Manual Of Cardiovascular Proteomics

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Manual of Cardiovascular Proteomics

Author : Giulio Agnetti
Publisher : Springer
ISBN 13 : 3319318284
Total Pages : 442 pages
Book Rating : 4.3/5 (193 download)

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Book Synopsis Manual of Cardiovascular Proteomics by : Giulio Agnetti

Download or read book Manual of Cardiovascular Proteomics written by Giulio Agnetti and published by Springer. This book was released on 2016-09-15 with total page 442 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book fulfils the need to keep up with the high number of innovations in proteomics, and at the same time to warn the readers about the danger of manufacturers and scientists claims around new technologies. Mass spectrometry stands as the core technology in proteomics. The emerging field of targeted proteomics and its potential applications in the cardiovascular arena are also reviewed and discussed. A concluding section highilghts the promise of proteomics in the light of these recent developments. As this technique and its applications have undergone remarkable advances in the past years, recent updates on proteomic applications are covered. Another key concept revealed by proteomic technologies is that the extent of protein post-translational modifications (PTMs) as well as their impact on the phenotype has been underestimated by pre-proteomics science. As such, part of the manual focuses on the emerging role of PTMs in basic cardiovascular sciences and in the clinics. In fact, there is an emerging consensus that the detailed annotation of protein PTMs could lead to a more in-depth representation of biological systems, translating into more specific targets for therapy as well as biomarkers. Moreover, a recent trend is so-called “targeted proteomics”. The approach was awarded the title of “Method of the Year” by Nature in 2013 (see the editorial by Vivien Marx in 1st issue of Nature in Jan 2013). According to a few proteomic scientists the emphasis should not be placed on generating long lists of proteins but lists of proteins with a true biological meaning.

Cardiovascular Proteomics

Author : Fernando Vivanco
Publisher : Springer Science & Business Media
ISBN 13 : 1597452149
Total Pages : 412 pages
Book Rating : 4.5/5 (974 download)

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Book Synopsis Cardiovascular Proteomics by : Fernando Vivanco

Download or read book Cardiovascular Proteomics written by Fernando Vivanco and published by Springer Science & Business Media. This book was released on 2008-02-05 with total page 412 pages. Available in PDF, EPUB and Kindle. Book excerpt: This cutting-edge book presents protocols and strategies for proteomic evaluation of cardiovascular disease written by pioneering researchers in the field. Topics explored in this comprehensive volume include obtaining specific heart proteins, techniques for identifying risk biomarkers of atherome plaque rupture, analyzing the secretome of explanted endarterectomies cultured in vitro, and phage display techniques for deciphering the molecular diversity of blood vessels.

Proteomic and Genomic Analysis of Cardiovascular Disease

Author : Jennifer E. Van Eyk
Publisher : John Wiley & Sons
ISBN 13 : 3527605452
Total Pages : 423 pages
Book Rating : 4.5/5 (276 download)

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Book Synopsis Proteomic and Genomic Analysis of Cardiovascular Disease by : Jennifer E. Van Eyk

Download or read book Proteomic and Genomic Analysis of Cardiovascular Disease written by Jennifer E. Van Eyk and published by John Wiley & Sons. This book was released on 2006-03-06 with total page 423 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is the very first book to focus on this new approach that will eventually aid in developing new diagnostic markers and therapies for controlling and treating heart disease - the number-one killer in the industrialized world. Divided into two parts, the book describes not only the potentials, but also the limitations of these technologies. The editors, both well known within the scientific community, provide new insights into the biochemical and cellular mechanisms of cardiovascular disease, as well as covering the transition into clinical applications. In so doing, they highlight the various strategies and technical aspects so as to assist the growing number of researchers intending to utilize these approaches. The result is an excellent way of educating and informing graduate students, post-doctoral fellows as well as researchers in academia and industry about the latest developments in this area.

Textbook of Pulmonary Vascular Disease

Author : Jason X. -J. Yuan
Publisher : Springer Science & Business Media
ISBN 13 : 0387874291
Total Pages : 1640 pages
Book Rating : 4.3/5 (878 download)

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Book Synopsis Textbook of Pulmonary Vascular Disease by : Jason X. -J. Yuan

Download or read book Textbook of Pulmonary Vascular Disease written by Jason X. -J. Yuan and published by Springer Science & Business Media. This book was released on 2011-03-24 with total page 1640 pages. Available in PDF, EPUB and Kindle. Book excerpt: Textbook of Pulmonary Vascular Diseases combines basic scientific knowledge on the pulmonary circulatory system at levels of the molecule, cell, tissue, and organ with clinical diagnosis and treatment of pulmonary vascular diseases. State-of-the-art techniques and their potential applications in research, diagnosis, and treatment of pulmonary vascular diseases are also covered.

Fibrosis in Disease

Author : Monte S. Willis
Publisher : Springer
ISBN 13 : 3319981439
Total Pages : 474 pages
Book Rating : 4.3/5 (199 download)

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Book Synopsis Fibrosis in Disease by : Monte S. Willis

Download or read book Fibrosis in Disease written by Monte S. Willis and published by Springer. This book was released on 2018-11-10 with total page 474 pages. Available in PDF, EPUB and Kindle. Book excerpt: Fibroproliferative diseases are a broad spectrum of entities from organ-specific involvement (e.g., pulmonary, heart, liver, and kidney fibrosis) to multi-system diseases such as systemic sclerosis and sclerodermatous graft vs. host disease. These diseases also encompass pathophysiologies not readily recognizably related, such as macular degeneration and cancer metastasis. Fibroproliferative diseases are a leading cause of morbidity and mortality and can affect all tissues and organ systems. Remarkable progress in elucidating the pathogenesis of these common diseases with fibrotic components, including the critical roles of myofibroblasts and the molecular mechanisms driving the transcriptional activation involved in the induction of fibrosis. As the importance of these processes is realized in the long-term recovery and treatment of diseases, effective anti-fibrotic therapies targeting the underlying ongoing disease processes are lacking. The complexity of discovering and applying therapies to fibroproliferative disease may be due to the diversity of the systems the pathogenesis of disease itself involves. By nature, fibroproliferative diseases are interdisciplinary, involving multiple cell types (organ-specific epithelial cells), immune cells, endothelial cells, and fibroblasts. Bone marrow, cytokines, and organ-specific pathologies further speckle both the clinical and scientific disciplines in such a way that communication is often limited to the clinical or scientific tribes we live in, despite the greatest access to information known to man available today. Therefore, the primary focus of this text is to bring together authors from a diversity of both clinical, scientific, and therapeutic backgrounds for readers to more fully appreciate that fantastic platform that is available to build upon to lessen the isolation of the clinical and scientific disciplines. With advances in the discovery of pre-clinical therapeutic targets (at least 20+ to date) involving TGF-beta (and other cytokines), transcription factors, and downstream kinases, it’s important to both recognize the broader impact and potential opportunities that exist even today. This book will serve as a state-of-the-art resource for physicians and translational medical researchers alike who are interested in the rapidly evolving field of fibroproliferative diseases. The book will provide new insight into the fundamental mechanisms of classic fibrotic pathophysiologic processes like myocardial infarction, idiopathic pulmonary fibrosis, chronic kidney disease, wound healing, and systemic sclerosis. It will also highlight the many new areas of therapeutic investigation currently underway. Lastly, we will touch upon newly emerging fields investigating the role of fibrosis in macular degeneration and cancer metastasis. The chapters will be written by established experts in their fields, including clinicians (cardiologists, cardiovascular surgeons, pathologists, and general practitioners) and translational biomedical researchers in a wide range of disciplines. However, the material will certainly have a broader audience including medical residents, fellows, and general practitioners as well as M.D. or Ph.D. post-doctoral research fellows. While comprehensive, we'll attempt to present the material in a manner that simplifies the complex pathophysiologic mechanisms that underlie common fibroproliferative diseases while making it appealing to a broad audience.

Proceedings and Predictions in Cardiac Amyloidosis: Unsolved mysteries and challenges for the future

Author : Aldostefano Porcari
Publisher : Frontiers Media SA
ISBN 13 : 2832531245
Total Pages : 107 pages
Book Rating : 4.8/5 (325 download)

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Book Synopsis Proceedings and Predictions in Cardiac Amyloidosis: Unsolved mysteries and challenges for the future by : Aldostefano Porcari

Download or read book Proceedings and Predictions in Cardiac Amyloidosis: Unsolved mysteries and challenges for the future written by Aldostefano Porcari and published by Frontiers Media SA. This book was released on 2023-08-02 with total page 107 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Biomedical Applications of Proteomics

Author : Jean-Charles Sanchez
Publisher : John Wiley & Sons
ISBN 13 : 3527605835
Total Pages : 452 pages
Book Rating : 4.5/5 (276 download)

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Book Synopsis Biomedical Applications of Proteomics by : Jean-Charles Sanchez

Download or read book Biomedical Applications of Proteomics written by Jean-Charles Sanchez and published by John Wiley & Sons. This book was released on 2006-03-06 with total page 452 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this first book to provide an overview of applications of proteomics in the discovery of new diagnostic, prognostic and therapeutic targets, a team of international specialists from research institutions, hospitals and companies contribute with their specific expertise. They cover a wide range of example applications for the most important diseases, such as heart and cardiovascular disorders, cancer, pharmatoxicology, infectious diseases and diseases of the nervous system. Denis Hochstrasser is an eminent scientist in the field of bioinformatics and proteomics and one of the founders of the Swiss Prot Databank as well as of the Swiss biotech company Genebio.

Integrative Physiology in the Proteomics and Post-Genomics Age

Author : Wolfgang Walz
Publisher : Springer Science & Business Media
ISBN 13 : 1592599257
Total Pages : 271 pages
Book Rating : 4.5/5 (925 download)

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Book Synopsis Integrative Physiology in the Proteomics and Post-Genomics Age by : Wolfgang Walz

Download or read book Integrative Physiology in the Proteomics and Post-Genomics Age written by Wolfgang Walz and published by Springer Science & Business Media. This book was released on 2007-11-10 with total page 271 pages. Available in PDF, EPUB and Kindle. Book excerpt: There is a perception in the scientific community that the discipline of Physiology is in crisis, or at least, in a phase of profound transition and change. At the root of the problem is confusion between objectives (the biological questions to be solved) and the methods and technologies to be applied. Traditionally, ever since Claude Bernard’s concept of the “milieu interieur,” Physiology was an integrative science with the prime concern of studying regulatory mechanisms leading to adaptation and homeostasis in the presence of challenges from a dynamic internal and external environment. This study of control mechanisms can be applied on any level of fu- tion whether subcellular, cellular, and organ, but reaches its highest level of complexity with the functioning of the body as a whole and its interaction with the external environment. This involves the determination of the interaction of genetic with environmental factors and the resulting integrated body adaptation. It might seem obvious that in the pursuit of these questions any appropriate combination of techniques on any organizational level could be used. Yet the advent of molecular techniques has resulted in a preoccupation with the problems and challenges inherent in these techniques, sometimes at the expense of the original perspectives and concepts. The many new mechanisms that have been discovered at the molecular level, as well as their economical exploitation, have contributed to a climate of reductionism.

Platelet Proteomics

Author : Ángel García-Alonso
Publisher : John Wiley & Sons
ISBN 13 : 1118002075
Total Pages : 432 pages
Book Rating : 4.1/5 (18 download)

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Book Synopsis Platelet Proteomics by : Ángel García-Alonso

Download or read book Platelet Proteomics written by Ángel García-Alonso and published by John Wiley & Sons. This book was released on 2011-04-27 with total page 432 pages. Available in PDF, EPUB and Kindle. Book excerpt: The purpose of the book is to introduce platelets, and their functional role in thrombotic and cardiovascular disease, justifying the relevance of platelet proteomics research. Focus then shifts to the recent developments on mass spectrometry (MS)-based proteomics. This chapter shows potential applications for platelet proteomics not yet carried out. It includes examples of post-translational modifications (PTMs) analysis in platelets. The second part of the book focuses on the main research done so far on platelet proteomics. This includes general proteome mapping by non-gel based separation methods (MudPit), analysis of the general platelet proteome and signaling cascades by gel-based separation methods (2-DE), sub-proteome analyses (secretome/releasate, membrane proteins, organelles). Finally, the last section links the platelet transcriptome and application to disease. This section is highly relevant and includes chapters on proteomics, transcriptomics, functional genomics, systems biology, and their applications to platelet-related diseases.

Manual of High-Risk Pregnancy

Author : Richa Baharani
Publisher : JP Medical Ltd
ISBN 13 : 9352703928
Total Pages : 466 pages
Book Rating : 4.3/5 (527 download)

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Book Synopsis Manual of High-Risk Pregnancy by : Richa Baharani

Download or read book Manual of High-Risk Pregnancy written by Richa Baharani and published by JP Medical Ltd. This book was released on 2018-05-31 with total page 466 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is a comprehensive guide to the assessment and management of high risk pregnancy. Divided into eleven sections, the text begins with discussion on antenatal care, nutrition, genetic screening and ultrasonography-guided interventions in pregnancy. The following sections cover different factors that cause a pregnancy to be high risk including haematological disorders, early pregnancy complications, medical disorders such as gestational diabetes and cardiac disease, obstetric complications such as eclampsia and preterm labour, infections, foetal growth problems, and autoimmune diseases. The finals chapters discuss delivery complications and miscellaneous topics such as intrauterine foetal death, cerebrovascular accidents, ART pregnancies, and medicolegal aspects. The book is further enhanced by clinical photographs, diagrams and tables. Key points Comprehensive guide to management of high risk pregnancy Detailed discussion on screening and prevention of complications Presents recent advances in the field Highly illustrated with clinical photographs, diagrams and tables

Genomics, Proteomics and Metabolomics in Nutraceuticals and Functional Foods

Author : Debasis Bagchi
Publisher : John Wiley & Sons
ISBN 13 : 1118930436
Total Pages : 685 pages
Book Rating : 4.1/5 (189 download)

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Book Synopsis Genomics, Proteomics and Metabolomics in Nutraceuticals and Functional Foods by : Debasis Bagchi

Download or read book Genomics, Proteomics and Metabolomics in Nutraceuticals and Functional Foods written by Debasis Bagchi and published by John Wiley & Sons. This book was released on 2015-08-18 with total page 685 pages. Available in PDF, EPUB and Kindle. Book excerpt: Functional foods and nutraceuticals have received considerable interest in the past decade largely due to increasing consumer awareness of the health benefits associated with food. Diet in human health is no longer a matter of simple nutrition: consumers are more proactive and increasingly interested in the health benefits of functional foods and their role in the prevention of illness and chronic conditions. This, combined with an aging population that focuses not only on longevity but also quality of life, has created a market for functional foods and nutraceuticals. A fully updated and revised second edition, Genomics, Proteomics and Metabolomics in Nutraceuticals and Functional Foods reflects the recent upsurge in "omics" technologies and features 48 chapters that cover topics including genomics, proteomics, metabolomics, epigenetics, peptidomics, nutrigenomics and human health, transcriptomics, nutriethics and nanotechnology. This cutting-edge volume, written by a panel of experts from around the globe reviews the latest developments in the field with an emphasis on the application of these novel technologies to functional foods and nutraceuticals.

Braunwald's Heart Disease E-Book

Author : Robert O. Bonow
Publisher : Elsevier Health Sciences
ISBN 13 : 1437727700
Total Pages : 2049 pages
Book Rating : 4.4/5 (377 download)

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Book Synopsis Braunwald's Heart Disease E-Book by : Robert O. Bonow

Download or read book Braunwald's Heart Disease E-Book written by Robert O. Bonow and published by Elsevier Health Sciences. This book was released on 2011-02-25 with total page 2049 pages. Available in PDF, EPUB and Kindle. Book excerpt: Braunwald’s Heart Disease remains your indispensable source for definitive, state-of-the-art answers on every aspect of contemporary cardiology. Edited by Drs. Robert O. Bonow, Douglas L. Mann, Douglas P. Zipes, and Peter Libby, this dynamic, multimedia reference helps you apply the most recent knowledge in molecular biology and genetics, imaging, pharmacology, interventional cardiology, electrophysiology, and much more. Weekly updates online, personally selected by Dr. Braunwald, continuously keep you current on the most important new developments affecting your practice. Enhanced premium online content includes new dynamic cardiac imaging videos, heart sound recordings, and podcasts. With sweeping updates throughout, and contributions from a "who’s who" of global cardiology, Braunwald’s is the cornerstone of effective practice. Continuously access the most important new developments affecting your practice with weekly updates personally selected by Dr. Braunwald, including focused reviews, "hot off the press" commentaries, and late-breaking clinical trials. Practice with confidence and overcome your toughest challenges with advice from the top minds in cardiology today, who synthesize the entire state of current knowledge and summarize all of the most recent ACC/AHA practice guidelines. Locate the answers you need fast thanks to a user-friendly, full-color design with more than 1,200 color illustrations. Search the complete contents online at www.expertconsult.com. Stay on top of the latest advances in molecular imaging, intravascular ultrasound, cardiovascular regeneration and tissue engineering, device therapy for advanced heart failure, atrial fibrillation management, structural heart disease, Chagasic heart disease, ethics in cardiovascular medicine, the design and conduct of clinical trials, and many other timely topics. Hone your clinical skills with new dynamic cardiac imaging videos, heart sound recordings, and podcasts at www.expertconsult.com.

Braunwald's Heart Disease

Author : Eugene Braunwald
Publisher :
ISBN 13 : 9781437727081
Total Pages : 112 pages
Book Rating : 4.7/5 (27 download)

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Book Synopsis Braunwald's Heart Disease by : Eugene Braunwald

Download or read book Braunwald's Heart Disease written by Eugene Braunwald and published by . This book was released on 2012 with total page 112 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Braunwald's Heart Disease

Author : Douglas P. Zipes
Publisher : Saunders
ISBN 13 :
Total Pages : 1192 pages
Book Rating : 4.6/5 (993 download)

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Book Synopsis Braunwald's Heart Disease by : Douglas P. Zipes

Download or read book Braunwald's Heart Disease written by Douglas P. Zipes and published by Saunders. This book was released on 2005 with total page 1192 pages. Available in PDF, EPUB and Kindle. Book excerpt: With 35 new chapters as well as comprehensive updates throughout, the New Edition of the cardiology masterwork represents the most complete revision to date. Hundreds of world authorities synthesize all of the developments that are revolutionizing practice-from the newest findings in molecular biology and genetics to the latest imaging modalities, interventional procedures, and medications. Plus, it now features an exciting full-color layout with many new illustrations, a brand-new section on preventive cardiology, 20 new contributors, and a wealth of e-dition options to meet any reference need.

Proteomic and Metabolomic Approaches to Biomarker Discovery

Author : Haleem J. Issaq
Publisher : Academic Press
ISBN 13 : 0128197889
Total Pages : 506 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis Proteomic and Metabolomic Approaches to Biomarker Discovery by : Haleem J. Issaq

Download or read book Proteomic and Metabolomic Approaches to Biomarker Discovery written by Haleem J. Issaq and published by Academic Press. This book was released on 2019-10-24 with total page 506 pages. Available in PDF, EPUB and Kindle. Book excerpt: Proteomic and Metabolomic Approaches to Biomarker Discovery, Second Edition covers techniques from both proteomics and metabolomics and includes all steps involved in biomarker discovery, from study design to study execution. The book describes methods and presents a standard operating procedure for sample selection, preparation and storage, as well as data analysis and modeling. This new standard effectively eliminates the differing methodologies used in studies and creates a unified approach. Readers will learn the advantages and disadvantages of the various techniques discussed, as well as potential difficulties inherent to all steps in the biomarker discovery process. This second edition has been fully updated and revised to address recent advances in MS and NMR instrumentation, high-field NMR, proteomics and metabolomics for biomarker validation, clinical assays of biomarkers and clinical MS and NMR, identifying microRNAs and autoantibodies as biomarkers, MRM-MS assay development, top-down MS, glycosylation-based serum biomarkers, cell surface proteins in biomarker discovery, lipodomics for cancer biomarker discovery, and strategies to design studies to identify predictive biomarkers in cancer research. - Addresses the full range of proteomic and metabolomic methods and technologies used for biomarker discovery and validation - Covers all steps involved in biomarker discovery, from study design to study execution - Serves as a vital resource for biochemists, biologists, analytical chemists, bioanalytical chemists, clinical and medical technicians, researchers in pharmaceuticals and graduate students

Machine Learning in Cardiovascular Medicine

Author : Subhi J. Al'Aref, M.D.
Publisher : Academic Press
ISBN 13 : 0128202734
Total Pages : 454 pages
Book Rating : 4.1/5 (282 download)

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Book Synopsis Machine Learning in Cardiovascular Medicine by : Subhi J. Al'Aref, M.D.

Download or read book Machine Learning in Cardiovascular Medicine written by Subhi J. Al'Aref, M.D. and published by Academic Press. This book was released on 2020-12-11 with total page 454 pages. Available in PDF, EPUB and Kindle. Book excerpt: Machine Learning in Cardiovascular Medicine addresses the ever-expanding applications of artificial intelligence (AI), specifically machine learning (ML), in healthcare and within cardiovascular medicine. The book focuses on emphasizing ML for biomedical applications and provides a comprehensive summary of the past and present of AI, basics of ML, and clinical applications of ML within cardiovascular medicine for predictive analytics and precision medicine. It helps readers understand how ML works along with its limitations and strengths, such that they can could harness its computational power to streamline workflow and improve patient care. It is suitable for both clinicians and engineers; providing a template for clinicians to understand areas of application of machine learning within cardiovascular research; and assist computer scientists and engineers in evaluating current and future impact of machine learning on cardiovascular medicine. Provides an overview of machine learning, both for a clinical and engineering audience Summarize recent advances in both cardiovascular medicine and artificial intelligence Discusses the advantages of using machine learning for outcomes research and image processing Addresses the ever-expanding application of this novel technology and discusses some of the unique challenges associated with such an approach

Redox Proteomics

Author : Isabella Dalle-Donne
Publisher : John Wiley & Sons
ISBN 13 : 0471723452
Total Pages : 980 pages
Book Rating : 4.4/5 (717 download)

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Book Synopsis Redox Proteomics by : Isabella Dalle-Donne

Download or read book Redox Proteomics written by Isabella Dalle-Donne and published by John Wiley & Sons. This book was released on 2006-06-12 with total page 980 pages. Available in PDF, EPUB and Kindle. Book excerpt: Methodology and applications of redox proteomics The relatively new and rapidly changing field of redox proteomics has the potential to revolutionize how we diagnose disease, assess risks, determine prognoses, and target therapeutic strategies for people with inflammatory and aging-associated diseases. This collection brings together, in one comprehensive volume, a broad array of information and insights into normal and altered physiology, molecular mechanisms of disease states, and new applications of the rapidly evolving techniques of proteomics. Written by some of the finest investigators in this area, Redox Proteomics: From Protein Modifications to Cellular Dysfunction and Diseases examines the key topics of redox proteomics and redox control of cellular function, including: * The role of oxidized proteins in various disorders * Pioneering studies on the development of redox proteomics * Analytical methodologies for identification and structural characterization of proteins affected by oxidative/nitrosative modifications * The response and regulation of protein oxidation in different cell types * The pathological implications of protein oxidation for conditions, including asthma, cardiovascular disease, diabetes, preeclampsia, and Alzheimer's disease Distinguished by its in-depth discussions, balanced methodological approach, and emphasis on medical applications and diagnosis development, Redox Proteomics is a rich resource for all professionals with an interest in proteomics, cellular physiology and its alterations in disease states, and related fields.