Pain Management and the Opioid Epidemic

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Author :
Publisher : National Academies Press
ISBN 13 : 0309459575
Total Pages : 483 pages
Book Rating : 4.3/5 (94 download)

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Book Synopsis Pain Management and the Opioid Epidemic by : National Academies of Sciences, Engineering, and Medicine

Download or read book Pain Management and the Opioid Epidemic written by National Academies of Sciences, Engineering, and Medicine and published by National Academies Press. This book was released on 2017-09-28 with total page 483 pages. Available in PDF, EPUB and Kindle. Book excerpt: Drug overdose, driven largely by overdose related to the use of opioids, is now the leading cause of unintentional injury death in the United States. The ongoing opioid crisis lies at the intersection of two public health challenges: reducing the burden of suffering from pain and containing the rising toll of the harms that can arise from the use of opioid medications. Chronic pain and opioid use disorder both represent complex human conditions affecting millions of Americans and causing untold disability and loss of function. In the context of the growing opioid problem, the U.S. Food and Drug Administration (FDA) launched an Opioids Action Plan in early 2016. As part of this plan, the FDA asked the National Academies of Sciences, Engineering, and Medicine to convene a committee to update the state of the science on pain research, care, and education and to identify actions the FDA and others can take to respond to the opioid epidemic, with a particular focus on informing FDA's development of a formal method for incorporating individual and societal considerations into its risk-benefit framework for opioid approval and monitoring.

Cytokines and Pain

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Author :
Publisher : Springer Science & Business Media
ISBN 13 : 9783764358495
Total Pages : 248 pages
Book Rating : 4.3/5 (584 download)

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Book Synopsis Cytokines and Pain by : L.R. Watkins

Download or read book Cytokines and Pain written by L.R. Watkins and published by Springer Science & Business Media. This book was released on 1999 with total page 248 pages. Available in PDF, EPUB and Kindle. Book excerpt: The purpose of this book is to examine immune-to-brain communication from the viewpoint of its effect on pain processing, and to clarify the major role that substances released by immune cells play in pain modulation. In these chapters, contributed by major laboratories whose focus is understanding how cytokines modulate pain, the perspectives examined range from evolutionary approaches across diverse species, to the basics of the immune response, to the effect of cytokines on peripheral and central nervous system sites, to therapeutic potential in humans. -- book cover.

Translational Pain Research

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Author :
Publisher : CRC Press
ISBN 13 : 1439812101
Total Pages : 458 pages
Book Rating : 4.4/5 (398 download)

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Book Synopsis Translational Pain Research by : Lawrence Kruger

Download or read book Translational Pain Research written by Lawrence Kruger and published by CRC Press. This book was released on 2009-11-24 with total page 458 pages. Available in PDF, EPUB and Kindle. Book excerpt: One of the Most Rapidly Advancing Fields in Modern Neuroscience The success of molecular biology and the new tools derived from molecular genetics have revolutionized pain research and its translation to therapeutic effectiveness. Bringing together recent advances in modern neuroscience regarding genetic studies in mice and humans and the practical

Multiple Sclerosis

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Publisher :
ISBN 13 : 9780994438133
Total Pages : 137 pages
Book Rating : 4.4/5 (381 download)

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Book Synopsis Multiple Sclerosis by : Ian S. Zagon

Download or read book Multiple Sclerosis written by Ian S. Zagon and published by . This book was released on 2017 with total page 137 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Caring for Children Who Have Severe Neurological Impairment

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Author :
Publisher : JHU Press
ISBN 13 : 1421409380
Total Pages : 480 pages
Book Rating : 4.4/5 (214 download)

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Book Synopsis Caring for Children Who Have Severe Neurological Impairment by : Julie M. Hauer

Download or read book Caring for Children Who Have Severe Neurological Impairment written by Julie M. Hauer and published by JHU Press. This book was released on 2013-08-01 with total page 480 pages. Available in PDF, EPUB and Kindle. Book excerpt: Hauer offers hope and practical coping strategies in equal measure.

Neuroimmune Interactions in Pain

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Author :
Publisher : Springer Nature
ISBN 13 : 3031292316
Total Pages : 365 pages
Book Rating : 4.0/5 (312 download)

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Book Synopsis Neuroimmune Interactions in Pain by : Ru-Rong Ji

Download or read book Neuroimmune Interactions in Pain written by Ru-Rong Ji and published by Springer Nature. This book was released on 2023-05-05 with total page 365 pages. Available in PDF, EPUB and Kindle. Book excerpt: As lifespans increase, more people around the world find themselves victims of chronic pain. In spite of this, treatment options continue to be severely limited. Anti-inflammatory drugs can only do so much, while painkillers like opioids have led to crippling addictions and fatal overdoses. The subject of the book is the role of immune cells, including glial cells, and neuroimmune interactions in chronic pain. The book begins by examining the preclinical and clinical evidence supporting the involvement of non-neuronal cells in chronic pain. It discusses the interactions between non-neuronal cells and neurons in the regulation of chronic pain. It then presents the implications of these findings, including promising and emerging treatments such as specialized pro-resolving mediators (SPMs, such as resolvins and protectins), immune cell therapy, and complementary and alternative medicine, as well as neuromodulation and regenerative medicine, which may prove to be the turning point for hundreds of millions of patients world-wide who struggle to escape from the shadow of chronic pain. The book presents ground-breaking research that will alter current perspectives on chronic pain.

Neuroimaging of Pain

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Author :
Publisher : Springer
ISBN 13 : 3319480464
Total Pages : 509 pages
Book Rating : 4.3/5 (194 download)

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Book Synopsis Neuroimaging of Pain by : Luca Saba

Download or read book Neuroimaging of Pain written by Luca Saba and published by Springer. This book was released on 2017-06-08 with total page 509 pages. Available in PDF, EPUB and Kindle. Book excerpt: Authored by world renowned scientists, this book expertly reviews all the imaging techniques and exciting new methods for the analysis of the pain, including novel tracers, biomarker, metabolomic and gene-array profiling, together with cellular, genetic, and molecular approaches. Recent advances in human brain imaging techniques have allowed a better understand of the functional connectivity in pain pathways, as well as the functional and anatomical alterations that occur in chronic pain patients. Modern imaging techniques have permitted rapid progress in the understanding of networks in the brain related to pain processing and those related to different types of pain modulation. Neuroimaging of Pain is designed to be a valuable resource for radiologists, neuroradiologists, neurologists and neuroscientists, working in hospitals and universities from junior trainees to consultants.

Case Studies in Pain Management

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Author :
Publisher : Cambridge University Press
ISBN 13 : 1107682894
Total Pages : 547 pages
Book Rating : 4.1/5 (76 download)

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Book Synopsis Case Studies in Pain Management by : Alan David Kaye

Download or read book Case Studies in Pain Management written by Alan David Kaye and published by Cambridge University Press. This book was released on 2014-10-16 with total page 547 pages. Available in PDF, EPUB and Kindle. Book excerpt: Edited by internationally recognized pain experts, this book offers 73 clinically relevant cases, accompanied by discussion in a question-and-answer format.

Practical Management of Pain E-Book

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Author :
Publisher : Elsevier Health Sciences
ISBN 13 : 0323711022
Total Pages : 1520 pages
Book Rating : 4.3/5 (237 download)

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Book Synopsis Practical Management of Pain E-Book by : Honorio Benzon

Download or read book Practical Management of Pain E-Book written by Honorio Benzon and published by Elsevier Health Sciences. This book was released on 2022-02-10 with total page 1520 pages. Available in PDF, EPUB and Kindle. Book excerpt: For more than 30 years, Practical Management of Pain has offered expert guidance to both clinicians and trainees, covering every aspect of acute and chronic pain medicine for adult and pediatric patients. The fully revised 6th Edition brings you fully up to date with new developments in patient evaluation, diagnosis of pain syndromes, rationales for management, treatment modalities, and much more. Edited by a team of renowned pain clinicians led by Dr. Honorio Benzon, this authoritative reference is a comprehensive, practical resource for pain diagnosis and treatment using a variety of pharmacologic and physical modalities. - Presents a wealth of information in a clearly written, easily accessible manner, enabling you to effectively assess and draw up an optimal treatment plan for patients with acute or chronic pain. - Takes a practical, multidisciplinary approach, making key concepts and techniques easier to apply to everyday practice. - Shares the knowledge and expertise of global contributors on all facets of pain management, from general principles to specific management techniques. - Discusses the latest, best management techniques, including joint injections, ultrasound-guided therapies, and new pharmacologic agents such as topical analgesics. - Covers recent global developments regarding opioid induced hyperalgesia, neuromodulation and pain management, and identification of specific targets for molecular based pain. - Includes current information on the use of cannabinoids in pain management and related regulatory, professional, and legal considerations. - Includes the latest guidelines on facet injections and safety of contrast agents. - Provides new, evidence-based critical analysis on treatment modality outcomes and the latest information on chronic pain as a result of surgical interventions. - Enhanced eBook version included with purchase. Your enhanced eBook allows you to access all of the text, figures, and references from the book on a variety of devices.

Comorbidity of Mental and Physical Disorders

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Author :
Publisher : Karger Medical and Scientific Publishers
ISBN 13 : 3318026042
Total Pages : 202 pages
Book Rating : 4.3/5 (18 download)

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Book Synopsis Comorbidity of Mental and Physical Disorders by : N. Sartorius

Download or read book Comorbidity of Mental and Physical Disorders written by N. Sartorius and published by Karger Medical and Scientific Publishers. This book was released on 2014-11-26 with total page 202 pages. Available in PDF, EPUB and Kindle. Book excerpt: This publication presents evidence about the magnitude and severe consequences of comorbidity of mental and physical illnesses from a personal and societal perspective. Leading experts address the huge burden of co-morbidity to the affected individual as well as the public health aspects, the costs to society and interaction with factors stemming from the context of socioeconomic developments. The authors discuss the clinical challenge of managing cardiovascular illnesses, cancer, infectious diseases and other physical illness when they occur with a range of mental and behavioral disorders, including substance abuse, eating disorders and anxiety. Also covered are the organization of health services, the training of different categories of health personnel and the multidisciplinary engagement necessary to prevent and manage comorbidity effectively. The book is essential reading for general practitioners, internists, public health specialists, psychiatrists, cardiologists, oncologists, medical educationalists and other health care professionals.

Sickle Cell Pain

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Publisher : Lippincott Williams & Wilkins
ISBN 13 : 1496331834
Total Pages : 1004 pages
Book Rating : 4.4/5 (963 download)

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Book Synopsis Sickle Cell Pain by : Samir K. Ballas

Download or read book Sickle Cell Pain written by Samir K. Ballas and published by Lippincott Williams & Wilkins. This book was released on 2015-06-01 with total page 1004 pages. Available in PDF, EPUB and Kindle. Book excerpt: Sickle Cell Pain is a panoramic, in-depth exploration of every scientific, human, and social dimension of this cruel disease. This comprehensive, definitive work is unique in that it is the only book devoted to sickle cell pain, as opposed to general aspects of the disease. The 752-page book links sickle cell pain to basic, clinical, and translational research, addressing various aspects of sickle pain from molecular biology to the psychosocial aspects of the disease. Supplemented with patient narratives, case studies, and visual art, Sickle Cell Pain’s scientific rigor extends through its discussion of analgesic pharmacology, including abuse-deterrent formulations. The book also addresses in great detail inequities in access to care, stereotyping and stigmatization of patients, the implications of rapidly evolving models of care, and recent legislation and litigation and their consequences.

Neuropathic Pain

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Author :
Publisher : Oxford University Press
ISBN 13 : 0190298359
Total Pages : 337 pages
Book Rating : 4.1/5 (92 download)

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Book Synopsis Neuropathic Pain by : Jianguo Cheng

Download or read book Neuropathic Pain written by Jianguo Cheng and published by Oxford University Press. This book was released on 2019-01-21 with total page 337 pages. Available in PDF, EPUB and Kindle. Book excerpt: Neuropathic pain is one of the most common, most debilitating, most costly, and most difficult to treat categories of chronic pain conditions that are characterized by a lesion or disease of the somatosensory nervous system. Managing neuropathic pain is challenging and requires skillful assessment and comprehensive and integrated treatment strategies that are mechanism-guided, evidence-based, and individualized. However, these critical and integral elements are very fragmented in the current literature. The mechanistic understanding of neuropathic pain is typically found in basic research articles. Clinical research evidence is presented in forms of clinical trials with emphasis on minimizing biases such as those from patient selection and assessment. Individualized considerations for each patient are usually presented in case reports and problem-based learning discussions. This book overcomes these barriers and integrates all the critical elements around individual patient care into a coherent management strategy that is practical and applicable to daily clinical practice. Rather than compiling what have been published in the literature, this work emphasizes on identifying and highlighting the key points or findings that guide decision-making in clinical practice. It integrates the key points around a typical case scenario that not only represents the core of the diagnostic and therapeutic processes but also allows introduction and differentiation of painful conditions that bare similarities with the case in hand. The overarching goal is to improve clinical outcomes through better understanding of the mechanisms, more accurate diagnosis, and wiser and more comprehensive treatment strategies.

Pain Modulation

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Author :
Publisher : Elsevier Publishing Company
ISBN 13 : 9780444809841
Total Pages : 454 pages
Book Rating : 4.8/5 (98 download)

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Book Synopsis Pain Modulation by : Howard L. Fields

Download or read book Pain Modulation written by Howard L. Fields and published by Elsevier Publishing Company. This book was released on 1988-01-01 with total page 454 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume represents edited material that was presented at a conference on brainstem modulation of spinal nociception held in Beaune, France during July, 1987. Pain Modulation, Volume 77 in the series Progress in Brain Research reviews, analyses and suggests new research strategies on several relevant topics including: the endogenous opioid peptides; sites of action of opiates; the role of biogenic animes and non-opioid peptides in analgesia; dorsal horn circuitry; behavioural factors in the activation of pain modulating networks and clinical studies of nociceptive modulation.

Sigma Receptors: Their Role in Disease and as Therapeutic Targets

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Author :
Publisher : Springer
ISBN 13 : 3319501747
Total Pages : 311 pages
Book Rating : 4.3/5 (195 download)

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Book Synopsis Sigma Receptors: Their Role in Disease and as Therapeutic Targets by : Sylvia B. Smith

Download or read book Sigma Receptors: Their Role in Disease and as Therapeutic Targets written by Sylvia B. Smith and published by Springer. This book was released on 2017-03-16 with total page 311 pages. Available in PDF, EPUB and Kindle. Book excerpt: Originally confused with opioid receptors and then orphan receptors with no biological function, Sigma Receptors are now recognized as relevant to many degenerative diseases with remarkable potential as therapeutic targets. In this text, new information about the structure of sigma 1 receptor, its binding sites are provided as well as its expression in many cell types. It’s putative role in degenerative neuronal diseases including amyotrophic lateral sclerosis, Alzheimer’s disease, Parkinson’s disease, Huntington’s disease, pain, drug addiction and locomotor activity. Their roles in possible treatments for blinding retinal diseases emphasize the tremendous far-reaching potential for ligands for these receptors. Exciting breakthroughs in this dynamic field in the last decade are reported herein, which will guide future investigators in determining the full potential of this unique, yet abundantly expressed protein.

Frontiers in Clinical Drug Research - CNS and Neurological Disorders: Volume 10

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Author :
Publisher : Bentham Science Publishers
ISBN 13 : 9815040685
Total Pages : 362 pages
Book Rating : 4.8/5 (15 download)

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Book Synopsis Frontiers in Clinical Drug Research - CNS and Neurological Disorders: Volume 10 by : Atta-ur-Rahman

Download or read book Frontiers in Clinical Drug Research - CNS and Neurological Disorders: Volume 10 written by Atta-ur-Rahman and published by Bentham Science Publishers. This book was released on 2022-04-07 with total page 362 pages. Available in PDF, EPUB and Kindle. Book excerpt: Frontiers in Clinical Drug Research - CNS and Neurological Disorders is a book series that brings updated reviews to readers interested in advances in the development of pharmaceutical agents for the treatment of central nervous system (CNS) and other nerve disorders. The scope of the book series covers a range of topics including the medicinal chemistry, pharmacology, molecular biology and biochemistry of contemporary molecular targets involved in neurological and CNS disorders. Reviews presented in the series are mainly focused on clinical and therapeutic aspects of novel drugs intended for these targets. Frontiers in Clinical Drug Research - CNS and Neurological Disorders is a valuable resource for pharmaceutical scientists and postgraduate students seeking updated and critical information for developing clinical trials and devising research plans in the field of neurology. Volume 10 of the series continues to present novel information about new and interesting approaches to treat common neurological disorders, with a focus on neurodegeneration and pain medicine. The volume presents 7 detailed reviews in total. - Neurodegenerative disease: prevention and treatment through plant extracts therapy - Emerging novel approaches and recent advances in Parkinson’s disease treatment and diagnosis - Neurotrophic factors to combat neurodegeneration - Neural bases of executive function in ADHD children as assessed using FNIRS - Modulation of mesenchymal stem cells, glial cells and the immune system by oligodeoxynucleotides as a novel multi-target therapeutic approach against chronic pain - Chronic pain: focus on anticonvulsants - A review of the impact of testosterone on brain and aging-related decline in brain behavioural function

Relieving Pain in America

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Author :
Publisher : National Academies Press
ISBN 13 : 030921484X
Total Pages : 383 pages
Book Rating : 4.3/5 (92 download)

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Book Synopsis Relieving Pain in America by : Institute of Medicine

Download or read book Relieving Pain in America written by Institute of Medicine and published by National Academies Press. This book was released on 2011-10-26 with total page 383 pages. Available in PDF, EPUB and Kindle. Book excerpt: Chronic pain costs the nation up to $635 billion each year in medical treatment and lost productivity. The 2010 Patient Protection and Affordable Care Act required the Department of Health and Human Services (HHS) to enlist the Institute of Medicine (IOM) in examining pain as a public health problem. In this report, the IOM offers a blueprint for action in transforming prevention, care, education, and research, with the goal of providing relief for people with pain in America. To reach the vast multitude of people with various types of pain, the nation must adopt a population-level prevention and management strategy. The IOM recommends that HHS develop a comprehensive plan with specific goals, actions, and timeframes. Better data are needed to help shape efforts, especially on the groups of people currently underdiagnosed and undertreated, and the IOM encourages federal and state agencies and private organizations to accelerate the collection of data on pain incidence, prevalence, and treatments. Because pain varies from patient to patient, healthcare providers should increasingly aim at tailoring pain care to each person's experience, and self-management of pain should be promoted. In addition, because there are major gaps in knowledge about pain across health care and society alike, the IOM recommends that federal agencies and other stakeholders redesign education programs to bridge these gaps. Pain is a major driver for visits to physicians, a major reason for taking medications, a major cause of disability, and a key factor in quality of life and productivity. Given the burden of pain in human lives, dollars, and social consequences, relieving pain should be a national priority.

Chemotherapy-Induced Neuropathic Pain

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Author :
Publisher : CRC Press
ISBN 13 : 1439862192
Total Pages : 225 pages
Book Rating : 4.4/5 (398 download)

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Book Synopsis Chemotherapy-Induced Neuropathic Pain by : Robert B. Raffa

Download or read book Chemotherapy-Induced Neuropathic Pain written by Robert B. Raffa and published by CRC Press. This book was released on 2012-07-24 with total page 225 pages. Available in PDF, EPUB and Kindle. Book excerpt: There have been tremendous recent advances in the pharmacotherapy, dose regimens, and combinations used to treat cancer and for the treatment or prevention of the spread of disease. As a direct result of these advances, there are an increasing number of cancer survivors, although research dealing with chemotherapy-induced pain is still in its early