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Mechanisms Of Intestinal Inflammation
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Book Synopsis Inflammatory Bowel Disease: From Bench to Bedside by : Stephan R. Targan
Download or read book Inflammatory Bowel Disease: From Bench to Bedside written by Stephan R. Targan and published by Boom Koninklijke Uitgevers. This book was released on 2003-01-31 with total page 928 pages. Available in PDF, EPUB and Kindle. Book excerpt: A detailed and comprehensive story of the local and systemic pathophysiology of intestinal inflammation including management strategies. Research advances and current concepts of etiopathogenesis in the context of what is already known of the clinicopathologic features of these disorders are explored. This volume blends recent advances in the basic and clinical sciences as they relate to inflammatory bowel disease and emphasizes the effectiveness of a team approach of basic scientists and clinician investigators in this field.
Book Synopsis Fibrostenotic Inflammatory Bowel Disease by : Florian Rieder
Download or read book Fibrostenotic Inflammatory Bowel Disease written by Florian Rieder and published by Springer. This book was released on 2018-09-04 with total page 395 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides a comprehensive account of the pathogenesis and treatment of intestinal fibrosis, covering both the clinical and molecular aspects of the disease. It begins by describing the epidemiology and genetics of fibrostenosing IBD in Crohn’s disease and Ulcerative colitis as well as the epigenetics and cellular and molecular mechanisms of the disease. Readers will obtain an in-depth overview of the disease from biomarkers and histology to surgical intervention, imaging and current and future drug therapies. Medical management of fibrosis, endoscopy and imaging as well as surgical approaches are all discussed. Through the links to videos contained in the book, the reader will become familiar with interventional procedures such as endoscopic balloon dilation and surgical techniques for stricturing IBD, such as resection and strictureplasties. This is an indispensable volume for anyone working on fibrostenotic IBD, such as gastroenterologists, internists, radiologists, colorectal surgeons, pathologists and researchers. It has been written by a team of top experts from North America, Asia and Europe.
Book Synopsis The ASCRS Manual of Colon and Rectal Surgery by : David E. Beck
Download or read book The ASCRS Manual of Colon and Rectal Surgery written by David E. Beck and published by Springer Science & Business Media. This book was released on 2009-06-12 with total page 1042 pages. Available in PDF, EPUB and Kindle. Book excerpt: The ASCRS Textbook of Surgery of the Colon and Rectum offers a comprehensive textbook designed to provide state of the art information to residents in training and fully trained surgeons seeking recertification. The textbook also supports the mission of the ASCRS to be the world’s authority on colon and rectal disease. The combination of junior and senior authors selected from the membership of the ASCRS for each chapter will provide a comprehensive summary of each topic and allow the touch of experience to focus and temper the material. This approach should provide the reader with a very open minded, evidence based approach to all aspects of colorectal disease. Derived from the textbook, The ASCRS Manual of Surgery of the Colon and Rectum offers a “hands on” version of the textbook, written with the same comprehensive, evidence-based approach but distilled to the clinical essentials. In a handy pocket format, readers will find the bread and butter information for the broad spectrum of practice. In a consistent style, each chapter outlines the condition or procedure being discussed in a concise outline format – easy to read, appropriately illustrated and referenced.
Book Synopsis Mechanisms of Intestinal Inflammation by : R. Duchmann
Download or read book Mechanisms of Intestinal Inflammation written by R. Duchmann and published by Springer Science & Business Media. This book was released on 2004-04-30 with total page 246 pages. Available in PDF, EPUB and Kindle. Book excerpt: In recent years considerable progress has been achieved in regard to our understanding of the induction and modulation of the immune response in the intestinal mucosa. It is clear that this mucosal immune reaction is predominantly steered by certain T-cell populations, which are characterized by their cytokine secretion profile. Less well known are the conditions under which the uptake and processing of a specific antigen leads to a certain immune response, whether it be protective, tolerant or inflammatory. However, here again distinct progress has been made in our understanding. Equally significant for immune regulation in the gut appears to be so-called innate immunity. Every shift of equilibrium in the highly regulated mucosal immune reaction is accompanied by an inflammatory reaction and destruction of the mucosa. In nearly all cases, this inflammatory response is dependent on the presence of bacterial intestinal flora. This book, the proceedings of Falk Symposium 133 on Mechanisms of Intestinal Inflammation: Implications for Therapeutic Intervention in IBD', held in Berlin, Germany, on 10-11 June 2003, summarizes present knowledge in the area of unspecific and specific immune reactions in the gut, recording the gaps in our knowledge and, in particular, presenting the possibilities of targeted intervention. The link to inflammatory bowel diseases - Crohn's disease and ulcerative colitis - is always in focus. Chapters by an international panel of basic scientists, clinical researchers and clinicians also record the problems which can originate through today's possible modulation of the immune reaction, setting the basis for review of clinical problems. This book is valuable readings for all scientists and physicians, who, from different perspectives, have an interest in research on IBD and in the clinical management of these diseases.
Book Synopsis Cytokines in Inflammatory Bowel Disease by : Claudio Fiocchi
Download or read book Cytokines in Inflammatory Bowel Disease written by Claudio Fiocchi and published by . This book was released on 1996 with total page 270 pages. Available in PDF, EPUB and Kindle. Book excerpt: The pathogenesis of both forms of inflammatory bowel disease, Crohn's disease and ulcerative colitis, depends on complex immune abnormalities, and the investigation of cytokines has become critical to basic, clinical and therapeutic aspects of these enigmatic entities. This book offers clear, concise, state-of-the-art information on the role of various immunoregulatory and pro-inflammatory mediators in Crohn's disease and ulcerative colitis. Each cytokine is analyzed in regard to pathogenic and clinical implications, taking advantage of information derived from patients, animal models, as well as immunological and molecular in vitro systems. This volume is of interest to gastroenterologists, clinical investigators, immunologists, cell biologists and any professional interested in mucosal immunity and inflammation.
Book Synopsis Colonic Motility by : Sushil K. Sarna
Download or read book Colonic Motility written by Sushil K. Sarna and published by Biota Publishing. This book was released on 2010-11-01 with total page 159 pages. Available in PDF, EPUB and Kindle. Book excerpt: Three distinct types of contractions perform colonic motility functions. Rhythmic phasic contractions (RPCs) cause slow net distal propulsion with extensive mixing/turning over. Infrequently occurring giant migrating contractions (GMCs) produce mass movements. Tonic contractions aid RPCs in their motor function. The spatiotemporal patterns of these contractions differ markedly. The amplitude and distance of propagation of a GMC are several-fold larger than those of an RPC. The enteric neurons and smooth muscle cells are the core regulators of all three types of contractions. The regulation of contractions by these mechanisms is modifiable by extrinsic factors: CNS, autonomic neurons, hormones, inflammatory mediators, and stress mediators. Only the GMCs produce descending inhibition, which accommodates the large bolus being propelled without increasing muscle tone. The strong compression of the colon wall generates afferent signals that are below nociceptive threshold in healthy subjects. However, these signals become nociceptive; if the amplitudes of GMCs increase, afferent nerves become hypersensitive, or descending inhibition is impaired. The GMCs also provide the force for rapid propulsion of feces and descending inhibition to relax the internal anal sphincter during defecation. The dysregulation of GMCs is a major factor in colonic motility disorders: irritable bowel syndrome (IBS), inflammatory bowel disease (IBD), and diverticular disease (DD). Frequent mass movements by GMCs cause diarrhea in diarrhea predominant IBS, IBD, and DD, while a decrease in the frequency of GMCs causes constipation. The GMCs generate the afferent signals for intermittent short-lived episodes of abdominal cramping in these disorders. Epigenetic dysregulation due to adverse events in early life is one of the major factors in generating the symptoms of IBS in adulthood.
Book Synopsis Inflammatory Bowel Disease by : Stephan R. Targan
Download or read book Inflammatory Bowel Disease written by Stephan R. Targan and published by John Wiley & Sons. This book was released on 2011-08-24 with total page 1429 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is the state-of–the-art book on inflammatory bowel disease you have been waiting for Written and edited by international experts in gastroenterology this up-to-date volume provides a complete review of the basic science behind inflammatory bowel disease (IBD), as well as evidence-based clinical guidance on diagnosis, treatment and long-term management of IBD. In 50 chapters the authors cover the latest and most promising treatment modalities and the science behind them. There are chapters which cover the advances in the medical and surgical treatment of conditions such as Crohn's disease and ulcerative colitis, as well as chapters focusing on nutrition, imaging and complementary medicine. This is an invaluable information resource for all those in the medical team treating patients with IBD. Whether you are a gastroenterologist, gastrointestinal surgeon or GI nurse specialist this book deserves a place in your library.
Book Synopsis NLR-protein functions in immunity by : Thomas A. Kufer
Download or read book NLR-protein functions in immunity written by Thomas A. Kufer and published by Frontiers Media SA. This book was released on 2015-07-08 with total page 222 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Nod-like receptor (NLR) family of proteins are evolutionary conserved molecules that in plants and mammals have been implicated in innate immune sensing of microbes and infection-associated physiological changes, contributing to immune protection of the challenged host organism through the instruction of inflammatory responses, antimicrobial defense and adaptive immunity. Recent data however suggests that the biological roles of NLR go beyond the function of classical pattern recognition molecules (PRM) as they have been implicated in essential cellular processes including autophagy, apoptosis, modification of signal transduction and gene transcription as well as reproductive biology. In this research topic, we aim to provide a comprehensive state-of the art overview of the emerging functions of NLR in plant and mammalian immunity, cell biology and reproductive biology. Potential topics may include, but are not limited to the following areas: • Functions of NLRs as PRMs in infection • Cross-talk of NLRs with other PRMs • Signal transduction pathways of NLRs • New functions of NLRs other than pattern recognition • Structural aspects of NLR activation • Mechanisms of NLRs in cell biological processes • Aspects of NLRs in reproductive biology • Functions of NLRs in plant immune responses
Book Synopsis Immune Mechanisms in Inflammatory Bowel Disease by : Richard Blumberg
Download or read book Immune Mechanisms in Inflammatory Bowel Disease written by Richard Blumberg and published by Springer Science & Business Media. This book was released on 2006-03-10 with total page 272 pages. Available in PDF, EPUB and Kindle. Book excerpt: Immune Mechanisms in Inflammatory Bowel Disease is a highly, concise update of the most recent advances in the immunobiology, genetics and microbiology related to Inflammatory Bowel Disease. This book broadly treats the topics that lead to understanding of the pathogenesis of this disease in an organized, systematic approach.
Book Synopsis Colitis-Associated Cancer by : Masato Kusunoki
Download or read book Colitis-Associated Cancer written by Masato Kusunoki and published by Springer. This book was released on 2015-10-01 with total page 151 pages. Available in PDF, EPUB and Kindle. Book excerpt: As the number of patients with colitis-associated cancer (CAC) is on the increase, the purpose of this book is to review the latest topics concerning management of the disease. In recent years, the diagnostic power of endoscopy and molecular pathology has also grown tremendously, as a result of which they now have a far greater influence on the treatment of CAC. At the moment, appropriate monitoring programs for ulcerative colitis and Crohn’s disease remain uncertain. At the same time, the latest findings on DNA methylation and microRNAs hold the promise of making revolutionary changes in these areas. Moreover, recent drug advances in the treatment of inflammatory bowel diseases have changed surgical indications. On the other hand, the indication of mucosectomy on colorectal cancer in ulcerative colitis and prophylactic abdominoperineal resection for Crohn’s disease remain controversial. This book provides the latest information on the remaining issues of CAC from the point of view of expert surgeons.
Book Synopsis Pediatric Inflammatory Bowel Disease by : Petar Mamula
Download or read book Pediatric Inflammatory Bowel Disease written by Petar Mamula and published by Springer Science & Business Media. This book was released on 2012-12-14 with total page 573 pages. Available in PDF, EPUB and Kindle. Book excerpt: Pediatric Inflammatory Bowel Disease, Second Edition provides an essential reference with an emphasis on the unique pediatric issues of IBD. Chapters focus on complications of IBD specific to children and adolescents. Treatment recommendations are based on the latest clinical research available. The textbook also presents sections dedicated to the aspects of participation in clinical research unique to children and adolescents and the complicated yet vital process of successfully transitioning a patient from a pediatric to adult specialist. Controversies in pediatric IBD care such as the off-label use of medications are also covered. The format incorporates multiple tables, graphs, and figures to improve readability and make for an efficient reference for clinicians to use. Thoroughly revised and updated from the first edition, the volumes includes new therapies that are currently being used or tested for treatment of IBD, important areas regarding incidence and prevalence, immunization and response to vaccine administration as well as advancements in our understanding of growth and development with particular to the use of growth hormone therapy. Other new areas covered include important topics of complementary and alternative medicine use in IBD, immunization, and liver disease in IBD. Pediatric Inflammatory Bowel Disease, Second Edition is a valuable resource for pediatric gastroenterologists as well as adult gastroenterologists.
Book Synopsis Fighting Campylobacter Infections by : Steffen Backert
Download or read book Fighting Campylobacter Infections written by Steffen Backert and published by Springer Nature. This book was released on 2021-02-23 with total page 334 pages. Available in PDF, EPUB and Kindle. Book excerpt: This edited volume explores Campylobacter species, which are some of the most important foodborne pathogens. Above all, contaminated poultry meat can cause human gastroenteritis in both developed and developing countries. The respective contributions reveal how these infections can also increase the risk of generalized paralytic diseases such as Guillain-Barré syndrome, Miller-Fisher syndrome, and Chinese paralytic syndrome. Due to their influence on the nervous system, circulatory system, and various organs, Campylobacter infections represent a serious public health concern. Campylobacter can be effectively combated by addressing the hygienic conditions in both food production and human lifestyles. Accordingly, the authors put forward a One Health perspective, which provides readers with essential insights into the basic biology of Campylobacter, as well as practical guidance on aspects ranging from food production to the clinical treatment of infections. Chapters 'Population Biology and Comparative Genomics of Campylobacter Species' and 'Natural Competence and Horizontal Gene Transfer in Campylobacter' are available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.
Book Synopsis Molecular Genetics of Inflammatory Bowel Disease by : Mauro D'Amato
Download or read book Molecular Genetics of Inflammatory Bowel Disease written by Mauro D'Amato and published by Springer Science & Business Media. This book was released on 2013-10-05 with total page 344 pages. Available in PDF, EPUB and Kindle. Book excerpt: Research in Crohn’s disease (CD) and ulcerative colitis (UC), together known as the inflammatory bowel diseases (IBD), has truly seen a revolution in the last 5-10 years. This book examines how these genetic discoveries have led to the identification of biological functions not previously associated with IBD pathophysiology (e.g. autophagy), how multiple genetic risk factors for IBD converge on given biological functions and that together the identified variants in these genes have predisposing and protective roles (e.g. the multiple variants in the receptor for the IL23 cytokine and its signaling cascade), and how having such a large number of known genetic risk factors has changed our understanding not only about the genetic and molecular overlap between CD and UC, but also between these diseases and other chronic inflammatory diseases (e.g. psoriasis, multiple sclerosis, type 1 diabetes and many others).
Book Synopsis Crohn's Disease and Ulcerative Colitis by : Daniel C. Baumgart
Download or read book Crohn's Disease and Ulcerative Colitis written by Daniel C. Baumgart and published by Springer. This book was released on 2017-03-01 with total page 671 pages. Available in PDF, EPUB and Kindle. Book excerpt: This new edition is a unique combined resource for physicians and scientists addressing the needs of both groups. In addition to stimulating exchange and collaboration and shortening the path between discovery and application of new knowledge, the book helps clinicians understand new therapeutic concepts from their origins. The volume serves as a comprehensive guide to the current diagnostic modalities, including enhanced imaging techniques such as MRI and CT enterography, virtual colonoscopy, ultrasound, and endomicroscopy, as well as conventional and complex immunomodulatory principles. The latest edition also includes revised chapters from the previous edition, as well as new chapters reflecting current developments in the field. Written by experts in their field, Crohn’s Disease and Ulcerative Colitis: From Epidemiology and Immunobiology to a Rational Diagnostic and Therapeutic Approach, Second Edition is of great value to gastroenterologists, surgeons, internists, pediatricians and gynecologists trainees, as well as all those involved in Crohn’s disease, ulcerative colitis, and related autoimmune disorders.
Book Synopsis Inflammatory Bowel Disease Nursing Manual by : Andreas Sturm
Download or read book Inflammatory Bowel Disease Nursing Manual written by Andreas Sturm and published by Springer. This book was released on 2019-01-24 with total page 481 pages. Available in PDF, EPUB and Kindle. Book excerpt: This comprehensive manual discusses the many aspects of inflammatory bowel disease (IBD), providing relevant information along with practical guidance. The reader is also directed to additional resources for extra and current information. This book comes at a time when the number of people suffering from the two major forms of IBD, ulcerative colitis (UC) and Crohn’s disease (CD), is rising around the globe. Despite their huge impact on daily life and health economics, these diseases are not fully understood, and diagnosis and treatment remains a significant challenge. IBD nurses are increasingly recognised as key clinicians within the multidisciplinary team caring for people with IBD. Through experience and specialist knowledge IBD nurses provide timely support, advice, and treatment for people living with this unpredictable condition. IBD nurses are also well placed to liaise with the wider team, developing patient centred services which best fit their local health framework. The combined international expertise and accessible guidance here will equip nurses, or any clinician wanting to increase their competence in IBD management. Thereby this manual aims to contribute to the optimisation of IBD care throughout the world.
Download or read book Intestinal Stem Cell Niche written by and published by Academic Press. This book was released on 2018-04-24 with total page 150 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advances in Stem Cells and Their Niches addresses stem cells during development, homeostasis, and disease/injury of the respective organs, presenting new developments in the field, including new data on disease and clinical applications. Video content illustrates such areas as protocols, transplantation techniques, and work with mice. Explores not only reviews of research, but also shares methods, protocols, and transplantation techniques Contains video content to illustrate such areas as protocols, transplantation techniques, and work with mice Each volume concentrates on one organ, making this a unique publication
Book Synopsis Janeway's Immunobiology by : Kenneth Murphy
Download or read book Janeway's Immunobiology written by Kenneth Murphy and published by Garland Science. This book was released on 2010-06-22 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: The Janeway's Immunobiology CD-ROM, Immunobiology Interactive, is included with each book, and can be purchased separately. It contains animations and videos with voiceover narration, as well as the figures from the text for presentation purposes.
