Are Rodent Models Fit for Investigation of Human Obesity and Related Diseases?

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Publisher : Frontiers Media SA
ISBN 13 : 2889454258
Total Pages : 161 pages
Book Rating : 4.8/5 (894 download)

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Book Synopsis Are Rodent Models Fit for Investigation of Human Obesity and Related Diseases? by : Patrick C. Even

Download or read book Are Rodent Models Fit for Investigation of Human Obesity and Related Diseases? written by Patrick C. Even and published by Frontiers Media SA. This book was released on 2018-02-15 with total page 161 pages. Available in PDF, EPUB and Kindle. Book excerpt: Not only developed countries, but also most developing areas of the world, have experienced a surge in obesity prevalence over recent decades. Obesity complications are now among the leading causes of premature mortality, encompassing conditions such as coronary heart disease, stroke, and type 2 diabetes. This places a heavy burden on contemporary healthcare systems. While rodent models have limitations as experimental models of human obesity-related disease, study of rats and mice either spontaneously prone - or resistant - to obesity, or genetically engineered to illuminate underlying mechanisms has yielded key information about the metabolic defects linked to obesity, and their associated diseases. This topic includes both original research studies and reviews of the use of animal studies in specific areas of obesity-related disease. Various methodological approaches are discussed, with evaluation of the extent to which use of animal models has facilitated progress, or, conversely, has proved a cul de sac in investigation of human disease mechanisms. Consideration is also given to future strategies to use such rodent models optimally to enhance comprehension and treatment of pandemic human obesity-related diseases.

Mitochondria in Obesity and Type 2 Diabetes

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Publisher : Academic Press
ISBN 13 : 0128117524
Total Pages : 460 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis Mitochondria in Obesity and Type 2 Diabetes by : Beatrice Morio

Download or read book Mitochondria in Obesity and Type 2 Diabetes written by Beatrice Morio and published by Academic Press. This book was released on 2019-04-12 with total page 460 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mitochondria in Obesity and Type 2 Diabetes: Comprehensive Review on Mitochondrial Functioning and Involvement in Metabolic Diseases synthesizes discoveries from laboratories around the world, enhancing our understanding of the involvement of mitochondria in the etiology of diseases, such as obesity and type 2 diabetes. Chapters illustrate and provide an overview of key concepts on topics such as the role of mitochondria in adipose tissue, cancer, cardiovascular comorbidities, skeletal muscle, the liver, kidney, and more. This book is a must-have reference for students and educational teams in biology, physiology and medicine, and researchers.

Mechanisms of Insulin Action

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Publisher : Springer Science & Business Media
ISBN 13 : 0387722041
Total Pages : 223 pages
Book Rating : 4.3/5 (877 download)

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Book Synopsis Mechanisms of Insulin Action by : Alan R. Saltiel

Download or read book Mechanisms of Insulin Action written by Alan R. Saltiel and published by Springer Science & Business Media. This book was released on 2007-10-05 with total page 223 pages. Available in PDF, EPUB and Kindle. Book excerpt: More than 18 million people in the United States have diabetes mellitus, and about 90% of these have the type 2 form of the disease. This book attempts to dissect the complexity of the molecular mechanisms of insulin action with a special emphasis on those features of the system that are subject to alteration in type 2 diabetes and other insulin resistant states. It explores insulin action at the most basic levels, through complex systems.

Neural and Metabolic Control of Macronutrient Intake

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Publisher : CRC Press
ISBN 13 : 9781420048933
Total Pages : 536 pages
Book Rating : 4.0/5 (489 download)

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Book Synopsis Neural and Metabolic Control of Macronutrient Intake by : Hans-Rudolf Berthoud

Download or read book Neural and Metabolic Control of Macronutrient Intake written by Hans-Rudolf Berthoud and published by CRC Press. This book was released on 1999-10-25 with total page 536 pages. Available in PDF, EPUB and Kindle. Book excerpt: When an excessive proportion of the human energy requirement is derived from fat, the likelihood of obesity increases. Any such individual is at risk for diabetes and cardiovascular disease- grave and costly health hazards. The selective control of fat ingestion is a promising solution to these concerns. Existing data suggests that macronutrient intake can be manipulated. Further research is working to create pharmacological tools that will suppress fat consumption. It will also be possible to fight obesity, heart disease and diabetes. Neural and Metabolic Control of Macronutrient Intake systematically discusses the known physiological mechanisms involved in macronutrientselection, including their molecular, genetic and neurochemical aspects. The book is also a critical review of the hypothesis that ingestion of the three nutrients is regulated by separate neural control mechanisms, leaving open the possibility that strategies could be devised to intervene in bodily control systems and alter the proportion of fat in the diet. This reference provides three types of information: First, the basic background of the biochemical and physiological systems as they relate to macronutrient selection. Second, opinions and data concerning to what degree animals and humans show evidence of macronutrient selection. And, third, evidence about how the central nervous system might be involved in the choices animals make among macronutrients.

Obesity and Diabetes Mellitus

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Publisher : VSP
ISBN 13 : 9789067642125
Total Pages : 338 pages
Book Rating : 4.6/5 (421 download)

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Book Synopsis Obesity and Diabetes Mellitus by : E. I. Sokolov

Download or read book Obesity and Diabetes Mellitus written by E. I. Sokolov and published by VSP. This book was released on 1997-04 with total page 338 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is the result of the study of metabolic and hormonal disorders in patients suffering obesity and diabetes mellitus, focusing on mechanisms of formation of atherosclerotic changes in the myocardium and vessels in diabetes mellitus patient.

Diabetes

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Publisher : John Wiley & Sons
ISBN 13 : 1118367480
Total Pages : 355 pages
Book Rating : 4.1/5 (183 download)

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Book Synopsis Diabetes by : Kenneth M. Shaw

Download or read book Diabetes written by Kenneth M. Shaw and published by John Wiley & Sons. This book was released on 2012-04-25 with total page 355 pages. Available in PDF, EPUB and Kindle. Book excerpt: This edition of Diabetes: Chronic Complications provides both the experienced and trainee endocrinologist with easy-to-read, up-to-date practical guidance on the management of the many complications that can result from the onset of diabetes, such as kidney failure, cardiovascular disease, retinal failure, and cerebrovascular disease. Reflecting the rapid developments currently taking place in the field, the second edition introduces a brand-new section on liver complications in diabetes, additional material on mental health complications in the section on diabetes and the brain, coverage of dyslipidaemia and hypertension in the section on diabetes and the heart, five MCQ's in each section to help improve clinical skills, and a case study and key points summary box in every chapter.

Principles of Metabolic Surgery

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Publisher : Springer Science & Business Media
ISBN 13 : 3642024114
Total Pages : 410 pages
Book Rating : 4.6/5 (42 download)

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Book Synopsis Principles of Metabolic Surgery by : Konrad Karcz

Download or read book Principles of Metabolic Surgery written by Konrad Karcz and published by Springer Science & Business Media. This book was released on 2012-05-15 with total page 410 pages. Available in PDF, EPUB and Kindle. Book excerpt: For physicians and surgeons entrusted with the care of patients with morbid obesity and related diseases; also for nurses and other professionals on the team. „Principles of Metabolic Surgery“ delivers a succinct account of current knowledge and an excellent overview of modern treatment strategies for morbid obesity. Attractively designed, this user-friendly textbook provides the latest on therapy, monitoring, and management, including: -Completely up-to-date coverage of modern metabolic surgery -Current understanding of the pathophysiology of morbid obesity -Current clinical therapy strategies for conservative and surgical approaches -Recent references In concise, readable chapters, this well-illustrated textbook outlines major concerns and considerations surrounding metabolic surgery. With respect to new insights from basic and clinical research, clear guidelines and practical clinical advice are given to improve the outcome of treatment for morbid obesity.

Fat Detection

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Publisher : CRC Press
ISBN 13 : 1420067761
Total Pages : 646 pages
Book Rating : 4.4/5 (2 download)

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Book Synopsis Fat Detection by : Jean-Pierre Montmayeur

Download or read book Fat Detection written by Jean-Pierre Montmayeur and published by CRC Press. This book was released on 2009-09-14 with total page 646 pages. Available in PDF, EPUB and Kindle. Book excerpt: Presents the State-of-the-Art in Fat Taste TransductionA bite of cheese, a few potato chips, a delectable piece of bacon - a small taste of high-fat foods often draws you back for more. But why are fatty foods so appealing? Why do we crave them? Fat Detection: Taste, Texture, and Post Ingestive Effects covers the many factors responsible for the se

High Calorie Diet and the Human Brain

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Publisher : Springer
ISBN 13 : 3319152548
Total Pages : 325 pages
Book Rating : 4.3/5 (191 download)

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Book Synopsis High Calorie Diet and the Human Brain by : Akhlaq A. Farooqui

Download or read book High Calorie Diet and the Human Brain written by Akhlaq A. Farooqui and published by Springer. This book was released on 2015-03-25 with total page 325 pages. Available in PDF, EPUB and Kindle. Book excerpt: The purpose of this monograph is to present readers with a comprehensive and cutting edge description of neurochemical effects of diet (beneficial and harmful effects) in normal human brain and to discuss how present day diet promotes pathogenesis of stroke, AD, PD, and depression in a manner that is useful not only to students and teachers but also to researchers, dietitians, nutritionists and physicians. A diet in sufficient amount and appropriate macronutrients is essential for optimal health of human body tissues. In brain, over-nutrition, particularly with high-calorie diet, not only alters cellular homeostasis, but also results in changes in the intensity of signal transduction processes in reward centers of the brain resulting in food addiction. Over-nutrition produces detrimental effects on human health in general and brain health in particular because it chronically increases the systemic and brain inflammation and oxidative stress along with induction of insulin resistance and leptin resistance in the brain as well as visceral organs. Onset of chronic inflammation and oxidative stress not only leads to obesity and heart disease, but also promotes type II diabetes and metabolic syndrome, which are risk factors for both acute neural trauma (stroke) and chronic age-related neurodegenerative and neuropsychological disorders, such as Alzheimer disease (AD), Parkinson disease (PD) and depression.

Laparoscopic Sleeve Gastrectomy

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Publisher : Springer Nature
ISBN 13 : 3030573737
Total Pages : 674 pages
Book Rating : 4.0/5 (35 download)

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Book Synopsis Laparoscopic Sleeve Gastrectomy by : Salman Al-Sabah

Download or read book Laparoscopic Sleeve Gastrectomy written by Salman Al-Sabah and published by Springer Nature. This book was released on 2021-01-04 with total page 674 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides a complete guide to laparoscopic sleeve gastrectomy and the management of obesity. The chapters discuss guidelines for healthcare providers for the management of patients with obesity, the rationale behind choosing patients, performing the procedure in line with the patient’s condition, the perioperative period, postoperative requirements, and postoperative complications. This book aims to give readers an understanding of the surgical techniques involved in laparoscopic sleeve gastrectomy and the wider treatment options available. It is relevant to bariatric, metabolic, and general surgeons, physicians, clinical nutritionists as well as students.

Obesity and Diabetes

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Publisher : Springer
ISBN 13 : 3319131265
Total Pages : 286 pages
Book Rating : 4.3/5 (191 download)

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Book Synopsis Obesity and Diabetes by : Joel Faintuch

Download or read book Obesity and Diabetes written by Joel Faintuch and published by Springer. This book was released on 2014-12-29 with total page 286 pages. Available in PDF, EPUB and Kindle. Book excerpt: This timely and clinically oriented book uniquely addresses the entire spectrum of treatment for severe obesity and diabetes. It thoroughly examines all aspects from robotic surgery to cell therapy, from the latest antidiabetic drugs to endoscopic procedures and devices, from appetite-inhibiting signals and nutrients to gastric arterial embolization. It offers objective and authoritative information for practicing professionals; not only are successful interventions discussed and updated, but cutting-edge and experimental pathways are also anticipated. Obesity is the foremost nutritional challenge worldwide. Its companion is type-2 diabetes, the most prevalent metabolic disease. Together they represent the diabesity epidemic, which is draining resources, overwhelming healthcare facilities, and impacting life expectancy and quality of life everywhere. No country has been spared, and most medical specialties have been affected. Many books focus on the surgical options for obesity and diabetes, namely bariatric and metabolic operations. Information on the clinical and pharmacological treatment is also available, conveyed by standard texts on internal medicine and endocrinology. Yet endoscopic maneuvers and prostheses, cell therapy for diabetes, and other innovative approaches are hard to come by, as conventional texts overlook such therapies. This timely publication bridges the gaps between all different therapeutic options, also covering advances in the conservative, surgical and parasurgical domains. This book will appeal to seasoned specialists, students and healthcare professionals in training alike.

The Human Microbiome, Diet, and Health

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Publisher : National Academies Press
ISBN 13 : 030926586X
Total Pages : 197 pages
Book Rating : 4.3/5 (92 download)

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Book Synopsis The Human Microbiome, Diet, and Health by : Food Forum

Download or read book The Human Microbiome, Diet, and Health written by Food Forum and published by National Academies Press. This book was released on 2013-02-27 with total page 197 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Food Forum convened a public workshop on February 22-23, 2012, to explore current and emerging knowledge of the human microbiome, its role in human health, its interaction with the diet, and the translation of new research findings into tools and products that improve the nutritional quality of the food supply. The Human Microbiome, Diet, and Health: Workshop Summary summarizes the presentations and discussions that took place during the workshop. Over the two day workshop, several themes covered included: The microbiome is integral to human physiology, health, and disease. The microbiome is arguably the most intimate connection that humans have with their external environment, mostly through diet. Given the emerging nature of research on the microbiome, some important methodology issues might still have to be resolved with respect to undersampling and a lack of causal and mechanistic studies. Dietary interventions intended to have an impact on host biology via their impact on the microbiome are being developed, and the market for these products is seeing tremendous success. However, the current regulatory framework poses challenges to industry interest and investment.

Clinical Guidelines on the Identification, Evaluation, and Treatment of Overweight and Obesity in Adults

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Publisher :
ISBN 13 :
Total Pages : 306 pages
Book Rating : 4.:/5 (319 download)

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Book Synopsis Clinical Guidelines on the Identification, Evaluation, and Treatment of Overweight and Obesity in Adults by : Expert Panel on the Identification, Evaluation, and Treatment of Overweight and Obesity in Adults (U.S.)

Download or read book Clinical Guidelines on the Identification, Evaluation, and Treatment of Overweight and Obesity in Adults written by Expert Panel on the Identification, Evaluation, and Treatment of Overweight and Obesity in Adults (U.S.) and published by . This book was released on 1998 with total page 306 pages. Available in PDF, EPUB and Kindle. Book excerpt: Of evidence-based recommendations -- Introduction -- Overweight and obesity: background -- Examination of randomized controlled trial evidence -- Treatment guidelines -- Summary of recommendations -- Future research.

Sleep Hypoventilation: A State-of-the-Art Overview, An Issue of Sleep Medicine Clinics

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Publisher : Elsevier Health Sciences
ISBN 13 : 0323326811
Total Pages : 201 pages
Book Rating : 4.3/5 (233 download)

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Book Synopsis Sleep Hypoventilation: A State-of-the-Art Overview, An Issue of Sleep Medicine Clinics by : Babak Mokhlesi

Download or read book Sleep Hypoventilation: A State-of-the-Art Overview, An Issue of Sleep Medicine Clinics written by Babak Mokhlesi and published by Elsevier Health Sciences. This book was released on 2014-10-07 with total page 201 pages. Available in PDF, EPUB and Kindle. Book excerpt: This issue on Hypoventilation Syndrome covers a variety of topics such as Sleep hypoventilation: Diagnostic considerations and technological limitations,Pathophysiology of hypoventilation during sleep,Advances in PAP treatment modalities for hypoventilation syndromes,Scoring abnormal respiratory events on polysomnography during noninvasive ventilation,OHS Epidemiology and diagnosis,OHS outcomes,Non-PAP treatment modalities in OHS, Pulmonary overlap syndromes,Noninvasive ventilation during sleep in stable COPD and more!

Gut Hormones

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Publisher :
ISBN 13 :
Total Pages : 640 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Gut Hormones by : Stephen Robert Bloom

Download or read book Gut Hormones written by Stephen Robert Bloom and published by . This book was released on 1981 with total page 640 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Adipose Tissue in Health and Disease

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Publisher : John Wiley & Sons
ISBN 13 : 9783527629534
Total Pages : 530 pages
Book Rating : 4.6/5 (295 download)

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Book Synopsis Adipose Tissue in Health and Disease by : Todd Leff

Download or read book Adipose Tissue in Health and Disease written by Todd Leff and published by John Wiley & Sons. This book was released on 2010-03-19 with total page 530 pages. Available in PDF, EPUB and Kindle. Book excerpt: This timely and most comprehensive reference available on the topic covers all the different aspects vital in the fight against the global obesity epidemic. Following a look at adipose tissue development and morphology, the authors go on to examine its metabolic and endocrine functions and its role in disease. The final section deals with comparative and evolutionary aspects of the tissue. The result is an essential resource for cell and molecular biologists, physiologists, biochemists, pharmacologists, and those working in the pharmaceutical industry.

Microbial Endocrinology

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Publisher : Springer
ISBN 13 : 9781441956026
Total Pages : 316 pages
Book Rating : 4.9/5 (56 download)

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Book Synopsis Microbial Endocrinology by : Mark Lyte

Download or read book Microbial Endocrinology written by Mark Lyte and published by Springer. This book was released on 2010-10-22 with total page 316 pages. Available in PDF, EPUB and Kindle. Book excerpt: Microbial endocrinology represents a newly emerging interdisciplinary field that is formed by the intersection of the fields of neurobiology and microbiology. This book will introduce a new perspective to the current understanding not only of the factors that mediate the ability of microbes to cause disease, but also to the mechanisms that maintain normal homeostasis. The discovery that microbes can directly respond to neuroendocrine hormones, as evidenced by increased growth and production of virulence-associated factors, provides for a new framework with which to investigate how microorganisms interface not only with vertebrates, but also with invertebrates and even plants. The reader will learn that the neuroendocrine hormones that one most commonly associates with mammals are actually found throughout the plant, insect and microbial communities to an extent that will undoubtedly surprise many, and most importantly, how interactions between microbes and neuroendocrine hormones can influence the pathophysiology of infectious disease.