Iron As Therapeutic Targets In Human Diseases Volume 2

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Iron as Therapeutic Targets in Human Diseases

Author : Paolo Arosio
Publisher : MDPI
ISBN 13 : 3039281143
Total Pages : 440 pages
Book Rating : 4.0/5 (392 download)

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Book Synopsis Iron as Therapeutic Targets in Human Diseases by : Paolo Arosio

Download or read book Iron as Therapeutic Targets in Human Diseases written by Paolo Arosio and published by MDPI. This book was released on 2020-02-11 with total page 440 pages. Available in PDF, EPUB and Kindle. Book excerpt: Iron is an essential element for almost all organisms, a cofactor playing a crucial role in a number of vital functions, including oxygen transport, DNA synthesis, and respiration. However, its ability to exchange electrons renders excess iron potentially toxic, since it is capable of catalyzing the formation of highly poisonous free radicals. As a consequence, iron homeostasis is tightly controlled by sophisticated mechanisms that have been partially elucidated. Because of its biological importance, numerous disorders have been recently linked to the deregulation of iron homeostasis, which include not only the typical disorders of iron overload and deficiency but also cancer and neurodegenerative diseases. This leads iron metabolism to become an interesting therapeutic target for novel pharmacological treatments against these diseases. Several therapies are currently under development for hematological disorders, while other are being considered for different pathologies. The therapeutic targeting under study includes the hepcidin/ferroportin axis for the regulation of systemic iron homeostasis, complex cytosolic machineries for the regulation of the intracellular iron status and its association with oxidative damage, and reagents exploiting proteins of iron metabolism such as ferritin and transferrin receptor. A promising potential target is a recently described form of programmed cell death named ferroptosis, in which the role of iron is essential but not completely clarified. This Special Issue has the aim to summarize the state-of-the-art, and the latest findings published in the iron field, as well as to elucidate future directions.

Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc

Download Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc PDF Online Free

Author : Institute of Medicine
Publisher : National Academies Press
ISBN 13 : 9780309072793
Total Pages : 804 pages
Book Rating : 4.0/5 (727 download)

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Book Synopsis Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc by : Institute of Medicine

Download or read book Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc written by Institute of Medicine and published by National Academies Press. This book was released on 2002-07-19 with total page 804 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume is the newest release in the authoritative series issued by the National Academy of Sciences on dietary reference intakes (DRIs). This series provides recommended intakes, such as Recommended Dietary Allowances (RDAs), for use in planning nutritionally adequate diets for individuals based on age and gender. In addition, a new reference intake, the Tolerable Upper Intake Level (UL), has also been established to assist an individual in knowing how much is "too much" of a nutrient. Based on the Institute of Medicine's review of the scientific literature regarding dietary micronutrients, recommendations have been formulated regarding vitamins A and K, iron, iodine, chromium, copper, manganese, molybdenum, zinc, and other potentially beneficial trace elements such as boron to determine the roles, if any, they play in health. The book also: Reviews selected components of food that may influence the bioavailability of these compounds. Develops estimates of dietary intake of these compounds that are compatible with good nutrition throughout the life span and that may decrease risk of chronic disease where data indicate they play a role. Determines Tolerable Upper Intake levels for each nutrient reviewed where adequate scientific data are available in specific population subgroups. Identifies research needed to improve knowledge of the role of these micronutrients in human health. This book will be important to professionals in nutrition research and education.

Damage-Associated Molecular Patterns in Human Diseases

Author : Walter Gottlieb Land
Publisher : Springer Nature
ISBN 13 : 3031217764
Total Pages : 708 pages
Book Rating : 4.0/5 (312 download)

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Book Synopsis Damage-Associated Molecular Patterns in Human Diseases by : Walter Gottlieb Land

Download or read book Damage-Associated Molecular Patterns in Human Diseases written by Walter Gottlieb Land and published by Springer Nature. This book was released on 2023-03-10 with total page 708 pages. Available in PDF, EPUB and Kindle. Book excerpt: The core of this three-volume book deals with damage-associated molecular patterns abbreviated “DAMPs”, which are unique molecules that save life and fight for survival of all organisms on this planet by triggering robust inflammatory/immune defense responses upon any injury, including those caused by pathogens such as viruses and bacteria. However, these molecules also have a dark side: when produced in excess upon severe insults, they can trigger serious human diseases. The three volumes present current understanding of the importance of DAMP-promoted immune responses in the etiopathogenesis of human diseases and explore how this understanding is impacting diagnosis, prognosis, and future treatment. This third volume addresses the potential of DAMPs in clinical practice, as therapeutic targets and therapeutics, by focusing on a description of antigen-related diseases, which are pathogenetically dominated by DAMPs, that is, infectious and autoimmune disorders and allograft rejection (as an undesired function of these molecules), as well as tumor rejection (as the desired function of these molecules). The book is written for professionals from all medical and paramedical disciplines who are interested in the introduction of innovative data from modern inflammation and immunity research into clinical practice. In this sense, the book reflects an approach to translational medicine. The readership will include all practitioners and clinicians, in particular, ICU clinicians, infectiologists, microbiologists, virologists, hematologists, rheumatologists, diabetologists, neurologists, transplantologists, oncologists, and pharmacists. Also available: Damage-Associated Molecular Patterns in Human Diseases - Vol. 1: Injury-Induced Innate Immune Responses; Damage-Associated Molecular Patterns in Human Diseases - Vol. 2: Danger Signals as Diagnostics, Prognostics, and Therapeutic Targets.

Nutrition and HIV

Author : Saurabh Mehta
Publisher : CRC Press
ISBN 13 : 1351058185
Total Pages : 326 pages
Book Rating : 4.3/5 (51 download)

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Book Synopsis Nutrition and HIV by : Saurabh Mehta

Download or read book Nutrition and HIV written by Saurabh Mehta and published by CRC Press. This book was released on 2018-05-15 with total page 326 pages. Available in PDF, EPUB and Kindle. Book excerpt: The world continues to lose more than a million lives each year to the HIV epidemic, and nearly two million individuals were infected with HIV in 2017 alone. The new Sustainable Development Goals, adopted by countries of the United Nations in September 2015, include a commitment to end the AIDS epidemic by 2030. Considerable emphasis on prevention of new infections and treatment of those living with HIV will be needed to make this goal achievable. With nearly 37 million people now living with HIV, it is a communicable disease that behaves like a noncommunicable disease. Nutritional management is integral to comprehensive HIV care and treatment. Improved nutritional status and weight gain can increase recovery and strength of individuals living with HIV/AIDS, improve dietary diversity and caloric intake, and improve quality of life. This book highlights evidence-based research linking nutrition and HIV and identifies research gaps to inform the development of guidelines and policies for the United Nations’ Sustainable Development Goals. A comprehensive approach that includes nutritional interventions is likely to maximize the benefit of antiretroviral therapy in preventing HIV disease progression and other adverse outcomes in HIV-infected men and women. Modification of nutritional status has been shown to enhance the quality of life of those suffering HIV/AIDS, both physically in terms of improved body mass index and immunological markers, and psychologically, by improving symptoms of depression. While the primary focus for those infected should remain on antiretroviral treatment and increasing its availability and coverage, improvement of nutritional status plays a complementary role in the management of HIV infection.

Disease Control Priorities, Third Edition (Volume 6)

Author : King K. Holmes
Publisher : World Bank Publications
ISBN 13 : 1464805253
Total Pages : 1027 pages
Book Rating : 4.4/5 (648 download)

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Book Synopsis Disease Control Priorities, Third Edition (Volume 6) by : King K. Holmes

Download or read book Disease Control Priorities, Third Edition (Volume 6) written by King K. Holmes and published by World Bank Publications. This book was released on 2017-11-06 with total page 1027 pages. Available in PDF, EPUB and Kindle. Book excerpt: Infectious diseases are the leading cause of death globally, particularly among children and young adults. The spread of new pathogens and the threat of antimicrobial resistance pose particular challenges in combating these diseases. Major Infectious Diseases identifies feasible, cost-effective packages of interventions and strategies across delivery platforms to prevent and treat HIV/AIDS, other sexually transmitted infections, tuberculosis, malaria, adult febrile illness, viral hepatitis, and neglected tropical diseases. The volume emphasizes the need to effectively address emerging antimicrobial resistance, strengthen health systems, and increase access to care. The attainable goals are to reduce incidence, develop innovative approaches, and optimize existing tools in resource-constrained settings.

Iron Deficiency Anemia

Author : Institute of Medicine
Publisher : National Academies Press
ISBN 13 : 0309049873
Total Pages : 139 pages
Book Rating : 4.3/5 (9 download)

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Book Synopsis Iron Deficiency Anemia by : Institute of Medicine

Download or read book Iron Deficiency Anemia written by Institute of Medicine and published by National Academies Press. This book was released on 1994-02-01 with total page 139 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book summarizes information related to public health measures on the prevention, detection, and management of iron deficiency anemia. It presents draft guidelines and recommendations related to this area, as applicable in primary health care and public health clinic settings, and it formulates recommendations for research. This volume is intended both to provide a common frame of reference for health professionals in preventing and treating iron deficiency anemia and to enable the U.S. Centers for Disease Control and Prevention to prepare national guidelines and recommendations for the prevention and control of iron deficiency anemia.

Middleton's Allergy E-Book

Author : A Wesley Burks
Publisher : Elsevier Health Sciences
ISBN 13 : 0323546986
Total Pages : 828 pages
Book Rating : 4.3/5 (235 download)

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Book Synopsis Middleton's Allergy E-Book by : A Wesley Burks

Download or read book Middleton's Allergy E-Book written by A Wesley Burks and published by Elsevier Health Sciences. This book was released on 2019-09-25 with total page 828 pages. Available in PDF, EPUB and Kindle. Book excerpt: Through eight outstanding editions, Middleton's Allergy: Principles and Practice has been the reference of choice for both clinicians and researchers as both a practical reference and an effective self-assessment tool for board preparation. The 9th Edition continues the tradition of excellence with comprehensive coverage of all basic science and clinical applications regarding allergy practice and disease mechanisms. It brings you fully up to date with recent innovations in the diagnosis, prevention, and management of allergic disorders, including emerging global issues, the advent of precision medicine, and new immunologic therapies. - Offers unparalleled depth and up-to-date guidance on the full spectrum of allergy across the lifespan, with significant updates throughout. - Contains new chapters on Innate Lymphoid Cells, Systems Biology, and Treatment of Primary Immunodeficiency Diseases. - Discusses emerging topics such as epidemic thunderstorm asthma and precision medicine in allergic disorders. - Features more than 730 full-color illustrations, including many new cellular and molecular drawings of disease mechanisms. - Includes new Summary of Important Concepts boxes, plus new multiple-choice questions online with explanations and answers. - Features a new team of expert editors and more international contributors for a global perspective of this complex field. - Enhanced eBook version included with purchase. Your enhanced eBook allows you to access all of the text, figures, and references from the book on a variety of devices.

Diagnostic Pathology: Blood and Bone Marrow - E-Book

Author : Kathryn Foucar
Publisher : Elsevier Health Sciences
ISBN 13 : 0323879071
Total Pages : 1005 pages
Book Rating : 4.3/5 (238 download)

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Book Synopsis Diagnostic Pathology: Blood and Bone Marrow - E-Book by : Kathryn Foucar

Download or read book Diagnostic Pathology: Blood and Bone Marrow - E-Book written by Kathryn Foucar and published by Elsevier Health Sciences. This book was released on 2023-09-12 with total page 1005 pages. Available in PDF, EPUB and Kindle. Book excerpt: This expert volume in the Diagnostic Pathology series is an excellent point-of-care resource for practitioners at all levels of experience and training. Covering the full range of nonneoplastic and neoplastic conditions of blood and bone marrow, it incorporates the most recent scientific and technical knowledge in the field to provide a comprehensive overview of all key issues relevant to today's practice. Richly illustrated and easy to use, the third edition of Diagnostic Pathology: Blood and Bone Marrow is a visually stunning, one-stop resource for every practicing pathologist, hematopathologist, oncologist, hematologist, resident, student, or fellow as an ideal day-to-day reference or as a reliable training resource. - Provides practicing pathologists with key details about new entities, newly recognized causes of morphologic change in blood and bone marrow abnormalities, and new strategies for appropriate workup of neoplastic processes—all with a focus on key tests and key differential diagnostic considerations - Helps pathologists recognize unique blood and bone marrow findings that can be an indicator for specific exposures, such as new medications, new targeted therapies, or toxins - Integrates updated technologies, newly recognized disorders, complications/features in blood and bone marrow, new targeted therapies, and the increased use of homeopathic remedies - Contains new chapters covering SARS-CoV-2 infection features in blood and bone marrow, myelodysplastic syndrome (MDS) mimics, blood and bone marrow findings linked to targeted therapies, blood and bone marrow findings linked to other medications, and more - Updates all existing chapters and contains expanded information on T-cell neoplasms in blood and bone marrow and intravascular large B-cell lymphoma in blood and bone marrow - Includes details from the World Health Organization (WHO) fifth edition Classification of Haematolymphoid Tumours and the very latest 2023 International Consensus Classification (ICC) publications, reflecting new and renamed diagnostic entities, tumor classification changes and updates, and terminology changes and updates - Discusses molecular testing strategies based on specific neoplasms and specific differential diagnostic consideration - Clearly delineates numerous genetic disorders often found in blood and bone marrow - Features more than 2,500 superb images, including histology and gross pathology photographs, full-color illustrations and graphics, clinical photographs and radiologic images, and many new tables and charts/algorithms - Employs consistently templated chapters, bulleted content, key facts, a variety of tables, annotated images, pertinent references, and an extensive index for quick, expert reference at the point of care - Includes the enhanced eBook version, which allows you to search all text, figures, and references on a variety of devices

Ferroptosis in cancer and beyond, volume II

Author : Yanqing Liu
Publisher : Frontiers Media SA
ISBN 13 : 283253466X
Total Pages : 174 pages
Book Rating : 4.8/5 (325 download)

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Book Synopsis Ferroptosis in cancer and beyond, volume II by : Yanqing Liu

Download or read book Ferroptosis in cancer and beyond, volume II written by Yanqing Liu and published by Frontiers Media SA. This book was released on 2023-09-29 with total page 174 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Field Trials of Health Interventions

Author : Peter G. Smith
Publisher :
ISBN 13 : 0198732864
Total Pages : 479 pages
Book Rating : 4.1/5 (987 download)

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Book Synopsis Field Trials of Health Interventions by : Peter G. Smith

Download or read book Field Trials of Health Interventions written by Peter G. Smith and published by . This book was released on 2015 with total page 479 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is an open access title available under the terms of a CC BY-NC 4.0 International licence. It is free to read at Oxford Scholarship Online and offered as a free PDF download from OUP and selected open access locations. Before new interventions are released into disease control programmes, it is essential that they are carefully evaluated in field trials'. These may be complex and expensive undertakings, requiring the follow-up of hundreds, or thousands, of individuals, often for long periods. Descriptions of the detailed procedures and methods used in the trials that have been conducted have rarely been published. A consequence of this, individuals planning such trials have few guidelines available and little access to knowledge accumulated previously, other than their own. In this manual, practical issues in trial design and conduct are discussed fully and in sufficient detail, that Field Trials of Health Interventions may be used as a toolbox' by field investigators. It has been compiled by an international group of over 30 authors with direct experience in the design, conduct, and analysis of field trials in low and middle income countries and is based on their accumulated knowledge and experience. Available as an open access book via Oxford Medicine Online, this new edition is a comprehensive revision, incorporating the new developments that have taken place in recent years with respect to trials, including seven new chapters on subjects ranging from trial governance, and preliminary studies to pilot testing.

How Tobacco Smoke Causes Disease

Author : United States. Public Health Service. Office of the Surgeon General
Publisher :
ISBN 13 :
Total Pages : 728 pages
Book Rating : 4.:/5 (318 download)

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Book Synopsis How Tobacco Smoke Causes Disease by : United States. Public Health Service. Office of the Surgeon General

Download or read book How Tobacco Smoke Causes Disease written by United States. Public Health Service. Office of the Surgeon General and published by . This book was released on 2010 with total page 728 pages. Available in PDF, EPUB and Kindle. Book excerpt: This report considers the biological and behavioral mechanisms that may underlie the pathogenicity of tobacco smoke. Many Surgeon General's reports have considered research findings on mechanisms in assessing the biological plausibility of associations observed in epidemiologic studies. Mechanisms of disease are important because they may provide plausibility, which is one of the guideline criteria for assessing evidence on causation. This report specifically reviews the evidence on the potential mechanisms by which smoking causes diseases and considers whether a mechanism is likely to be operative in the production of human disease by tobacco smoke. This evidence is relevant to understanding how smoking causes disease, to identifying those who may be particularly susceptible, and to assessing the potential risks of tobacco products.

New progress in understanding and treatment of osteoporosis

Author : Zhiyong Hou
Publisher : Frontiers Media SA
ISBN 13 : 2832520979
Total Pages : 327 pages
Book Rating : 4.8/5 (325 download)

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Book Synopsis New progress in understanding and treatment of osteoporosis by : Zhiyong Hou

Download or read book New progress in understanding and treatment of osteoporosis written by Zhiyong Hou and published by Frontiers Media SA. This book was released on 2023-04-17 with total page 327 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Hf2cancer: Exploring bidirectional interaction between cardiovascular diseases and cancer

Author : Canan G. Nebigil
Publisher : Frontiers Media SA
ISBN 13 : 2832516920
Total Pages : 200 pages
Book Rating : 4.8/5 (325 download)

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Book Synopsis Hf2cancer: Exploring bidirectional interaction between cardiovascular diseases and cancer by : Canan G. Nebigil

Download or read book Hf2cancer: Exploring bidirectional interaction between cardiovascular diseases and cancer written by Canan G. Nebigil and published by Frontiers Media SA. This book was released on 2023-03-07 with total page 200 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Scheuer's Liver Biopsy Interpretation E-Book

Author : Jay H. Lefkowitch
Publisher : Elsevier Health Sciences
ISBN 13 : 0702066559
Total Pages : 433 pages
Book Rating : 4.7/5 (2 download)

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Book Synopsis Scheuer's Liver Biopsy Interpretation E-Book by : Jay H. Lefkowitch

Download or read book Scheuer's Liver Biopsy Interpretation E-Book written by Jay H. Lefkowitch and published by Elsevier Health Sciences. This book was released on 2015-05-19 with total page 433 pages. Available in PDF, EPUB and Kindle. Book excerpt: For more than 40 years, Scheuer’s Liver Biopsy Interpretation has been the pathologist’s go-to resource for help in solving diagnostic problems at the microscope. The 9th Edition brings you fully up to date in the field, with coverage of new diagnostic tools, new information on drug-induced liver injury and cytopathology, and many new high-quality illustrations. Throughout the text, you’ll find technical tips, diagnostic clues, and pearls that reflect the extensive experience and insight of the late Dr. Peter Scheuer and internationally renowned author Dr. Jay Lefkowitch, making this new edition your standard bench-side guide to today’s liver biopsy diagnosis. Avoid diagnostic errors with the extensive coverage of histological differential diagnoses in each chapter. Minimize reporting errors with practical advice on diagnostic pitfalls and how to avoid them. Clearly see how pathology impacts the diagnosis and management of liver disease thanks to histopathologic and clinical correlations throughout. Find terms and descriptions used frequently in pathology reports in the handy glossary – a useful quick reference for trainee pathologists and clinical hepatologists. Use the extensive online image bank to enhance your presentations and reports. Get up-to-date information on all aspects of liver pathology, including acute and chronic hepatitis, biliary tract diseases, childhood disorders and hepatic neoplasms. Stay current with the latest diagnostic tools: histopathology is correlated with clinically relevant molecular genetics and immunohistochemistry to keep you up to date.

Ferroptosis as New Therapeutic Targets in Cancer: from Molecular Mechanisms to Therapeutic Opportunities

Author : Xu Chen
Publisher : Frontiers Media SA
ISBN 13 : 2832504272
Total Pages : 223 pages
Book Rating : 4.8/5 (325 download)

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Book Synopsis Ferroptosis as New Therapeutic Targets in Cancer: from Molecular Mechanisms to Therapeutic Opportunities by : Xu Chen

Download or read book Ferroptosis as New Therapeutic Targets in Cancer: from Molecular Mechanisms to Therapeutic Opportunities written by Xu Chen and published by Frontiers Media SA. This book was released on 2022-11-08 with total page 223 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Ferroptosis in Stroke, Neurotrauma and Neurodegeneration

Author : Anwen Shao
Publisher : Frontiers Media SA
ISBN 13 : 2889746356
Total Pages : 224 pages
Book Rating : 4.8/5 (897 download)

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Book Synopsis Ferroptosis in Stroke, Neurotrauma and Neurodegeneration by : Anwen Shao

Download or read book Ferroptosis in Stroke, Neurotrauma and Neurodegeneration written by Anwen Shao and published by Frontiers Media SA. This book was released on 2022-03-09 with total page 224 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Nuclear Science Abstracts

Author :
Publisher :
ISBN 13 :
Total Pages : 1020 pages
Book Rating : 4.3/5 (555 download)

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Book Synopsis Nuclear Science Abstracts by :

Download or read book Nuclear Science Abstracts written by and published by . This book was released on 1971 with total page 1020 pages. Available in PDF, EPUB and Kindle. Book excerpt: NSA is a comprehensive collection of international nuclear science and technology literature for the period 1948 through 1976, pre-dating the prestigious INIS database, which began in 1970. NSA existed as a printed product (Volumes 1-33) initially, created by DOE's predecessor, the U.S. Atomic Energy Commission (AEC). NSA includes citations to scientific and technical reports from the AEC, the U.S. Energy Research and Development Administration and its contractors, plus other agencies and international organizations, universities, and industrial and research organizations. References to books, conference proceedings, papers, patents, dissertations, engineering drawings, and journal articles from worldwide sources are also included. Abstracts and full text are provided if available.