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Long Range Control Of Gene Expression
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Book Synopsis Long-Range Control of Gene Expression by : Veronica van Heyningen
Download or read book Long-Range Control of Gene Expression written by Veronica van Heyningen and published by Academic Press. This book was released on 2011-09-02 with total page 415 pages. Available in PDF, EPUB and Kindle. Book excerpt: Long-Range Control of Gene Expression covers the current progress in understanding the mechanisms for genomic control of gene expression, which has grown considerably in the last few years as insight into genome organization and chromatin regulation has advanced. Discusses the evolution of cis-regulatory sequences in drosophila Includes information on genomic imprinting and imprinting defects in humans Includes a chapter on epigenetic gene regulation in cancer
Book Synopsis Computational Genomics with R by : Altuna Akalin
Download or read book Computational Genomics with R written by Altuna Akalin and published by CRC Press. This book was released on 2020-12-16 with total page 463 pages. Available in PDF, EPUB and Kindle. Book excerpt: Computational Genomics with R provides a starting point for beginners in genomic data analysis and also guides more advanced practitioners to sophisticated data analysis techniques in genomics. The book covers topics from R programming, to machine learning and statistics, to the latest genomic data analysis techniques. The text provides accessible information and explanations, always with the genomics context in the background. This also contains practical and well-documented examples in R so readers can analyze their data by simply reusing the code presented. As the field of computational genomics is interdisciplinary, it requires different starting points for people with different backgrounds. For example, a biologist might skip sections on basic genome biology and start with R programming, whereas a computer scientist might want to start with genome biology. After reading: You will have the basics of R and be able to dive right into specialized uses of R for computational genomics such as using Bioconductor packages. You will be familiar with statistics, supervised and unsupervised learning techniques that are important in data modeling, and exploratory analysis of high-dimensional data. You will understand genomic intervals and operations on them that are used for tasks such as aligned read counting and genomic feature annotation. You will know the basics of processing and quality checking high-throughput sequencing data. You will be able to do sequence analysis, such as calculating GC content for parts of a genome or finding transcription factor binding sites. You will know about visualization techniques used in genomics, such as heatmaps, meta-gene plots, and genomic track visualization. You will be familiar with analysis of different high-throughput sequencing data sets, such as RNA-seq, ChIP-seq, and BS-seq. You will know basic techniques for integrating and interpreting multi-omics datasets. Altuna Akalin is a group leader and head of the Bioinformatics and Omics Data Science Platform at the Berlin Institute of Medical Systems Biology, Max Delbrück Center, Berlin. He has been developing computational methods for analyzing and integrating large-scale genomics data sets since 2002. He has published an extensive body of work in this area. The framework for this book grew out of the yearly computational genomics courses he has been organizing and teaching since 2015.
Book Synopsis Long-range Control of Gene Expression by : Aghajan
Download or read book Long-range Control of Gene Expression written by Aghajan and published by . This book was released on 2008 with total page 416 pages. Available in PDF, EPUB and Kindle. Book excerpt: Not Available.
Book Synopsis Regulation of gene expression by : U Satyanarayana
Download or read book Regulation of gene expression written by U Satyanarayana and published by Elsevier Health Sciences. This book was released on 2014-11-07 with total page 25 pages. Available in PDF, EPUB and Kindle. Book excerpt: Regulation of gene expression Regulation of gene expression
Book Synopsis Administration and coordination of genetic expression by proteins structuring the genome by : Michèle Amouyal
Download or read book Administration and coordination of genetic expression by proteins structuring the genome written by Michèle Amouyal and published by Frontiers E-books. This book was released on 2013-06-03 with total page 109 pages. Available in PDF, EPUB and Kindle. Book excerpt: These last years, a new class of proteins involved in the regulation of gene expression has been unraveled besides such classical elements as polymerases, transcription factors or enhancers, directly responsible for gene expression. This class introduces a second order level of regulation which is superimposed on that of the standard regulators and is revealed by epigenetic modifications. One end of this group is occupied by the so-called gene insulators such as CTCF that organize the action of the standard regulators and of invasive chromatin in order to limit and target their action to a specific gene or genetic entity. At the other end, one would find the proteins operating at the level of the whole genome and of cellular programming, such as SATB1. They are specific proteins nearly totally dedicated to organization and coordination of gene expression, like CTCF, or proteins also found involved in other cellular devices, like transcription factors extracted from the transcriptional machinery , such as TFIIIC, or proteins involved in sister chromatid cohesion, like cohesin. But they share in common to generally act over long distances or between chromosomes, to structure a true intra- or inter-chromosomal genomic architecture, and to mainly act at the epigenetic level. Their role in the control of gene expression is certified by the increasing number of pathologies to which their dysfunction contributes.
Book Synopsis Epigenetic Gene Expression and Regulation by : Suming Huang
Download or read book Epigenetic Gene Expression and Regulation written by Suming Huang and published by Academic Press. This book was released on 2015-10-19 with total page 484 pages. Available in PDF, EPUB and Kindle. Book excerpt: Epigenetic Gene Expression and Regulation reviews current knowledge on the heritable molecular mechanisms that regulate gene expression, contribute to disease susceptibility, and point to potential treatment in future therapies. The book shows how these heritable mechanisms allow individual cells to establish stable and unique patterns of gene expression that can be passed through cell divisions without DNA mutations, thereby establishing how different heritable patterns of gene regulation control cell differentiation and organogenesis, resulting in a distinct human organism with a variety of differing cellular functions and tissues. The work begins with basic biology, encompasses methods, cellular and tissue organization, topical issues in epigenetic evolution and environmental epigenesis, and lastly clinical disease discovery and treatment. Each highly illustrated chapter is organized to briefly summarize current research, provide appropriate pedagogical guidance, pertinent methods, relevant model organisms, and clinical examples. Reviews current knowledge on the heritable molecular mechanisms that regulate gene expression, contribute to disease susceptibility, and point to potential treatment in future therapies Helps readers understand how epigenetic marks are targeted, and to what extent transgenerational epigenetic changes are instilled and possibly passed onto offspring Chapters are replete with clinical examples to empower the basic biology with translational significance Offers more than 100 illustrations to distill key concepts and decipher complex science
Book Synopsis Regulation from a Distance by : Veronica Van Heyningen
Download or read book Regulation from a Distance written by Veronica Van Heyningen and published by . This book was released on 2013 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Molecular Biology of the Cell written by and published by . This book was released on 2002 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Translational Regulation of Gene Expression 2 by : J. Ilan
Download or read book Translational Regulation of Gene Expression 2 written by J. Ilan and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 508 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book, which results from the dramatic increase in interest in the control mechanism employed in gene expression and the importance of the regulated proteins, presents new information not covered in Translational Regulation of Gene Expression, which was published in 1987. It is not a revision of the earlier book but, rather, an extension of that volume witl, special emphasis on mecha nIsm. As the reader will discover, there is enormous diversity in the systems employing genes for translational regulation in order to regulate the appearance of the final product-the protein. Thus, we find that important proteins such as protooncogenes, growth factors, stress proteins, cytokines, lymphokines, iron storage and iron-uptake proteins, and a panorama of prokaryotic proteins, as well as eukaryotic viral proteins, are translationally regulated. Since for some gene products the degree of control is greater by a few orders of magnitude than their transcription, we can state that for these genes, at least, the expression is translationall y controlled. Translational regulation of gene expression in eukaryotes has emerged in the last few years as a major research field. The present book describes mechanisms of translational regulation in bacteria, yeast, and eukaryotic viruses, as well as in eukaryotic genes. In this book we try to provide in-depth coverage by including important examples from each group rather than systematically including all additional systems not described in the previous volume.
Book Synopsis Regulation of Gene Expression by : Gary H. Perdew
Download or read book Regulation of Gene Expression written by Gary H. Perdew and published by Springer Science & Business Media. This book was released on 2008-08-17 with total page 334 pages. Available in PDF, EPUB and Kindle. Book excerpt: The use of molecular biology and biochemistry to study the regulation of gene expression has become a major feature of research in the biological sciences. Many excellent books and reviews exist that examine the experimental methodology employed in specific areas of molecular biology and regulation of gene expression. However, we have noticed a lack of books, especially textbooks, that provide an overview of the rationale and general experimental approaches used to examine chemically or disease-mediated alterations in gene expression in mammalian systems. For example, it has been difficult to find appropriate texts that examine specific experimental goals, such as proving that an increased level of mRNA for a given gene is attributable to an increase in transcription rates. Regulation of Gene Expression: Molecular Mechanisms is intended to serve as either a textbook for graduate students or as a basic reference for laboratory personnel. Indeed, we are using this book to teach a graduate-level class at The Pennsylvania State University. For more details about this class, please visit http://moltox. cas. psu. edu and select “Courses. ” The goal for our work is to provide an overview of the various methods and approaches to characterize possible mechanisms of gene regulation. Further, we have attempted to provide a framework for students to develop an understanding of how to determine the various mechanisms that lead to altered activity of a specific protein within a cell.
Book Synopsis Eucaryotic Gene Regulation by : Richard Axel
Download or read book Eucaryotic Gene Regulation written by Richard Axel and published by Elsevier. This book was released on 2012-12-02 with total page 682 pages. Available in PDF, EPUB and Kindle. Book excerpt: Eukaryotic Gene Regulation covers the aspects and mechanisms of gene regulation of selected eukaryotes, such as yeast, Drosophila, and insect. This book is organized into eight parts, encompassing 52 chapters. The majority of the chapters are presented in an experimental manner containing an abstract, methods, results and discussion, and conclusion. This book first gives a short overview of the evolutionary role of interspersion in eukaryotic genes. It then presents considerable chapters on control of gene expression in yeast; gene mutation and isolation; structure and function; and analysis. Part III focuses on genetic and DNA sequence analysis in Drosophila. It includes discussions on allelic complementation and transvection, genetic organization, histone gene, and gene transcription. Part IV examines cell lineage; gene expression and sequences; and protein synthesis of insects, sea urchin, and mammalian cells. This is followed by discussions on structure and expression of specific eukaryotic genes from chicken, rat, rabbit, and human. Topics on the transfer of genetic information within and between cells and the structure and function of chromosome are significantly considered in Parts VI and VII. Genes evaluated in these sections include heavy chain immunoglobulin, light chain, beta-globin, and dihydrofolate reductase. Furthermore, this book describes the in vitro transcription and the factors involved; internal organization and mechanism of assembly of nucleosome; and chromatin structure. The concluding section focuses on aspects of viral genome expression including gene regulation, synthesis, processing, and alternative RNA splicing. Research biologists, geneticists, scientists, teachers, and students will greatly benefit from this book.
Book Synopsis Regulation of Gene Expression in Eukaryotic Cells by : Maureen I. Harris
Download or read book Regulation of Gene Expression in Eukaryotic Cells written by Maureen I. Harris and published by . This book was released on 1974 with total page 138 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Long-range Control of Gene Expression by Imprinting Control Regions During Development and Neoplasia by : Noopur Thakur
Download or read book Long-range Control of Gene Expression by Imprinting Control Regions During Development and Neoplasia written by Noopur Thakur and published by . This book was released on 2005 with total page 53 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Translational Control of Gene Expression by : Nahum Sonenberg
Download or read book Translational Control of Gene Expression written by Nahum Sonenberg and published by CSHL Press. This book was released on 2001 with total page 1034 pages. Available in PDF, EPUB and Kindle. Book excerpt: Since the 1996 publication of Translational Control, there has been fresh interest in protein synthesis and recognition of the key role of translation control mechanisms in regulating gene expression. This new monograph updates and expands the scope of the earlier book but it also takes a fresh look at the field. In a new format, the first eight chapters provide broad overviews, while each of the additional twenty-eight has a focus on a research topic of more specific interest. The result is a thoroughly up-to-date account of initiation, elongation, and termination of translation, control mechanisms in development in response to extracellular stimuli, and the effects on the translation machinery of virus infection and disease. This book is essential reading for students entering the field and an invaluable resource for investigators of gene expression and its control.
Book Synopsis Gene Expression and Regulation in Mammalian Cells by : Fumiaki Uchiumi
Download or read book Gene Expression and Regulation in Mammalian Cells written by Fumiaki Uchiumi and published by BoD – Books on Demand. This book was released on 2018-02-28 with total page 374 pages. Available in PDF, EPUB and Kindle. Book excerpt: Sixty years after the "central dogma," great achievements have been developed in molecular biology. We have also learned the important functions of noncoding RNAs and epigenetic regulations. More importantly, whole genome sequencing and transcriptome analyses enabled us to diagnose specific diseases. This book is not only intended for students and researchers working in laboratory but also physicians and pharmacists. This volume consists of 14 chapters, divided into 4 parts. Each chapter is written by experts investigating biological stresses, epigenetic regulation, and functions of transcription factors in human diseases. All articles presented in this volume by excellent investigators provide new insights into the studies in transcriptional control in mammalian cells and will inspire us to develop or establish novel therapeutics against human diseases.
Book Synopsis Gene Regulation : A Eukaryotic Perspective by : David S. Latchman
Download or read book Gene Regulation : A Eukaryotic Perspective written by David S. Latchman and published by Springer. This book was released on 1990-05-24 with total page 298 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Transcriptional and Epigenetic Mechanisms Regulating Normal and Aberrant Blood Cell Development by : Constanze Bonifer
Download or read book Transcriptional and Epigenetic Mechanisms Regulating Normal and Aberrant Blood Cell Development written by Constanze Bonifer and published by Springer Science & Business Media. This book was released on 2014-03-12 with total page 414 pages. Available in PDF, EPUB and Kindle. Book excerpt: During vertebrate hematopoiesis many specialized cell types are formed with vastly different functions such as B cells, T cells, granulocytes, macrophages, erythrocytes and megakaryocytes. To tightly control the enormous proliferative potential of developing blood cells, an intricately balanced signaling and transcription network has evolved that ensures that the different cell types are formed at the right time and in the right numbers. Intricate regulatory mechanisms ensure that blood cells function properly and have a determined life span. Moreover, in the adaptive immune system, long-lived memory cells have evolved that ensure that when pathogens have been seen once they will never cause a problem again. In this book we will therefore make a journey from asking how more primitive organisms use the epigenetic regulatory machinery to balance growth with differentiation control towards digging deep into what controls the function of specialized cells of the human immune system. We will first discover that flies make blood but exist without blood vessels, why fish make blood cells in the kidney and which precise genetic circuitries are required for these developmental pathways. We will then learn the regulatory principles that drive the differentiation of mature blood cells from stem cells and what controls their function in mammals. In the process, we will find out what unites hematopoietic stem cells and endothelial cells. Finally, we will shed light on the molecular mechanisms that either alter hematopoietic cell differentiation or lead to the development of cells with impaired function.
