Mass Spectrometry And Hyphenated Techniques In Neuropeptide Research

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Mass Spectrometry and Hyphenated Techniques in Neuropeptide Research

Author : Jerzy Silberring
Publisher : John Wiley & Sons
ISBN 13 : 9780471354932
Total Pages : 576 pages
Book Rating : 4.3/5 (549 download)

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Book Synopsis Mass Spectrometry and Hyphenated Techniques in Neuropeptide Research by : Jerzy Silberring

Download or read book Mass Spectrometry and Hyphenated Techniques in Neuropeptide Research written by Jerzy Silberring and published by John Wiley & Sons. This book was released on 2002-05-02 with total page 576 pages. Available in PDF, EPUB and Kindle. Book excerpt: The first authoritative guide to the application of this vital analytical technique Mass spectrometry is a powerful analytical technique that is used to identify unknown compounds, to quantify known materials, and to elucidate the structural and chemical properties of molecules. In analyzing the effects of experimental drugs on the brain, it is the sole technique for identifying the presence and structure of neuropeptides-substances that indicate the effect of the drug. Mass Spectrometry and Hyphenated Techniques in Neuropeptide Research specifically explains how to apply the technology to this process. Because the book is written by mass spectrometry users, as opposed to mass spectrometrists, the focus remains on practical applications of the technique. The authors demonstrate how mass spectrometry works, how to apply the technique to research, which types of instrumentation should be used for particular requirements, and how to plan experiments. Readers will learn why mass spectrometry provides more outcome features than other techniques in neuropeptide analysis, including simultaneous detection, identification of substances present in mixtures, and sequence information even when the residues are modified, blocked, or unusual. Among the chapters in this comprehensive text are: * Sequencing of Peptides by Nanospray Mass Spectrometry * Laser-Machined Microdevices for Mass Spectrometry * Electron Capture Dissociation of Peptides * Synthesis of Combinatorial Peptide Libraries * Analysis of Tissues That Reflect Nervous System Disease Doctoral students, researchers, and industry professionals in pharmacology, chemistry, biochemistry/biotechnology, and medicine will find Mass Spectrometry and Hyphenated Techniques in Neuropeptide Research to be an indispensable starting point for understanding peptides, their function, and identification.

Analysis of Neuropeptides by Liquid Chromatography and Mass Spectrometry

Author : D.M. Desiderio
Publisher : Elsevier
ISBN 13 : 9780080875545
Total Pages : 234 pages
Book Rating : 4.8/5 (755 download)

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Book Synopsis Analysis of Neuropeptides by Liquid Chromatography and Mass Spectrometry by : D.M. Desiderio

Download or read book Analysis of Neuropeptides by Liquid Chromatography and Mass Spectrometry written by D.M. Desiderio and published by Elsevier. This book was released on 2000-04-01 with total page 234 pages. Available in PDF, EPUB and Kindle. Book excerpt: Analysis of Neuropeptides by Liquid Chromatography and Mass Spectrometry

Mass Spectrometry and Hyphenated Techniques in Neu Ropeptide Research

Author : Silberring
Publisher :
ISBN 13 : 9780471224235
Total Pages : pages
Book Rating : 4.2/5 (242 download)

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Book Synopsis Mass Spectrometry and Hyphenated Techniques in Neu Ropeptide Research by : Silberring

Download or read book Mass Spectrometry and Hyphenated Techniques in Neu Ropeptide Research written by Silberring and published by . This book was released on 2002-07-01 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Methods in Neurotransmitter and Neuropeptide Research

Author : S.H. Parvez
Publisher : Elsevier
ISBN 13 : 1483290220
Total Pages : 436 pages
Book Rating : 4.4/5 (832 download)

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Book Synopsis Methods in Neurotransmitter and Neuropeptide Research by : S.H. Parvez

Download or read book Methods in Neurotransmitter and Neuropeptide Research written by S.H. Parvez and published by Elsevier. This book was released on 2013-10-22 with total page 436 pages. Available in PDF, EPUB and Kindle. Book excerpt: This two-part book provides the most advanced biochemical and histochemical analytical methods on neurotransmitters, neuromodulators, and neuropeptides described by international specialists. The biochemical methods include liquid chromatography/electrochemistry, liquid chromatography/fluorescence and chemiluminescence detection, gas chromatography or liquid chromatography with mass spectrometry, and immunoassays. Morphological and physiological methods are also described, including immunohistochemistry, in situ hybridization, in vivo microdialysis, electrophysiological analysis, microwave irradiation, electrophysiological analysis, micro-anatomical dissection, peptide sequence analysis, quantitative autoradiographic analysis, and isolated CNS preparations. The neurotransmitters and neuropeptides include catecholamines, indoleamines, histamine, polyamines, and various neuropeptides, and their related enzymes. The book is the most comprehensive, advanced and versatile volume on the biochemical, morphological and physiological analysis of neurotransmitters and neuropeptides.

Analysis of Neuropeptides by Liquid Chromatography and Mass Spectrometry

Author : Dominic M. Desiderio
Publisher :
ISBN 13 : 9780444417442
Total Pages : 0 pages
Book Rating : 4.4/5 (174 download)

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Book Synopsis Analysis of Neuropeptides by Liquid Chromatography and Mass Spectrometry by : Dominic M. Desiderio

Download or read book Analysis of Neuropeptides by Liquid Chromatography and Mass Spectrometry written by Dominic M. Desiderio and published by . This book was released on 1984 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Development of Mass Spectrometric Techniques for the Analysis of Neuropeptides

Author : Stephanie Shannon Dekeyser
Publisher :
ISBN 13 :
Total Pages : 252 pages
Book Rating : 4.:/5 (891 download)

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Book Synopsis Development of Mass Spectrometric Techniques for the Analysis of Neuropeptides by : Stephanie Shannon Dekeyser

Download or read book Development of Mass Spectrometric Techniques for the Analysis of Neuropeptides written by Stephanie Shannon Dekeyser and published by . This book was released on 2007 with total page 252 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Monitoring Forest Damage with Mass Spectrometry-Based Metabolomics Methods

Author : Carla Antonio
Publisher : John Wiley & Sons
ISBN 13 : 1119868726
Total Pages : 468 pages
Book Rating : 4.1/5 (198 download)

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Book Synopsis Monitoring Forest Damage with Mass Spectrometry-Based Metabolomics Methods by : Carla Antonio

Download or read book Monitoring Forest Damage with Mass Spectrometry-Based Metabolomics Methods written by Carla Antonio and published by John Wiley & Sons. This book was released on 2024-02-21 with total page 468 pages. Available in PDF, EPUB and Kindle. Book excerpt: Understand forest responses to climate change with this timely introduction Forests are among the most critical parts of our global ecosystem, responsible for the air we breathe, home to most of the earth’s species, and crucial sources of food and raw materials. Forest development is therefore one of the most important areas of ecological study, and damage to forests is potentially existential. Metabolomics, a toolkit which accrues data on interactions between genetic and environmental conditions, promises to advance our understanding of how these vital ecosystems respond to dramatic changes in climate and environment. Monitoring Forest Damage with Mass Spectrometry-Based Metabolomics Methods offers a thorough, accessible discussion of metabolomic techniques and their applications in forest tree research. It promises to enrich the reader’s understanding of how forests are being transformed by globe-spanning changes, and to arm researchers with tools for reacting to these potentially epochal developments. Monitoring Forest Damage with Mass Spectrometry-Based Metabolomics Methods readers will also find: Analysis of specialized secondary metabolites such as phytohormones Detailed discussion of ecologically important tree genera such as Pinus, Populus, Quercus, and many more Supplementary materials related to study design, sample preparation, and instrumental analysis protocols Monitoring Forest Damage with Mass Spectrometry-Based Metabolomics Methods is ideal for researchers in analytical chemistry, mass spectrometry, metabolomics, forest research, the life sciences, and all other related fields.

Mass Spectrometry and Stable Isotopes in Nutritional and Pediatric Research

Author : Henk Schierbeek
Publisher : John Wiley & Sons
ISBN 13 : 1119341248
Total Pages : 416 pages
Book Rating : 4.1/5 (193 download)

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Book Synopsis Mass Spectrometry and Stable Isotopes in Nutritional and Pediatric Research by : Henk Schierbeek

Download or read book Mass Spectrometry and Stable Isotopes in Nutritional and Pediatric Research written by Henk Schierbeek and published by John Wiley & Sons. This book was released on 2017-01-23 with total page 416 pages. Available in PDF, EPUB and Kindle. Book excerpt: A guide for scientists, pediatricians and students involved in metabolic studies in pediatric research Addresses the availability of modern analytical techniques and how to apply these techniques in metabolic studies Covers the whole range of available mass spectrometric techniques used for metabolic studies including Stable Isotope Methodology Presents the relevance of mass spectrometry and stable isotope methodology in pediatric research covering applications in Nutrition, Obesity, Metabolic Disorders, and Kidney Disorders Focuses on the interactions between nutrients and the endogenous metabolism within the body and how these factors affect the health of a growing infant

Mass Spectrometry

Author : Marek Smoluch
Publisher : John Wiley & Sons
ISBN 13 : 111937734X
Total Pages : 361 pages
Book Rating : 4.1/5 (193 download)

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Book Synopsis Mass Spectrometry by : Marek Smoluch

Download or read book Mass Spectrometry written by Marek Smoluch and published by John Wiley & Sons. This book was released on 2019-06-17 with total page 361 pages. Available in PDF, EPUB and Kindle. Book excerpt: Provides a comprehensive description of mass spectrometry basics, applications, and perspectives Mass spectrometry is a modern analytical technique, allowing for fast and ultrasensitive detection and identification of chemical species. It can serve for analysis of narcotics, counterfeit medicines, components of explosives, but also in clinical chemistry, forensic research and anti-doping analysis, for identification of clinically relevant molecules as biomarkers of various diseases. This book describes everything readers need to know about mass spectrometry—from the instrumentation to the theory and applications. It looks at all aspects of mass spectrometry, including inorganic, organic, forensic, and biological MS (paying special attention to various methodologies and data interpretation). It also contains a list of key terms for easier and faster understanding of the material by newcomers to the subject and test questions to assist lecturers. Knowing how crucial it is for young researchers to fully understand both the power of mass spectrometry and the importance of other complementary methodologies, Mass Spectrometry: An Applied Approach teaches that it should be used in conjunction with other techniques such as NMR, pharmacological tests, structural identification, molecular biology, in order to reveal the true function(s) of the identified molecule. Provides a description of mass spectrometry basics, applications and perspectives of the technique Oriented to a broad audience with limited or basic knowledge in mass spectrometry instrumentation, theory, and its applications in order to enhance their competence in this field Covers all aspects of mass spectrometry, including inorganic, organic, forensic, and biological MS with special attention to application of various methodologies and data interpretation Includes a list of key terms, and test questions, for easier and faster understanding of the material Mass Spectrometry: An Applied Approach is highly recommended for advanced students, young scientists, and anyone involved in a field that utilizes the technique.

Mass Spectrometry for the Analysis of Pesticide Residues and their Metabolites

Author : Despina Tsipi
Publisher : John Wiley & Sons
ISBN 13 : 111906998X
Total Pages : 288 pages
Book Rating : 4.1/5 (19 download)

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Book Synopsis Mass Spectrometry for the Analysis of Pesticide Residues and their Metabolites by : Despina Tsipi

Download or read book Mass Spectrometry for the Analysis of Pesticide Residues and their Metabolites written by Despina Tsipi and published by John Wiley & Sons. This book was released on 2015-05-11 with total page 288 pages. Available in PDF, EPUB and Kindle. Book excerpt: Provides an overview of the use of mass spectrometry (MS) for the analysis of pesticide residues and their metabolites. Presents state of the-art MS techniques for the identification of pesticides and their transformation products in food and environment Covers important advances in MS techniques including MS instrumentation and chromatographic separations (e.g. UPLC, HILIC, comprehensive GCxGC) and applications Illustrates the main sample preparation techniques (SPE, QuEChERS, microextraction) used in combination with MS for the analysis of pesticides Describes various established and new ionization techniques as well as the main MS platforms, software tools and mass spectral libraries

Mass Spectrometry

Author : Agnieszka Kraj
Publisher : John Wiley & Sons
ISBN 13 : 047039580X
Total Pages : 358 pages
Book Rating : 4.4/5 (73 download)

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Book Synopsis Mass Spectrometry by : Agnieszka Kraj

Download or read book Mass Spectrometry written by Agnieszka Kraj and published by John Wiley & Sons. This book was released on 2008-12-01 with total page 358 pages. Available in PDF, EPUB and Kindle. Book excerpt: With contributions from noted experts from Europe and North America, Mass Spectrometry Instrumentation, Interpretation, and Applications serves as a forum to introduce students to the whole world of mass spectrometry and to the many different perspectives that each scientific field brings to its use. The book emphasizes the use of this important analytical technique in many different fields, including applications for organic and inorganic chemistry, forensic science, biotechnology, and many other areas. After describing the history of mass spectrometry, the book moves on to discuss instrumentation, theory, and basic applications.

Mass Spectrometry in Structural Biology and Biophysics

Author : Igor A. Kaltashov
Publisher : John Wiley & Sons
ISBN 13 : 0470937793
Total Pages : 312 pages
Book Rating : 4.4/5 (79 download)

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Book Synopsis Mass Spectrometry in Structural Biology and Biophysics by : Igor A. Kaltashov

Download or read book Mass Spectrometry in Structural Biology and Biophysics written by Igor A. Kaltashov and published by John Wiley & Sons. This book was released on 2012-04-03 with total page 312 pages. Available in PDF, EPUB and Kindle. Book excerpt: The definitive guide to mass spectrometry techniques in biology and biophysics The use of mass spectrometry (MS) to study the architecture and dynamics of proteins is increasingly common within the biophysical community, and Mass Spectrometry in Structural Biology and Biophysics: Architecture, Dynamics, and Interaction of Biomolecules, Second Edition provides readers with detailed, systematic coverage of the current state of the art. Offering an unrivalled overview of modern MS-based armamentarium that can be used to solve the most challenging problems in biophysics, structural biology, and biopharmaceuticals, the book is a practical guide to understanding the role of MS techniques in biophysical research. Designed to meet the needs of both academic and industrial researchers, it makes mass spectrometry accessible to professionals in a range of fields, including biopharmaceuticals. This new edition has been significantly expanded and updated to include the most recent experimental methodologies and techniques, MS applications in biophysics and structural biology, methods for studying higher order structure and dynamics of proteins, an examination of other biopolymers and synthetic polymers, such as nucleic acids and oligosaccharides, and much more. Featuring high-quality illustrations that illuminate the concepts described in the text, as well as extensive references that enable the reader to pursue further study, Mass Spectrometry in Structural Biology and Biophysics is an indispensable resource for researchers and graduate students working in biophysics, structural biology, protein chemistry, and related fields.

Comprehensive Chromatography in Combination with Mass Spectrometry

Author : Luigi Mondello
Publisher : John Wiley & Sons
ISBN 13 : 1118003454
Total Pages : 438 pages
Book Rating : 4.1/5 (18 download)

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Book Synopsis Comprehensive Chromatography in Combination with Mass Spectrometry by : Luigi Mondello

Download or read book Comprehensive Chromatography in Combination with Mass Spectrometry written by Luigi Mondello and published by John Wiley & Sons. This book was released on 2011-08-24 with total page 438 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides a detailed description of various multidimensional chromatographic separation techniques. The editor first provides an introduction to the area and then dives right into the various complex separation techniques. While still not used routinely comprehensive chromatography techniques will help acquaint the readers with the fundamentals and possible benefits of multi-dimensional separations coupled with mass spectrometry. The topics include a wide range of material that will appease all interested in either entering the field of multidimensional chromatography and those looking to gain a better understanding of the topic.

Mass Spectrometry for Drug Discovery and Drug Development

Author : Walter A. Korfmacher
Publisher : John Wiley & Sons
ISBN 13 : 1118516141
Total Pages : 686 pages
Book Rating : 4.1/5 (185 download)

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Book Synopsis Mass Spectrometry for Drug Discovery and Drug Development by : Walter A. Korfmacher

Download or read book Mass Spectrometry for Drug Discovery and Drug Development written by Walter A. Korfmacher and published by John Wiley & Sons. This book was released on 2012-12-12 with total page 686 pages. Available in PDF, EPUB and Kindle. Book excerpt: Facilitates the discovery and development of new, effective therapeutics With coverage of the latest mass spectrometry technology, this book explains how mass spectrometry can be used to enhance almost all phases of drug discovery and drug development, including new and emerging applications. The book's fifteen chapters have been written by leading pharmaceutical and analytical scientists. Their contributions are based on a thorough review of the current literature as well as their own experience developing new mass spectrometry techniques to improve the ability to discover and develop new and effective therapeutics. Mass Spectrometry for Drug Discovery and Drug Development begins with an overview of the types of mass spectrometers that facilitate drug discovery and development. Next it covers: HPLC high-resolution mass spectrometry for quantitative assays Mass spectrometry for siRNA Quantitative analysis of peptides Mass spectrometry analysis of biological drugs Applications that support medicinal chemistry investigations Mass spectrometry imaging and profiling Throughout the book, detailed examples underscore the growing role of mass spectrometry throughout the drug discovery and development process. In addition, images of mass spectra are provided to explain how results are interpreted. Extensive references at the end of each chapter guide readers to the primary literature in the field. Mass Spectrometry for Drug Discovery and Drug Development is recommended for readers in pharmaceutics, including medicinal chemists, analytical chemists, and drug metabolism scientists. All readers will discover how mass spectrometry can streamline and advance new drug discovery and development efforts.

Cluster Secondary Ion Mass Spectrometry

Author : Christine M. Mahoney
Publisher : John Wiley & Sons
ISBN 13 : 1118589246
Total Pages : 325 pages
Book Rating : 4.1/5 (185 download)

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Book Synopsis Cluster Secondary Ion Mass Spectrometry by : Christine M. Mahoney

Download or read book Cluster Secondary Ion Mass Spectrometry written by Christine M. Mahoney and published by John Wiley & Sons. This book was released on 2013-04-17 with total page 325 pages. Available in PDF, EPUB and Kindle. Book excerpt: Explores the impact of the latest breakthroughs in cluster SIMS technology Cluster secondary ion mass spectrometry (SIMS) is a high spatial resolution imaging mass spectrometry technique, which can be used to characterize the three-dimensional chemical structure in complex organic and molecular systems. It works by using a cluster ion source to sputter desorb material from a solid sample surface. Prior to the advent of the cluster source, SIMS was severely limited in its ability to characterize soft samples as a result of damage from the atomic source. Molecular samples were essentially destroyed during analysis, limiting the method's sensitivity and precluding compositional depth profiling. The use of new and emerging cluster ion beam technologies has all but eliminated these limitations, enabling researchers to enter into new fields once considered unattainable by the SIMS method. With contributions from leading mass spectrometry researchers around the world, Cluster Secondary Ion Mass Spectrometry: Principles and Applications describes the latest breakthroughs in instrumentation, and addresses best practices in cluster SIMS analysis. It serves as a compendium of knowledge on organic and polymeric surface and in-depth characterization using cluster ion beams. It covers topics ranging from the fundamentals and theory of cluster SIMS, to the important chemistries behind the success of the technique, as well as the wide-ranging applications of the technology. Examples of subjects covered include: Cluster SIMS theory and modeling Cluster ion source types and performance expectations Cluster ion beams for surface analysis experiments Molecular depth profiling and 3-D analysis with cluster ion beams Specialty applications ranging from biological samples analysis to semiconductors/metals analysis Future challenges and prospects for cluster SIMS This book is intended to benefit any scientist, ranging from beginning to advanced in level, with plenty of figures to help better understand complex concepts and processes. In addition, each chapter ends with a detailed reference set to the primary literature, facilitating further research into individual topics where desired. Cluster Secondary Ion Mass Spectrometry: Principles and Applications is a must-have read for any researcher in the surface analysis and/or imaging mass spectrometry fields.

Mass Spectrometry in Sports Drug Testing

Author : Mario Thevis
Publisher : John Wiley & Sons
ISBN 13 : 1118035143
Total Pages : 294 pages
Book Rating : 4.1/5 (18 download)

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Book Synopsis Mass Spectrometry in Sports Drug Testing by : Mario Thevis

Download or read book Mass Spectrometry in Sports Drug Testing written by Mario Thevis and published by John Wiley & Sons. This book was released on 2010-12-13 with total page 294 pages. Available in PDF, EPUB and Kindle. Book excerpt: Enables you to detect, identify, and characterize hundreds of drugs that may be used by athletes Mass spectrometry has become essential to sports drug testing. This book examines both the principles of sports drug testing and the use of mass spectrometry techniques and mass spectral data to detect, identify, and characterize hundreds of known and unknown drugs that athletes may use to enhance their performance. The author provides a detailed overview of the mass spectrometry of numerous classes of therapeutics and agents, various analyzers to detect low- and high-molecular weight drugs, as well as techniques to discriminate between endogenously produced and synthetically derived compounds. Mass Spectrometry in Sports Drug Testing begins with a full chapter dedicated to the history of sports drug testing. Next, the book provides the principles and techniques needed to maximize the specificity and sensitivity of mass spectrometric assays, including: Detailed, step-by-step assays with sample preparation Discussion of both chromatographic separation and mass spectrometric analysis Characterization of analytes in order to unequivocally identify banned substances Mass spectrometric behavior of low- and high-molecular weight analytes Throughout the book, descriptive examples illustrate the principles, advantages, and limitations of different assays. Mass Spectrometry in Sports Drug Testing not only sets forth the role mass spectrometry plays in detecting drug use among athletes, it also adds new insights into the health and ethical issues of doping in sports.

Mass Spectrometry of Non-Covalent Complexes

Author : Christoph A. Schalley
Publisher : John Wiley & Sons
ISBN 13 : 0470131152
Total Pages : 593 pages
Book Rating : 4.4/5 (71 download)

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Book Synopsis Mass Spectrometry of Non-Covalent Complexes by : Christoph A. Schalley

Download or read book Mass Spectrometry of Non-Covalent Complexes written by Christoph A. Schalley and published by John Wiley & Sons. This book was released on 2009-09-08 with total page 593 pages. Available in PDF, EPUB and Kindle. Book excerpt: Details the many benefits of applying mass spectrometry to supramolecular chemistry Except as a method for the most basic measurements, mass spectrometry (MS) has long been considered incompatible with supramolecular chemistry. Yet, with today's methods, the disconnect between these two fields is not warranted. Mass Spectrometry and Gas-Phase Chemistry of Non-Covalent Complexes provides a convincing look at how modern MS techniques offer supramolecular chemists a powerful investigatory toolset. Bringing the two fields together in an interdisciplinary manner, this reference details the many different topics associated with the study of non-covalent complexes in the gas phase. The text begins with brief introductions to supramolecular chemistry and such relevant mass spectrometric methods as ionization techniques, analyzers, and tandem MS experiments. The coverage continues with: How the analyte's transition into the gas phase changes covalent bonding How limitations and pitfalls in analytical methods may produce data misinterpretations Artificial supramolecular aggregates and their examination Biomolecules, their complexes, and their examination After the general remarks making up the first section of the book, the following sections describe specific experimental procedures and are illustrated with numerous examples and short tutorials. Detailed citations end each chapter. Mass spectrometrists, supramolecular chemists, students in these fields, and interested readers from other disciplines involving the study of non-covalent bonds will all value Mass Spectrometry and Gas-Phase Chemistry of Non-Covalent Complexes as an innovative and practical resource.