Maternal Fetal Transmission Of Human Viruses And Their Influence On Tumorigenesis

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Maternal Fetal Transmission of Human Viruses and their Influence on Tumorigenesis

Author : György Berencsi III
Publisher : Springer Science & Business Media
ISBN 13 : 9400742169
Total Pages : 467 pages
Book Rating : 4.4/5 (7 download)

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Book Synopsis Maternal Fetal Transmission of Human Viruses and their Influence on Tumorigenesis by : György Berencsi III

Download or read book Maternal Fetal Transmission of Human Viruses and their Influence on Tumorigenesis written by György Berencsi III and published by Springer Science & Business Media. This book was released on 2012-04-05 with total page 467 pages. Available in PDF, EPUB and Kindle. Book excerpt: The human foetus is separated from the maternal blood by the syncytiotrophoblast induced by endogeneous human retrovirus-encoded proteins. This barrier is a highly developed one, which suppors apical-basolateral transport of maternal idiotype and anti-idiotype IgG, IgG-virus complexes. The selective maternal-fetal transport of epitope- and paratope-bearing entities can influence the developping fetal immune system during pregnancy. The bidirectional maternal-fetal transfer of cells are of even more importance during pregnancy. Maternal cells with latent viruses transport viruses without impairment of fetal development. Cells with premaligant and malignant genetic transformation are also transported to the fetus. Fetal and neonatal tumours are initiated by such cells in spite of the antitumour potential of fetal organism. On the contary, the fetal cells repair maternal tissue injouries and survive in the organisms of the recipients for decades. These possess new consequences for the neonatal immunity and organ transplatation surgery.

Maternal Fetal Transmission of Human Viruses and Their Influence on Tumorigenesis

Author :
Publisher : Springer
ISBN 13 : 9789400742178
Total Pages : 474 pages
Book Rating : 4.7/5 (421 download)

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Book Synopsis Maternal Fetal Transmission of Human Viruses and Their Influence on Tumorigenesis by :

Download or read book Maternal Fetal Transmission of Human Viruses and Their Influence on Tumorigenesis written by and published by Springer. This book was released on 2012-04-06 with total page 474 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Maternal Fetal Transmission of Human Viruses and their Influence on Tumorigenesis

Author : György Berencsi III
Publisher : Springer Science & Business Media
ISBN 13 : 9400742150
Total Pages : 467 pages
Book Rating : 4.4/5 (7 download)

DOWNLOAD NOW!

Book Synopsis Maternal Fetal Transmission of Human Viruses and their Influence on Tumorigenesis by : György Berencsi III

Download or read book Maternal Fetal Transmission of Human Viruses and their Influence on Tumorigenesis written by György Berencsi III and published by Springer Science & Business Media. This book was released on 2012-04-07 with total page 467 pages. Available in PDF, EPUB and Kindle. Book excerpt: The human foetus is separated from the maternal blood by the syncytiotrophoblast induced by endogeneous human retrovirus-encoded proteins. This barrier is a highly developed one, which suppors apical-basolateral transport of maternal idiotype and anti-idiotype IgG, IgG-virus complexes. The selective maternal-fetal transport of epitope- and paratope-bearing entities can influence the developping fetal immune system during pregnancy. The bidirectional maternal-fetal transfer of cells are of even more importance during pregnancy. Maternal cells with latent viruses transport viruses without impairment of fetal development. Cells with premaligant and malignant genetic transformation are also transported to the fetus. Fetal and neonatal tumours are initiated by such cells in spite of the antitumour potential of fetal organism. On the contary, the fetal cells repair maternal tissue injouries and survive in the organisms of the recipients for decades. These possess new consequences for the neonatal immunity and organ transplatation surgery.

Patho-Epigenetics of Infectious Disease

Author : Janos Minarovits
Publisher : Springer
ISBN 13 : 3319247387
Total Pages : 150 pages
Book Rating : 4.3/5 (192 download)

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Book Synopsis Patho-Epigenetics of Infectious Disease by : Janos Minarovits

Download or read book Patho-Epigenetics of Infectious Disease written by Janos Minarovits and published by Springer. This book was released on 2015-12-11 with total page 150 pages. Available in PDF, EPUB and Kindle. Book excerpt: Epigenetic modification of cellular genomes is a fascinating means of regulating tissue- and cell type-specific gene expression in all developmental stages of the life of an organism. Carefully orchestrated processes, such as DNA methylation and a plenitude of specific histone modifications secure the faithful transmission of gene expression patterns to progeny cells. Upon chronic infection, the epigenetic cellular balance can become disrupted and, in the long run, through the epigenetic reprogramming of host cell genomes, contribute to the malignant conversion of formerly healthy cells, in many cases preceded by the establishment of an epigenetic field of cancerization. The present volume undertakes to highlight the interactions of infectious pathogens and their effector molecules with the epigenetic regulatory machinery of the cell. Clearly, the recent take-off of epigenetics research did not leave Research on Infectious Diseases and Infection-Associated Cancer untouched. This resulted in a great many of clinically relevant data on understanding the molecular mechanisms of chronic infectious disease. Infectious pathogen- and disease-specific epigenetic alterations are already being used for the early detection of malignant disease and for the prediction of chemotherapy resistance or response to treatment.

Human Herpesviruses HHV-6A, HHV-6B and HHV-7

Author : Louis Flamand
Publisher : Elsevier
ISBN 13 : 0444627162
Total Pages : 362 pages
Book Rating : 4.4/5 (446 download)

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Book Synopsis Human Herpesviruses HHV-6A, HHV-6B and HHV-7 by : Louis Flamand

Download or read book Human Herpesviruses HHV-6A, HHV-6B and HHV-7 written by Louis Flamand and published by Elsevier. This book was released on 2014-02-11 with total page 362 pages. Available in PDF, EPUB and Kindle. Book excerpt: Completely revised and updated, Human Herpesviruses HHV-6A, HHV-6B & HHV-7, Third Edition, delivers a contemporary and thorough review of HHV-6, beginning with foundational explorations of classification, molecular biology, and chromosomal integration of the virus, through to clinical details, including pathologic features of infection, and clinical effects on various organ systems. The work now includes coverage of HHV-7, a virus that remains underestimated in transplant reactivation, seizures, and encephalitis. The book examines the role of HHV-6 in myriad diseases, including cognitive disorders following bone marrow transplant, mesial temporal lobe epilepsy, multiple sclerosis, autoimmune disease, encephalitis, Hodgkin's disease lymphoma (HHV-6B), and glioma (HHV-6A). Descriptions of current and novel molecular and serological diagnostic assays, along with detailed protocols, are included to aid researchers and clinicians in discriminating potential false positives originating from chromosomally integrated HHV-6, and in differentiating between active and latent infection. Human Herpesviruses HHV-6A, HHV-6B & HHV-7, Third Edition is a valuable reference for both clinical and basic scientists, including epidemiologists, virologists, practicing clinicians, infectious disease specialists, pathologists, and all scientists entering the field of herpes virus research. The work is a practical and thorough resource for a foundational understanding of HHV-6 and HHV-7, while providing a cutting-edge translational and clinical reference to those looking to understand and diagnose associated viral diseases. - Delivers the latest molecular diagnostic tests, the present-day gold standard for monitoring HHV-6 - Provides expert analysis of T-cell immune response against HHV-6 - Presents tools for differential diagnosis in HHV-6 viral infections - Includes new information on the previously-largely-unknown biological consequences of ciHHV-6 - Offers coverage of new discoveries relating to HHV-7

RNA/DNA and Cancer

Author : Joseph G. Sinkovics
Publisher : Springer
ISBN 13 : 3319222791
Total Pages : 807 pages
Book Rating : 4.3/5 (192 download)

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Book Synopsis RNA/DNA and Cancer by : Joseph G. Sinkovics

Download or read book RNA/DNA and Cancer written by Joseph G. Sinkovics and published by Springer. This book was released on 2016-04-01 with total page 807 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this book, the author Joseph G. Sinkovics liberally shares his views on the cancer cell which he has been observing in vivo and in vitro, over a life time. Readers will learn how, as an inherent faculty of the RNA/DNA complex, the primordial cell survival pathways are endogenously reactivated in an amplified or constitutive manner in the multicellular host, and are either masquerading as self-elements or as placentas, to which the multicellular host is evolutionarily trained to extend full support. The host obliges. The author explains that there is no such evidence that “malignantly transformed” human cells survive in nature. However, when cared for in the laboratory, these cells live and replicate as immortalized cultures. These cells retain their vitality upon storage in liquid nitrogen. One can only imagine an astrophysical environment in which such cells could survive; perhaps, first their seemingly humble exosomes would populate that environment. Immortal cell populations so created may survive as individuals, or may even re-organize themselves into multicellular colonies, as representatives of life for the duration of the Universe. This thought-provoking book is the work of a disciplined investigator and clinician with an impeccable reputation, and he enters a territory that very few if any before him have approached from the same angles. It will appeal to researchers with an interest in cell survival pathways and those researching cancer cells.

Science-Based Bioethics

Author : John Loike
Publisher : Lulu.com
ISBN 13 : 1304768589
Total Pages : 249 pages
Book Rating : 4.3/5 (47 download)

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Book Synopsis Science-Based Bioethics by : John Loike

Download or read book Science-Based Bioethics written by John Loike and published by Lulu.com. This book was released on 2014 with total page 249 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book has two primary aims, to analyze how advancing scientific discoveries uncover or elicit bioethical concerns and challenges and to provide the essential scientific background and bioethical information that allows scientists, healthcare professionals and clinical researchers to better comprehend, appreciate and address the complex bioethical dilemmas that our society confronts.

Research Awards Index

Author :
Publisher :
ISBN 13 :
Total Pages : 742 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Research Awards Index by :

Download or read book Research Awards Index written by and published by . This book was released on 1989 with total page 742 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Carcinogenesis Abstracts

Author :
Publisher :
ISBN 13 :
Total Pages : 90 pages
Book Rating : 4.3/5 (126 download)

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Book Synopsis Carcinogenesis Abstracts by :

Download or read book Carcinogenesis Abstracts written by and published by . This book was released on 1964 with total page 90 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Viral Pathogenesis

Author : Michael G. Katze
Publisher : Academic Press
ISBN 13 : 0128011742
Total Pages : 368 pages
Book Rating : 4.1/5 (28 download)

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Book Synopsis Viral Pathogenesis by : Michael G. Katze

Download or read book Viral Pathogenesis written by Michael G. Katze and published by Academic Press. This book was released on 2015-12-30 with total page 368 pages. Available in PDF, EPUB and Kindle. Book excerpt: Viral Pathogenesis: From Basics to Systems Biology, Third Edition, has been thoroughly updated to cover topical advances in the evolving field of viral pathogenesis, while also providing the requisite classic foundational information for which it is recognized. The book provides key coverage of the newfound ability to profile molecular events on a system-wide scale, which has led to a deeper understanding of virus-host interactions, host signaling and molecular-interaction networks, and the role of host genetics in determining disease outcome. In addition, the content has been augmented with short chapters on seminal breakthroughs and profiles of their progenitors, as well as short commentaries on important or controversial issues in the field. Thus, the reader will be given a view of virology research with perspectives on issues such as biomedical ethics, public health policy, and human health. In summary, the third edition will give the student a sense of the exciting new perspectives on viral pathogenesis that have been provided by recent developments in genomics, computation, modeling, and systems biology. - Covers all aspects of viral infection, including viral entry, replication, and release, as well as innate and adaptive immunity and viral pathogenesis - Provides a fresh perspective on the approaches used to understand how viruses cause disease - Features molecular profiling techniques, whole genome sequencing, and innovative computational methods - Highlights the use of contemporary approaches and the insights they provide to the field

Research Grants Index

Author : National Institutes of Health (U.S.). Division of Research Grants
Publisher :
ISBN 13 :
Total Pages : 1232 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Research Grants Index by : National Institutes of Health (U.S.). Division of Research Grants

Download or read book Research Grants Index written by National Institutes of Health (U.S.). Division of Research Grants and published by . This book was released on 1963 with total page 1232 pages. Available in PDF, EPUB and Kindle. Book excerpt:

RNA Tumor Viruses: Supplements and appendixes

Author :
Publisher :
ISBN 13 :
Total Pages : 1254 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis RNA Tumor Viruses: Supplements and appendixes by :

Download or read book RNA Tumor Viruses: Supplements and appendixes written by and published by . This book was released on 1984 with total page 1254 pages. Available in PDF, EPUB and Kindle. Book excerpt:

The Epstein-Barr Virus

Author : M. A. Epstein
Publisher : Springer Science & Business Media
ISBN 13 : 3642672361
Total Pages : 467 pages
Book Rating : 4.6/5 (426 download)

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Book Synopsis The Epstein-Barr Virus by : M. A. Epstein

Download or read book The Epstein-Barr Virus written by M. A. Epstein and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 467 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Epstein-Barr virus was discovered 15 years ago. Since that time an immense body of information has been accumu lated on this agent which has come to assume great signifi cance in many different fields of biological science. Thus, the virus has very special relevance in human medicine and oncology, in tumor virology, in immunology, and in mole cular virology, since it is the cause of infectious mononu cleosis and also the first human cancer virus, etiologically related to endemic Burkitt's lymphoma and probably to nasopharyngeal carcinoma. In addition, continuous human lymphoid cell lines initiated and maintained by the transform ing function of the virus genome provide a laboratory tool with wide and ever-growing applications. Innumerable papers on the Epstein-Barr virus have ap peared over recent years and reports of work with this agent now constitute a veritable flood. The present book provides the first and only comprehensive, authoritative over-view of all aspects of the virus by authors who have been the original and major contributors in their particular disciplines. A complete and up-to-date survey of this unique and important agent is thus provided which should be of great interest to experts, teachers, and students engaged in cancer research, virology, immunology, molecular biology, epide miology, and cell culture. Where topics have been dealt with from more than one of these viewpoints, some inevitable overlap and duplication has resulted; although this has been kept to a minimum, it has been retained in some places because of positive usefulness.

Comparative Oncology

Author : Alecsandru Ioan Baba
Publisher :
ISBN 13 : 9789732714577
Total Pages : 787 pages
Book Rating : 4.7/5 (145 download)

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Book Synopsis Comparative Oncology by : Alecsandru Ioan Baba

Download or read book Comparative Oncology written by Alecsandru Ioan Baba and published by . This book was released on 2007 with total page 787 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Modern Infectious Disease Epidemiology

Author : Alexander Krämer
Publisher : Springer Science & Business Media
ISBN 13 : 0387938354
Total Pages : 441 pages
Book Rating : 4.3/5 (879 download)

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Book Synopsis Modern Infectious Disease Epidemiology by : Alexander Krämer

Download or read book Modern Infectious Disease Epidemiology written by Alexander Krämer and published by Springer Science & Business Media. This book was released on 2010-01-23 with total page 441 pages. Available in PDF, EPUB and Kindle. Book excerpt: Hardly a day goes by without news headlines concerning infectious disease threats. Currently the spectre of a pandemic of influenza A|H1N1 is raising its head, and heated debates are taking place about the pro’s and con’s of vaccinating young girls against human papilloma virus. For an evidence-based and responsible communication of infectious disease topics to avoid misunderstandings and overreaction of the public, we need solid scientific knowledge and an understanding of all aspects of infectious diseases and their control. The aim of our book is to present the reader with the general picture and the main ideas of the subject. The book introduces the reader to methodological aspects of epidemiology that are specific for infectious diseases and provides insight into the epidemiology of some classes of infectious diseases characterized by their main modes of transmission. This choice of topics bridges the gap between scientific research on the clinical, biological, mathematical, social and economic aspects of infectious diseases and their applications in public health. The book will help the reader to understand the impact of infectious diseases on modern society and the instruments that policy makers have at their disposal to deal with these challenges. It is written for students of the health sciences, both of curative medicine and public health, and for experts that are active in these and related domains, and it may be of interest for the educated layman since the technical level is kept relatively low.

Viruses and Human Cancer

Author : Mei Hwei Chang
Publisher : Springer Science & Business Media
ISBN 13 : 3642389651
Total Pages : 293 pages
Book Rating : 4.6/5 (423 download)

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Book Synopsis Viruses and Human Cancer by : Mei Hwei Chang

Download or read book Viruses and Human Cancer written by Mei Hwei Chang and published by Springer Science & Business Media. This book was released on 2013-09-06 with total page 293 pages. Available in PDF, EPUB and Kindle. Book excerpt: Research on oncogenic viruses and related human cancers has advanced rapidly in the past decade. Most articles, however, focus on a specific oncogenic virus and cancer. There is consequently a need for a comprehensive, up-to-date monograph that offers broad and integrated knowledge. Viruses and Human Cancer – From Basic Science to Clinical Prevention is designed to meet this need by providing an advanced overview on the basic and clinical aspects of oncogenic viruses and the human cancers that they cause. Virology, virus-induced inflammation and tissue injuries, oncogenic mechanisms, epidemiology, and current and emerging preventive and therapeutic strategies are all discussed in detail. In addition, the book covers the individual aspects of seven oncogenic viruses, i.e., hepatitis B virus, hepatitis C virus, human papilloma virus, Epstein-Barr virus, human T-cell lymphotropic virus, Kaposi sarcoma-associated herpes virus, and Merkel cell polyomavirus, and the related human cancers.

How Tobacco Smoke Causes Disease

Author : United States. Public Health Service. Office of the Surgeon General
Publisher :
ISBN 13 :
Total Pages : 728 pages
Book Rating : 4.:/5 (318 download)

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Book Synopsis How Tobacco Smoke Causes Disease by : United States. Public Health Service. Office of the Surgeon General

Download or read book How Tobacco Smoke Causes Disease written by United States. Public Health Service. Office of the Surgeon General and published by . This book was released on 2010 with total page 728 pages. Available in PDF, EPUB and Kindle. Book excerpt: This report considers the biological and behavioral mechanisms that may underlie the pathogenicity of tobacco smoke. Many Surgeon General's reports have considered research findings on mechanisms in assessing the biological plausibility of associations observed in epidemiologic studies. Mechanisms of disease are important because they may provide plausibility, which is one of the guideline criteria for assessing evidence on causation. This report specifically reviews the evidence on the potential mechanisms by which smoking causes diseases and considers whether a mechanism is likely to be operative in the production of human disease by tobacco smoke. This evidence is relevant to understanding how smoking causes disease, to identifying those who may be particularly susceptible, and to assessing the potential risks of tobacco products.