Read Books Online and Download eBooks, EPub, PDF, Mobi, Kindle, Text Full Free.
Download Investigation Of The Role Of Groove Hydration And Charged Nucleosides In Dna Charge Transfer full books in PDF, epub, and Kindle. Read online Investigation Of The Role Of Groove Hydration And Charged Nucleosides In Dna Charge Transfer ebook anywhere anytime directly on your device. Fast Download speed and no annoying ads. We cannot guarantee that every ebooks is available!
Author :
Publisher :
ISBN 13 :
Total Pages : 924 pages
Book Rating : 4.F/5 ( download)
Download or read book Dissertation Abstracts International written by and published by . This book was released on 2007 with total page 924 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Westhof
Publisher : CRC Press
ISBN 13 : 9780849375705
Total Pages : 492 pages
Book Rating : 4.3/5 (757 download)
Download or read book Water and Biological Macromolecules written by Westhof and published by CRC Press. This book was released on 1993-08-16 with total page 492 pages. Available in PDF, EPUB and Kindle. Book excerpt: Water and Biological Macromolecules presents an excellent description of the structural aspects of water molecules around biological macromolecules. Topics discussed include the properties of water in solid and liquid states; proteins, nucleic acids, polysaccharides, and lipids; and theoretical approaches for understanding the macroscopic observations and integrating microscopic descriptions. The nature and roles of hydration forces in macromolecular complexation and cell-cell interactions are explained, in addition to phenomena such as entropy-enthalpy compensation and the thermodynamic treatment of water bridging. Water and Biological Macromolecules will be a valuable reference for biophysicists, biochemists, and macromolecular biologists.
Author : Wolfram Saenger
Publisher : Springer Science & Business Media
ISBN 13 : 1461251907
Total Pages : 574 pages
Book Rating : 4.4/5 (612 download)
Download or read book Principles of Nucleic Acid Structure written by Wolfram Saenger and published by Springer Science & Business Media. This book was released on 2013-12-01 with total page 574 pages. Available in PDF, EPUB and Kindle. Book excerpt: New textbooks at all levels of chemistry appear with great regularity. Some fields like basic biochemistry, organic reaction mechanisms, and chemical ther modynamics are well represented by many excellent texts, and new or revised editions are published sufficiently often to keep up with progress in research. However, some areas of chemistry, especially many of those taught at the grad uate level, suffer from a real lack of up-to-date textbooks. The most serious needs occur in fields that are rapidly changing. Textbooks in these subjects usually have to be written by scientists actually involved in the research which is advancing the field. It is not often easy to persuade such individuals to set time aside to help spread the knowledge they have accumulated. Our goal, in this series, is to pinpoint areas of chemistry where recent progress has outpaced what is covered in any available textbooks, and then seek out and persuade experts in these fields to produce relatively concise but instructive introductions to their fields. These should serve the needs of one semester or one quarter graduate courses in chemistry and biochemistry. In some cases the availability of texts in active research areas should help stimulate the creation of new courses. CHARLES R. CANTOR New York Preface This monograph is based on a review on polynucleotide structures written for a book series in 1976.
Author : Paul J. Flory
Publisher : Cornell University Press
ISBN 13 : 9780801401343
Total Pages : 696 pages
Book Rating : 4.4/5 (13 download)
Download or read book Principles of Polymer Chemistry written by Paul J. Flory and published by Cornell University Press. This book was released on 1953 with total page 696 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Nicholas V Hud
Publisher : Royal Society of Chemistry
ISBN 13 : 1847558763
Total Pages : 448 pages
Book Rating : 4.8/5 (475 download)
Download or read book Nucleic Acid-Metal Ion Interactions written by Nicholas V Hud and published by Royal Society of Chemistry. This book was released on 2008-10-16 with total page 448 pages. Available in PDF, EPUB and Kindle. Book excerpt: Natural biochemical processes are routinely being discovered in living cells that involve RNA. Some of these processes, such as RNA interference, are now being exploited for biotechnology and medicinal applications. DNA has also proven in recent years to be more than a passive storehouse of information. For example, non-B-form DNA structures formed by G-rich DNA have been shown to participate in the regulation of gene expression, a discovery that presents new possibilities for drug targets in the genome. The current quest to understand how nucleic acid functions at the most fundamental level requires that we have a detailed understanding of nucleic acid-metal ion interactions. Because RNA and DNA are polyanions the structure and biological function of these biopolymers depends strongly on their association with metal ions. While this intimate connection between metal ions and nucleic function has been appreciated for decades, the noncovalent and dynamic nature of these interactions has continually presented challenges to the development of accurate and quantitative descriptions. Over the past few years the development of solution state spectroscopic techniques and the achievement of high resolution X-ray crystal structures have provided tremendous insights into the nature of nucleic acid-metal ion interactions, including direct evidence for their importance in determining nucleic acid structure, from the dictation of folding pathways followed by large RNA molecules to the subtle modulation of DNA groove widths. This new book provides a comprehensive review of the experimental studies that define our current understanding of nucleic acid-metal ion interactions with a particular emphasis being placed on experimental biophysical studies. However, the book is not merely a current review of the literature, as original material and fresh perspectives on published results are also presented. Particularly noteworthy topics include: -The chapter by Williams and fellow workers which reviews information provided by x-ray crystal structures and discusses what this information has revealed about the unique nature of Mg2+ interactions with RNA phosphate groups. The authors provide fresh insights, based upon structural comparisons, for how these interactions govern the local folding pathways of RNA. By dedicating separate chapters to the participation of metal ions in the kinetics and thermodynamics of RNA folding, this volume provides a more in depth treatise of both areas than is typically possible for reviews in which these two related, but distinct, topics are combined -Polyelectrolyte models of nucleic acids have proven to be extremely valuable for understanding the sequestering counterions in a so-called diffuse cloud around polymeric DNA. J. Michael Schurr provides a comprehensive review of polyanion models. Despite the success of polyelectrolyte models in describing some physical properties of nucleic acids, this topic is not always sufficiently understood by many researchers to make use of these models and this chapter serves as a valuable and up to date introduction to this topic. -The chapter by Pizarro and Sadler on metal ion-nucleic acid interactions in disease and medicine is complemented by a chapter by Lippert on coordinative bond formation between metal ions and nucleic acid bases. Together, these two chapters provide an overview of transition metal ion interactions with nucleic acids that illustrates the promise and peril that is associated with direct metal ion coordination to nucleic acid bases in living cells. The book is sufficiently detailed to serve as a reference source for researchers active in the field of nucleic acids biophysics and molecular biology. In addition, chapter authors have added introductory material and enough background material in each chapter so that the book can also can serve as an entry point for students and researchers that have not previously worked in the field which will make the book of lasting value and more accessible by a wider audience.
Author : Nancy C. Stellwagen
Publisher :
ISBN 13 :
Total Pages : 284 pages
Book Rating : 4.3/5 (91 download)
Download or read book Nucleic Acids written by Nancy C. Stellwagen and published by . This book was released on 2004 with total page 284 pages. Available in PDF, EPUB and Kindle. Book excerpt: Curvature and Deformation of Nucleic Acids: Recent Advances, New Paradigms presents an up-to-date review on the curvature and deformation of nucleic acids. Chapter 1 sets the various chapters in context, as well as describing several controversial topics. Chapter 2 gives a comprehensive review of the literature on DNA bending and describes the current status of molecular dynamics simulations of DNA and protein-DNA complexes. Chapter 3 describes the structural basis for A-tract DNA helix bending, based on recent NMR structures and other biophysical measurements. Chapter 4 describes the localization of Mg++ ions in the crystal structure of a B-form DNA dodecamer and discusses the relevance of these bound ions to sequence-dependent bending. Chapter 5 discusses the electrostatic energy penalties that result from phosphate crowding in curved DNA oligomers. Chapter 6 presents a quantitative model that predicts the magnitude of the bend caused by asymmetric charge neutralization of DNA phosphate residues. Chapter 7 reviews the structural and dynamic properties of four-way DNA junctions in the presence of metal ions, and it describes the exchange between alternative stacking conformers in solution. Chapter 8 documents the fact that a conserved pseudouridine residue in an RNA duplex containing a precursor messenger branch site makes an important contribution to the structure of the molecule. Chapter 9 describes structural perturbations that are observed in disease-related mutants of human mitochondrial transfer RNAs. Chapter 10 reviews the thermodynamics of the folding and unfolding of DNA oligomers distorted by the binding of small ligands. Chapter 11 describes a method of constructing DNA fragments for cyclization studies that uses single strand gaps as flexible hinges that allow the correct torsional orientation of the helix ends. Chapter 12 reviews a statistical mechanical model that predicts the stability of reconstituted nucleosomes based on sequence-dependent DNA curvature and flexibility.
Author :
Publisher :
ISBN 13 :
Total Pages : 1938 pages
Book Rating : 4.:/5 (319 download)
Download or read book Index Medicus written by and published by . This book was released on 2004 with total page 1938 pages. Available in PDF, EPUB and Kindle. Book excerpt: Vols. for 1963- include as pt. 2 of the Jan. issue: Medical subject headings.
Author : James D. Watson
Publisher : Knopf
ISBN 13 : 0307521486
Total Pages : 464 pages
Book Rating : 4.3/5 (75 download)
Download or read book DNA written by James D. Watson and published by Knopf. This book was released on 2009-01-21 with total page 464 pages. Available in PDF, EPUB and Kindle. Book excerpt: Fifty years ago, James D. Watson, then just twentyfour, helped launch the greatest ongoing scientific quest of our time. Now, with unique authority and sweeping vision, he gives us the first full account of the genetic revolution—from Mendel’s garden to the double helix to the sequencing of the human genome and beyond. Watson’s lively, panoramic narrative begins with the fanciful speculations of the ancients as to why “like begets like” before skipping ahead to 1866, when an Austrian monk named Gregor Mendel first deduced the basic laws of inheritance. But genetics as we recognize it today—with its capacity, both thrilling and sobering, to manipulate the very essence of living things—came into being only with the rise of molecular investigations culminating in the breakthrough discovery of the structure of DNA, for which Watson shared a Nobel prize in 1962. In the DNA molecule’s graceful curves was the key to a whole new science. Having shown that the secret of life is chemical, modern genetics has set mankind off on a journey unimaginable just a few decades ago. Watson provides the general reader with clear explanations of molecular processes and emerging technologies. He shows us how DNA continues to alter our understanding of human origins, and of our identities as groups and as individuals. And with the insight of one who has remained close to every advance in research since the double helix, he reveals how genetics has unleashed a wealth of possibilities to alter the human condition—from genetically modified foods to genetically modified babies—and transformed itself from a domain of pure research into one of big business as well. It is a sometimes topsy-turvy world full of great minds and great egos, driven by ambitions to improve the human condition as well as to improve investment portfolios, a world vividly captured in these pages. Facing a future of choices and social and ethical implications of which we dare not remain uninformed, we could have no better guide than James Watson, who leads us with the same bravura storytelling that made The Double Helix one of the most successful books on science ever published. Infused with a scientist’s awe at nature’s marvels and a humanist’s profound sympathies, DNA is destined to become the classic telling of the defining scientific saga of our age.
Author : Thomas A. Steitz
Publisher : CUP Archive
ISBN 13 : 9780521414890
Total Pages : 108 pages
Book Rating : 4.4/5 (148 download)
Download or read book Structural Studies of Protein-Nucleic Acid Interaction written by Thomas A. Steitz and published by CUP Archive. This book was released on 1993-09-16 with total page 108 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this 1993 text, Nobel Prize winner Professor Steitz reviews the wide-ranging research in structural studies of DNA-binding proteins and their complexes with DNA. The author clearly and concisely describes the uses of techniques in molecular genetics, DNA synthesis, protein crystallography and nuclear magnetic response.
Author : J.B. Chaires
Publisher : Elsevier
ISBN 13 : 0080526144
Total Pages : 257 pages
Book Rating : 4.0/5 (85 download)
Download or read book Advances in DNA Sequence-Specific Agents written by J.B. Chaires and published by Elsevier. This book was released on 1996-07-09 with total page 257 pages. Available in PDF, EPUB and Kindle. Book excerpt: DNA sequence specificity is a sub-specialty in the general area of molecular recognition. This area includes macromolecular-molecular interactions (e.g., protein-DNA), oligomer-DNA interacitons (e.g., triple strands), and ligand-DNA interactions (e.g., drug-DNA). It is this latter group of DNA sequence specificity interactions that is the subject of Volumes 1 and 2 of Advances in DNA Sequence Specific Agents. As was the case for Volume 1, Part A also covers methodology, but in Volume 2 we include calorimetric titrations, molecular modeling, X-ray crystallographic and NMR structural studies, and transcriptional assays. Part B also follows the same format as Volume 1 and describes the sequence specificities and covalent and noncovalent interactions of small ligands with DNA.This volume is aimed in general at scientists who have an interest in deciphering the molecular mechanisms for sequence recognition of DNA. The methods have general applicability to small molecules as well as oligomers and proteins, while the examples provide general principles involved in sequence recognition.
Author :
Publisher :
ISBN 13 :
Total Pages : 918 pages
Book Rating : 4.X/5 (6 download)
Download or read book Nucleic Acids Abstracts written by and published by . This book was released on 1997 with total page 918 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Fernando Langa De La Puente
Publisher : Royal Society of Chemistry
ISBN 13 : 1849732957
Total Pages : 651 pages
Book Rating : 4.8/5 (497 download)
Download or read book Fullerenes written by Fernando Langa De La Puente and published by Royal Society of Chemistry. This book was released on 2011-10-31 with total page 651 pages. Available in PDF, EPUB and Kindle. Book excerpt: The discovery of caged carbon structures, in 1985, established a whole new field of carbon chemistry. Unlike graphite and diamond, these structures known as fullerenes are finite in structure and are relevant to a wide variety of fields including supramolecular assemblies, nanostructures, optoelectronic devices and a whole range of biological activities. Fullerenes: Principles and Applications discusses all aspects of this exciting field. Sections include: the basic principles for the chemical reactivity of fullerenes, electrochemistry, light induced processes, fullerenes for material sciences, fullerenes and solar cells, biological applications and multifunctional carbon nanotube materials. Written by leading experts in the field the book summarises the basic principles of fullerene chemistry but also highlights some of the most remarkable advances that have occurred in recent years. Fullerenes: Principles and Applications will appeal to researchers in both academia and industry.
Author : S. N. Ananchenko
Publisher : Elsevier
ISBN 13 : 1483278832
Total Pages : 485 pages
Book Rating : 4.4/5 (832 download)
Download or read book Frontiers of Bioorganic Chemistry and Molecular Biology written by S. N. Ananchenko and published by Elsevier. This book was released on 2017-05-04 with total page 485 pages. Available in PDF, EPUB and Kindle. Book excerpt: Frontiers of Bioorganic Chemistry and Molecular Biology covers the proceedings of the International Symposium on Frontiers of Bioorganic Chemistry and Molecular Biology, held in Moscow and Tashkent, USSR on September 25-October 2, 1978. This symposium is devoted to a discussion of the physico-chemical basis of life processes. This book contains 56 chapters, and reflects the results in the study of peptides and proteins, nucleic acids, polysaccharides, and other biopolymers. Other chapters deal with the study of low molecular regulators, including steroids, alkaloids, and antibiotics. This book also includes discussion of the achievements in the study of genetic structures and of cellular protein synthesizing systems of the molecular basis of enzymic catalysis and of bioenergetic processes. This book will be of value to biochemists and molecular biologists.
Author : Leonid Gorb
Publisher : Springer
ISBN 13 : 9401792577
Total Pages : 556 pages
Book Rating : 4.4/5 (17 download)
Download or read book Application of Computational Techniques in Pharmacy and Medicine written by Leonid Gorb and published by Springer. This book was released on 2014-11-07 with total page 556 pages. Available in PDF, EPUB and Kindle. Book excerpt: The proposed volume provides both fundamental and detailed information about the computational and computational-experimental studies which improve our knowledge of how leaving matter functions, the different properties of drugs (including the calculation and the design of new ones), and the creation of completely new ways of treating numerical diseases. Whenever it is possible, the interplay between theory and experiment is provided. The book features computational techniques such as quantum-chemical and molecular dynamic approaches and quantitative structure–activity relationships. The initial chapters describe the state-of-the art research on the computational investigations in molecular biology, molecular pharmacy, and molecular medicine performed with the use of pure quantum-chemical techniques. The central part of the book illustrates the status of computational techniques that utilize hybrid, so called QM/MM approximations as well as the results of the QSAR studies which now are the most popular in predicting drugs’ efficiency. The last chapters describe combined computational and experimental investigations.
Author :
Publisher :
ISBN 13 :
Total Pages : 1484 pages
Book Rating : 4.:/5 (31 download)
Download or read book Cumulated Index Medicus written by and published by . This book was released on 1991 with total page 1484 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Stephen Neidle
Publisher : Oxford University Press on Demand
ISBN 13 : 0198500386
Total Pages : 662 pages
Book Rating : 4.1/5 (985 download)
Download or read book Oxford Handbook of Nucleic Acid Structure written by Stephen Neidle and published by Oxford University Press on Demand. This book was released on 1999 with total page 662 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Oxford Handbook of Nucleic Acid Structure is a comprehensive reference text on all aspects of nucleic acid sturcture. Particular emphasis is placed on the results from X-ray crystallography and NMR studies, with both methods being given equal weight. The nineteen chapters describe in detail the variety of DNA and RNA structural types discovered to date with all the major 'native' structures being represented. The text progresses systematically through the polymorphs of double helicalDNA through to the higher-order organizations of triplexes, quadruplexes, and junctions, then to RNA structures in their various degrees of complexity. Each chapter has been written by authorities in the field who have worked together to provide this comprehensive text on nucleic acid structure. The whole project has been brought together and edited by Professor Stephen Neidle who is Director of the CRC Biomolecular Structure Unit at the Institute of Cancer Research.
Author : Kazuhiko Nakatani
Publisher : Springer
ISBN 13 : 3319271113
Total Pages : 280 pages
Book Rating : 4.3/5 (192 download)
Download or read book Modified Nucleic Acids written by Kazuhiko Nakatani and published by Springer. This book was released on 2016-04-04 with total page 280 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book spans diverse aspects of modified nucleic acids, from chemical synthesis and spectroscopy to in vivo applications, and highlights studies on chemical modifications of the backbone and nucleobases. Topics discussed include fluorescent pyrimidine and purine analogs, enzymatic approaches to the preparation of modified nucleic acids, emission and electron paramagnetic resonance (EPR) spectroscopy for studying nucleic acid structure and dynamics, non-covalent binding of low- and high-MW ligands to nucleic acids and the design of unnatural base pairs. This unique book addresses new developments and is designed for graduate level and professional research purposes.
