, Emery and Rimoin's Principles and Practice of Medical Genetics and Genomics, Seventh Edition bridges the gap between high-level molecular genetics and practical application and serves as an invaluable clinical tool for health professionals and researchers. · Thoroughly introduces genetic researchers, students, and healthcare professionals to the principles of human developmental genetics · Examines a wide range of developmental disorders, including craniofacial development as well as disorders affecting hearing and vision · Includes color images supporting identification, concept illustration, and method processing · Features contributions by leading international researchers and practitioners of medical genetics

Metabolism and Medicine

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Publisher : CRC Press
ISBN 13 : 9781032126692
Total Pages : 858 pages
Book Rating : 4.1/5 (266 download)

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Book Synopsis Metabolism and Medicine by : Brian Fertig

Download or read book Metabolism and Medicine written by Brian Fertig and published by CRC Press. This book was released on 2021-11-12 with total page 858 pages. Available in PDF, EPUB and Kindle. Book excerpt: Chronic disease states of aging should be viewed through the prism of metabolism and biophysical processes at all levels of physiological organization present in the human body. The first volumeconnects these insights to what causes them to go awry in the context of unhealthy human behaviors and aging, aiming to buttress scientific creativity. It also provides links between the art and science of medicine that strengthens problem-solving in patient care. New and important discoveries in the area of metabolic health and metabolic diseases are discussed in exquisite detail. The second volume describes the building blocks of understanding from a reasonable but not high-level technical language viewpoint, employing the perspective of a clinical physician. It brings together concepts from five specific branches of physics relevant to biology and medicine, namely, biophysics, classical electromagnetism, thermodynamics, systems biology and quantum mechanics.

Physician's Guide to the Treatment and Follow-Up of Metabolic Diseases

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Author :
Publisher : Springer Science & Business Media
ISBN 13 : 3540289623
Total Pages : 404 pages
Book Rating : 4.5/5 (42 download)

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Book Synopsis Physician's Guide to the Treatment and Follow-Up of Metabolic Diseases by : Nenad Blau

Download or read book Physician's Guide to the Treatment and Follow-Up of Metabolic Diseases written by Nenad Blau and published by Springer Science & Business Media. This book was released on 2006-01-16 with total page 404 pages. Available in PDF, EPUB and Kindle. Book excerpt: This reference provides concise information on the treatment and management of inherited metabolic diseases for the clinician. World experts cover all commonalities of therapy giving practical advice and guidance for daily practice. All established treatment protocols in this quickly developing area of medicine are clearly described, including follow-up protocols and monitoring. Alternative and experimental therapies are also described and evaluated. Numerous tables, figures, and several indices (symptom, disease name, tests, etc.) allow rapid access to specific details. This book is invaluable to anyone dealing with patients with inherited metabolic diseases, pediatricians, internists, neurologists, and clinical geneticists.

Metabolism and Practical Medicine

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Publisher :
ISBN 13 :
Total Pages : 824 pages
Book Rating : 4.3/5 (243 download)

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Book Synopsis Metabolism and Practical Medicine by : Carl von Noorden

Download or read book Metabolism and Practical Medicine written by Carl von Noorden and published by . This book was released on 1907 with total page 824 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Principles and Practice of Endocrinology and Metabolism

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Publisher : Lippincott Williams & Wilkins
ISBN 13 : 9780781717502
Total Pages : 2500 pages
Book Rating : 4.7/5 (175 download)

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Book Synopsis Principles and Practice of Endocrinology and Metabolism by : Kenneth L. Becker

Download or read book Principles and Practice of Endocrinology and Metabolism written by Kenneth L. Becker and published by Lippincott Williams & Wilkins. This book was released on 2001 with total page 2500 pages. Available in PDF, EPUB and Kindle. Book excerpt: Established as the foremost text in the field, Principles and Practice of Endocrinology and Metabolism is now in its thoroughly revised, updated Third Edition. This practical, clinically relevant, and comprehensive text covers the entire field of endocrinology and metabolism, including the diffuse endocrine system; morphology and physiology; diagnosis and treatment of endocrine diseases; endocrinology of the female; hormones and cancer; and much more. The Third Edition contains new chapters reflecting the latest advances and features expanded coverage of genetics and the endocrinology of sepsis. More than 1,400 illustrations complement the text. A drug formulary appears at the back of the book.

Metabolism and practical medicine v.1

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Publisher :
ISBN 13 :
Total Pages : 504 pages
Book Rating : 4.F/5 ( download)

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Book Synopsis Metabolism and practical medicine v.1 by : Karl Harko von Noorden

Download or read book Metabolism and practical medicine v.1 written by Karl Harko von Noorden and published by . This book was released on 1907 with total page 504 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Essentials of Endocrinology and Metabolism

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Author :
Publisher : Springer Nature
ISBN 13 : 3030395723
Total Pages : 279 pages
Book Rating : 4.0/5 (33 download)

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Book Synopsis Essentials of Endocrinology and Metabolism by : Fredric E. Wondisford

Download or read book Essentials of Endocrinology and Metabolism written by Fredric E. Wondisford and published by Springer Nature. This book was released on 2020-05-23 with total page 279 pages. Available in PDF, EPUB and Kindle. Book excerpt: Developed from time-tested material utilized in endocrinology courses for medical students, this comprehensive and practical guide draws together a number of related disciplines to create a straightforward and accessible approach to the study of endocrine and metabolic diseases. Designed with the student in mind, each of the main endocrine organs and disorders are covered in thematic sections on diabetes, thyroid disorders, calcium disorders, adrenal disorders, and hypothalamus and pituitary disorders. Opening with clear learning objectives, chapters within each section discuss core concepts, anatomy, embryology, histology, testing, diagnosis and pharmacology, and include clinical case scenarios and multiple choice review questions. Full-color figures and diagrams enhance and extend the content. Perfect for in-class reference or board licensing review, Essentials of Endocrinology and Metabolism is an indispensable resource for medical and nursing students alike.

Metabolism and practical medicine v.2

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Publisher :
ISBN 13 :
Total Pages : 576 pages
Book Rating : 4.F/5 ( download)

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Book Synopsis Metabolism and practical medicine v.2 by : Karl Harko von Noorden

Download or read book Metabolism and practical medicine v.2 written by Karl Harko von Noorden and published by . This book was released on 1907 with total page 576 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Holland-Frei Cancer Medicine

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Publisher : John Wiley & Sons
ISBN 13 : 111900084X
Total Pages : 2004 pages
Book Rating : 4.1/5 (19 download)

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Book Synopsis Holland-Frei Cancer Medicine by : Robert C. Bast, Jr.

Download or read book Holland-Frei Cancer Medicine written by Robert C. Bast, Jr. and published by John Wiley & Sons. This book was released on 2017-03-10 with total page 2004 pages. Available in PDF, EPUB and Kindle. Book excerpt: Holland-Frei Cancer Medicine, Ninth Edition, offers a balanced view of the most current knowledge of cancer science and clinical oncology practice. This all-new edition is the consummate reference source for medical oncologists, radiation oncologists, internists, surgical oncologists, and others who treat cancer patients. A translational perspective throughout, integrating cancer biology with cancer management providing an in depth understanding of the disease An emphasis on multidisciplinary, research-driven patient care to improve outcomes and optimal use of all appropriate therapies Cutting-edge coverage of personalized cancer care, including molecular diagnostics and therapeutics Concise, readable, clinically relevant text with algorithms, guidelines and insight into the use of both conventional and novel drugs Includes free access to the Wiley Digital Edition providing search across the book, the full reference list with web links, illustrations and photographs, and post-publication updates

Handbook of Drug Metabolism, Third Edition

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Publisher : CRC Press
ISBN 13 : 1482262045
Total Pages : 755 pages
Book Rating : 4.4/5 (822 download)

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Book Synopsis Handbook of Drug Metabolism, Third Edition by : Paul G. Pearson

Download or read book Handbook of Drug Metabolism, Third Edition written by Paul G. Pearson and published by CRC Press. This book was released on 2019-05-20 with total page 755 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book continues to be the definitive reference on drug metabolism with an emphasis on new scientific and regulatory developments. It has been updated based on developments that have occurred in the last 5 years, with new chapters on large molecules disposition, stereo-selectivity in drug metabolism, drug transporters and metabolic activation of drugs. Some chapters have been prepared by new authors who have emerged as subject area experts in the decade that has passed since publication of the first edition.

Clinical Biochemistry and Metabolic Medicine

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Publisher : CRC Press
ISBN 13 : 1444144154
Total Pages : 441 pages
Book Rating : 4.4/5 (441 download)

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Book Synopsis Clinical Biochemistry and Metabolic Medicine by : Martin Crook

Download or read book Clinical Biochemistry and Metabolic Medicine written by Martin Crook and published by CRC Press. This book was released on 2013-03-21 with total page 441 pages. Available in PDF, EPUB and Kindle. Book excerpt: Whether you are following a problem-based, an integrated, or a more traditional medical course, clinical biochemistry is often viewed as one of the more challenging subjects to grasp. What you need is a single resource that not only explains the biochemical underpinnings of metabolic medicine, but also integrates laboratory findings with clinical p

Metabolism of Drugs and Other Xenobiotics

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Publisher : John Wiley & Sons
ISBN 13 : 352732903X
Total Pages : 755 pages
Book Rating : 4.5/5 (273 download)

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Book Synopsis Metabolism of Drugs and Other Xenobiotics by : Pavel Anzenbacher

Download or read book Metabolism of Drugs and Other Xenobiotics written by Pavel Anzenbacher and published by John Wiley & Sons. This book was released on 2012-05-29 with total page 755 pages. Available in PDF, EPUB and Kindle. Book excerpt: A practice-oriented desktop reference for medical professionals, toxicologists and pharmaceutical researchers, this handbook provides systematic coverage of the metabolic pathways of all major classes of xenobiotics in the human body. The first part comprehensively reviews the main enzyme systems involved in biotransformation and how they are orchestrated in the body, while parts two to four cover the three main classes of xenobiotics: drugs, natural products, environmental pollutants. The part on drugs includes more than 300 substances from five major therapeutic groups (central nervous system, cardiovascular system, cancer, infection, and pain) as well as most drugs of abuse including nicotine, alcohol and "designer" drugs. Selected, well-documented case studies from the most important xenobiotics classes illustrate general principles of metabolism, making this equally useful for teaching courses on pharmacology, drug metabolism or molecular toxicology. Of particular interest, and unique to this volume is the inclusion of a wide range of additional xenobiotic compounds, including food supplements, herbal preparations, and agrochemicals.

Drug Metabolism

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Publisher : CRC Press
ISBN 13 : 1420061089
Total Pages : 191 pages
Book Rating : 4.4/5 (2 download)

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Book Synopsis Drug Metabolism by : Jack P. Uetrecht

Download or read book Drug Metabolism written by Jack P. Uetrecht and published by CRC Press. This book was released on 2007-06-21 with total page 191 pages. Available in PDF, EPUB and Kindle. Book excerpt: In order to understand drug metabolism at its most fundamental level, pharmaceutical scientists must be able to analyze drug compound structures and predict possible metabolic pathways in order to avoid the risk of adverse reactions that lead to the withdrawal of a drug from the market. This comprehensive textbook will aid in guiding students throu

Clinical Chemistry and Metabolic Medicine

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Publisher :
ISBN 13 : 9780340906187
Total Pages : pages
Book Rating : 4.9/5 (61 download)

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Book Synopsis Clinical Chemistry and Metabolic Medicine by : Martin Crook

Download or read book Clinical Chemistry and Metabolic Medicine written by Martin Crook and published by . This book was released on 2006-03 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Whether you are following an integrated or a more traditional medical course, you may find chemical pathology and metabolic medicine constitutes one of the more difficult subjects to grasp. What you need is a textbook that not only explains the biochemical underpinnings of metabolic medicine, but one that also integrates laboratory findings with clincal practice. Look no further...Clinical Chemistry and Metabolic Medicine is entirely updated to reflect the new curriculum and the changes in our understanding of clinical biochemistry. The text is revised by an author with years of teaching experience who has carefully retained the strengh of Zilva and Pannall's classic textbook - readability, a firm basis in the underlying science, and a clear focus on clinical relevance. The seventh edition of Clinical Chemistry and Metabolic Medicine re-establishes the title as the premier textbook in the field, and is essential reading for all medical students through to postgraduate trainees in medicine and candidates for the MRCP and MRCPath. General practitioners and hospital doctors may also find this text helpful in the diagnosis and management of patients with metabolic disorders.