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Logic Synthesis For Genetic Diseases
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Book Synopsis Logic Synthesis for Genetic Diseases by : Pey-Chang Kent Lin
Download or read book Logic Synthesis for Genetic Diseases written by Pey-Chang Kent Lin and published by Springer Science & Business Media. This book was released on 2013-10-31 with total page 112 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book brings to bear a body of logic synthesis techniques, in order to contribute to the analysis and control of Boolean Networks (BN) for modeling genetic diseases such as cancer. The authors provide several VLSI logic techniques to model the genetic disease behavior as a BN, with powerful implicit enumeration techniques. Coverage also includes techniques from VLSI testing to control a faulty BN, transforming its behavior to a healthy BN, potentially aiding in efforts to find the best candidates for treatment of genetic diseases.
Book Synopsis Application of Logic Synthesis Toward the Inference and Control of Gene Regulatory Networks by : Pey Chang K Lin
Download or read book Application of Logic Synthesis Toward the Inference and Control of Gene Regulatory Networks written by Pey Chang K Lin and published by . This book was released on 2013 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: In the quest to understand cell behavior and cure genetic diseases such as cancer, the fundamental approach being taken is undergoing a gradual change. It is becoming more acceptable to view these diseases as an engineering problem, and systems engineering approaches are being deployed to tackle genetic diseases. In this light, we believe that logic synthesis techniques can play a very important role. Several techniques from the field of logic synthesis can be adapted to assist in the arguably huge effort of modeling cell behavior, inferring biological networks, and controlling genetic diseases. Genes interact with other genes in a Gene Regulatory Network (GRN) and can be modeled as a Boolean Network (BN) or equivalently as a Finite State Machine (FSM). As the expression of genes determine cell behavior, important problems include (i) inferring the GRN from observed gene expression data from biological measurements, and (ii) using the inferred GRN to explain how genetic diseases occur and determine the "best" therapy towards treatment of disease. We report results on the application of logic synthesis techniques that we have developed to address both these problems. In the first technique, we present Boolean Satisfiability (SAT) based approaches to infer the predictor (logical support) of each gene that regulates melanoma, using gene expression data from patients who are suffering from the disease. From the output of such a tool, biologists can construct targeted experiments to understand the logic functions that regulate a particular target gene. Our second technique builds upon the first, in which we use a logic synthesis technique; implemented using SAT, to determine gene regulating functions for predictors and gene expression data. This technique determines a BN (or family of BNs) to describe the GRN and is validated on a synthetic network and the p53 network. The first two techniques assume binary valued gene expression data. In the third technique, we utilize continuous (analog) expression data, and present an algorithm to infer and rank predictors using modified Zhegalkin polynomials. We demonstrate our method to rank predictors for genes in the mutated mammalian and melanoma networks. The final technique assumes that the GRN is known, and uses weighted partial Max-SAT (WPMS) towards cancer therapy. In this technique, the GRN is assumed to be known. Cancer is modeled using a stuck-at fault model, and ATPG techniques are used to characterize genes leading to cancer and select drugs to treat cancer. To steer the GRN state towards a desirable healthy state, the optimal selection of drugs is formulated using WPMS. Our techniques can be used to find a set of drugs with the least side-effects, and is demonstrated in the context of growth factor pathways for colon cancer. The electronic version of this dissertation is accessible from http://hdl.handle.net/1969.1/151088
Book Synopsis Logic Synthesis and Technology Mapping Using Genetic Algorithms by : Nan Zhuang
Download or read book Logic Synthesis and Technology Mapping Using Genetic Algorithms written by Nan Zhuang and published by . This book was released on 1998 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Genetic Medicine written by Barton Childs and published by JHU Press. This book was released on 2003-09-15 with total page 345 pages. Available in PDF, EPUB and Kindle. Book excerpt: In Genetic Medicine: A Logic of Disease, Barton Childs demonstrates that knowledge of the ways both genes and environment contribute to disease provides a rational basis for medical thinking. This "genetic" medicine, he explains, should help the physician use the results of laboratory tests to perceive the uniqueness of the patient as well as that of the family and the cultural conditions in which the patient's condition arose. Childs thus provides a conceptual framework within which to teach and practice a humane medicine.
Book Synopsis Growing Digital Circuits by : Karen M. Dill
Download or read book Growing Digital Circuits written by Karen M. Dill and published by . This book was released on 1996 with total page 408 pages. Available in PDF, EPUB and Kindle. Book excerpt: This research applies the biologically inspired, artificial evolutionary processes of Genetic Algorithms and Genetic Programming to digital hardware circuit synthesis and minimization. In this new application, three approaches are taken to genetic hardware development. First, as a method for logic synthesis, Genetic Programming is applied to the building of logic functions. Experimental results have shown the logic equations from this technique produce better than 88% coverage of the given truth-tables, but the method cannot guarantee complete (100%) coverage. Secondly, to better achieve complete function coverage, an XOR Correction Circuit Algorithm used in conjunction with the Genetic Logic Synthesis was developed. With this algorithm, the genetic logic synthesis can reiteratively attempt coverage by formulating its own selective "correction" functions, for input combinations where complete truth table coverage has not previously been achieved. With this technique, complete function coverage was synthesized in all experiments conducted. The third application of the paradigm is to the minimization of Reed-Muller Equations. In this application, a Genetic Algorithm is implemented only in the search space of all "correct", functionally equivalent equations, with only the task of finding reductions. With this limited search space the solutions have absolute guaranteed function coverage, as well as a better defined focus for the genetic evolutionary process. In both the logic synthesis and minimization processes the genetic operators determine efficient circuit implementations and reductions. The results are often different from those of human designers. Because the genetic techniques incorporate logical testing into the design and build process, one can be assured that the circuit will function as derived on completion. For all three applications, the effects of a number of evolutionary parameters on the genetic operators' problem solving capability are examined. The resulting logic and logic minimizations are also compared with both arbitrarily defined functions and well known logic synthesis benchmarks. It has been shown that genetic operators applied to digital logic can effectively find good solutions for both logic synthesis and logic minimization.
Book Synopsis Genetic Design Automation by : Hasan Baig
Download or read book Genetic Design Automation written by Hasan Baig and published by Springer. This book was released on 2020-10-01 with total page 164 pages. Available in PDF, EPUB and Kindle. Book excerpt: This textbook introduces readers to the recent advances in the emerging field of genetic design automation (GDA). Starting with an introduction and the basic concepts of molecular biology, the authors provide an overview of various genetic design automation tools. The authors then present the DVASim tool (Dynamic Virtual Analyzer and Simulator) which is used for the analysis and verification of genetic logic circuits. This includes methods and algorithms for the timing and threshold value analyses of genetic logic circuits. Next, the book presents the GeneTech tool (A technology mapping tool for genetic circuits) and the methods developed for optimization, synthesis, and technology mapping of genetic circuits. Chapters are followed by exercises which give readers hands-on practice with the tools presented. The concepts and algorithms are thoroughly described, enabling readers to improve the tools or use them as a starting point to develop new tools. Both DVASim and GeneTech are available from the developer’s website, free of charge. This book is intended for a multidisciplinary audience of computer scientists, engineers and biologists. It provides enough background knowledge for computer scientists and engineers, who usually do not have any background in biology but are interested to get involved in this domain. This book not only presents an accessible basic introduction to molecular biology, it also includes software tools which allow users to perform laboratory experiments in a virtual in-silico environment. This helps newbies to get a quick start in understanding and developing genetic design automation tools. The third part of this book is particular useful for biologists who usually find it difficult to grasp programming and are reluctant to developing computer software. They are introduced to the graphical programming language, LabVIEW, from which they can start developing computer programs rapidly. Readers are further provided with small projects which will help them to start developing GDA tools.
Book Synopsis The Science and Applications of Synthetic and Systems Biology by : Institute of Medicine
Download or read book The Science and Applications of Synthetic and Systems Biology written by Institute of Medicine and published by National Academies Press. This book was released on 2011-12-30 with total page 570 pages. Available in PDF, EPUB and Kindle. Book excerpt: Many potential applications of synthetic and systems biology are relevant to the challenges associated with the detection, surveillance, and responses to emerging and re-emerging infectious diseases. On March 14 and 15, 2011, the Institute of Medicine's (IOM's) Forum on Microbial Threats convened a public workshop in Washington, DC, to explore the current state of the science of synthetic biology, including its dependency on systems biology; discussed the different approaches that scientists are taking to engineer, or reengineer, biological systems; and discussed how the tools and approaches of synthetic and systems biology were being applied to mitigate the risks associated with emerging infectious diseases. The Science and Applications of Synthetic and Systems Biology is organized into sections as a topic-by-topic distillation of the presentations and discussions that took place at the workshop. Its purpose is to present information from relevant experience, to delineate a range of pivotal issues and their respective challenges, and to offer differing perspectives on the topic as discussed and described by the workshop participants. This report also includes a collection of individually authored papers and commentary.
Book Synopsis Simulation and Modeling Methodologies, Technologies and Applications by : Mohammad S. Obaidat
Download or read book Simulation and Modeling Methodologies, Technologies and Applications written by Mohammad S. Obaidat and published by Springer. This book was released on 2017-10-26 with total page 327 pages. Available in PDF, EPUB and Kindle. Book excerpt: This Proceedings book reports on new and innovative solutions regarding methodologies and applications of modeling and simulation. It includes a set of selected, extended papers from the 6th International Conference on Simulation and Modeling Methodologies, Technologies and Applications (SIMULTECH 2016), held in Lisbon, Portugal, from 29 to 31 July, 2016. The conference brought together researchers, engineers and practitioners interested in methodologies and applications of modeling and simulation. SIMULTECH 2016 received 76 submissions from 35 countries and all continents. After a double-blind paper review performed by the Program Committee, 18% were accepted as full papers and thus selected for oral presentations. Additional papers were accepted as short papers and posters. A further selection was made after the Conference, based also on the assessment of presentation quality and audience interest, so that this book includes the extended and revised versions of the very best papers from SIMULTECH 2016.
Book Synopsis Perspectives on Genetic Discrimination by : Thomas Lemke
Download or read book Perspectives on Genetic Discrimination written by Thomas Lemke and published by Routledge. This book was released on 2013-07-18 with total page 172 pages. Available in PDF, EPUB and Kindle. Book excerpt: Over the past 15 years, a series of empirical studies in different countries have shown that our increasing genetic knowledge leads to new forms of exclusion, disadvantaging and stigmatization. The spectrum of this "genetic discrimination" ranges from disadvantages at work, via problems with insurance policies, to difficulties with adoption agencies. The empirical studies on the problem of genetic discrimination have not gone unnoticed. Since the beginning of the 1990s, a series of legislative initiatives and statements, both on the national level and on the part of international and supranational organizations and commissions, have been put forward as ways of protecting people from genetic discrimination. This is the first book to critically evaluate the empirical evidence and the theoretical usefulness of the concept of "genetic discrimination." It discusses the advantages and limitations of adopting the concept, and offers a more complex account distinguishing between several dimensions and forms of genetic discrimination.
Book Synopsis Molecular Biology of The Cell by : Bruce Alberts
Download or read book Molecular Biology of The Cell written by Bruce Alberts and published by . This book was released on 2002 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Journal of Nervous and Mental Disease by :
Download or read book Journal of Nervous and Mental Disease written by and published by . This book was released on 1917 with total page 624 pages. Available in PDF, EPUB and Kindle. Book excerpt: July 1918-1943 include reports of various neurological and psychiatric societies.
Book Synopsis Liver Disease in Children by : Frederick J. Suchy
Download or read book Liver Disease in Children written by Frederick J. Suchy and published by Cambridge University Press. This book was released on 2007-05-07 with total page 995 pages. Available in PDF, EPUB and Kindle. Book excerpt: Completely revised new edition of the premier reference on pediatric liver disease. Liver Disease in Children, 3rd Edition provides authoritative coverage of every aspect of liver disease affecting infants, children, and adolescents. The book offers an integrated approach to the science and clinical practice of pediatric hepatology and charts the substantial progress in understanding and treating these diseases. Chapters are written by international experts and address the unique pathophysiology, manifestations, and management of these disorders in the pediatric population. The third edition has been thoroughly updated and features new contributions on liver development, cholestatic and autoimmune disorders, fatty liver disease, and inborn errors of metabolism. With the continued evolution of pediatric hepatology as a discipline, this text remains an essential reference for all physicians involved in the care of children with liver disease.
Book Synopsis Genetic Diagnosis of Endocrine Disorders by : Roy E. Weiss
Download or read book Genetic Diagnosis of Endocrine Disorders written by Roy E. Weiss and published by Academic Press. This book was released on 2010-06-03 with total page 343 pages. Available in PDF, EPUB and Kindle. Book excerpt: Since the beginning of the current century, endocrine disease diagnosis and treatment have moved beyond the standard hormone measurements. While, indeed elevated thyroid hormone levels or low insulin levels signal a specific endocrine disease, correct diagnosis (and therefore correct treatment) depends on an understanding of the molecular basis for the disease. This book presents the "bench to bedside" approach of our understanding of the genetic basis for endocrine disease. It is organized by endocrine grouping (e.g. Thyroid, Pancreas, Parathyroid, Pituitary, Adrenal, Reproductive and Bone) and genetic/molecular basis for the diagnosis of the various disorders will be discussed. Emphasis will be placed on the practical nature of diagnosing a disease. For example: 1. Which tests should be done for the diagnosis of Diabetes mellitus Type I in children who presented at less than 6 months; at less than 12 years, in adulthood, etc., and why should those tests be done?; 2. Which genes should be evaluated for subjects with congenital hypothyroidism; 3. Which genetic tests should be ordered in obesity?; 4. Which genetic test should be ordered in a patient with Parathyroid Carcinoma?; 5. What is the rationale behind testing for Multiple Endocrine Neoplasia? The field of genetic diagnosis of disease is exploding now, with multiple laboratories developing tests for current clinical use. Most practicing endocrinologists, pediatricians and internal medicine physicians don't understand which test to order, how the tests are done, or how to interpret the results. One of the most exciting development in medicine today is the pharmacogenomics revolution - enocrinologists and geneticists need to understand how personalized medicine will fit into the daily care of patients. While this is a quickly growing area and there are textbooks on pharmacogenomics, there is no one source for the spectrum of Endocrine diseases. Selected for inclusion in Doody's Core Titles 2013, an essential collection development tool for health sciences libraries Presents a comprehensive, translational look at all aspects of genetic diagnosis of endocrine disorders in one reference work Endocrinology experts (the researchers who discovered the majority of the gene mutations for a particular disease) teach readers about the molecular basis for diseases in each major endocrine organ system Clear presentation by geneticists of pharmacogenetics and the actual assays used in detecting endocrine diseases Genetic counselors offer expert advice on how to use genetic information in counseling patients
Book Synopsis Genetic Design Automation by : Hasan Baig
Download or read book Genetic Design Automation written by Hasan Baig and published by Springer Nature. This book was released on 2020-09-25 with total page 171 pages. Available in PDF, EPUB and Kindle. Book excerpt: This textbook introduces readers to the recent advances in the emerging field of genetic design automation (GDA). Starting with an introduction and the basic concepts of molecular biology, the authors provide an overview of various genetic design automation tools. The authors then present the DVASim tool (Dynamic Virtual Analyzer and Simulator) which is used for the analysis and verification of genetic logic circuits. This includes methods and algorithms for the timing and threshold value analyses of genetic logic circuits. Next, the book presents the GeneTech tool (A technology mapping tool for genetic circuits) and the methods developed for optimization, synthesis, and technology mapping of genetic circuits. Chapters are followed by exercises which give readers hands-on practice with the tools presented. The concepts and algorithms are thoroughly described, enabling readers to improve the tools or use them as a starting point to develop new tools. Both DVASim and GeneTech are available from the developer’s website, free of charge. This book is intended for a multidisciplinary audience of computer scientists, engineers and biologists. It provides enough background knowledge for computer scientists and engineers, who usually do not have any background in biology but are interested to get involved in this domain. This book not only presents an accessible basic introduction to molecular biology, it also includes software tools which allow users to perform laboratory experiments in a virtual in-silico environment. This helps newbies to get a quick start in understanding and developing genetic design automation tools. The third part of this book is particular useful for biologists who usually find it difficult to grasp programming and are reluctant to developing computer software. They are introduced to the graphical programming language, LabVIEW, from which they can start developing computer programs rapidly. Readers are further provided with small projects which will help them to start developing GDA tools.
Book Synopsis The Anatomy of an English Paragraph by : Mahmoud Elsayess
Download or read book The Anatomy of an English Paragraph written by Mahmoud Elsayess and published by AuthorHouse. This book was released on 2023-06-25 with total page 509 pages. Available in PDF, EPUB and Kindle. Book excerpt: The intent of my book is to assist writers of all ages and levels of expertise in improving their skills in discovering the attributes of successful paragraph construction with an in-depth understanding of the dynamics of writing award-winning essays. The most critical component of competitive success is the ability to translate an idea into a comprehensive written report. The MEALS (Main point, Evidence, Analysis, Logic, and synonym), an acronym, is a tool designed to act as a guide to promote ease and excellence in writing endeavors. During his graduate work, Dr. Elsayess developed a new tool with the acronym MEALS. The MEALS method could assist while creating written works to earn a degree. In addition, using this method could allow students to move ahead with a good competency level for writing. Dr. Elsayess utilized the MEALS tool for assessing his students and developing his book. Not only did Lovitts (2007) report a high rate of unacceptable dissertations would lead to university dropout, but also, Lovitts (2007) reported that the Council of Graduate Schools indicated that “a 50% student dropout rate, writing the dissertation reported as the major stumbling block.” Reference: Lovitts, B. E. (2007). Making the implicit explicit: Creating performance expectations for the dissertation. Stylus Publishing, LLC
Book Synopsis Logic Synthesis and Verification by : Soha Hassoun
Download or read book Logic Synthesis and Verification written by Soha Hassoun and published by Springer Science & Business Media. This book was released on 2001-11-30 with total page 474 pages. Available in PDF, EPUB and Kindle. Book excerpt: Research and development of logic synthesis and verification have matured considerably over the past two decades. Many commercial products are available, and they have been critical in harnessing advances in fabrication technology to produce today's plethora of electronic components. While this maturity is assuring, the advances in fabrication continue to seemingly present unwieldy challenges. Logic Synthesis and Verification provides a state-of-the-art view of logic synthesis and verification. It consists of fifteen chapters, each focusing on a distinct aspect. Each chapter presents key developments, outlines future challenges, and lists essential references. Two unique features of this book are technical strength and comprehensiveness. The book chapters are written by twenty-eight recognized leaders in the field and reviewed by equally qualified experts. The topics collectively span the field. Logic Synthesis and Verification fills a current gap in the existing CAD literature. Each chapter contains essential information to study a topic at a great depth, and to understand further developments in the field. The book is intended for seniors, graduate students, researchers, and developers of related Computer-Aided Design (CAD) tools. From the foreword: "The commercial success of logic synthesis and verification is due in large part to the ideas of many of the authors of this book. Their innovative work contributed to design automation tools that permanently changed the course of electronic design." by Aart J. de Geus, Chairman and CEO, Synopsys, Inc.
Book Synopsis Disorders of Hemoglobin by : Martin H. Steinberg
Download or read book Disorders of Hemoglobin written by Martin H. Steinberg and published by Cambridge University Press. This book was released on 2001 with total page 1254 pages. Available in PDF, EPUB and Kindle. Book excerpt: Disorders of Hemoglobin stands tall as the definitive work on the genetics, pathophysiology, and clinical management of hemoglobinopathies and thalassemia. Drs. Steinberg, Forget, Higgs, and Nagel have gathered the world authorities on the science and clinical management of these disorders and created the authoritative textbook for researchers and clinicians alike.Authors describe the scientific basis of clinical features and provide clinicians with a clear background of disorders they treat and scientists with an essential link between their research and its clinical manifestation. Disorders of Hemoglobin is the only single-source reference on hemoglobinopathies for hematologists, pediatricians, clinical investigators, and geneticists worldwide.
