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Iron Phenolate And Catecholate Complexes As Models For The Non Heme Iron Dioxygenases
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Book Synopsis Iron Phenolate and Catecholate Complexes as Models for the Non-heme Iron Dioxygenases by : Robert Heyler Heistand
Download or read book Iron Phenolate and Catecholate Complexes as Models for the Non-heme Iron Dioxygenases written by Robert Heyler Heistand and published by . This book was released on 1982 with total page 430 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Modeling Ring Cleaving Dioxygenases by : Sara S. Rocks
Download or read book Modeling Ring Cleaving Dioxygenases written by Sara S. Rocks and published by . This book was released on 2009 with total page 448 pages. Available in PDF, EPUB and Kindle. Book excerpt: "Extradiol catechol dioxygenases (EDOs), which regiospecifically cleave catechols, have been identified as the bottleneck in the catabolism of PCBs. The sensitivity of EDOs to chlorinated substrates has led to extensive studies of the ring cleaving mechanism both in enzyme systems and with synthetic model complexes. The active site of the enzyme contains a mononuclear iron(II) ligated to the enzyme through two histidines and a glutamate, yet no fully characterized iron(II)-catecholate model complexes supported on tridentate ligands have been reported. Unlike the well studied EDOs, hydroquinone cleaving enzymes (HQDOs) have yet to be studied via model chemistry. The active site of HQDOs is proposed to be similar to that of EDOs, however HQDOs prefer chlorinated substrates while EDOs can be mechanistically inactivated by chlorinated substrates. In Chapters 2 and 3, iron(II) complexes of tridentate ligands with N,N,O and N,N,N donor sets were investigated with X-ray crystallography and NMR spectroscopy. The N,N,O donor ligands were labile, forming a mixture of 1:1 and 2:1 ligand:iron complexes in aqueous solution. A series of triaminocyclohexane (TACH) based N,N,N donor ligands that varied by sterics were bound to iron(II), and the 1:1 and 2:1 complexes were evaluated by NMR spectroscopy. When mixed with catecholate, the iron complexes produced NMR silent purple colored products regardless of ligand donor set, steric modulation, iron(II) source or catecholate substitution. An investigation of the purple colored products resulting from mixing a tridentate ligand, iron(II) and catecholate is discussed in Chapter 4. The purple product was determined to contain high-spin iron(II) despite it being NMR silent. Based on UV-visible spectroscopy, the catecholate and N-donor are structural components of the purple material. The formation of the purple product was an inevitable consequence of mixing iron(II) with a tridentate ligand and catecholate. Chapter 5 presents TACH-ligand iron(II) phenolate and chlorophenolate complexes characterized by NMR spectroscopy and in the solid state. The tolylidene substituted TACH ligand thermally isomerized in the presence of iron(II). Preliminary evidence of an iron-chlorine secondary bonding interaction were determined based on solid state structures, which may shed light on the substrate specificity of the hydroquinone dioxygenases"--Leaves vi-vii.
Book Synopsis Coordination Chemistry of Mononuclear Non-heme Iron Oxygenase Enzymes by : Paul C. Tarves
Download or read book Coordination Chemistry of Mononuclear Non-heme Iron Oxygenase Enzymes written by Paul C. Tarves and published by . This book was released on 2013 with total page 468 pages. Available in PDF, EPUB and Kindle. Book excerpt: Abstract: Mononuclear non-heme iron oxygenase (MNO) enzymes utilize ferrous iron and dioxygen to perform a variety of thermodynamically challenging reactions at standard temperatures and pressures. The potent oxidizing power of these enzymatic systems has led to increased interest from the bioinorganic and synthetic organic communities. Presented herein is the preparation and characterization of an a-keto acid dependent synthetic system that closely models the active site electronic and dioxygen reactivity properties of the Fe II/a-ketoglutarate dependent class of MNH iron oxygenase enzymes. The ferrous complex utilized possesses a facially coordinating N,N,O- donor ligand reminiscent of a common active site motif observed for MNO iron enzymes. The labile coordination sites opposite the ligand framework allow for the ligation of exogenous a-keto acid cofactor as well as the binding and activation of dioxygen. The coordination of exogenous a-keto acid cofactor has been shown to greatly enhance the rate of dioxygen reactivity of the ferrous complex and lead to the catalytic decarboxylation of the cofactor. The enhancement in rate is attributed to the coupling of the dioxygen reduction step to the oxidative decarboxylation of the bound cofactor, which is a thermodynamically favorable process. The oxidative decarboxylation pathway suggests the formation of a high valent iron-oxo intermediate, which has been further supported by the concentration dependence of solvent oxidation during catalysis. The mechanism of dioxygen reactivity was further probed by Hammett analysis using substituted aromatic a-keto acid cofactors. The data presented suggest that the model system prepared proceeds via a biomimetic mechanism capable of catalytic dioxygen activation and substrate oxidation under ambient conditions. Investigation of differential carboxylate and phenolate ligation as it pertains to MNO iron enzymes is also reported. The synthesis and characterization of both ferrous and ferric compounds containing ligands with similar ethylene diamine backbones and either one or two phenolate moities: 2-(((2-(dimethylamino)ethyl)(methyl)amino)-methyl)phenol (N2O1-Ph) and 2,2'-((ethane-1,2-diylbis(methylazanediyl))bis-(methylene))diphenol (N2O2-Ph). The replacement of carboxylate moiety with a phenolate led to a significant decrease in reduction potential and subsequent enhancement in dioxygen sensitivity. This observation may provide insight into the reactivity of other iron containing enzymes with coordinated tyrosine residues, such as intradiol catechol dioxygenases.
Book Synopsis Oxygenases and Model Systems by : T. Funabiki
Download or read book Oxygenases and Model Systems written by T. Funabiki and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 403 pages. Available in PDF, EPUB and Kindle. Book excerpt: Oxygenases have been the subject of much study and are of great interest and application. Biomimetic chemistry of oxygenases has yielded clarification of enzyme structures and reaction mechanisms and has also led to the development of synthetic oxygenation processes. This volume contains 8 chapters written by leading researchers which together present an overview of di- and mono-oxygenases and their model systems from the point of view of functions, structures and mechanisms. An up-to-date clarification of structures around active centres of heme- and nonheme-oxygenases is given with reference to the design of model complexes. Various contributions also discuss in detail the formation, structure and reactivity of metal-oxygen and metal-substrate species in both enzyme and model systems. The contents of the volume address the interface between bioinorganic chemistry and homogeneous catalysis and contains much to emphasize the importance of catalytic studies in bio- and biomimetic chemistry. Audience: Research chemists interested in the use of oxygenases in catalysis.
Book Synopsis American Doctoral Dissertations by :
Download or read book American Doctoral Dissertations written by and published by . This book was released on 1981 with total page 552 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Dissertation Abstracts International by :
Download or read book Dissertation Abstracts International written by and published by . This book was released on 1996 with total page 780 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Biocatalysis written by Qayyum Husain and published by Springer Nature. This book was released on 2019-09-03 with total page 341 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book introduces readers to industrially important enzymes and discusses in detail their structures and functions, as well as their manifold applications. Due to their selective biocatalytic capabilities, enzymes are used in a broad range of industries and processes. The book highlights selected enzymes and their applications in agriculture, food processing and discoloration, as well as their role in biomedicine. In turn, it discusses biochemical engineering strategies such as enzyme immobilization, metabolic engineering, and cross-linkage of enzyme aggregates, and critically weighs their pros and cons. Offering a wealth of information, and stimulating further research by presenting new concepts on enzymatic catalytic functions in basic and applied contexts, the book represents a valuable asset for researchers from academia and industry who are engaged in biochemical engineering, microbiology and biotechnology.
Book Synopsis Oxidases and Related Redox Systems by : Tsso E. King
Download or read book Oxidases and Related Redox Systems written by Tsso E. King and published by Elsevier. This book was released on 2013-10-22 with total page 1295 pages. Available in PDF, EPUB and Kindle. Book excerpt: Oxidases and Related Redox Systems is a collection of papers from the Third International Symposium on Oxidases and Related Reduction Systems held in Albany, New York on July 3-7, 1979. This book deals with the oxygen and peroxide activating enzymes field. The book addresses electron transfer related to oxygen biochemistry by comparing quantum, semiclassical, and classical methods of electron transfer reactions. Several papers then discuss the active and toxic states of oxygen and superoxide as the discovery of superoxide dismutase activity of erythrocuprein can provide a means to studying oxygen reaction in biological systems. One paper then compares the active sites of molluskan and arthropodan hemocyanins, which are known as reversible oxygen-carriers. The result of this study is presented in a table. Other papers discuss the flavin catalyzed reactions of molecular oxygen and the implications of the physiological function of D-amino acid oxidase from inhibition studies. The book then explains the role of carbon monoxide in the reaction mechanism of oxygen with cytochrome oxidase. This collection will prove beneficial for research students and professors in the field of biochemistry and chemical physics.
Book Synopsis Iron Carriers and Iron Proteins by : Thomas M. Loehr
Download or read book Iron Carriers and Iron Proteins written by Thomas M. Loehr and published by Wiley-VCH. This book was released on 1989 with total page 560 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Directory of Graduate Research by : American Chemical Society. Committee on Professional Training
Download or read book Directory of Graduate Research written by American Chemical Society. Committee on Professional Training and published by . This book was released on 1983 with total page 1294 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Critical Reviews in Biotechnology by :
Download or read book Critical Reviews in Biotechnology written by and published by . This book was released on 1989 with total page 398 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Book of Abstracts by : American Chemical Society. Meeting
Download or read book Book of Abstracts written by American Chemical Society. Meeting and published by . This book was released on 1985 with total page 1398 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Biodegradation of Hazardous and Special Products by : Rolando Chamy
Download or read book Biodegradation of Hazardous and Special Products written by Rolando Chamy and published by BoD – Books on Demand. This book was released on 2013-06-14 with total page 189 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book contains a collection of different research activities that include the biodegradation compounds with contaminant characteristics and special products of different interests as an added value product or that allows following up various biological processes. The chapters consider the degradation of contaminant compounds generated by industrial activities, i.e., oil industry by-product compounds and halogen compounds or compound generated by natural phenomena such as tsunamis, which require interventions to recover damaged soils. In addition, the book contains chapters that involve special product degradation processes such as chlorophyll, which corresponds to a biological process indicator as photosynthesis.
Book Synopsis Natural Product Biosynthesis by : Christopher T. Walsh
Download or read book Natural Product Biosynthesis written by Christopher T. Walsh and published by Royal Society of Chemistry. This book was released on 2017-04-28 with total page 787 pages. Available in PDF, EPUB and Kindle. Book excerpt: This textbook describes the types of natural products, the biosynthetic pathways that enable the production of these molecules, and an update on the discovery of novel products in the post-genomic era.
Book Synopsis Comprehensive Dissertation Index by :
Download or read book Comprehensive Dissertation Index written by and published by . This book was released on 1984 with total page 920 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Recent Advances in Polyphenol Research, Volume 5 by : Kumi Yoshida
Download or read book Recent Advances in Polyphenol Research, Volume 5 written by Kumi Yoshida and published by John Wiley & Sons. This book was released on 2017-02-06 with total page 396 pages. Available in PDF, EPUB and Kindle. Book excerpt: Plant polyphenols are secondary metabolites that constitute one of the most common and widespread groups of natural products. They express a large and diverse panel of biological activities including beneficial effects on both plants and humans. Many polyphenols, from their structurally simplest representatives to their oligo/polymeric versions (also referred to as vegetable tannins), are notably known as phytoestrogens, plant pigments, potent antioxidants, and protein interacting agents. Sponsored by the scholarly society Groupe Polyphénols, this publication, which is the fifth volume in this highly regarded Recent Advances in Polyphenol Research series, is edited by Kumi Yoshida, Véronique Cheynier and Stéphane Quideau. They have once again, like their predecessors, put together an impressive collection of cutting-edge chapters written by expert scientists, internationally respected in their respective field of polyphenol sciences. This Volume 5 highlights some of the latest information and opinion on the following major research topics about polyphenols: • Chemistry, physicochemistry & materials science • Biosynthesis, genetic & metabolic engineering • Plant & ecosystem, lignocellulosic biomass • Food, nutrition & health • Natural medicine & Kampo • Tannins & their functions Chemists, biochemists, plant scientists, pharmacognosists and pharmacologists, biologists, ecologists, food scientists and nutritionists will all find this book an invaluable resource. Libraries in all universities and research institutions where these disciplines are studied and taught should have copies on their bookshelves.
Book Synopsis The Structure and Reactivity of Non-heme Iron(III) Proteins and Model Complexes by : Bruce Prentiss Murch
Download or read book The Structure and Reactivity of Non-heme Iron(III) Proteins and Model Complexes written by Bruce Prentiss Murch and published by . This book was released on 1987 with total page 534 pages. Available in PDF, EPUB and Kindle. Book excerpt:
