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Lead Seeking Approaches
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Book Synopsis Lead-Seeking Approaches by : Matthew M. Hayward
Download or read book Lead-Seeking Approaches written by Matthew M. Hayward and published by Springer Science & Business Media. This book was released on 2010-03-12 with total page 224 pages. Available in PDF, EPUB and Kindle. Book excerpt: High quality leads provide the foundation for the discovery of successful clinical development candidates, and therefore the identi?cation of leads is an essential part of drug discovery. The process for the identi?cation of leads generally starts with the screening of a compound collection, either an HTS of a relatively large compound collection (hundreds of thousands to one million plus compounds) or a more focused screen of a smaller set of compounds that have been preselected for the target of interest. Virtual screening methods such as structure-based or pharmacophore-based searches can complement or replace one of the above approaches. Once hits are identi?ed from one or more of these screening methods, they need to be thoroughly characterized in order to con?rm activity and identify areas in need of optimization. Finally, once fully characterized hits are identi?ed, preliminary optimization through synthetic modi?cation is carried out to generate leads. Parallel optimization of all properties, including biological, physicochemical, and ADME is the most ef?cient approach to the identi?cation of leads. Hit characterization is described in the previous chapter. The focus of this chapter is on hit optimization and the identi?- tion of leads. After a general overview of these processes, examples taken from the literature since 2001 will be used to illustrate speci?c points. There are also a number of excellent reviews covering the lead identi?cation process [1–6].
Author :National Academies of Sciences, Engineering, and Medicine Publisher :National Academies Press ISBN 13 :0309439124 Total Pages :171 pages Book Rating :4.3/5 (94 download)
Book Synopsis Ending Discrimination Against People with Mental and Substance Use Disorders by : National Academies of Sciences, Engineering, and Medicine
Download or read book Ending Discrimination Against People with Mental and Substance Use Disorders written by National Academies of Sciences, Engineering, and Medicine and published by National Academies Press. This book was released on 2016-09-03 with total page 171 pages. Available in PDF, EPUB and Kindle. Book excerpt: Estimates indicate that as many as 1 in 4 Americans will experience a mental health problem or will misuse alcohol or drugs in their lifetimes. These disorders are among the most highly stigmatized health conditions in the United States, and they remain barriers to full participation in society in areas as basic as education, housing, and employment. Improving the lives of people with mental health and substance abuse disorders has been a priority in the United States for more than 50 years. The Community Mental Health Act of 1963 is considered a major turning point in America's efforts to improve behavioral healthcare. It ushered in an era of optimism and hope and laid the groundwork for the consumer movement and new models of recovery. The consumer movement gave voice to people with mental and substance use disorders and brought their perspectives and experience into national discussions about mental health. However over the same 50-year period, positive change in American public attitudes and beliefs about mental and substance use disorders has lagged behind these advances. Stigma is a complex social phenomenon based on a relationship between an attribute and a stereotype that assigns undesirable labels, qualities, and behaviors to a person with that attribute. Labeled individuals are then socially devalued, which leads to inequality and discrimination. This report contributes to national efforts to understand and change attitudes, beliefs and behaviors that can lead to stigma and discrimination. Changing stigma in a lasting way will require coordinated efforts, which are based on the best possible evidence, supported at the national level with multiyear funding, and planned and implemented by an effective coalition of representative stakeholders. Ending Discrimination Against People with Mental and Substance Use Disorders: The Evidence for Stigma Change explores stigma and discrimination faced by individuals with mental or substance use disorders and recommends effective strategies for reducing stigma and encouraging people to seek treatment and other supportive services. It offers a set of conclusions and recommendations about successful stigma change strategies and the research needed to inform and evaluate these efforts in the United States.
Book Synopsis Everyone Deserves a Great Manager by : Scott Jeffrey Miller
Download or read book Everyone Deserves a Great Manager written by Scott Jeffrey Miller and published by Simon & Schuster. This book was released on 2019-10-08 with total page 208 pages. Available in PDF, EPUB and Kindle. Book excerpt: ***A WALL STREET JOURNAL BESTSELLER*** From the organizational experts at FranklinCovey, an essential guide to becoming the great manager every team deserves. A practical must-read, FranklinCovey’s Everyone Deserves a Great Manager is the essential guide for the millions of people all over the world making the challenging and rewarding leap to manager. Based on nearly a decade of research on what makes managers successful—and includes new ways of thinking, tips and techniques—this volume has been field-tested with hundreds of thousands of managers all over the world. Organized under four main roles every manager is expected to fill, Everyone Deserves a Great Manager focuses on how to lead yourself, people, teams, and change. Readers can start anywhere and go everywhere with this guide—depending on their current problem or time constraint. They can pick up a helpful tip in ten minutes or glean an entire skillset with deeper reading. The goal is for the busy manager to know what to do and how to do it without interrupting their regular workflow. Each role highlights the current, authentic problems managers face and briefly explores the limiting mindsets or common mistakes that led to those problems. With skill-based chapters that cover managerial skills like one-on-ones, giving feedback, delegating, hiring, building team culture, and leading remote teams, the book also includes more than thirty unique tools, such as a prep worksheets and a list of behavioral questions for your next interview. An approachable, engaging style using real-world stories, Everyone Deserves a Great Manager provides the blueprint for becoming the great manager every team deserves.
Author :Office of the Surgeon General Publisher :Createspace Independent Publishing Platform ISBN 13 :9781974580620 Total Pages :420 pages Book Rating :4.5/5 (86 download)
Book Synopsis Facing Addiction in America by : Office of the Surgeon General
Download or read book Facing Addiction in America written by Office of the Surgeon General and published by Createspace Independent Publishing Platform. This book was released on 2017-08-15 with total page 420 pages. Available in PDF, EPUB and Kindle. Book excerpt: All across the United States, individuals, families, communities, and health care systems are struggling to cope with substance use, misuse, and substance use disorders. Substance misuse and substance use disorders have devastating effects, disrupt the future plans of too many young people, and all too often, end lives prematurely and tragically. Substance misuse is a major public health challenge and a priority for our nation to address. The effects of substance use are cumulative and costly for our society, placing burdens on workplaces, the health care system, families, states, and communities. The Report discusses opportunities to bring substance use disorder treatment and mainstream health care systems into alignment so that they can address a person's overall health, rather than a substance misuse or a physical health condition alone or in isolation. It also provides suggestions and recommendations for action that everyone-individuals, families, community leaders, law enforcement, health care professionals, policymakers, and researchers-can take to prevent substance misuse and reduce its consequences.
Author :National Academies of Sciences, Engineering, and Medicine Publisher :National Academies Press ISBN 13 :0309459575 Total Pages :483 pages Book Rating :4.3/5 (94 download)
Book Synopsis Pain Management and the Opioid Epidemic by : National Academies of Sciences, Engineering, and Medicine
Download or read book Pain Management and the Opioid Epidemic written by National Academies of Sciences, Engineering, and Medicine and published by National Academies Press. This book was released on 2017-09-28 with total page 483 pages. Available in PDF, EPUB and Kindle. Book excerpt: Drug overdose, driven largely by overdose related to the use of opioids, is now the leading cause of unintentional injury death in the United States. The ongoing opioid crisis lies at the intersection of two public health challenges: reducing the burden of suffering from pain and containing the rising toll of the harms that can arise from the use of opioid medications. Chronic pain and opioid use disorder both represent complex human conditions affecting millions of Americans and causing untold disability and loss of function. In the context of the growing opioid problem, the U.S. Food and Drug Administration (FDA) launched an Opioids Action Plan in early 2016. As part of this plan, the FDA asked the National Academies of Sciences, Engineering, and Medicine to convene a committee to update the state of the science on pain research, care, and education and to identify actions the FDA and others can take to respond to the opioid epidemic, with a particular focus on informing FDA's development of a formal method for incorporating individual and societal considerations into its risk-benefit framework for opioid approval and monitoring.
Book Synopsis Exploring Welfare Bricolage in Europe’s Superdiverse Neighbourhoods by : Jenny Phillimore
Download or read book Exploring Welfare Bricolage in Europe’s Superdiverse Neighbourhoods written by Jenny Phillimore and published by Routledge. This book was released on 2021-05-24 with total page 174 pages. Available in PDF, EPUB and Kindle. Book excerpt: Migration-driven diversity means European cities are becoming increasingly superdiverse. Some European neighbourhoods have become places where newcomers arrive from across the world, speaking many different languages, from a range of socio-economic backgrounds and with diverse religious beliefs and practices, while living alongside long-established migrant and white European populations. This book focuses on what this increasing population diversity means for how people and local health and welfare service providers seek to address everyday health concerns – from minor and chronic conditions to acute and urgent problems. Using an innovative mixed-method approach crossing multiple disciplines and drawing together rich qualitative and robust quantitative data, this book offers unique insight into the complex and intricate actions, which often vary over space and time, implemented by both residents and care providers from eight superdiverse localities in four European countries, each with different health and welfare traditions. The book introduces the concept of welfare bricolage, using it as a mechanism to explore the structures and rationales underpinning need and actions, and how resources are connected across welfare regimes and borders and within locales. The book illustrates how, in the face of increasingly marketised, cash-strapped, restrictive and institutionally racist welfare states and healthcare regimes, individuals and service providers strive to address need. By focusing on welfare regimes, migration histories, everyday actions and resources within neighbourhoods, Exploring Welfare Bricolage in Europe’s Superdiverse Neighbourhoods offers a unique insight into what people and providers actually do when faced with health concerns. The book highlights the role of structure and agency and moves beyond conventional approaches that focus on specific groups or sectors to research health and welfare by looking at whole populations and entire welfare ecosystems. The book’s theoretical, methodological and empirical contributions will be of use to scholars, practitioners and policymakers interested in welfare, healthcare, diversity and migration.
Download or read book Sacred Matters written by Wesley R. Burr and published by Routledge. This book was released on 2011 with total page 340 pages. Available in PDF, EPUB and Kindle. Book excerpt: First Published in 2012. Routledge is an imprint of Taylor & Francis, an informa company.
Book Synopsis Handbook of Motivation Science by : James Y. Shah
Download or read book Handbook of Motivation Science written by James Y. Shah and published by Guilford Publications. This book was released on 2013-12-09 with total page 658 pages. Available in PDF, EPUB and Kindle. Book excerpt: Integrating significant advances in motivation science that have occurred over the last two decades, this volume thoroughly examines the ways in which motivation interacts with social, developmental, and emotional processes, as well as personality more generally. The Handbook comprises 39 clearly written chapters from leaders in the field. Cutting-edge theory and research is presented on core psychological motives, such as the need for esteem, security, consistency, and achievement; motivational systems that arise to address these fundamental needs; the process and consequences of goal pursuit, including the role of individual differences and contextual moderators; and implications for personal well-being and interpersonal and intergroup relations.
Download or read book NASA Technical Memorandum written by and published by . This book was released on 1991 with total page 84 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Integrated Performance Management by : Kurt Verweire
Download or read book Integrated Performance Management written by Kurt Verweire and published by SAGE. This book was released on 2004-12-23 with total page 356 pages. Available in PDF, EPUB and Kindle. Book excerpt: Linking various disciplines and management functions, Integrated Performance Management provides the reader with a concrete framework to manage organizations successfully. The authors do not isolate a single strategy to manage performance. Instead, the book focuses on a range of strategies providing the reader with an introduction to each one. The concepts under analysis were developed through intense dialogue with business managers. While maintaining academic rigour, Integrated Performance Management presents ideas that students will find relevant outside of the classroom. Postgraduate and MBA students in a range of areas including strategy, accounting, finance, operations management, marketing, leadership and human resource management will find this book useful.
Book Synopsis Graduating with Honor by : Thomas G. Plante Ph.D.
Download or read book Graduating with Honor written by Thomas G. Plante Ph.D. and published by Bloomsbury Publishing USA. This book was released on 2016-11-21 with total page 278 pages. Available in PDF, EPUB and Kindle. Book excerpt: A comprehensive summary of best practices in ethics development on campus, providing a variety of practical ways to promote formation of ethics and character among college students and young adults. We are all called upon to make ethical decisions every day—ones regarding being honest with others, not cheating in order to save effort or get ahead, or avoiding involvement in situations that will result in injury to ourselves or others—in short, choosing whether or not to do the "right thing" in all types of situations. On every relational level and throughout an unlimited range of everyday choices and actions, ethical issues come into play. This is especially true for students and young adults. Graduating with Honor: Best Practices to Promote Ethics Development in College Students offers best practices for ethical formation on campus, covering subjects such as how to create an organizational culture of ethics; ethical decision-making situations and circumstances on- and off-campus, curricular and extracurricular; specific developmental goals and challenges in the college setting; ethical principles for decision making; and how faith communities can serve the promotion of student ethics. The book also provides multiple resources and examples of successful efforts to mediate unethical behavior by colleges, supplies a theoretical foundation for ethical formation in college, and outlines what colleges, parents, and students themselves can do to nurture ethical development during the college years.
Book Synopsis Annual Report of the Tennessee Valley Authority by : Tennessee Valley Authority
Download or read book Annual Report of the Tennessee Valley Authority written by Tennessee Valley Authority and published by . This book was released on 1966 with total page 772 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Nursing Practice written by Ian Peate and published by John Wiley & Sons. This book was released on 2017-11-20 with total page 987 pages. Available in PDF, EPUB and Kindle. Book excerpt: The second edition of the successful and definitive nursing textbook, Nursing Practice is designed to support the student throughout the entire nursing degree. Structured around the latest Nursing and Midwifery Council Code of Conduct, it explores a range of clinical and professional issues that the student will need to know, in one complete and accessible volume. Thoroughly updated and with full-colour, high quality illustrations throughout, this new edition features an additional chapter on the principles of supporting families and carers in practice, advice on revalidation, as well as a number of learning features and activities to help consolidate learning. Nursing Practice provides invaluable information to enable not just student nurses, but also those who are qualified and members of the extended nursing family, to develop a deeper understanding of their patients’ needs and to ensure that they are practicing safely and effectively.
Book Synopsis Pregnancy and Mental Wellness: A Holistic Approach for Every Woman by : Dr.Samuel Shamaun
Download or read book Pregnancy and Mental Wellness: A Holistic Approach for Every Woman written by Dr.Samuel Shamaun and published by Samuel Shamaun . This book was released on 2024-04-19 with total page 37 pages. Available in PDF, EPUB and Kindle. Book excerpt: "Pregnancy and Mental Wellness: A Holistic Approach for Every Woman" offers a comprehensive exploration of the intricate relationship between pregnancy and mental well-being. Written with clarity and compassion, this book delves into the myriad emotional, psychological, and physical changes that accompany the journey of pregnancy. Drawing upon both traditional and contemporary perspectives, the authors provide invaluable insights into the holistic needs of expectant mothers. From addressing common concerns such as anxiety and mood swings to navigating the complexities of prenatal depression and stress, this book offers practical guidance and supportive strategies for maintaining optimal mental health throughout pregnancy. With a focus on empowerment and self-care, "Pregnancy and Mental Wellness" emphasizes the importance of holistic approaches, including mindfulness practices, nutrition, and supportive therapies. By integrating mind, body, and spirit, this book advocates for a holistic framework that honors the unique experiences and challenges of every woman during this transformative time. Whether you are an expectant mother, a healthcare professional, or a supportive loved one, "Pregnancy and Mental Wellness" serves as a vital resource for fostering a nurturing and emotionally resilient pregnancy journey. Through its blend of evidence-based insights and compassionate guidance, this book offers a beacon of hope and empowerment for women seeking to prioritize their mental well-being during pregnancy.
Book Synopsis A Critical Approach to Human Growth and Development by : Paula Nicolson
Download or read book A Critical Approach to Human Growth and Development written by Paula Nicolson and published by Bloomsbury Publishing. This book was released on 2014-04-25 with total page 304 pages. Available in PDF, EPUB and Kindle. Book excerpt: What does it mean to be human? This critical text from a well-respected author captures and interrogates the many models which have been developed to explore and explain human behaviour. Informed by sociological, psychological and biological perspectives, the book plots the key stages of the life course from childhood through to older age.
Book Synopsis A Cockpit-display Concept for Executing a Multiple Glide-slope Approach for Wake-vortex Avoidance by : Terence S. Abbott
Download or read book A Cockpit-display Concept for Executing a Multiple Glide-slope Approach for Wake-vortex Avoidance written by Terence S. Abbott and published by . This book was released on 1985 with total page 48 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Ethics in Health Administration: A Practical Approach for Decision Makers by : Eileen E. Morrison
Download or read book Ethics in Health Administration: A Practical Approach for Decision Makers written by Eileen E. Morrison and published by Jones & Bartlett Learning. This book was released on 2019-01-29 with total page 312 pages. Available in PDF, EPUB and Kindle. Book excerpt: Given the many advances in technology as well as the ongoing discussion of health care reform post-Affordable Care Act, today’s healthcare administrators require a strong foundation in practice-based ethics to confront the challenges of the current healthcare landscape. Ethics in Health Administration, Fourth Edition focuses on the application of ethics to the critical issues faced by today's healthcare administrators. After establishing a foundation in the theory and principles of ethics, the text encourages students to apply ethics to such areas change, regulation, technology and fiscal responsibility. Thoroughly updated, the Fourth Edition includes 12 new, contemporary case studies that encourage students to apply ethics. A new chapter on the Ethics in the Epoch of Change stresses major changes in healthcare, including the digital revolution, population health, ethics temptations and ethic resilience. Other chapters have been revised to include new cases, and more.
