Lactoferrin And Its Role In Wound Healing

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Lactoferrin and its Role in Wound Healing

Author : Yoshiharu Takayama
Publisher : Springer Science & Business Media
ISBN 13 : 9400724675
Total Pages : 118 pages
Book Rating : 4.4/5 (7 download)

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Book Synopsis Lactoferrin and its Role in Wound Healing by : Yoshiharu Takayama

Download or read book Lactoferrin and its Role in Wound Healing written by Yoshiharu Takayama and published by Springer Science & Business Media. This book was released on 2011-10-25 with total page 118 pages. Available in PDF, EPUB and Kindle. Book excerpt: Lactoferrin is an iron-binding glycoprotein belonging to the transferrin family. It acts as a defense in host animals against microbes and viruses, since it has a broad spectrum of antimicrobial and antiviral activities. Lactoferrin has been shown to regulate the growth and differentiation of many types of cells. The results of recent studies indicate that lactoferrin is a potent regulator of dermal fibroblasts, and promotes cutaneous wound healing. The collagen gel contraction, a model of wound contraction during wound healing process, and migration of human fibroblasts were enhanced by lactoferrin. LRP-1 (LDL Receptor related Protein-1) acts as a signaling receptor for lactoferrin that mediate fibroblast response to lactoferrin by activating ERK/MAPK signaling pathway. In addition, lactoferrin promotes biosynthesis of extracellular matrix (ECM) component such as type-I collagen and hyaluronan. Hyaluronan is a major component of ECM in connective tissue and promotes wound healing. The promoting effect of lactoferrin on hyaluronan production was accompanied by promotion of HAS2 (hyaluronan synthase 2) expression. These observations suggest that lactoferrin promotes the wound healing by providing an ECM that promotes fibroblast migration. Lactoferrin is also known for its anti-inflammatory and immune modulating properties. According to recent in vivo study, lactoferrin promotes wound repair by promoting the early inflammatory phase of wound healing. Based on this, recombinant human lactoferrin was subsequently tested clinically in a Phase II trial in patients with diabetic ulcers and was found to be effective. Lactoferrin should be further evaluated in patients with diabetic and other types of ulcers.

Peptidomics

Author : Mikhail Soloviev
Publisher : John Wiley & Sons
ISBN 13 : 0470196491
Total Pages : 432 pages
Book Rating : 4.4/5 (71 download)

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Book Synopsis Peptidomics by : Mikhail Soloviev

Download or read book Peptidomics written by Mikhail Soloviev and published by John Wiley & Sons. This book was released on 2007-12-21 with total page 432 pages. Available in PDF, EPUB and Kindle. Book excerpt: The definitive guide to peptidomics- a hands-on lab reference The first truly comprehensive book about peptidomics for protein and peptide analysis, this reference provides a detailed description of the hows and whys of peptidomics and how the techniques have evolved. With chapters contributed by leading experts, it covers naturally occurring peptides, peptidomics methods and new developments, and the peptidomics approach to biomarker discovery. Explaining both the principles and the applications, Peptidomics: Methods and Applications: * Features examples of applications in diverse fields, including pharmaceutical science, toxicity biomarkers, and neuroscience * Details the successful peptidomic analyses of biological material ranging from plants to mammals * Describes a cross section of analytical techniques, including traditional methodologies, emerging trends, and new techniques for high throughput approaches An enlightening reference for experienced professionals, this book is sufficiently detailed to serve as a step-by-step guide for beginning researchers and an excellent resource for students taking biotechnology and proteomics courses. It is an invaluable reference for protein chemists and biochemists, professionals and researchers in drug and biopharmaceutical development, analytical and bioanalytical chemists, toxicologists, and others.

Inflammation, 4 Volume Set

Author : Jean-Marc Cavaillon
Publisher : John Wiley & Sons
ISBN 13 : 3527338993
Total Pages : 1818 pages
Book Rating : 4.5/5 (273 download)

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Book Synopsis Inflammation, 4 Volume Set by : Jean-Marc Cavaillon

Download or read book Inflammation, 4 Volume Set written by Jean-Marc Cavaillon and published by John Wiley & Sons. This book was released on 2018-02-20 with total page 1818 pages. Available in PDF, EPUB and Kindle. Book excerpt: Dieses Fachbuch erläutert die molekularen Grundlagen von Entzündungen, spannt den Bogen zu Infektionskrankheiten und den Zusammenhang zwischen Entzündungen und chronischen Erkrankungen, behandelt abschließend den Heilungsprozess und zeigt Therapiemöglichkeiten.

Adenoviral Vectors for Gene Therapy

Author : David T. Curiel
Publisher : Academic Press
ISBN 13 : 0128005106
Total Pages : 870 pages
Book Rating : 4.1/5 (28 download)

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Book Synopsis Adenoviral Vectors for Gene Therapy by : David T. Curiel

Download or read book Adenoviral Vectors for Gene Therapy written by David T. Curiel and published by Academic Press. This book was released on 2016-03-10 with total page 870 pages. Available in PDF, EPUB and Kindle. Book excerpt: Adenoviral Vectors for Gene Therapy, Second Edition provides detailed, comprehensive coverage of the gene delivery vehicles that are based on the adenovirus that is emerging as an important tool in gene therapy. These exciting new therapeutic agents have great potential for the treatment of disease, making gene therapy a fast-growing field for research. This book presents topics ranging from the basic biology of adenoviruses, through the construction and purification of adenoviral vectors, cutting-edge vectorology, and the use of adenoviral vectors in preclinical animal models, with final consideration of the regulatory issues surrounding human clinical gene therapy trials. This broad scope of information provides a solid overview of the field, allowing the reader to gain a complete understanding of the development and use of adenoviral vectors. - Provides complete coverage of the basic biology of adenoviruses, as well as their construction, propagation, and purification of adenoviral vectors - Introduces common strategies for the development of adenoviral vectors, along with cutting-edge methods for their improvement - Demonstrates noninvasive imaging of adenovirus-mediated gene transfer - Discusses utility of adenoviral vectors in animal disease models - Considers Federal Drug Administration regulations for human clinical trials

Wound Healing

Author : Vlad Alexandrescu
Publisher : BoD – Books on Demand
ISBN 13 : 9535126784
Total Pages : 546 pages
Book Rating : 4.5/5 (351 download)

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Book Synopsis Wound Healing by : Vlad Alexandrescu

Download or read book Wound Healing written by Vlad Alexandrescu and published by BoD – Books on Demand. This book was released on 2016-10-12 with total page 546 pages. Available in PDF, EPUB and Kindle. Book excerpt: Outstanding scientific advances over the last decades unceasingly reveal real complexity of wound-healing process, astonishing in its staged progression, as life is unfolding itself. This natural course of tissue repair seems to bear thousands of overlapping molecular and macroscopic processes that nowadays only start to unfold to our knowledge. The present volume collecting recent scientific references proposes to readers a two-folded audacious goal. First, an updated design of intimate cellular mechanisms is entailed in tissue regeneration that emanates from the first section of the book. Next, a multidisciplinary therapeutic perspective that focuses on macroscopic healing throughout the second part of this work adds clinically integrated observation. Practical diagnostic and treatment information is appended in each chapter that may equally help experienced clinicians or dedicated students and researchers in broadening essential breaking points of their work. It is the wish of all multidisciplinary experts who gather prominent author's panel of this volume to incorporate latest medical reports and compel limits of current understanding for better tissue regeneration, limb salvage, and improved quality of life of our patients.

Cutaneous Wounds

Author : F. Joseph Dagher
Publisher : Blackwell/Futura
ISBN 13 :
Total Pages : 316 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Cutaneous Wounds by : F. Joseph Dagher

Download or read book Cutaneous Wounds written by F. Joseph Dagher and published by Blackwell/Futura. This book was released on 1985 with total page 316 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Microbial Biofilms

Author : Dharumadurai Dhanasekaran
Publisher : BoD – Books on Demand
ISBN 13 : 9535124358
Total Pages : 526 pages
Book Rating : 4.5/5 (351 download)

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Book Synopsis Microbial Biofilms by : Dharumadurai Dhanasekaran

Download or read book Microbial Biofilms written by Dharumadurai Dhanasekaran and published by BoD – Books on Demand. This book was released on 2016-07-13 with total page 526 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the book Microbial Biofilms: Importance and applications, eminent scientists provide an up-to-date review of the present and future trends on biofilm-related research. This book is divided with four subdivisions as biofilm fundamentals, applications, health aspects, and their control. Moreover, this book also provides a comprehensive account on microbial interactions in biofilms, pyocyanin, and extracellular DNA in facilitating Pseudomonas aeruginosa biofilm formation, atomic force microscopic studies of biofilms, and biofilms in beverage industry. The book comprises a total of 21 chapters from valued contributions from world leading experts in Australia, Bulgaria, Canada, China, Serbia, Germany, Italy, Japan, the United Kingdom, the Kingdom of Saudi Arabia, Republic of Korea, Mexico, Poland, Portugal, and Turkey. This book may be used as a text or reference for everyone interested in biofilms and their applications. It is also highly recommended for environmental microbiologists, soil scientists, medical microbiologists, bioremediation experts, and microbiologists working in biocorrosion, biofouling, biodegradation, water microbiology, quorum sensing, and many other related areas. Scientists in academia, research laboratories, and industry will also find it of interest.

Advanced Dairy Chemistry

Author : Paul L. H. McSweeney
Publisher : Springer
ISBN 13 : 9781493927999
Total Pages : 0 pages
Book Rating : 4.9/5 (279 download)

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Book Synopsis Advanced Dairy Chemistry by : Paul L. H. McSweeney

Download or read book Advanced Dairy Chemistry written by Paul L. H. McSweeney and published by Springer. This book was released on 2015-11-04 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: The chemistry and physico-chemical properties of milk proteins are perhaps the largest and most rapidly evolving major areas in dairy chemistry. Advanced Dairy Chemistry-1B: Proteins: Applied Aspects covers the applied, technologically-focused chemical aspects of dairy proteins, the most commercially valuable constituents of milk. This fourth edition contains most chapters in the third edition on applied aspects of dairy proteins. The original chapter on production and utilization of functional milk proteins has been split into two new chapters focusing on casein- and whey-based ingredients separately by new authors. The chapters on denaturation, aggregation and gelation of whey proteins (Chapter 6), heat stability of milk (Chapter 7) and protein stability in sterilised milk (Chapter 10) have been revised and expanded considerably by new authors and new chapters have been included on rehydration properties of dairy protein powders (Chapter 4) and sensory properties of dairy protein ingredients (Chapter 8). This authoritative work describes current knowledge on the applied and technologically-focused chemistry and physico-chemical aspects of milk proteins and will be very valuable to dairy scientists, chemists, technologists and others working in dairy research or in the dairy industry.

Microbiology of Wounds

Author : Steven Percival
Publisher : CRC Press
ISBN 13 : 1420079948
Total Pages : 410 pages
Book Rating : 4.4/5 (2 download)

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Book Synopsis Microbiology of Wounds by : Steven Percival

Download or read book Microbiology of Wounds written by Steven Percival and published by CRC Press. This book was released on 2010-04-26 with total page 410 pages. Available in PDF, EPUB and Kindle. Book excerpt: It is not the presence of microorganisms, but their interaction with patients that determines their influence on wound healing. Documenting this critical but often ignored aspect of the treatment process, Microbiology of Wounds discusses the microbiology and biology of human wounds in relation to infection and non-healing. Gain the Necessary Scient

Local Wound Care for Dermatologists

Author : Afsaneh Alavi
Publisher : Springer Nature
ISBN 13 : 3030288722
Total Pages : 211 pages
Book Rating : 4.0/5 (32 download)

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Book Synopsis Local Wound Care for Dermatologists by : Afsaneh Alavi

Download or read book Local Wound Care for Dermatologists written by Afsaneh Alavi and published by Springer Nature. This book was released on 2020-03-26 with total page 211 pages. Available in PDF, EPUB and Kindle. Book excerpt: Focusing on local wound care specifically for the dermatologist, this concise text provides a go-to source for practitioners looking for a quick solution for many of the most common wounds as well as an update on what's new in the field. From the most basic principles of local wound care to a look at what upcoming therapies like stem cells and lasers can do, this text is comprehensive and informed. Providing quality local wound care requires an ample knowledge of available products, their cost effectiveness, and the principles for the optimal interventions; Local Wound Care for Dermatologists includes these three guiding points in each chapter that focuses on a specific therapy. Expertly written text is accompanied by multiple tables of drug-specific names, current price points, and comparable products. Chapters include many color images, thereby providing insight to a given wound and the various therapies available to treat it. While the basics are reviewed in the opening chapters, later chapters feature updates in therapies including discussions on what's new in skin substitutes, negative pressure wound therapy, oxygen therapy, and an update in cell based therapy. Written with the dermatologist in mind, Local Wound Care for Dermatologists is an indispensable reference for students, residents, and practicing doctors alike. General practitioners and plastic surgeons will also find this title a useful refresher.

The Importance Of Iron In Pathophysiologic Conditions

Author : Raffaella Gozzelino
Publisher : Frontiers Media SA
ISBN 13 : 2889195244
Total Pages : 481 pages
Book Rating : 4.8/5 (891 download)

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Book Synopsis The Importance Of Iron In Pathophysiologic Conditions by : Raffaella Gozzelino

Download or read book The Importance Of Iron In Pathophysiologic Conditions written by Raffaella Gozzelino and published by Frontiers Media SA. This book was released on 2015-06-09 with total page 481 pages. Available in PDF, EPUB and Kindle. Book excerpt: The iron element (Fe) is strictly required for the survival of most forms of life, including bacteria, plants and humans. Fine-tuned regulatory mechanisms for Fe absorption, mobilization and recycling operate to maintain Fe homeostasis, the disruption of which leads to Fe overload or Fe depletion. Whereas the deleterious effect of Fe deficiency relies on reduced oxygen transport and diminished activity of Fe-dependent enzymes, the cytotoxicity induced by Fe overload is due to the ability of this metal to act as a pro-oxidant and catalyze the formation of highly reactive hydroxyl radicals via the Fenton chemistry. This results in unfettered oxidative stress generation that, by inducing protein, lipid and DNA oxidation, leads to Fe-mediated programmed cell death and organ dysfunction. Major and systemic Fe overloads occurring in hemochromatosis and Fe-loading anemias have been extensively studied. However, localized tissue Fe overload was recently associated to a variety of pathologies, such as infection, inflammation, cancer, cardiovascular and neurodegenerative disorders. In keeping with the existence of cross-regulatory interactions between Fe homeostasis and the pathophysiology of these diseases, further investigations on the mechanisms that provide cellular and systemic adaptation to tissue Fe overload are instrumental for future therapeutic approaches. Thus, we encourage our colleagues to submit original research papers, reviews, perspectives, methods and technology reports to contribute their findings to a current state of the art on a comprehensive overview of the importance of iron metabolism in pathophysiologic conditions.

Lactoferrin

Author : T. William Hutchens
Publisher : Springer Science & Business Media
ISBN 13 : 1461525489
Total Pages : 295 pages
Book Rating : 4.4/5 (615 download)

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Book Synopsis Lactoferrin by : T. William Hutchens

Download or read book Lactoferrin written by T. William Hutchens and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 295 pages. Available in PDF, EPUB and Kindle. Book excerpt: Lactoferrin is an intriguing protein with an interesting structure and several known or suggested biological activities. We feel that attention on this protein has been too limited and diffuse, partly because it has been "hidden" among other well-known iron-binding proteins such as hemoglobin, ferritin and transferrin, but also perhaps because its biological functions are so diverse. Investigators that focus on lactoferrin represent a wide variety of medical and scientific disciplines that do not usually come together. It was our intention to improve that situation with this symposium. In this book, experts from a variety of disciplines describe the present knowledge of the structural features of lactoferrin, its carbohydrate side chains and its capacity to bind different metal ions and anions. Several of the possible physiological functions of lactoferrin are described in detail, including the role of lactoferrin in bacterial killing, its involvement in growth and proliferation, in immune function and in iron absorption. Aspects of the molecular biology of lactoferrin and its specific interactions with different cell types are also included. Finally, as lactoferrin now has become commercially available in larger quantities, possible industrial applications are discussed. The book should give the interested reader a thorough insight into our present knowledge of lactoferrin.

Concise Encyclopedia of Biomedical Polymers and Polymeric Biomaterials

Author : Munmaya Mishra
Publisher : CRC Press
ISBN 13 : 1351653032
Total Pages : 1800 pages
Book Rating : 4.3/5 (516 download)

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Book Synopsis Concise Encyclopedia of Biomedical Polymers and Polymeric Biomaterials by : Munmaya Mishra

Download or read book Concise Encyclopedia of Biomedical Polymers and Polymeric Biomaterials written by Munmaya Mishra and published by CRC Press. This book was released on 2017-08-16 with total page 1800 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Concise Encyclopedia of Biomedical Polymers and Polymeric Biomaterials presents new and selected content from the 11-volume Biomedical Polymers and Polymeric Biomaterials Encyclopedia. The carefully culled content includes groundbreaking work from the earlier published work as well as exclusive online material added since its publication in print. A diverse and global team of renowned scientists provide cutting edge information concerning polymers and polymeric biomaterials. Acknowledging the evolving nature of the field, the encyclopedia also features newly added content in areas such as tissue engineering, tissue repair and reconstruction, and biomimetic materials.

Measurements in Wound Healing

Author : Raj Mani
Publisher : Springer Science & Business Media
ISBN 13 : 1447129873
Total Pages : 407 pages
Book Rating : 4.4/5 (471 download)

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Book Synopsis Measurements in Wound Healing by : Raj Mani

Download or read book Measurements in Wound Healing written by Raj Mani and published by Springer Science & Business Media. This book was released on 2012-08-15 with total page 407 pages. Available in PDF, EPUB and Kindle. Book excerpt: Measurement of Wound Healing will update the knowledge base and promote the use of measurements in order to improve both understanding of wounds and their management. This book will feature well used vascular measurements, pathological measurements, imaging measurements and so on. There will be chapters on techniques/measurements that have much promise. This book is led by 3 experienced clinician scientists from different backgrounds who have successfully worked together on projects.

ABC of Wound Healing

Author : Annie Price
Publisher : John Wiley & Sons
ISBN 13 : 0470658975
Total Pages : 114 pages
Book Rating : 4.4/5 (76 download)

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Book Synopsis ABC of Wound Healing by : Annie Price

Download or read book ABC of Wound Healing written by Annie Price and published by John Wiley & Sons. This book was released on 2022-03-22 with total page 114 pages. Available in PDF, EPUB and Kindle. Book excerpt: ABC of Wound Healing, Second Edition ABC of Wound Healing is a practical, highly illustrated guide to assessment, diagnosis and management of all common types of acute and chronic wounds. This concise yet comprehensive reference covers all essential aspects of wound healing care, including epidemiology, pathophysiology, assessment, treatment, long-term management, and prevention This revised second edition contains several new chapters on lymphoedema, nutrition, skin care, continence, and scarring. Updated and expanded chapters cover a wider range of devices and therapies, and discuss additional factors that impact wound healing processes, offering new clinical photographs as a visual guide. Applying a multidisciplinary approach to the provision of wound care, ABC of Wound Healing: Covers common wounds including traumatic wounds, surgical wounds, diabetic foot ulcers, pressure injuries, and venous and arterial leg ulcers Emphasises the importance of reaching a diagnosis, the fundamental step in managing any wound Provides up-to-date information on physical, chemical, biological and emerging therapies for patients with various types of wounds Contains hundreds of full-colour illustrations and clinical photographs of wounds and treatments ABC of Wound Healing, Second Edition, remains a must-have guide for junior doctors, specialist registrars in medicine and surgery, specialist nurses, general practitioners and medical students.

Bacterial Biofilms

Author : Sadik Dincer
Publisher : BoD – Books on Demand
ISBN 13 : 1789858992
Total Pages : 362 pages
Book Rating : 4.7/5 (898 download)

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Book Synopsis Bacterial Biofilms by : Sadik Dincer

Download or read book Bacterial Biofilms written by Sadik Dincer and published by BoD – Books on Demand. This book was released on 2020-10-07 with total page 362 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book examines biofilms in nature. Organized into four parts, this book addresses biofilms in wastewater treatment, inhibition of biofilm formation, biofilms and infection, and ecology of biofilms. It is designed for clinicians, researchers, and industry professionals in the fields of microbiology, biotechnology, ecology, and medicine as well as graduate and postgraduate students.

The Role of Biofilms in Device-Related Infections

Author : Mark Shirtliff
Publisher : Springer Science & Business Media
ISBN 13 : 3540681191
Total Pages : 276 pages
Book Rating : 4.5/5 (46 download)

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Book Synopsis The Role of Biofilms in Device-Related Infections by : Mark Shirtliff

Download or read book The Role of Biofilms in Device-Related Infections written by Mark Shirtliff and published by Springer Science & Business Media. This book was released on 2008-12-19 with total page 276 pages. Available in PDF, EPUB and Kindle. Book excerpt: Approximately 60% of all hospital-associated infections, over one million cases per year, are due to biofilms that have formed on indwelling medical devices. Device-related biofilm infections increase hospital stays and add over one billion dollars/year to U.S. hospitalization costs. Since the use and the types of indwelling medical devices commonly used in modern healthcare are continuously expanding, especially with an aging population, the incidence of biofilm infections will also continue to rise. The central problem with microbial biofilm infections of foreign bodies is their propensity to resist clearance by the host immune system and all antimicrobial agents tested to date. In fact, compared to their free floating, planktonic counterparts, microbes within a biofilm are 50 – 500 times more resistant to antimicrobial agents. Therefore, achieving therapeutic and non-lethal dosing regimens within the human host is impossible. The end result is a conversion from an acute infection to one that is persistent, chronic, and recurrent, most often requiring device removal in order to eliminate the infection. This text will describe the major types of device-related infections, and will explain the host, pathogen, and the unique properties of their interactions in order to gain a better understanding of these recalcitrant infections.