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Iron Uptake And Homeostasis In Microorganisms
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Book Synopsis Iron Uptake and Homeostasis in Microorganisms by : Pierre Cornelis
Download or read book Iron Uptake and Homeostasis in Microorganisms written by Pierre Cornelis and published by Caister Academic Press Limited. This book was released on 2010 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Iron is essential for almost all living organisms as it is involved in a wide variety of important metabolic processes. However, iron is not readily available and microorganisms therefore employ various iron uptake systems to secure sufficient supplies from their surroundings. There is considerable variation in the range of iron transporters and iron sources utilised by different microbial species. Pathogens, in particular, require efficient iron acquisition mechanisms to enable them to compete successfully for iron in the highly iron-restricted environment of the host's tissues and body fluids. In this book, an international team of authors presents a comprehensive collection of reviews on iron uptake and metabolism in various microorganisms including rhizobia, Bordetella, Shigella, E. coli, Erwinia, Vibrio, Aeromonas, Francisella, Bacteroides, Campylobacter, cyanobacteria, Bacillus, staphylococci and yeasts. An entire chapter is dedicated to siderophores and another to heme uptake. The volume provides an expert and timely summary of current knowledge, with a focus on molecular and genetic aspects, and highlights some of the most exciting recent developments. Aimed at research scientists, advanced students and other specialists, this book is highly recommended for everyone interested in iron uptake and metabolism, microbial pathogenesis and microbial ecology.
Book Synopsis Iron Uptake in Bacteria with Emphasis on E. coli and Pseudomonas by : Ranjan Chakraborty
Download or read book Iron Uptake in Bacteria with Emphasis on E. coli and Pseudomonas written by Ranjan Chakraborty and published by Springer Science & Business Media. This book was released on 2013-02-02 with total page 98 pages. Available in PDF, EPUB and Kindle. Book excerpt: Iron is essential for the growth of most bacteria because it serves as a cofactor for vital enzymes and for the components of the electron transport chain. Moreover, Iron plays an important role in bacterial pathogenicity; in fact, the iron transport systems in bacteria works as target for designing novel antibiotics. Because iron is not soluble under aerobic conditions, bacteria have had to find ways to overcome iron deficiency. One of them is producing an iron-chelating small organic molecule called siderophore. Indeed, most bacteria and fungi produce structurally and chemically diverse siderophores which are transported back to the cytoplasm using complex energy dependent transport systems. Escherichia coli and Pseudomonas were the first ones to be tested; however, nowadays iron transport systems have been investigated in many other bacteria. Iron Uptake in Bacteria with Emphasis on E. coli and Pseudomonas reviews the recent advancements in the field of iron transport systems in bacteria. Chapter 1 is dedicated to Dr. Dick van der Helm’s contribution to the field of siderophore biology. It then describes and discusses the structural advances in the components and the mechanism of siderophore mediated iron transport systems in E.coli. Chapter 2 details the variety of iron transport and iron regulatory systems of both gram negative and gram positive bacteria. Finally, chapter 3 describes the iron transport systems of Pseudomonas. This book is aimed at researchers in the fields of iron metabolism in multiple organisms, and to those who are interested in studying iron transport systems of bacteria. It appeals also to scientists researching structure and function relationship of proteins.
Book Synopsis Iron Metabolism by : Robert Crichton
Download or read book Iron Metabolism written by Robert Crichton and published by John Wiley & Sons. This book was released on 2016-03-30 with total page 576 pages. Available in PDF, EPUB and Kindle. Book excerpt: Iron is indispensable for the growth, development and well-being of almost all living organisms. Biological systems from bacteria, fungi and plants to humans have evolved systems for the uptake, utilisation, storage and homeostasis of iron. Its importance for microbial growth makes its uptake systems a natural target for pathogenic microorganisms and parasites. Uniquely, humans suffer from both iron deficiency and iron overload, while the capacity of iron to generate highly reactive free radicals, causing oxidative stress, is associated with a wide range of human pathologies, including many neurodegenerative diseases. Whereas some essential metal ions like copper and zinc are closely linked with iron metabolism, toxic metals like aluminium and cadmium can interfere with iron metabolism. Finally, iron metabolism and homeostasis are key targets for the development of new drugs for human health. The 4th edition of Iron Metabolism is written in a lively style by one of the leaders in the field, presented in colour and covers the latest discoveries in this exciting area. It will be essential reading for researchers and students in biochemistry, molecular biology, microbiology, cell biology, nutrition and medical sciences. Other interested groups include biological inorganic chemists with an interest in iron metabolism, health professionals with an interest in diseases of iron metabolism, or of diseases in which iron uptake systems are involved (eg. microbial and fungal infections, cancer, neurodegenerative disorders), and researchers in the pharmaceutical industry interested in developing novel drugs targeting iron metabolism/homeostasis.
Book Synopsis Molecular Aspects of Iron Metabolism in Pathogenic and Symbiotic Plant-Microbe Associations by : Dominique Expert
Download or read book Molecular Aspects of Iron Metabolism in Pathogenic and Symbiotic Plant-Microbe Associations written by Dominique Expert and published by Springer Science & Business Media. This book was released on 2012-08-23 with total page 91 pages. Available in PDF, EPUB and Kindle. Book excerpt: Iron plays a key role in biology as essential cofactor of numerous proteins. However, since it is only slightly soluble its bioavailability can be readily compromised under aerobic conditions. Moreover, due to its ability to catalyze the generation of free radicals, iron can also be toxic. Thus, it doesn’t surprise that living organisms have developed sophisticated means for acquiring iron whilst tightly controlling the intracellular concentrations of this metal in response to environmental conditions. Also, the critical role of iron has long been acknowledged in host vertebrate-parasite relationships where both partners compete for the acquisition of this essential element and activate complex signaling cascades to control their iron homeostasis during infection. Following the great interest that the mechanisms regulating the acquisition of iron and the control of iron homeostasis have generated among researchers studying plant-pathogen and legume-rhizobia interactions, this book offers a comprehensive analysis of irons’ various roles in the plant-microbial associations. The introductory chapter stresses the essentiality of iron in biological systems. The second chapter surveys the abundance of information on iron’s pivotal role in microbial plant pathogenesis and defence. Finally, the third chapter reviews the advances in our understanding of iron metabolism in the rhizobia, soil bacteria able to establish a symbiotic association with legumes and carry out nitrogen fixation. Molecular Aspects of Iron Metabolism in Pathogenic and Symbiotic Plant-Microbe Associations is a valuable resource to microbiologists, pathologists and scientists interested in iron uptake and metabolism in microbial pathogenesis, rhizobia legume associations, and plant physiology and immunity.
Book Synopsis The Role of Iron in Bacterial Pathogenesis by : Susu M Zughaier
Download or read book The Role of Iron in Bacterial Pathogenesis written by Susu M Zughaier and published by Frontiers Media SA. This book was released on 2018-12-27 with total page 156 pages. Available in PDF, EPUB and Kindle. Book excerpt: The collection of articles published in this eBook represent different facets of the interactions between pathogens and their host concerning the battle for iron. Pathogens have developed different strategies to acquire iron from their host. These include the production of siderophores, heme acquisition and ferrous iron uptake.
Book Synopsis Military Strategies for Sustainment of Nutrition and Immune Function in the Field by : Institute of Medicine
Download or read book Military Strategies for Sustainment of Nutrition and Immune Function in the Field written by Institute of Medicine and published by National Academies Press. This book was released on 1999-05-13 with total page 722 pages. Available in PDF, EPUB and Kindle. Book excerpt: Every aspect of immune function and host defense is dependent upon a proper supply and balance of nutrients. Severe malnutrition can cause significant alteration in immune response, but even subclinical deficits may be associated with an impaired immune response, and an increased risk of infection. Infectious diseases have accounted for more off-duty days during major wars than combat wounds or nonbattle injuries. Combined stressors may reduce the normal ability of soldiers to resist pathogens, increase their susceptibility to biological warfare agents, and reduce the effectiveness of vaccines intended to protect them. There is also a concern with the inappropriate use of dietary supplements. This book, one of a series, examines the impact of various types of stressors and the role of specific dietary nutrients in maintaining immune function of military personnel in the field. It reviews the impact of compromised nutrition status on immune function; the interaction of health, exercise, and stress (both physical and psychological) in immune function; and the role of nutritional supplements and newer biotechnology methods reported to enhance immune function. The first part of the book contains the committee's workshop summary and evaluation of ongoing research by Army scientists on immune status in special forces troops, responses to the Army's questions, conclusions, and recommendations. The rest of the book contains papers contributed by workshop speakers, grouped under such broad topics as an introduction to what is known about immune function, the assessment of immune function, the effect of nutrition, and the relation between the many and varied stresses encountered by military personnel and their effect on health.
Book Synopsis Inorganic Biochemistry of Iron Metabolism by : Robert R. Crichton
Download or read book Inorganic Biochemistry of Iron Metabolism written by Robert R. Crichton and published by John Wiley & Sons. This book was released on 2001-10-17 with total page 370 pages. Available in PDF, EPUB and Kindle. Book excerpt: Iron is of fundamental importance for the growth, development and well being of almost all living organisms. Multiple biological systems have been developed for the uptake, utilisation, storage and homeostasis of iron in microbes, plants and mammals. e.g. Both iron deficiency and iron overload are found extensively in man: the intimate links between iron and oxidative stress are associated with a wide range of pathologies; iron has a well established role in infections by a wide range of microorganisms and parasites; there is a close link between iron requirements and cellular division with implications for cancers and other metals such as copper and zinc are closely linked with iron metabolism. The first edition of this book was published in 1991. Since then the extensive impact of molecular cell biology on the field of iron biochemistry has opened new horizons in our understanding of the transport and storage of iron and of its homeostasis. The explosive use of molecular biological techniques applied to cellular biology of iron metabolism has resulted in a rapid expansion in the literature which has led to the need for this second edition. This second edition also: Introduces many illustrations and colour photos to make the basic concepts far clearer Includes new chapters on iron and cell division and interactions of iron with other metals - particularly copper and zinc Provides additional anecdotes Incorporates an extensive and up-to-date bibliography
Book Synopsis Transition Metals in Microbial Metabolism by : Gunther Winkelmann
Download or read book Transition Metals in Microbial Metabolism written by Gunther Winkelmann and published by CRC Press. This book was released on 2022-02-15 with total page 516 pages. Available in PDF, EPUB and Kindle. Book excerpt: The key role played by iron, as well as other transition metals, in microbial metabolism is investigated in this volume. Topics covered include: iron chelation and siderophores; receptor-mediated bacterial iron transport; and the nitogenases.
Book Synopsis Iron Nutrition in Plants and Rhizospheric Microorganisms by : Larry L. Barton
Download or read book Iron Nutrition in Plants and Rhizospheric Microorganisms written by Larry L. Barton and published by Springer Science & Business Media. This book was released on 2007-08-20 with total page 500 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides a comprehensive review on the status of iron nutrition in plants. It contains updated reviews of most relevant issues involving Fe in plants and combines research on molecular biology with physiological studies of plant-iron nutrition. It also covers molecular aspects of iron uptake and storage in Arabidopsis and transmembrane movement and translocation of iron in plants. This book should serve to stimulate continued exploration in the field.
Book Synopsis Plant Iron Homeostasis by : Jeeyon Jeong
Download or read book Plant Iron Homeostasis written by Jeeyon Jeong and published by Springer Nature. This book was released on 2023-05-11 with total page 221 pages. Available in PDF, EPUB and Kindle. Book excerpt: This detailed volume focuses on iron homeostasis in plants, iron being an essential micronutrient that serves as a cofactor in numerous metabolic processes but is harmful in excess. Specifically, the content ranges from protocols to study the iron deficiency response, the interaction between root and microbes under iron deficient conditions, the transcriptional network of iron homeostasis, systemic signaling of iron, chloroplast iron regulation, as well as methods on quantitative proteomics, histochemical iron staining, metal imaging using x-ray fluorescence microscopy, and more. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step and readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Plant Iron Homeostasis: Methods and Protocols serves as a valuable resource for the plant iron homeostasis research community and will be of broad interest to plant biologists, soil scientists, and molecular biologists.
Book Synopsis Molecular Biology of Metal Homeostasis and Detoxification by : Markus J. Tamás
Download or read book Molecular Biology of Metal Homeostasis and Detoxification written by Markus J. Tamás and published by Springer Science & Business Media. This book was released on 2006-07-07 with total page 519 pages. Available in PDF, EPUB and Kindle. Book excerpt: One of the challenges faced by every cell as well as by whole organisms is to maintain appropriate concentrations of essential nutrient metals while excluding nonessential toxic metals. Toward that end, all organisms have developed mechanisms for metal homeostasis and detoxification to maintain metal levels within physiological limits. This book brings together current knowledge of the molecular basis of metal homeostasis and detoxification in various eukaryotic model systems, including yeasts, plants, and mammals. It focuses on the cellular systems controlling metal transport, intracellular distribution, and immobilization as well as on systems regulating metal-dependent transcription. In addition to environmental aspects (including phytoremediation), the book treats the pathophysiology of metal deficiency and overload in relation to disease.
Book Synopsis The Importance Of Iron In Pathophysiologic Conditions by : Raffaella Gozzelino
Download or read book The Importance Of Iron In Pathophysiologic Conditions written by Raffaella Gozzelino and published by Frontiers Media SA. This book was released on 2015-06-09 with total page 481 pages. Available in PDF, EPUB and Kindle. Book excerpt: The iron element (Fe) is strictly required for the survival of most forms of life, including bacteria, plants and humans. Fine-tuned regulatory mechanisms for Fe absorption, mobilization and recycling operate to maintain Fe homeostasis, the disruption of which leads to Fe overload or Fe depletion. Whereas the deleterious effect of Fe deficiency relies on reduced oxygen transport and diminished activity of Fe-dependent enzymes, the cytotoxicity induced by Fe overload is due to the ability of this metal to act as a pro-oxidant and catalyze the formation of highly reactive hydroxyl radicals via the Fenton chemistry. This results in unfettered oxidative stress generation that, by inducing protein, lipid and DNA oxidation, leads to Fe-mediated programmed cell death and organ dysfunction. Major and systemic Fe overloads occurring in hemochromatosis and Fe-loading anemias have been extensively studied. However, localized tissue Fe overload was recently associated to a variety of pathologies, such as infection, inflammation, cancer, cardiovascular and neurodegenerative disorders. In keeping with the existence of cross-regulatory interactions between Fe homeostasis and the pathophysiology of these diseases, further investigations on the mechanisms that provide cellular and systemic adaptation to tissue Fe overload are instrumental for future therapeutic approaches. Thus, we encourage our colleagues to submit original research papers, reviews, perspectives, methods and technology reports to contribute their findings to a current state of the art on a comprehensive overview of the importance of iron metabolism in pathophysiologic conditions.
Book Synopsis Metal Ions in Biological Systems by : Astrid Sigel
Download or read book Metal Ions in Biological Systems written by Astrid Sigel and published by CRC Press. This book was released on 1998-01-09 with total page 826 pages. Available in PDF, EPUB and Kindle. Book excerpt: "Volume 35 covers the biological cycling of iron in oceans; the transport of iron in microorganisms, fungi, and plants; the roles and properties of siderophores; the regulation of iron transport and uptake in animals, plants, and microorganisms, and more. "
Book Synopsis Binding, Transport and Storage of Metal Ions in Biological Cells by : Wolfgang Maret
Download or read book Binding, Transport and Storage of Metal Ions in Biological Cells written by Wolfgang Maret and published by Royal Society of Chemistry. This book was released on 2014-07-09 with total page 990 pages. Available in PDF, EPUB and Kindle. Book excerpt: Metal ions play key roles in biology. Many are essential for catalysis, for electron transfer and for the fixation, sensing, and metabolism of gases. Others compete with those essential metal ions or have toxic or pharmacological effects. This book is structured around the periodic table and focuses on the control of metal ions in cells. It addresses the molecular aspects of binding, transport and storage that ensure balanced levels of the essential elements. Organisms have also developed mechanisms to deal with the non-essential metal ions. However, through new uses and manufacturing processes, organisms are increasingly exposed to changing levels of both essential and non-essential ions in new chemical forms. They may not have developed defenses against some of these forms (such as nanoparticles). Many diseases such as cancer, diabetes and neurodegeneration are associated with metal ion imbalance. There may be a deficiency of the essential metals, overload of either essential or non-essential metals or perturbation of the overall natural balance. This book is the first to comprehensively survey the molecular nature of the overall natural balance of metal ions in nutrition, toxicology and pharmacology. It is written as an introduction to research for students and researchers in academia and industry and begins with a chapter by Professor R J P Williams FRS.
Book Synopsis Iron Transport in Bacteria by : Jorge H. Crosa
Download or read book Iron Transport in Bacteria written by Jorge H. Crosa and published by Amer Society for Microbiology. This book was released on 2004 with total page 499 pages. Available in PDF, EPUB and Kindle. Book excerpt: provides an up–to–date survey of iron transport systems in bacteria; details iron transport and its regulation in E.colias a prototype for iron transport systems in gram–negative bacteria; includes chapters on the major gram–negative, gram–positive and acid–fast bacterial pathogens – their iron transport systems and the roles of these systems in virulence; presents structural studies of siderophores, heme carriers, and iron transport proteins; discusses the ecology of siderophores and potential therapeutic uses of siderophores.
Book Synopsis Fungal Siderophores by : Kalyani Dhusia
Download or read book Fungal Siderophores written by Kalyani Dhusia and published by Springer Nature. This book was released on 2021-02-08 with total page 220 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the past few decades, it has been realized through research that fungal siderophores epitomize the uptake of iron as well as other essential elements like zinc, magnesium, copper, nickel and arsenic. Understanding the chemical structures of different fungal siderophores and the membrane receptors involved in uptake of mineral ions has opened new areas for research. In this edited volume, recent research is presented on fungal siderophores in one comprehensive volume to provide researchers a strong base for future research. Siderophores are the low molecular weight, high affinity iron-chelating compounds produced by bacteria and fungi. They are responsible for transporting iron across the cell membrane. Fungi produce a range of hydroxamate siderophores involved in the uptake of essential elements in almost all microorganisms and plants. In recent years, siderophores have been used in molecular imaging applications to visualize and understand cellular functions, which thus provide an opportunity to identify new drug targets. Therefore, knowledge of fungal siderophores has become vital in current research. Siderophores have received much attention in recent years because of their potential roles and applications in various research areas. Their significance in these applications is because siderophores have the ability to bind a variety of metals in addition to iron, and they have a wide range of chemical structures and specific properties. For instance, siderophores function as biocontrols, biosensors, and bioremediation and chelation agents, in addition to their important role in weathering soil minerals and enhancing plant growth. This book focuses on siderophores with the following significant points. It discusses leading, state-of-the-art research in all possible areas on fungal siderophores. The contributors are well-known and recognized authorities in the field of fungal siderophores. It discusses a projection of practical applications of fungal siderophores in various domains. This is the first book exclusively on fungal siderophores. In this comprehensive, edited volume, we show leading research on fungal siderophores and provide the most recent knowledge of researchers' work on siderophores. This book presents in-depth knowledge on siderophores to researchers working in areas of health sciences, microbiology, plant sciences, biotechnology, and bioinformatics.
Book Synopsis The Physiology of Microalgae by : Michael A. Borowitzka
Download or read book The Physiology of Microalgae written by Michael A. Borowitzka and published by Springer. This book was released on 2016-03-21 with total page 673 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book covers the state-of-the-art of microalgae physiology and biochemistry (and the several –omics). It serves as a key reference work for those working with microalgae, whether in the lab, the field, or for commercial applications. It is aimed at new entrants into the field (i.e. PhD students) as well as experienced practitioners. It has been over 40 years since the publication of a book on algal physiology. Apart from reviews and chapters no other comprehensive book on this topic has been published. Research on microalgae has expanded enormously since then, as has the commercial exploitation of microalgae. This volume thoroughly deals with the most critical physiological and biochemical processes governing algal growth and production.
