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Mejora De Los Modelos Preclinicos De Tumores Cerebrales
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Book Synopsis Mejora de los modelos preclínicos de tumores cerebrales by : Nidia Milena Acosta González
Download or read book Mejora de los modelos preclínicos de tumores cerebrales written by Nidia Milena Acosta González and published by . This book was released on 2017-06-26 with total page 304 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Mejora de los modelos preclínicos de tumores cerebrales by : Milena Acosta González
Download or read book Mejora de los modelos preclínicos de tumores cerebrales written by Milena Acosta González and published by . This book was released on 2013 with total page 294 pages. Available in PDF, EPUB and Kindle. Book excerpt: Los tumores cerebrales afectan a 9 de cada 100.000 adultos en España, observándose una mayor frecuencia de tumores de tipo glial. Estos tumores presentan un importante impacto en la calidad de vida de los pacientes afectados y un mal pronóstico, sobre todo en los tumores de grado alto. La monitorización no invasiva de los tumores cerebrales es muy importante para el diagnóstico y seguimiento de la enfermedad y se hace sobre todo por técnicas de Imagen por Resonancia Magnética (IRM), la cual aporta información morfológica. La Espectroscopía de Resonancia Magnética (ERM), tanto en su modalidad voxel único como imagen espectroscópica (IERM) son técnicas complementarias de gran utilidad, por aportar información del entorno metabólico, que no puede conseguirse mediante la IRM. Las dificultades éticas para desarrollar mejoras en los protocolos de IRM/ERM, así como para la prueba de nuevos agentes de contraste en pacientes humanos han llevado al desarrollo de los modelos murinos de cáncer cerebral. Los modelos más utilizados son los creados por inyección estereotáxica, aunque también se han desarrollado modelos transgénicos (GEM, genetically engineered mice) que desarrollan tumores cerebrales espontáneamente y reproducen las características infiltrativas de tumores humanos. En esta tesis, se llevó a cabo en el capítulo 2 un amplio estudio de caracterización de diferentes colonias GEM. Se comprobó la baja penetrancia de tumores en estos modelos (16,7% en la colonia que mejores resultados produjo), lo que plantea dificultades para realizar estudios con grupos homogéneos. Este hecho, sumado a la escasez de modelos preclínicos de tumores cerebrales de bajo grado actualmente disponibles, motivaron a su vez el estudio que se llevó a cabo en el capítulo 3 de ésta tesis. Dicho capítulo trata del establecimiento de una línea transplantable de tumor cerebral murino de bajo grado a partir de un tumor desarrollado por un animal de la colonia GEM. El objetivo de éste capítulo consistía en generar un tumor inducible mediante inyección estereotáctica intracraneal de gliosferas generadas en cultivo a partir de la disgregación del tumor glial de origen. Se llevó a cabo una puesta a punto con tumores murinos de tipo GL261 y en un siguiente paso, se continúo con el establecimiento y caracterización de la línea transplantable a partir de un oligodendroglioma anaplásico desarrollado por un especimen de la colonia GEM. Esta línea transplantable ha sido ampliamente caracterizada de manera no invasiva mediante IRM/ERM y también mediante estudios de imagen espectroscópica con perturbación del patrón espectral (PE-IERM).Se obtuvieron resultados prometedores, con un 60% de penetrancia del fenotipo tumoral, y manteniendo en la mayoria (1 de 12 analizados por histopatologia) de los casos la misma patología del tumor de origen. Paralelamente, en el último capítulo se realizaron estudios con nuevos agentes de contraste (AC) que actualmente se están desarrollando para IRM con potencial interés para tumores cerebrales y que permitirán superponer información funcional a la información anatómica. Para ello, se ha desarrollado un método de análisis postmortem de estos AC. Dicho método permite no sólo reducir el número de animales utilizados en la experimentación, sino también reducir en 800 veces la cantidad de agente necesaria para estudios preliminares en IRM preclínica. Nuestros resultados preliminares apuntan a que este método es más preciso que los análisis de relajatividad in vitro, debido a una mejor simulación del entorno in vivo y de la posible interacción del AC con tejidos, moléculas y receptores presentes en el entorno de utilización. Los resultados obtenidos con el mejor agente analizado (GNP(E), con un incremento de contraste relativo, IRC, 330% en comparación con contralateral) se han corroborado en un análisis de IRM in vivo en el modelo preclínico de tumor glial GL261 (IRC 122% en comparación con contralateral), siendo a su vez sensiblemente más eficiente que el AC comercial de tipo comparable actualmente disponible y en uso en clínica.
Book Synopsis Melatonin for treatment of sleep disorders by :
Download or read book Melatonin for treatment of sleep disorders written by and published by . This book was released on 2004 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Topics in Anti-Cancer Research: Volume 8 by : Atta-ur-Rahman
Download or read book Topics in Anti-Cancer Research: Volume 8 written by Atta-ur-Rahman and published by Bentham Science Publishers. This book was released on 2019-12-31 with total page 182 pages. Available in PDF, EPUB and Kindle. Book excerpt: Topics in Anti-Cancer Research covers new developments in the field of cancer. Novel drugs as anticancer agents include natural and synthetic phenazines and other anti-cancer compounds. It also encompasses the role of estrogen as endocrine disruptors and strategies targeting cancer stem cells for the treatment of different types of cancers, including myeloma and renal cell cancer. The diversity of researches and topics published in this eBook Series will be valuable to cancer researchers, clinicians, and cancer professionals aiming to develop novel anti-cancer targets for the treatment of various cancers. The topics covered in the eighth volume of this series are as follows: -Novel Drugs for Multiple Myeloma -Synthetic Estrogens are Endocrine Disruptors via Inhibition of AF1 Domain of ERs -Recent Progress of Phenazines as Anticancer Agents -Cancer Stem Cell Targeting for Anticancer Therapy: Strategies and Challenges
Book Synopsis Experimental Design for Laboratory Biologists by : Stanley E. Lazic
Download or read book Experimental Design for Laboratory Biologists written by Stanley E. Lazic and published by Cambridge University Press. This book was released on 2016-12-08 with total page 429 pages. Available in PDF, EPUB and Kindle. Book excerpt: Specifically intended for lab-based biomedical researchers, this practical guide shows how to design experiments that are reproducible, with low bias, high precision, and widely applicable results. With specific examples from research using both cell cultures and model organisms, it explores key ideas in experimental design, assesses common designs, and shows how to plan a successful experiment. It demonstrates how to control biological and technical factors that can introduce bias or add noise, and covers rarely discussed topics such as graphical data exploration, choosing outcome variables, data quality control checks, and data pre-processing. It also shows how to use R for analysis, and is designed for those with no prior experience. An accompanying website (https://stanlazic.github.io/EDLB.html) includes all R code, data sets, and the labstats R package. This is an ideal guide for anyone conducting lab-based biological research, from students to principle investigators working in either academia or industry.
Author :Council for International Organizations of Medical Sciences (CIOMS) Publisher : ISBN 13 :9789290360834 Total Pages :0 pages Book Rating :4.3/5 (68 download)
Book Synopsis Definition and Application of Terms for Vaccine Pharmacovigilance by : Council for International Organizations of Medical Sciences (CIOMS)
Download or read book Definition and Application of Terms for Vaccine Pharmacovigilance written by Council for International Organizations of Medical Sciences (CIOMS) and published by . This book was released on 2012 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This report from the Council for International Organizations of Medical Sciences (CIOMS) in collaboration with WHO covers the activities and outputs of the CIOMS/WHO Working Group on Vaccine Pharmacovigilance (2005-2010). This working group brought together experts from both industrialized and emerging countries representing regulatory agencies, vaccine industry, national and international public health bodies including WHO and CIOMS, academia and clinical care, contributing from their different perspectives. The report covers general terms and definitions for vaccine safety and discusses the application of such harmonized tools in vaccine safety surveillance and studies. As well, the report highlights case definitions for adverse events typically reported for vaccines. The report is addressed to those engaged in vaccine safety data collection and evaluation, and will also make a useful reading for others who want to familiarize themselves with vaccine safety terminology.
Book Synopsis Neurologic Complications of Cancer by : Lisa M. DeAngelis
Download or read book Neurologic Complications of Cancer written by Lisa M. DeAngelis and published by OUP USA. This book was released on 2009 with total page 652 pages. Available in PDF, EPUB and Kindle. Book excerpt: Patients with cancer can suffer from a bewildering variety of neurologic signs and symptoms. The neurologic symptoms are often more disabling than the primary cancer. Symptoms including confusion, seizures, pain and paralysis may be a result of either metastases to the nervous system or one of several nonmetastatic complications of cancer. The physician who promptly recognizes neurologic symptoms occurring in a patient with cancer and makes an early diagnosis may prevent the symptoms from becoming permanently disabling or sometimes lethal. This monograph, an update of the first edition published in 1995, is divided into 3 sections. The first classifies the wide variety of disorders that can cause neurologic symptoms the patient with cancer, discusses the pathophysiology of nervous system metastases, the pathophysiology and treatment of brain edema and the approach to supportive care of common neurologic symptoms such as seizures, pain, and side effects of commonly used supportive care agents. The second section is devoted to nervous system metastases, addressing in turn, brain, spinal cord, meningeal and cranial and peripheral nerve metastases, describing clinical symptoms, approach to diagnosis and current treatment. The third section addresses several nonmetastatic complications of cancer and includes sections on vascular disease, infections, metabolic and nutritional disorders, side chemotherapy, radiation and other diagnostic and therapeutic procedures. The final chapter addresses paraneoplastic syndromes.The book is intended for practicing oncologists, neurologists, neurosurgeons and radiation oncologists as well as internists who treated patients with cancer. Our attempt was to write a book that would assist oncologists in understanding neurologic problems and neurologists in understanding oncologic problems. The book is also intended for physicians training to specialize in any of the above areas. It includes a practical approach to the diagnosis and management of patients with neurologic disease who are with known to have cancer or in whom cancer is suspected.
Book Synopsis Treatment Planning in Radiation Oncology by : Faiz M. Khan
Download or read book Treatment Planning in Radiation Oncology written by Faiz M. Khan and published by Lippincott Williams & Wilkins. This book was released on 1998 with total page 645 pages. Available in PDF, EPUB and Kindle. Book excerpt: Radiation oncology is integrated with medical physics for a unique look at the state of the art in cancer patient care. World-renowned authors provide a complete discussion of treatment planning featuring the clinical, physical, and technical aspects involved. Coverage includes 3-D conformal treatment and other advancements in computer technology and medical imaging to bring the reader a modern perspective on treatment planning.
Book Synopsis Nonparametric Methods by : P. R. Krishnaiah
Download or read book Nonparametric Methods written by P. R. Krishnaiah and published by Elsevier Health Sciences. This book was released on 1984 with total page 1016 pages. Available in PDF, EPUB and Kindle. Book excerpt: Classical developments. Linear models. Order statistics and empitical distribution. Estimation procedures. Stochastic aproximation and density estimation. Life testing and reliability. Miscellaneous topics. Applications. Tables.
Book Synopsis Type 2 Diabetes by : Anthony Barnett
Download or read book Type 2 Diabetes written by Anthony Barnett and published by Oxford University Press. This book was released on 2012-10-25 with total page 175 pages. Available in PDF, EPUB and Kindle. Book excerpt: This second edition has been updated throughout to aacount for the latest trial data, including new chapters on pathophysiology, and interpretation of recent clinical trials. This pocketbook is a concise, practical guide to the diagnosis, assessment and management of Type 2 Diabetes aimed at clinicians, GPs and nurse specialists.
Book Synopsis Cancer Neurology in Clinical Practice by : David Schiff
Download or read book Cancer Neurology in Clinical Practice written by David Schiff and published by Springer Science & Business Media. This book was released on 2008-07-11 with total page 629 pages. Available in PDF, EPUB and Kindle. Book excerpt: Neuro-oncology has evolved substantially as a clinical and research discipline over the past few decades. Cancer Neurology in Clinical Practice: Neurologic Complications of Cancer and its Treatment, Second Edition provides clinicians from various backgrounds and levels of training with a reference to help focus the differential diagnosis, treatment strategy, and management plan for the cancer patient with neurologic symptoms and findings. The volume begins with an overview of the field of neuro-oncology and a review of the role of neuroimaging in the diagnosis of neuro-oncologic disease. Several chapters on interpretation and management of common neuro-oncologic symptoms follow. Subsequent sections contain chapters on the direct and indirect neurologic complications of cancer as well as complications of therapy. The final section focuses on the spectrum and management of neurologic disease in patients with cancer of specific organs. Cancer Neurology in Clinical Practice: Neurologic Complications of Cancer and its Treatment, Second Edition is an important new work that aims to broaden and deepen the familiarity of clinicians with the range and management of neuro-oncologic diseases in order to improve the quality of care for cancer patients.
Book Synopsis Sources and Effects of Ionizing Radiation: Effects by :
Download or read book Sources and Effects of Ionizing Radiation: Effects written by and published by Bernan Assoc. This book was released on 2000-01-01 with total page 566 pages. Available in PDF, EPUB and Kindle. Book excerpt: The second volume of the Scientific Committee's report adds five more annexes to the five in volume one. They cover DNA repair and mutagenesis; biological effects at low radiation doses; combined effects of radiation and other agents; epidemiological evaluation of radiation-induced cancer; and exposures and effects of the Chernobyl accident. Each ends with an impressive number of references. Annotation copyrighted by Book News, Inc., Portland, OR
Book Synopsis Xenotransplantation by : Institute of Medicine
Download or read book Xenotransplantation written by Institute of Medicine and published by National Academies Press. This book was released on 1996-07-12 with total page 134 pages. Available in PDF, EPUB and Kindle. Book excerpt: Xenotransplantation involves the transplantation of cells, tissues, and whole organs from one species to another. Interest in animal-to-human xenotransplants has been spurred by the continuing shortage of donated human organs and by advances in knowledge concerning the biology of organ and tissue rejection. The scientific advances and promise, however, raise complex questions that must be addressed. This book considers the scientific and medical feasibility of xenotransplantation and explores the ethical and public policy issues surrounding the possibility of renewed clinical trials. The volume focuses on the science base of xenotransplantation, public health risks of infectious disease transmission, and ethical and public policy issues, including the views of patients and their families.
Book Synopsis De Natura Fossilium (Textbook of Mineralogy) by : Georgius Agricola
Download or read book De Natura Fossilium (Textbook of Mineralogy) written by Georgius Agricola and published by Courier Corporation. This book was released on 2013-10-01 with total page 264 pages. Available in PDF, EPUB and Kindle. Book excerpt: This 1546 publication remains a landmark in geology, with unprecedented classifications by physical property and locality, simple standardized naming system, summaries of earlier studies, and employment of observation and personal experience.
Book Synopsis The Merck Manual of Geriatrics by : Mark H. Beers
Download or read book The Merck Manual of Geriatrics written by Mark H. Beers and published by Merck. This book was released on 2000-08-15 with total page 1507 pages. Available in PDF, EPUB and Kindle. Book excerpt: A unique interdisciplinary guide that addresses the challenges of geriatric care, now with a two-color design, all-new illustrations, and many redesigned tables.
Book Synopsis Breast Cancer Biology by : Dil Afroze
Download or read book Breast Cancer Biology written by Dil Afroze and published by BoD – Books on Demand. This book was released on 2020-07-08 with total page 127 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book offers a comprehensive overview of recent developments in the field of breast cancer biology. It is a complete and descriptive reference on motioning pathways and new treatment options for the future transnational scientists and clinicians working on cancer research and treatment. We greatly appreciate the work of all the contributors to this book. They have brought with them tremendous diversity of perspectives and fields, which is truly reflective of the complexity of the topic, and they have come together in this project to serve as the node of multidisciplinary collaboration in this field. Finally, we must acknowledge the thousands of cancer patients who have participated in the studies, and who have inspired us to gather information to significantly progress knowledge in the field in recent years.
Book Synopsis Cancer Cell Signalling by : Amanda Harvey
Download or read book Cancer Cell Signalling written by Amanda Harvey and published by John Wiley & Sons. This book was released on 2013-09-11 with total page 289 pages. Available in PDF, EPUB and Kindle. Book excerpt: A focused, accessible introduction to this key aspect of cancer biology. It covers the individual cell signalling pathways that are known to be involved in cancer development, and, most important, includes the cross- interactions between the pathways together with the current therapeutic approaches. This is a ‘must-have’ for advanced undergraduate and postgraduate students studying and researching within the field of cancer biology.