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Author : Giles Harvey Cunnick
Publisher :
ISBN 13 :
Total Pages : 452 pages
Book Rating : 4.:/5 (591 download)
Download or read book Lymphangiogenesis and Lymphatic Metastasis in Human Breast Cancer written by Giles Harvey Cunnick and published by . This book was released on 2002 with total page 452 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Mahir Ali Ahmed Al-Rawi
Publisher :
ISBN 13 :
Total Pages : 0 pages
Book Rating : 4.:/5 (895 download)
Download or read book Regulation of Lymphangiogenesis by Interleukin-7 (IL7) and the Association with Lymphatic Metastasis in Human Breast Cancer written by Mahir Ali Ahmed Al-Rawi and published by . This book was released on 2004 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Steven A. Stacker
Publisher : Springer Science & Business Media
ISBN 13 : 9048122473
Total Pages : 255 pages
Book Rating : 4.0/5 (481 download)
Download or read book Lymphangiogenesis in Cancer Metastasis written by Steven A. Stacker and published by Springer Science & Business Media. This book was released on 2009-09-30 with total page 255 pages. Available in PDF, EPUB and Kindle. Book excerpt: Lymphangiogenesis and Cancer Metastasis introduces the new field of lymphatic vessel growth and development, and its relationship to the metastatic spread of cancer cells. The book covers all aspects of this new field from the fundamental role that protein growth factors and their receptors play in lymphangiogenesis to the potential application of these advances to cancer diagnosis and treatment. Other clinical aspects explored include the mechanisms and importance of lymph node metastasis, the role of the lymphatics in lymphangioleiomyomatosis and Kaposi’s sarcoma, and approaches for imaging lymphatics in cancer. The book also covers the innovative approaches taken by researchers to explore new roles for lymphatic vessel biology in the context of cancer. The information presented in this volume, which describes the revolutionary concepts of tumor lymphangiogenesis, will be of interest to all students, scientists and oncologists who are seeking to understand the complexities of tumor metastasis. Key Features: Presents fundamental concepts of tumor lymphangiogenesis and the molecules which control this process Provides a comprehensive summary of current research in this ground breaking area Provides a book which links progress in basic tumor and developmental biology with current and future oncology practise Is an essential text for molecular biologists, cell biologists and oncologists seeking to understand the implications of this rapidly developing area.
Author :
Publisher :
ISBN 13 :
Total Pages : 62 pages
Book Rating : 4.:/5 (742 download)
Download or read book Significance of Lymphangiogenesis for Metastatic Spread of Breast Cancer written by and published by . This book was released on 2002 with total page 62 pages. Available in PDF, EPUB and Kindle. Book excerpt: The lymphatic system serves as the primary route for the metastasis of breast cancer, and the extent of lymph node involvement is a key prognostic factor for the outcome of the disease. Whereas the significance of angiogenesis for tumor progression has been well documented, the ability of tumor cells to induce the growth of lymphatic vessels, (lymphangiogenesis) and the presence of intratumoral lymphatic vessels have been questioned. We demonstrate occurrence of intratumoral lymphangiogenesis within human breast cancers alter orthotopic transplantation onto nude mice, using a novel marker for lymphatic endothelium, LYVE-1-I. We show using green fluorescent protein-tagging that breast tumor cells which overexpress vascular endothelial growth factor-C (VEGF-C), display a potent increase in intratumoral lymphangiogenesis, and significantly enhanced metastasis to both regional lymph nodes and lungs. Furthermore we have found that the degree of tumor lymphangiogenesis is highly correlated with the extent of both lymph node and lung metastases. These results establish the occurrence and biological significance of intratumoral lymphangiogenesis in breast cancer and identify VEGF-C as a molecular link between tumor lymphangiogenesis and metastasis.
Author : Stanley P. L. Leong
Publisher : Springer Science & Business Media
ISBN 13 : 0387692193
Total Pages : 313 pages
Book Rating : 4.3/5 (876 download)
Download or read book Cancer Metastasis and the Lymphovascular System: written by Stanley P. L. Leong and published by Springer Science & Business Media. This book was released on 2007-09-05 with total page 313 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book details the anatomy and physiology of the lymphovascular system as well as describes the mechanisms of metastasis. It provides readers with an understanding of immune responses of draining lymph nodes against cancer. Coverage also explains the rationale of adopting molecular therapeutics against growth factor receptors, apoptotic factors, signaling pathways and angiogenesis.
Author : Shamil Gantsev
Publisher : Springer Nature
ISBN 13 : 3030409678
Total Pages : 69 pages
Book Rating : 4.0/5 (34 download)
Download or read book Atlas of Lymphatic System in Cancer written by Shamil Gantsev and published by Springer Nature. This book was released on 2020-04-01 with total page 69 pages. Available in PDF, EPUB and Kindle. Book excerpt: This atlas contains a large number of original photographs illustrating the anatomy, research methods, and structural features of the structure of the lymphatic apparatus in oncological diseases. The tissue complexes of the axillary region have been studied in detail. The lymphatic maps of the axillary region in cancer are presented, including those with manifestations of lymphangiogenesis; newly formed lymph nodes formed as a result of neolymphogenesis are also considered. Atlas of Lymphatic System in Cancer: Sentinel Lymph Node, Lymphangiogenesis and Neolymphogenesis is intended for oncologists, anatomists, morphologists and doctors of other specialties. The book is the result of ten years of research. The applied technology of ultrasonic isolation of anatomical structures made it possible to take a fresh look at the lymphatic apparatus in cancer and describe the phenomenon of neolymphogenesis.
Author : Stanley P. Leong
Publisher : Springer Nature
ISBN 13 : 303093084X
Total Pages : 785 pages
Book Rating : 4.0/5 (39 download)
Download or read book Cancer Metastasis Through the Lymphovascular System written by Stanley P. Leong and published by Springer Nature. This book was released on 2022-06-24 with total page 785 pages. Available in PDF, EPUB and Kindle. Book excerpt: This textbook describes in detail the process of cancer metastasis from a single cell in the primary site through its arduous journey to the sentinel lymph node as the main gateway and beyond to distant sites. The most up-to-date knowledge on key topics in the molecular biology, diagnosis, and treatment of metastatic cancer is highlighted by a large panel of experts. The book begins with a comprehensive overview of the genetic and molecular mechanisms that promote or inhibit cancer metastasis through lymphatic pathways to lymph nodes or through vascular pathways to distant sites, providing the reader with an essential basic knowledge. This is followed by further details on the role of the immune system within the primary tumor and the lymph node and the importance of the microenvironment at the metastatic site. The role of the sentinel lymph node in cancer metastasis is emphasized. Special attention is also given to state-of-the-art imaging techniques for the detection of early-stage cancer and cancer metastases, as well as the use of liquid biopsies in sarcoma, prostate, gastrointestinal, and lung cancer. Clinical patterns of malignant tumors arising in different organ systems are compared, described, and discussed with the goal of determining what similarities and/or differences exist. The book concludes with a detailed discussion of surgical intervention, radiation, and systemic therapy of primary and metastatic cancer, and briefly previews several emerging topics, such as the latest findings on personalized cancer therapy, cancer stem cells, unique molecular mechanisms of virus-induced cancer, the impact of the microbiome on cancer metastasis and the application of artificial intelligence in cancer metastasis research. By providing fundamental knowledge of the biological and clinical aspects of cancer metastasis, this book will be an important reference for cancer researchers, clinical oncologists, teachers, and students. Written by experts in the field, each chapter includes a summary of the chapter's key points and open-ended questions that address pressing issues in the field and encourage the reader to consider future directions.
Author : G. Marone
Publisher : Karger Medical and Scientific Publishers
ISBN 13 : 3318024813
Total Pages : 246 pages
Book Rating : 4.3/5 (18 download)
Download or read book Angiogenesis, Lymphangiogenesis and Clinical Implications written by G. Marone and published by Karger Medical and Scientific Publishers. This book was released on 2013-10-21 with total page 246 pages. Available in PDF, EPUB and Kindle. Book excerpt: Angiogenesis, the formation of new blood vessels, is fundamental for physiological processes such as embryonic and postnatal development, wound repair, and reproductive functions. Angiogenesis plays a major role in tumor growth and in several autoimmune and allergic disorders. Lymphangiogenesis, the formation of new lymphatic vessels, is also important for tumor growth, the formation of metastasis, and chronic inflammatory diseases. Judah Folkman, a pioneer in the study of angiogenesis, first proposed that macrophages and mast cells could be a relevant source of angiogenic factors. Since then, much effort has gone into the elucidation of the role of immune cells in the modulation of angiogenesis and lymphangiogenesis. There is now compelling evidence that several components of the innate and adaptive immune system are implicated in inflammatory and neoplastic angiogenesis and lymphangiogenesis. Articles in this volume deal with the emerging, intriguing possibility that immune cells are both a source and a target of angiogenic and lymphangiogenic factors. Therefore, cells of the immune system might play a role in inflammatory and neoplastic angiogenesis/lymphangiogenesis through the expression of several angiogenic factors and their receptors and co-receptors. The important new findings in this volume will be of special interest to vascular biologists, basic and clinical immunologists, oncologists and to specialists in allergic and immune disorders.
Author : Stanley P. L. Leong
Publisher : Springer Science & Business Media
ISBN 13 : 1603270876
Total Pages : 624 pages
Book Rating : 4.6/5 (32 download)
Download or read book From Local Invasion to Metastatic Cancer written by Stanley P. L. Leong and published by Springer Science & Business Media. This book was released on 2009-10-09 with total page 624 pages. Available in PDF, EPUB and Kindle. Book excerpt: In human solid tumors, nodal status is the most important prognostic indicator for patient outcome. Recent developments in the sentinel lymph node concept have resulted in new procedures to define the first draining node as the primary gateway through which the cancer will spread. In From Local Invasion to Metastatic Cancer: Involvement of Distant Sites Through the Lymphovascular System, a panel of international authorities takes an in-depth look at the role of the lymphovascular system in the spread of cancer. The authors summarize the findings of the Second International Symposium on Cancer Metastasis: Basis for Rational Therapy summit. Specifically, the book presents important developments in the biology and clinical understanding of cancer metastasis, describes the relationship between tumor microenvironment and proliferation, and defines the process of lymphangiogenesis and angiogenesis with special reference to cancer metastasis. From Local Invasion to Metastatic Cancer: Involvement of Distant Sites Through the Lymphovascular System provides oncologists, radiologists, and cancer researchers the necessary information to study and develop new strategies to curb the process of metastasis.
Author : R.E. Mansel
Publisher : Springer Science & Business Media
ISBN 13 : 1402058667
Total Pages : 439 pages
Book Rating : 4.4/5 (2 download)
Download or read book Metastasis of Breast Cancer written by R.E. Mansel and published by Springer Science & Business Media. This book was released on 2007-06-14 with total page 439 pages. Available in PDF, EPUB and Kindle. Book excerpt: Written by experts in the subject area, the book covers a broad range of topics in the metastasis of breast cancer, from genetics, biology to clinical management. Main topics include genetic control, biology, growth factors, cell adhesion, cell motility and invasion, natures of bone metastasis, sentinel node therapies, hormonal links, new biomarkers and detection of micrometastasis and diagnosis. This timely book also covers the current treatment options.
Author : Brandt D. Whitehurst
Publisher :
ISBN 13 :
Total Pages : 144 pages
Book Rating : 4.:/5 (144 download)
Download or read book VEGF-A Modulates Lymphangiogenic Mechanisms in an Orthotopic Model of Human Breast Carcinoma MDA-MB-231 written by Brandt D. Whitehurst and published by . This book was released on 2006 with total page 144 pages. Available in PDF, EPUB and Kindle. Book excerpt: Metastasis significantly contributes to cancer mortality and is facilitated by lymphangiogenesis. Recent reports indicate that VEGF-A can modulate this process. We therefore evaluated VEGF-A neutralization as a potential anti-lymphangiogenic treatment in an orthotopic model of human breast cancer MDA-MB-231. Anti-VEGF-A therapy caused an 80% reduction in lymphatic vessel density and inhibited metastasis. VEGF-A neutralization decreased expression of VEGF-C by 28% in cultured MDA-MB 231 cells but not affect global VEGF-C expression in vivo. Immunofluorescent staining of lymphatic vessels demonstrated robust expression of VEGFR-3 on LYVE-1-positive vessels in control tumors. However, decreased and aberrant expression of VEGFR-3 was detected on lymphatic vessels in VEGF-A depleted tumors. RT-PCR analysis revealed three-fold decreased expression of Ang-2 in treated tumors which correlated with decreased VEGFR-3 transcript. The study demonstrates VEGF-A neutralization is a potential target for anti-metastatic therapy and identifies a novel mechanism for VEGF-A dependent modulation of lymphangiogenesis.
Author : Joshua Scallan
Publisher : Morgan & Claypool Publishers
ISBN 13 : 1615040668
Total Pages : 86 pages
Book Rating : 4.6/5 (15 download)
Download or read book Capillary Fluid Exchange written by Joshua Scallan and published by Morgan & Claypool Publishers. This book was released on 2010 with total page 86 pages. Available in PDF, EPUB and Kindle. Book excerpt: The partition of fluid between the vascular and interstitial compartments is regulated by forces (hydrostatic and oncotic) operating across the microvascular walls and the surface areas of permeable structures comprising the endothelial barrier to fluid and solute exchange, as well as within the extracellular matrix and lymphatics. In addition to its role in the regulation of vascular volume, transcapillary fluid filtration also allows for continuous turnover of water bathing tissue cells, providing the medium for diffusional flux of oxygen and nutrients required for cellular metabolism and removal of metabolic byproducts. Transendothelial volume flow has also been shown to influence vascular smooth muscle tone in arterioles, hydraulic conductivity in capillaries, and neutrophil transmigration across postcapillary venules, while the flow of this filtrate through the interstitial spaces functions to modify the activities of parenchymal, resident tissue, and metastasizing tumor cells. Likewise, the flow of lymph, which is driven by capillary filtration, is important for the transport of immune and tumor cells, antigen delivery to lymph nodes, and for return of filtered fluid and extravasated proteins to the blood. Given this background, the aims of this treatise are to summarize our current understanding of the factors involved in the regulation of transcapillary fluid movement, how fluid movements across the endothelial barrier and through the interstitium and lymphatic vessels influence cell function and behavior, and the pathophysiology of edema formation. Table of Contents: Fluid Movement Across the Endothelial Barrier / The Interstitium / The Lymphatic Vasculature / Pathophysiology of Edema Formation
Author : Alfredo Martínez
Publisher : IOS Press
ISBN 13 : 9789051993608
Total Pages : 410 pages
Book Rating : 4.9/5 (936 download)
Download or read book Adrenomedullin written by Alfredo Martínez and published by IOS Press. This book was released on 1998 with total page 410 pages. Available in PDF, EPUB and Kindle. Book excerpt: Adrenomedullin is a recently discovered peptide hormone which involved in many physiological and pathological processes. This book reviews all the information available on this intriguing molecule, covering topics as diverse as blood pressure regulation, growth of tumours and normal cells, the central nervous system, and comparative studies from sharks to mammals. An international group of experts has contributed to this volume which will be of interest to professionals, researchers, and those who will benefit from a broad review of the literature and the main trends in adrenomedullin research.
Author : Vasiliki Gkretsi
Publisher : Frontiers Media SA
ISBN 13 : 2889459535
Total Pages : 93 pages
Book Rating : 4.8/5 (894 download)
Download or read book Metastasis: From Cell Adhesion and Beyond written by Vasiliki Gkretsi and published by Frontiers Media SA. This book was released on 2019-08-22 with total page 93 pages. Available in PDF, EPUB and Kindle. Book excerpt: This eBook consists of a collection of articles focused on fundamental processes of cancer cell metastasis, such as cell-Extracellular matrix adhesions, epithelial-to-mesenchymal transition (EMT) and lymph node metastasis as well as on upcoming research fields including the effects of biomechanical factors, the use of analytical and statistical tools and experimental techniques to further understand and characterize the invasive and metastatic potential of tumors.
Author : Giuliano Mariani
Publisher : Springer Science & Business Media
ISBN 13 : 8847027667
Total Pages : 306 pages
Book Rating : 4.8/5 (47 download)
Download or read book Atlas of Lymphoscintigraphy and Sentinel Node Mapping written by Giuliano Mariani and published by Springer Science & Business Media. This book was released on 2012-12-23 with total page 306 pages. Available in PDF, EPUB and Kindle. Book excerpt: Although lymphoscintigraphy was originally introduced into clinical routine for identification of the cause of peripheral edema, more recently it has been widely applied for radioguided biopsy of the sentinel lymph node in patients with solid cancers. The procedure is now considered crucial for adequate planning of oncologic surgery in a growing number of cancers. This atlas presents a collection of richly illustrated teaching cases that demonstrate the clinical relevance and impact of lymphoscintigraphy in different pathologic conditions. After introductory chapters on the anatomy, physiology, and pathophysiology of lymphatic circulation, the role of lymphoscintigraphy in differential diagnosis of peripheral edema and characterization of intracavitary lymph effusions is addressed. The principal focus of the book, however, is on the use of lymphoscintigraphic mapping for radioguided sentinel node biopsy in cutaneous melanoma and cancers at a range of anatomic sites. The most commonly observed lymphoscintigraphic patterns are depicted, and anatomic variants and technical pitfalls of the procedure receive careful attention. The role of tomographic multimodality imaging is also considered. The atlas will be an excellent learning tool for residents in nuclear medicine and other specialists with an interest in the field.
Author : Gaia Favero
Publisher : BoD – Books on Demand
ISBN 13 : 0854664319
Total Pages : 94 pages
Book Rating : 4.8/5 (546 download)
Download or read book Lymphatic System written by Gaia Favero and published by BoD – Books on Demand. This book was released on 2024-02 with total page 94 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Mahir Ali Ahmed Al-Rawi
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (111 download)
Download or read book Regulation of Lymphangiogenesis by Interleukin-7 (IL-7) and the Association with Lumphatic Metastasis in Human Breast Cancer written by Mahir Ali Ahmed Al-Rawi and published by . This book was released on 2004 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
