Lipid Signaling In Human Diseases

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Lipid Signaling in Human Diseases

Author : Julian Gomez-Cambronero
Publisher : Springer Nature
ISBN 13 : 3030336689
Total Pages : 338 pages
Book Rating : 4.0/5 (33 download)

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Book Synopsis Lipid Signaling in Human Diseases by : Julian Gomez-Cambronero

Download or read book Lipid Signaling in Human Diseases written by Julian Gomez-Cambronero and published by Springer Nature. This book was released on 2020-04-24 with total page 338 pages. Available in PDF, EPUB and Kindle. Book excerpt: Lipids are an integral part of cell membrane architecture, are intermediaries in cell metabolism, and are involved in transmitting cell signals from hormones, growth factors and nutrients. A number of lipases and phospholipases, lipid kinases, lipid phosphatases, sphingosine kinases, and their reaction products have been implicated in fundamental cellular processes including cell proliferation, division and migration. These enzymes and their products underlie the molecular mechanisms of numerous human diseases, in particular metabolic disease (diabetes), cancer, neurodegenerative disease and cardiovascular disease. Over the last decade, studies have advanced to the point that a number of inhibitors for these enzymes have been developed to attempt to ameliorate these conditions; some of the inhibitors are currently in human clinical trial. The need for this book is to review the current status of this field and the prospect for the inhibitors to be clinically important.

Lipid Signaling in Human Diseases

Author :
Publisher :
ISBN 13 : 9783030336691
Total Pages : pages
Book Rating : 4.3/5 (366 download)

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Book Synopsis Lipid Signaling in Human Diseases by :

Download or read book Lipid Signaling in Human Diseases written by and published by . This book was released on 2020 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Lipids are an integral part of cell membrane architecture, are intermediaries in cell metabolism, and are involved in transmitting cell signals from hormones, growth factors and nutrients. A number of lipases and phospholipases, lipid kinases, lipid phosphatases, sphingosine kinases, and their reaction products have been implicated in fundamental cellular processes including cell proliferation, division and migration. These enzymes and their products underlie the molecular mechanisms of numerous human diseases, in particular metabolic disease (diabetes), cancer, neurodegenerative disease and cardiovascular disease. Over the last decade, studies have advanced to the point that a number of inhibitors for these enzymes have been developed to attempt to ameliorate these conditions; some of the inhibitors are currently in human clinical trial. The need for this book is to review the current status of this field and the prospect for the inhibitors to be clinically important. .

Lipid Signaling and Metabolism

Author : James M. Ntambi
Publisher : Academic Press
ISBN 13 : 0128194057
Total Pages : 566 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis Lipid Signaling and Metabolism by : James M. Ntambi

Download or read book Lipid Signaling and Metabolism written by James M. Ntambi and published by Academic Press. This book was released on 2020-08-09 with total page 566 pages. Available in PDF, EPUB and Kindle. Book excerpt: Lipid Signaling and Metabolism provides foundational knowledge and methods to examine lipid metabolism and bioactive lipid signaling mediators that regulate a broad spectrum of biological processes and disease states. Here, world-renowned investigators offer a basic examination of general lipid, metabolism, intracellular lipid storage and utilization that is followed by an in-depth discussion of lipid signaling and metabolism across disease areas, including obesity, diabetes, fatty liver disease, inflammation, cancer, cardiovascular disease and mood-related disorders. Throughout, authors demonstrate how expanding our understanding of lipid mediators in metabolism and signaling enables opportunities for novel therapeutics. Emphasis is placed on bioactive lipid metabolism and research that has been impacted by new technologies and their new potential to transform precision medicine. Provides a clear, up-to-date understanding of lipid signaling and metabolism and the impact of recent technologies critical to advancing new studies Empowers researchers to examine bioactive lipid signaling and metabolism, supporting translation to clinical care and precision medicine Discusses the role of lipid signaling and metabolism in obesity, diabetes, fatty liver disease, inflammation, cancer, cardiovascular disease and mood-related disorders, among others

Caveolae and Lipid Rafts: Roles in Signal Transduction and the Pathogenesis of Human Disease

Author : Edward Bittar
Publisher : Elsevier
ISBN 13 : 9780080458601
Total Pages : 264 pages
Book Rating : 4.4/5 (586 download)

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Book Synopsis Caveolae and Lipid Rafts: Roles in Signal Transduction and the Pathogenesis of Human Disease by : Edward Bittar

Download or read book Caveolae and Lipid Rafts: Roles in Signal Transduction and the Pathogenesis of Human Disease written by Edward Bittar and published by Elsevier. This book was released on 2005-10-07 with total page 264 pages. Available in PDF, EPUB and Kindle. Book excerpt: Caveolae (latin for little caves) are small structures found at the surface of cells. They are responsible for the regulation of important metabolic pathway. As a consequence, they may play a critical role in several human diseases such as atherosclerosis, cancer, diabetes, and muscular dystrophies. This book analyzes the role and function of caveolae in these aspects and serves as the first textbook currently available on caveolae/caveolin.

Bioactive Lipids in Health and Disease

Author : Andres Trostchansky
Publisher : Springer
ISBN 13 : 3030114880
Total Pages : 198 pages
Book Rating : 4.0/5 (31 download)

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Book Synopsis Bioactive Lipids in Health and Disease by : Andres Trostchansky

Download or read book Bioactive Lipids in Health and Disease written by Andres Trostchansky and published by Springer. This book was released on 2019-05-28 with total page 198 pages. Available in PDF, EPUB and Kindle. Book excerpt: The purpose of this book is to introduce the readers on the perspective of the role that unsaturated fatty acids and complex lipids play on health and disease. Bioactive lipids can be modified affecting membrane composition, structure and fluidity in addition to changes in cell signaling associated to lipid-protein (membrane receptors) interactions, issues that are addressed by the authors. This book analyzes key topics involving bioactive lipids and their role in normal signaling and the mechanisms of disease. The book navigates from structural studies of oxidized and non-oxidized lipids to the reactions and cell signaling processes that bioactive lipids play in cardiovascular and neurodegenerative diseases. The book contains the recent advances reported in the literature about lipidomics as well as the role that lipid-derived compounds exert on unfolded protein response and lipid metabolism and disease. This book represents a state of the art introduction to lipid metabolism from a biochemical to an in vivo overview being an useful tool for students and investigators. We hope the mechanistic observations on the role of bioactive lipids in health and disease serve a perspective to improve the existing treatments or propose new lipid-based pharmacology

Lipid Metabolism and human diseases

Author : Da-wei Zhang
Publisher : Frontiers Media SA
ISBN 13 : 2832536247
Total Pages : 151 pages
Book Rating : 4.8/5 (325 download)

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Book Synopsis Lipid Metabolism and human diseases by : Da-wei Zhang

Download or read book Lipid Metabolism and human diseases written by Da-wei Zhang and published by Frontiers Media SA. This book was released on 2023-09-28 with total page 151 pages. Available in PDF, EPUB and Kindle. Book excerpt: Lipids such as cholesterol, phospholipids, triglycerides, and free fatty acids, play various essential physiological roles. Dysregulation of lipid metabolism causes dyslipidemia, which is a critical factor in the development of various human diseases, such as cardiovascular disease, diabetes, non-alcoholic fatty liver disease, Alzheimer's disease, and Niemann-Pick disease. Therefore, lipid homeostasis in humans is strictly regulated by a well-balanced mechanism of intestinal uptake, endogenous synthesis and metabolism, and transport in lipoprotein particles and excretion. The human body evolves multiple mechanisms to maintain lipid homeostasis, such as low-density lipoprotein receptor mediates clearance of circulating low-density lipoprotein cholesterol; phospholipid transfer protein mediates the transfer of phospholipids from apoB-containing triglyceride-rich lipoprotein to high-density lipoprotein, etc.

Membrane Lipid Signaling in Aging and Age-Related Disease

Author : M.P. Mattson
Publisher : Elsevier
ISBN 13 : 9780080522500
Total Pages : 236 pages
Book Rating : 4.5/5 (225 download)

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Book Synopsis Membrane Lipid Signaling in Aging and Age-Related Disease by : M.P. Mattson

Download or read book Membrane Lipid Signaling in Aging and Age-Related Disease written by M.P. Mattson and published by Elsevier. This book was released on 2003-05-06 with total page 236 pages. Available in PDF, EPUB and Kindle. Book excerpt: The lipids of cellular membranes not only serve roles in controlling the structure and fluidity of the membrane, but are increasingly recognized for their roles as signalling molecules and modifiers of membrane protein function. Recent studies described in this volume reveal striking changes in membrane lipids during aging and in age-related diseases such as cancer, cardiovascular disease and neurodegenerative disorders. Lipids including inositol phospholipids, cholesterol, sphingolipids and ceramides play important roles in signalling cellular responses to stress and specific stimuli such as growth factors, cytokines and neurotransmitters. One or more of these lipid mediators has been linked to the pathogenesis of age-related diseases. This book provides a comprehensive review of specific membrane lipid mediators and their roles in aging and age-related disease.

Lipid-mediated Protein Signaling

Author : Daniel G.S. Capelluto
Publisher : Springer Science & Business Media
ISBN 13 : 940076331X
Total Pages : 219 pages
Book Rating : 4.4/5 (7 download)

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Book Synopsis Lipid-mediated Protein Signaling by : Daniel G.S. Capelluto

Download or read book Lipid-mediated Protein Signaling written by Daniel G.S. Capelluto and published by Springer Science & Business Media. This book was released on 2013-06-17 with total page 219 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides the most updated information of how membrane lipids mediate protein signaling from studies carried out in animal and plant cells. Also, there are some chapters that go beyond and expand these studies of protein-lipid interactions at the structural level. The book begins with a literature review from investigations associated to sphingolipids, followed by studies that describe the role of phosphoinositides in signaling and closing with the function of other key lipids in signaling at the plasma membrane and intracellular organelles.

Lipid Signalling

Author : Marco Brotto
Publisher : Humana
ISBN 13 : 9781071639016
Total Pages : 0 pages
Book Rating : 4.6/5 (39 download)

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Book Synopsis Lipid Signalling by : Marco Brotto

Download or read book Lipid Signalling written by Marco Brotto and published by Humana. This book was released on 2024-08-24 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume covers the latest advancements in the study of lipid signaling. The chapters in this book cover topics such as neuronal cells such as retinal ganglion cells, microglial cells to muscle, and epithelial cells; extraction for signaling studies, including clinical studies in humans; and discussions on different cells, tissues, and diseases like Alzheimer’s disease, musculoskeletal diseases, eye diseases, and metabolic diseases. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and comprehensive, Lipid Signaling: Methods and Protocols is a valuable resource for researchers looking to expand their knowledge of this important and developing field.

Emerging Role of Lipids in Metabolism and Disease

Author : Marco Segatto
Publisher : MDPI
ISBN 13 : 3039437011
Total Pages : 308 pages
Book Rating : 4.0/5 (394 download)

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Book Synopsis Emerging Role of Lipids in Metabolism and Disease by : Marco Segatto

Download or read book Emerging Role of Lipids in Metabolism and Disease written by Marco Segatto and published by MDPI. This book was released on 2021-04-01 with total page 308 pages. Available in PDF, EPUB and Kindle. Book excerpt: Even though initially considered as a passive means for storing energy, lipids are now regarded as multifaceted molecules with crucial structural and functional activities. For instance, some of them play essential roles as key components of cell membranes whereas others act as signaling molecules in the regulation of cell homeostasis. In recent years, lipid research has attracted increasing interest because of the involvement of this class of compounds in human health. Indeed, a plethora of pathological conditions are characterized by alterations in lipid metabolism, such as cardiovascular diseases and brain disorders. This Special Issue is a collection of papers from different experts in lipid research, with the aim of providing new insights into the physiopathological involvement of lipids and their impact on human health. This collection also demonstrates the usefulness of interdisciplinary approaches in the development of novel methods to study and manipulate lipid metabolism, which may represent an attractive target for designing effective therapeutic strategies to counteract numerous pathologies.

Membrane Microdomain Signaling

Author : Mark P. Mattson
Publisher : Humana Press
ISBN 13 : 9781617375156
Total Pages : 0 pages
Book Rating : 4.3/5 (751 download)

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Book Synopsis Membrane Microdomain Signaling by : Mark P. Mattson

Download or read book Membrane Microdomain Signaling written by Mark P. Mattson and published by Humana Press. This book was released on 2010-11-05 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cutting-edge articles review our current understanding of lipid microdomain signaling mechanisms and their physiological and pathological importance. The book describes the role of lipid rafts in learning, memory, and cancer, presents the emerging evidence that lipid rafts play critical roles in signaling pathways and the regulation of synaptic function in the nervous system, and shows how alterations in lipid raft metabolism are implicated in the pathogenesis of neurodegenerative disorders. Techniques are also described for the isolation of lipid rafts, the analysis of the lipid and protein components of lipid rafts, the imaging of lipid rafts in living cells, and the analysis of signal transduction in lipid rafts.

Accenting Lipid Peroxidation

Author : Pınar Atukeren
Publisher : BoD – Books on Demand
ISBN 13 : 1839688254
Total Pages : 160 pages
Book Rating : 4.8/5 (396 download)

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Book Synopsis Accenting Lipid Peroxidation by : Pınar Atukeren

Download or read book Accenting Lipid Peroxidation written by Pınar Atukeren and published by BoD – Books on Demand. This book was released on 2021-12-08 with total page 160 pages. Available in PDF, EPUB and Kindle. Book excerpt: Lipid peroxidation can occur via either enzymatic or nonenzymatic reactions due to excess production of free radical molecules. This process culminates in cellular damage causing various diseases. This book examines lipid peroxidation as a current and future biomarker of oxidative stress.

Diet and Health

Author : National Research Council
Publisher : National Academies Press
ISBN 13 : 0309039940
Total Pages : 765 pages
Book Rating : 4.3/5 (9 download)

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Book Synopsis Diet and Health by : National Research Council

Download or read book Diet and Health written by National Research Council and published by National Academies Press. This book was released on 1989-01-01 with total page 765 pages. Available in PDF, EPUB and Kindle. Book excerpt: Diet and Health examines the many complex issues concerning diet and its role in increasing or decreasing the risk of chronic disease. It proposes dietary recommendations for reducing the risk of the major diseases and causes of death today: atherosclerotic cardiovascular diseases (including heart attack and stroke), cancer, high blood pressure, obesity, osteoporosis, diabetes mellitus, liver disease, and dental caries.

Comprehensive Guide to Autism

Author : Vinood B. Patel
Publisher : Springer
ISBN 13 : 9781461447870
Total Pages : 0 pages
Book Rating : 4.4/5 (478 download)

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Book Synopsis Comprehensive Guide to Autism by : Vinood B. Patel

Download or read book Comprehensive Guide to Autism written by Vinood B. Patel and published by Springer. This book was released on 2013-10-15 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Autism is a complex multifaceted disorder affecting neurodevelopment during the early years of life and, for many, throughout the life span. Inherent features include difficulties or deficits in communication, social interaction, cognition, and interpersonal behavioral coordination, to name just a few. Autism profoundly impacts the affected individual, the family, and, in many cases, the localized communities. The increased prevalence of childhood autism has resulted in rapid developments in a wide range of disciplines in recent years. Nevertheless, despite intensive research, the cause(s) remain unresolved and no single treatment strategy is employed. To address these issues, Comprehensive Guide to Autism is an all-embracing reference that offers analyses and discussions of contemporary issues in the field of autism. The work brings together scientific material from leading experts in the field relating to a wide range of important current topics, such as the early identification and treatment of children with autism, pertinent social and behavioral studies, recent developments in genetics and immunology, the influence of diet, models of autism, and future treatment prospects. Comprehensive Guide to Autism contains essential readings for behavioral science researchers, psychologists, physicians, social workers, parents, and caregivers.

Gene Regulation, Epigenetics and Hormone Signaling

Author : Subhrangsu S. Mandal
Publisher : John Wiley & Sons
ISBN 13 : 3527322817
Total Pages : 678 pages
Book Rating : 4.5/5 (273 download)

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Book Synopsis Gene Regulation, Epigenetics and Hormone Signaling by : Subhrangsu S. Mandal

Download or read book Gene Regulation, Epigenetics and Hormone Signaling written by Subhrangsu S. Mandal and published by John Wiley & Sons. This book was released on 2017-10-23 with total page 678 pages. Available in PDF, EPUB and Kindle. Book excerpt: The first of its kind, this reference gives a comprehensive but concise introduction to epigenetics before covering the many interactions between hormone regulation and epigenetics at all levels. The contents are very well structured with no overlaps between chapters, and each one features supplementary material for use in presentations. Throughout, major emphasis is placed on pathological conditions, aiming at the many physiologists and developmental biologists who are familiar with the importance and mechanisms of hormone regulation but have a limited background in epigenetics.

The Heterogeneity of Cancer Metabolism

Author : Anne Le
Publisher : Springer
ISBN 13 : 331977736X
Total Pages : 186 pages
Book Rating : 4.3/5 (197 download)

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Book Synopsis The Heterogeneity of Cancer Metabolism by : Anne Le

Download or read book The Heterogeneity of Cancer Metabolism written by Anne Le and published by Springer. This book was released on 2018-06-26 with total page 186 pages. Available in PDF, EPUB and Kindle. Book excerpt: Genetic alterations in cancer, in addition to being the fundamental drivers of tumorigenesis, can give rise to a variety of metabolic adaptations that allow cancer cells to survive and proliferate in diverse tumor microenvironments. This metabolic flexibility is different from normal cellular metabolic processes and leads to heterogeneity in cancer metabolism within the same cancer type or even within the same tumor. In this book, we delve into the complexity and diversity of cancer metabolism, and highlight how understanding the heterogeneity of cancer metabolism is fundamental to the development of effective metabolism-based therapeutic strategies. Deciphering how cancer cells utilize various nutrient resources will enable clinicians and researchers to pair specific chemotherapeutic agents with patients who are most likely to respond with positive outcomes, allowing for more cost-effective and personalized cancer therapeutic strategies.

Inherited Metabolic Disease in Adults

Author : Carla E. M. Hollak
Publisher : Oxford University Press
ISBN 13 : 0199972133
Total Pages : 657 pages
Book Rating : 4.1/5 (999 download)

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Book Synopsis Inherited Metabolic Disease in Adults by : Carla E. M. Hollak

Download or read book Inherited Metabolic Disease in Adults written by Carla E. M. Hollak and published by Oxford University Press. This book was released on 2016 with total page 657 pages. Available in PDF, EPUB and Kindle. Book excerpt: As clinical management of inherited metabolic diseases (IMDs) has improved, more patients affected by these conditions are surviving into adulthood. This trend, coupled with the widespread recognition that IMDs can present differently and for the first time during adulthood, makes the need for a working knowledge of these diseases more important than ever. Inherited Metabolic Disease in Adults offers an authoritative clinical guide to the adult manifestations of these challenging and myriad conditions. These include both the classic pediatric-onset conditions and a number of new diseases that can manifest at any age. It is the first book to give a clear and concise overview of how this group of conditions affects adult patients, a that topic will become a growing imperative for physicians across primary and specialized care.